Landscape of B cell immunity and related immune evasion in human cancers
Tumor-infiltrating B cells are an important component in the microenvironment but have unclear anti-tumor effects. We enhanced our previous computational algorithm TRUST to extract the B cell immunoglobulin hypervariable regions from bulk tumor RNA-sequencing data. TRUST assembled more than 30 milli...
Saved in:
| Published in: | Nature genetics Vol. 51; no. 3; pp. 560 - 567 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
New York
Nature Publishing Group US
01.03.2019
Nature Publishing Group |
| Subjects: | |
| ISSN: | 1061-4036, 1546-1718, 1546-1718 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Tumor-infiltrating B cells are an important component in the microenvironment but have unclear anti-tumor effects. We enhanced our previous computational algorithm TRUST to extract the B cell immunoglobulin hypervariable regions from bulk tumor RNA-sequencing data. TRUST assembled more than 30 million complementarity-determining region 3 sequences of the B cell heavy chain (IgH) from The Cancer Genome Atlas. Widespread B cell clonal expansions and immunoglobulin subclass switch events were observed in diverse human cancers. Prevalent somatic copy number alterations in the
MICA
and
MICB
genes related to antibody-dependent cell-mediated cytotoxicity were identified in tumors with elevated B cell activity. The IgG3–1 subclass switch interacts with B cell–receptor affinity maturation and defects in the antibody-dependent cell-mediated cytotoxicity pathway. Comprehensive pancancer analyses of tumor-infiltrating B cell–receptor repertoires identified novel tumor immune evasion mechanisms through genetic alterations. The IgH sequences identified here are potentially useful resources for future development of immunotherapies.
This comprehensive pancancer analysis of RNA-sequencing data from bulk tumors defines the landscape of tumor-infiltrating B cell–receptor repertoires and highlights new mechanisms of tumor immune evasion through genetic alterations. |
|---|---|
| AbstractList | Tumor-infiltrating B cells are an important component in the microenvironment with unclear anti-tumor impacts. We enhanced our previous computational algorithm TRUST to extract the B cell immunoglobulin (Ig) hypervariable regions from bulk tumor RNA-seq data. TRUST assembled over 30 million complementarity-determining region 3 (CDR3s) of the B cell heavy chain (IgH) from The Cancer Genome Atlas (TCGA). Widespread B cell clonal expansions and Ig subclass switch events were observed in diverse human cancers. Prevalent somatic copy number alterations in MICA and MICB genes related to antibody-dependent cell mediated cytotoxicity (ADCC) were identified in tumors with elevated B cell activity. IgG3-1 subclass switch interacts with the B cell receptor affinity maturation and defects in the ADCC pathway. Comprehensive pan-cancer analyses of tumor-infiltrating B cell receptor repertoires identified novel tumor immune evasion mechanisms through genetic alterations. The IgH sequences identified here are potentially useful resources for future development of immunotherapies. This comprehensive pan-cancer analysis of RNA sequencing data from bulk tumors defines the landscape of tumor-infiltrating B cell receptor repertoires and highlights new mechanisms of tumor immune evasion through genetic alterations. Tumor-infiltrating B cells are an important component in the microenvironment but have unclear anti-tumor effects. We enhanced our previous computational algorithm TRUST to extract the B cell immunoglobulin hypervariable regions from bulk tumor RNA-sequencing data. TRUST assembled more than 30 million complementarity-determining region 3 sequences of the B cell heavy chain (IgH) from The Cancer Genome Atlas. Widespread B cell clonal expansions and immunoglobulin subclass switch events were observed in diverse human cancers. Prevalent somatic copy number alterations in the MICA and MICB genes related to antibody-dependent cell-mediated cytotoxicity were identified in tumors with elevated B cell activity. The IgG3–1 subclass switch interacts with B cell–receptor affinity maturation and defects in the antibody-dependent cell-mediated cytotoxicity pathway. Comprehensive pancancer analyses of tumor-infiltrating B cell–receptor repertoires identified novel tumor immune evasion mechanisms through genetic alterations. The IgH sequences identified here are potentially useful resources for future development of immunotherapies. This comprehensive pancancer analysis of RNA-sequencing data from bulk tumors defines the landscape of tumor-infiltrating B cell–receptor repertoires and highlights new mechanisms of tumor immune evasion through genetic alterations. Tumor-infiltrating B cells are an important component in the microenvironment but have unclear anti-tumor effects. We enhanced our previous computational algorithm TRUST to extract the B cell immunoglobulin hypervariable regions from bulk tumor RNA-sequencing data. TRUST assembled more than 30 million complementarity-determining region 3 sequences of the B cell heavy chain (IgH) from The Cancer Genome Atlas. Widespread B cell clonal expansions and immunoglobulin subclass switch events were observed in diverse human cancers. Prevalent somatic copy number alterations in the MICA and MICB genes related to antibody-dependent cell-mediated cytotoxicity were identified in tumors with elevated B cell activity. The IgG3-1 subclass switch interacts with B cell-receptor affinity maturation and defects in the antibody-dependent cell-mediated cytotoxicity pathway. Comprehensive pancancer analyses of tumor-infiltrating B cell-receptor repertoires identified novel tumor immune evasion mechanisms through genetic alterations. The IgH sequences identified here are potentially useful resources for future development of immunotherapies. Tumor-infiltrating B cells are an important component in the microenvironment but have unclear anti-tumor effects. We enhanced our previous computational algorithm TRUST to extract the B cell immunoglobulin hypervariable regions from bulk tumor RNA-sequencing data. TRUST assembled more than 30 million complementarity-determining region 3 sequences of the B cell heavy chain (IgH) from The Cancer Genome Atlas. Widespread B cell clonal expansions and immunoglobulin subclass switch events were observed in diverse human cancers. Prevalent somatic copy number alterations in the MICA and MICB genes related to antibody-dependent cell-mediated cytotoxicity were identified in tumors with elevated B cell activity. The IgG3-1 subclass switch interacts with B cell-receptor affinity maturation and defects in the antibody-dependent cell-mediated cytotoxicity pathway. Comprehensive pancancer analyses of tumor-infiltrating B cell-receptor repertoires identified novel tumor immune evasion mechanisms through genetic alterations. The IgH sequences identified here are potentially useful resources for future development of immunotherapies.Tumor-infiltrating B cells are an important component in the microenvironment but have unclear anti-tumor effects. We enhanced our previous computational algorithm TRUST to extract the B cell immunoglobulin hypervariable regions from bulk tumor RNA-sequencing data. TRUST assembled more than 30 million complementarity-determining region 3 sequences of the B cell heavy chain (IgH) from The Cancer Genome Atlas. Widespread B cell clonal expansions and immunoglobulin subclass switch events were observed in diverse human cancers. Prevalent somatic copy number alterations in the MICA and MICB genes related to antibody-dependent cell-mediated cytotoxicity were identified in tumors with elevated B cell activity. The IgG3-1 subclass switch interacts with B cell-receptor affinity maturation and defects in the antibody-dependent cell-mediated cytotoxicity pathway. Comprehensive pancancer analyses of tumor-infiltrating B cell-receptor repertoires identified novel tumor immune evasion mechanisms through genetic alterations. The IgH sequences identified here are potentially useful resources for future development of immunotherapies. Tumor-infiltrating B cells are an important component in the microenvironment but have unclear anti-tumor effects. We enhanced our previous computational algorithm TRUST to extract the B cell immunoglobulin hypervariable regions from bulk tumor RNA-sequencing data. TRUST assembled more than 30 million complementarity-determining region 3 sequences of the B cell heavy chain (IgH) from The Cancer Genome Atlas. Widespread B cell clonal expansions and immunoglobulin subclass switch events were observed in diverse human cancers. Prevalent somatic copy number alterations in the MICA and MICB genes related to antibody-dependent cell-mediated cytotoxicity were identified in tumors with elevated B cell activity. The IgG3-1 subclass switch interacts with B cell-receptor affinity maturation and defects in the antibody-dependent cell-mediated cytotoxicity pathway. Comprehensive pancancer analyses of tumor-infiltrating B cell-receptor repertoires identified novel tumor immune evasion mechanisms through genetic alterations. The IgH sequences identified here are potentially useful resources for future development of immunotherapies. This comprehensive pancancer analysis of RNA-sequencing data from bulk tumors defines the landscape of tumor-infiltrating B cell-receptor repertoires and highlights new mechanisms of tumor immune evasion through genetic alterations. |
| Audience | Academic |
| Author | Gu, Shengqing Zhang, Peng Liu, X. Shirley Wang, Binbin Zhang, Jian Hacohen, Nir Li, Taiwen Zhang, Fan Zhang, Jing Li, Bo Zheng, Xiaoqi Carroll, Michael C. Wucherpfennig, Kai W. Liu, Jun S. Ying, Xiaomin Jiang, Peng Wang, Jin Fu, Jingxin Fan, Jingyu Hu, Xihao |
| AuthorAffiliation | 1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA 8 Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA 7 Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA 4 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China 5 Department of Mathematics, Shanghai Normal University, Shanghai, China 3 Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China 9 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China 6 Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA 10 Statistics Department, Harvard University, Cambridg |
| AuthorAffiliation_xml | – name: 4 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China – name: 12 These authors contributed equally to this work – name: 5 Department of Mathematics, Shanghai Normal University, Shanghai, China – name: 2 Center of Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing, China – name: 9 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China – name: 8 Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA – name: 3 Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China – name: 6 Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA – name: 11 Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, Texas, USA – name: 10 Statistics Department, Harvard University, Cambridge, Massachusetts, USA – name: 1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA – name: 7 Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA |
| Author_xml | – sequence: 1 givenname: Xihao orcidid: 0000-0002-3517-6351 surname: Hu fullname: Hu, Xihao organization: Department of Data Sciences, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health – sequence: 2 givenname: Jian surname: Zhang fullname: Zhang, Jian organization: Center for Computational Biology, Beijing Institute of Basic Medical Sciences – sequence: 3 givenname: Jin surname: Wang fullname: Wang, Jin organization: Department of Data Sciences, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University – sequence: 4 givenname: Jingxin surname: Fu fullname: Fu, Jingxin organization: Department of Data Sciences, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University – sequence: 5 givenname: Taiwen surname: Li fullname: Li, Taiwen organization: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University – sequence: 6 givenname: Xiaoqi surname: Zheng fullname: Zheng, Xiaoqi organization: Department of Mathematics, Shanghai Normal University – sequence: 7 givenname: Binbin surname: Wang fullname: Wang, Binbin organization: Department of Data Sciences, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University – sequence: 8 givenname: Shengqing surname: Gu fullname: Gu, Shengqing organization: Department of Data Sciences, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health – sequence: 9 givenname: Peng surname: Jiang fullname: Jiang, Peng organization: Department of Data Sciences, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health – sequence: 10 givenname: Jingyu surname: Fan fullname: Fan, Jingyu organization: Department of Data Sciences, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University – sequence: 11 givenname: Xiaomin surname: Ying fullname: Ying, Xiaomin organization: Center for Computational Biology, Beijing Institute of Basic Medical Sciences – sequence: 12 givenname: Jing surname: Zhang fullname: Zhang, Jing organization: Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University – sequence: 13 givenname: Michael C. surname: Carroll fullname: Carroll, Michael C. organization: Program in Cellular and Molecular Medicine, Boston Children’s Hospital – sequence: 14 givenname: Kai W. surname: Wucherpfennig fullname: Wucherpfennig, Kai W. organization: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute – sequence: 15 givenname: Nir surname: Hacohen fullname: Hacohen, Nir organization: Massachusetts General Hospital Cancer Center, Harvard Medical School – sequence: 16 givenname: Fan surname: Zhang fullname: Zhang, Fan organization: Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine – sequence: 17 givenname: Peng surname: Zhang fullname: Zhang, Peng organization: Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine – sequence: 18 givenname: Jun S. orcidid: 0000-0002-4450-7239 surname: Liu fullname: Liu, Jun S. email: jliu@stat.harvard.edu organization: Department of Statistics, Harvard University – sequence: 19 givenname: Bo orcidid: 0000-0002-8617-900X surname: Li fullname: Li, Bo email: bo.li@utsouthwestern.edu organization: Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center – sequence: 20 givenname: X. Shirley orcidid: 0000-0003-4736-7339 surname: Liu fullname: Liu, X. Shirley email: xsliu@jimmy.harvard.edu organization: Department of Data Sciences, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Department of Statistics, Harvard University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30742113$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkt1r1TAYxoNM3If-Ad5IwBu96Eya5qM3wjbUDQ4M_LoNb9P0LKNNjkk7zv57U7o5z1CREFKS3_M0ed_nEO354C1CLyk5poSpd6miXKmC0DwZq4vtE3RAeSUKKqnay99E0KIiTOyjw5SuCaFVRdQztM-IrEpK2QE6X4Fvk4GNxaHDp9jYvsduGCbvxlucz3C0PYy2XTYttjeQXPDYeXw1DeCxAW9sTM_R0w76ZF_crUfo28cPX8_Oi9Xlp4uzk1VhhKRj0ZRVWwMwKSSQfGlVEymMhE6yhksOpOuEVLwG0thWiUblaYQpjSRAFeXsCL1ffDdTM9jWWD9G6PUmugHirQ7g9O6Jd1d6HW60kJKVssoGb-4MYvgx2TTqwaX52eBtmJIuqZKcVTUnGX39CL0OU_T5eTOlOGMllw_UGnqrne9C_q-ZTfUJl2LuUTlTx3-g8mjt4Ezua-fy_o7g7Y4gM6PdjmuYUtIXXz7_P3v5fZd99XsBf1XuPhMZkAtgYkgp2k4bN8KYm55v7HpNiZ7Tp5f06Zw-PadPb7OSPlLem_9LUy6alFm_tvGhxn8X_QTszeh1 |
| CitedBy_id | crossref_primary_10_1016_j_canlet_2023_216408 crossref_primary_10_1038_s41591_020_1006_1 crossref_primary_10_3389_fimmu_2023_1236514 crossref_primary_10_1016_j_drup_2024_101170 crossref_primary_10_1038_s41577_022_00719_y crossref_primary_10_1002_cti2_1409 crossref_primary_10_1007_s10552_019_01177_z crossref_primary_10_3389_fimmu_2023_1233085 crossref_primary_10_1186_s12967_022_03319_5 crossref_primary_10_1093_nar_gkaa407 crossref_primary_10_1093_nargab_lqac049 crossref_primary_10_1016_j_crmeth_2023_100601 crossref_primary_10_1186_s13073_019_0681_3 crossref_primary_10_1016_j_ccell_2024_12_006 crossref_primary_10_1172_JCI154945 crossref_primary_10_1093_bioadv_vbab021 crossref_primary_10_1053_j_gastro_2023_03_008 crossref_primary_10_1038_s41577_019_0257_x crossref_primary_10_1016_j_it_2024_12_006 crossref_primary_10_1186_s12967_023_04151_1 crossref_primary_10_3389_fmolb_2021_679031 crossref_primary_10_1186_s13073_022_01024_y crossref_primary_10_1016_j_virs_2022_02_010 crossref_primary_10_3389_fimmu_2023_1161417 crossref_primary_10_3389_fcell_2021_678127 crossref_primary_10_1186_s12943_021_01450_3 crossref_primary_10_1111_pin_13284 crossref_primary_10_1007_s11060_025_04989_z crossref_primary_10_1080_14737159_2019_1627877 crossref_primary_10_3389_fimmu_2023_1245514 crossref_primary_10_3389_fonc_2020_00512 crossref_primary_10_1158_0008_5472_CAN_20_3773 crossref_primary_10_3390_medicina59020187 crossref_primary_10_1016_j_coi_2024_102431 crossref_primary_10_3389_fonc_2023_960502 crossref_primary_10_1016_j_immuni_2022_02_009 crossref_primary_10_1016_j_smim_2022_101707 crossref_primary_10_1186_s12967_024_05206_7 crossref_primary_10_1186_s13073_023_01219_x crossref_primary_10_1016_j_smim_2021_101479 crossref_primary_10_1016_j_smim_2024_101874 crossref_primary_10_1038_s41388_021_01918_y crossref_primary_10_1111_cas_15596 crossref_primary_10_1158_0008_5472_CAN_24_2829 crossref_primary_10_7554_eLife_53839 crossref_primary_10_1016_j_intimp_2019_106003 crossref_primary_10_1007_s00432_020_03159_0 crossref_primary_10_1186_s40164_024_00564_w crossref_primary_10_1016_j_isci_2023_106140 crossref_primary_10_1038_s41586_019_1922_8 crossref_primary_10_1016_j_crmeth_2023_100670 crossref_primary_10_1007_s11596_019_2092_5 crossref_primary_10_1002_inmd_70048 crossref_primary_10_1136_jitc_2023_008318 crossref_primary_10_1080_2162402X_2021_1900635 crossref_primary_10_1016_j_smim_2024_101864 crossref_primary_10_1016_j_cellimm_2020_104219 crossref_primary_10_1038_s41596_023_00841_8 crossref_primary_10_1158_2159_8290_CD_21_0219 crossref_primary_10_1080_2162402X_2021_1959978 crossref_primary_10_1002_advs_202101672 crossref_primary_10_1158_1078_0432_CCR_21_1130 crossref_primary_10_1186_s12575_025_00286_1 crossref_primary_10_1002_btm2_10554 crossref_primary_10_3389_fimmu_2022_896627 crossref_primary_10_1093_bib_bbad354 crossref_primary_10_1111_cas_14834 crossref_primary_10_1080_08820139_2022_2092407 crossref_primary_10_1016_j_medj_2024_10_023 crossref_primary_10_3390_vaccines10060879 crossref_primary_10_1111_pcmr_13031 crossref_primary_10_3389_fimmu_2024_1413067 crossref_primary_10_3389_fimmu_2022_992266 crossref_primary_10_1016_j_isci_2023_108661 crossref_primary_10_1186_s40164_025_00689_6 crossref_primary_10_3389_fimmu_2022_876509 crossref_primary_10_1002_ctm2_253 crossref_primary_10_1093_nargab_lqae137 crossref_primary_10_3389_fimmu_2022_1006136 crossref_primary_10_1007_s10555_020_09944_0 crossref_primary_10_1136_jitc_2019_000394 crossref_primary_10_1007_s13238_020_00807_6 crossref_primary_10_1038_s41392_024_01955_5 crossref_primary_10_1080_22221751_2023_2245931 crossref_primary_10_3389_fimmu_2024_1342285 crossref_primary_10_1186_s13059_020_02064_6 crossref_primary_10_7554_eLife_89506 crossref_primary_10_1038_s41568_022_00466_1 crossref_primary_10_1111_1759_7714_13719 crossref_primary_10_1016_j_cell_2022_02_012 crossref_primary_10_1002_smtd_202000451 crossref_primary_10_1016_j_yexcr_2020_112003 crossref_primary_10_3389_fonc_2023_990551 crossref_primary_10_1080_10428194_2021_1966783 crossref_primary_10_1097_JCMA_0000000000000535 crossref_primary_10_1016_j_ccell_2023_02_017 crossref_primary_10_1038_s41467_021_21245_w crossref_primary_10_1038_s41576_019_0166_7 crossref_primary_10_7554_eLife_89506_4 crossref_primary_10_1038_s41467_023_40349_z crossref_primary_10_1038_s41592_021_01142_2 crossref_primary_10_1186_s12885_021_08790_9 crossref_primary_10_1186_s12916_022_02696_4 crossref_primary_10_3389_fimmu_2022_881427 crossref_primary_10_1186_s13059_020_02166_1 |
| Cites_doi | 10.1371/journal.pone.0006412 10.1016/j.cell.2017.01.014 10.1038/nri3795 10.1073/pnas.0603503103 10.1093/nar/gku1056 10.1016/j.jaci.2009.09.046 10.1084/jem.183.3.1161 10.1186/s13073-015-0243-2 10.1158/1078-0432.CCR-08-0133 10.1038/nri2206 10.1093/bioinformatics/btw526 10.1126/science.1203486 10.1007/s10549-016-3801-4 10.1101/gad.1161904 10.1146/annurev.immunol.26.021607.090248 10.1093/bioinformatics/btg412 10.1038/icb.2011.64 10.1126/science.1073924 10.1186/gb-2011-12-4-r41 10.1007/s10555-005-6192-2 10.1073/pnas.1503587112 10.1038/ng.3557 10.1073/pnas.1417683112 10.4161/onci.21650 10.1038/ng.3820 10.1038/onc.2008.267 10.1007/s00262-003-0409-4 10.1182/blood-2008-09-179754 10.1038/nbt.3344 10.1182/blood-2015-03-635169 10.3389/fimmu.2017.00389 10.4049/jimmunol.171.12.6891 10.1186/gb-2013-14-4-r36 10.1101/gad.200014.112 10.1038/nri1896 10.4161/2162402X.2014.985082 10.1371/journal.pone.0160853 10.1186/s13059-016-1028-7 10.1146/annurev.biochem.76.061705.090740 10.4049/jimmunol.1001323 10.1016/j.celrep.2017.07.016 10.1016/0167-4781(92)90134-L 10.1038/icb.2014.44 10.1038/ng.3581 10.4161/onci.20641 10.1038/gene.2016.45 10.1158/0008-5472.CAN-07-6768 10.1093/nar/gkq622 10.1056/NEJMoa1604958 10.1016/j.molimm.2004.07.034 10.1016/j.immuni.2018.03.023 10.1016/j.immuni.2016.06.014 10.4049/jimmunol.0903789 10.1093/nar/22.22.4673 10.1073/pnas.1608649113 10.1038/nri1199 10.1016/S1074-7613(00)00006-6 10.1186/1742-4682-11-30 10.1182/blood-2008-02-078071 10.1093/bioinformatics/btv494 |
| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer Nature America, Inc. 2019 COPYRIGHT 2019 Nature Publishing Group Copyright Nature Publishing Group Mar 2019 |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Nature America, Inc. 2019 – notice: COPYRIGHT 2019 Nature Publishing Group – notice: Copyright Nature Publishing Group Mar 2019 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7N M7P MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 5PM |
| DOI | 10.1038/s41588-018-0339-x |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep (ProQuest) AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Research Library Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Research Library Prep MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Agriculture Biology |
| EISSN | 1546-1718 |
| EndPage | 567 |
| ExternalDocumentID | PMC6773274 A576415827 30742113 10_1038_s41588_018_0339_x |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | China |
| GeographicLocations_xml | – name: China |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: U01 CA226196 – fundername: NCI NIH HHS grantid: U24 CA224316 – fundername: NCI NIH HHS grantid: U01 CA180980 |
| GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 29M 2FS 36B 39C 3O- 3V. 4.4 53G 5BI 5M7 5RE 5S5 70F 7X7 85S 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AAEEF AAHBH AARCD AAYOK AAYZH AAZLF ABAWZ ABCQX ABDBF ABDPE ABEFU ABJNI ABLJU ABOCM ABTAH ABUWG ACBWK ACGFO ACGFS ACIWK ACMJI ACNCT ACPRK ACUHS ADBBV ADFRT AENEX AEUYN AFBBN AFFNX AFKRA AFRAH AFSHS AGAYW AGCDD AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 DB5 DU5 DWQXO EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH GX1 HCIFZ HMCUK HVGLF HZ~ IAO IH2 IHR INH INR IOV ISR ITC L7B LGEZI LK8 LOTEE M0L M1P M2O M7P MVM N9A NADUK NNMJJ NXXTH ODYON P2P PKN PQQKQ PROAC PSQYO Q2X RIG RNS RNT RNTTT RVV SHXYY SIXXV SJN SNYQT SOJ SV3 TAOOD TBHMF TDRGL TN5 TSG TUS UKHRP VQA X7M XJT XOL Y6R YHZ ZGI ZXP ZY4 ~8M ~KM AAYXX ABFSG ACSTC AETEA AEZWR AFANA AFFHD AFHIU AGSTI AHWEU AIEIU AIXLP ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NFIDA NPM 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c671t-b24d9aa3767a003389076c7af73b575a0ff67859a0bed86b886bc6c2c70a18153 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 124 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000459947200023&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1061-4036 1546-1718 |
| IngestDate | Tue Nov 04 01:58:20 EST 2025 Thu Oct 02 05:16:09 EDT 2025 Fri Oct 03 11:11:03 EDT 2025 Sat Nov 29 13:06:17 EST 2025 Mon Nov 24 15:48:02 EST 2025 Wed Nov 26 10:24:47 EST 2025 Wed Nov 26 10:12:16 EST 2025 Mon Jul 21 05:13:55 EDT 2025 Sat Nov 29 03:07:10 EST 2025 Tue Nov 18 22:40:04 EST 2025 Fri Feb 21 02:39:08 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c671t-b24d9aa3767a003389076c7af73b575a0ff67859a0bed86b886bc6c2c70a18153 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 B.L. conceived this project, modified TRUST codes to assemble B cell CDR3 sequences, and analyzed TCGA data. X.H. and J.Z. accelerated the TRUST codes, performed the validation analyses, and tested the clustering method. J.W., J.Fu, and T.L. helped with figures and data analyses, and B.W. and J.Fan helped generate intermediate data. P.Z. provided tumor samples, and S.G., F.Z., and X.Z. performed the BCR-seq and RNA-seq validation experiments. P.J., X.Y., J.Z., M.C.C., K.W.W., and N.H. provided expertise in immune evasive mechanisms and data analysis. J.S.L. and X.S.L. supervised the study and wrote the manuscript with X.H. and B.L. All co-authors contributed to manuscript preparation and research progress discussion. xsliu@mail.dfci.harvard.edu; bo.li@utsouthwestern.edu; jliu@stat.harvard.edu Author contributions |
| ORCID | 0000-0002-4450-7239 0000-0002-3517-6351 0000-0002-8617-900X 0000-0003-4736-7339 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC6773274 |
| PMID | 30742113 |
| PQID | 2188533257 |
| PQPubID | 33429 |
| PageCount | 8 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6773274 proquest_miscellaneous_2187534950 proquest_journals_2188533257 gale_infotracmisc_A576415827 gale_infotracacademiconefile_A576415827 gale_incontextgauss_ISR_A576415827 gale_incontextgauss_IOV_A576415827 pubmed_primary_30742113 crossref_citationtrail_10_1038_s41588_018_0339_x crossref_primary_10_1038_s41588_018_0339_x springer_journals_10_1038_s41588_018_0339_x |
| PublicationCentury | 2000 |
| PublicationDate | 2019-03-01 |
| PublicationDateYYYYMMDD | 2019-03-01 |
| PublicationDate_xml | – month: 03 year: 2019 text: 2019-03-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States |
| PublicationTitle | Nature genetics |
| PublicationTitleAbbrev | Nat Genet |
| PublicationTitleAlternate | Nat Genet |
| PublicationYear | 2019 |
| Publisher | Nature Publishing Group US Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group US – name: Nature Publishing Group |
| References | Coronella-Wood, Hersh (CR9) 2003; 52 Xu, Davis (CR12) 2000; 13 Shukla (CR41) 2015; 33 Zaretsky (CR42) 2016; 375 Liu (CR20) 2017; 18 Kim (CR62) 2016; 48 Li (CR36) 2016; 17 Nelson (CR5) 2010; 185 Thorsson (CR1) 2018; 48 Gadala-Maria, Yaari, Uduman, Kleinstein (CR15) 2015; 112 Raulet (CR49) 2003; 3 Nielsen, Nelson (CR7) 2012; 1 Odegard, Schatz (CR33) 2006; 6 Waldhauer (CR48) 2008; 68 Milne (CR10) 2009; 4 LeBien, Tedder (CR34) 2008; 112 Jinushi, Hodi, Dranoff (CR53) 2006; 103 Schreiber, Old, Smyth (CR40) 2011; 331 Liu, Mardis (CR11) 2017; 168 Mose (CR19) 2016; 32 Bruhns (CR47) 2009; 113 Smyth (CR46) 2005; 42 Keim, Kazadi, Rothschild, Basu (CR30) 2013; 27 Raposo (CR3) 1996; 183 Wang (CR56) 2010; 38 Jackson, Wang, Collins (CR35) 2014; 92 Doubrovina (CR50) 2003; 171 Blachly (CR18) 2015; 112 Rogozin, Kolchanov (CR29) 1992; 1171 Mermel (CR57) 2011; 12 Paradis, Claude, Strimmer (CR61) 2004; 20 Katoh (CR22) 2017; 20 Waldhauer, Steinle (CR45) 2008; 27 Li (CR24) 2017; 49 Linnebacher, Maletzki (CR6) 2012; 1 Zhang, Basher, Wu (CR52) 2015; 6 Lefranc (CR26) 2015; 43 Liu, Atteridge, Wang, Lundgren, Wu (CR51) 2010; 184 Stavnezer, Guikema, Schrader (CR13) 2008; 26 Nimmerjahn, Ravetch (CR44) 2008; 8 Hagn (CR4) 2012; 90 Thompson, Higgins, Gibson (CR59) 1994; 22 William, Euler, Christensen, Shlomchik (CR38) 2002; 297 Iannello, Ahmad (CR43) 2005; 24 Lin (CR16) 2016; 113 Krishnamurty (CR31) 2016; 45 DeWitt (CR58) 2016; 11 Kim (CR55) 2013; 14 Nutt, Hodgkin, Tarlinton, Corcoran (CR2) 2015; 15 Shi (CR25) 2014; 11 Di Noia, Neuberger (CR28) 2007; 76 Geissler (CR37) 2015; 4 Hwang, Alt, Yeap (CR39) 2015; 3 Kitaura (CR32) 2017; 8 Tabuchi (CR54) 2016; 157 CR63 Yaari, Kleinstein (CR17) 2015; 7 Li (CR23) 2016; 48 Bodenhofer, Bonatesta, Horejs-Kainrath, Hochreiter (CR60) 2015; 31 Schroeder, Cavacini (CR27) 2010; 125 Al-Shibli (CR8) 2008; 14 Li, Woo, Iglesias-Ussel, Ronai, Scharff (CR14) 2004; 18 Kurtz (CR21) 2015; 125 Z Li (339_CR14) 2004; 18 SG Lin (339_CR16) 2016; 113 AT Krishnamurty (339_CR31) 2016; 45 K Geissler (339_CR37) 2015; 4 B Li (339_CR24) 2017; 49 C Keim (339_CR30) 2013; 27 ES Doubrovina (339_CR50) 2003; 171 JM Zaretsky (339_CR42) 2016; 375 JA Coronella-Wood (339_CR9) 2003; 52 MP Lefranc (339_CR26) 2015; 43 J Kim (339_CR62) 2016; 48 A Iannello (339_CR43) 2005; 24 CH Mermel (339_CR57) 2011; 12 B Li (339_CR36) 2016; 17 G Yaari (339_CR17) 2015; 7 LE Mose (339_CR19) 2016; 32 DH Raulet (339_CR49) 2003; 3 SL Nutt (339_CR2) 2015; 15 WS DeWitt (339_CR58) 2016; 11 M Linnebacher (339_CR6) 2012; 1 K Wang (339_CR56) 2010; 38 HW Schroeder Jr (339_CR27) 2010; 125 I Waldhauer (339_CR45) 2008; 27 K Milne (339_CR10) 2009; 4 JL Xu (339_CR12) 2000; 13 M Jinushi (339_CR53) 2006; 103 KI Al-Shibli (339_CR8) 2008; 14 E Paradis (339_CR61) 2004; 20 P Bruhns (339_CR47) 2009; 113 JS Nielsen (339_CR7) 2012; 1 339_CR63 JK Hwang (339_CR39) 2015; 3 F Nimmerjahn (339_CR44) 2008; 8 VH Odegard (339_CR33) 2006; 6 IB Rogozin (339_CR29) 1992; 1171 U Bodenhofer (339_CR60) 2015; 31 H Katoh (339_CR22) 2017; 20 K Kitaura (339_CR32) 2017; 8 I Waldhauer (339_CR48) 2008; 68 KJ Jackson (339_CR35) 2014; 92 TW LeBien (339_CR34) 2008; 112 M Hagn (339_CR4) 2012; 90 J William (339_CR38) 2002; 297 JS Blachly (339_CR18) 2015; 112 V Thorsson (339_CR1) 2018; 48 S Liu (339_CR20) 2017; 18 DM Kurtz (339_CR21) 2015; 125 G Liu (339_CR51) 2010; 184 BH Nelson (339_CR5) 2010; 185 J Stavnezer (339_CR13) 2008; 26 J Zhang (339_CR52) 2015; 6 RD Schreiber (339_CR40) 2011; 331 SA Shukla (339_CR41) 2015; 33 XS Liu (339_CR11) 2017; 168 D Gadala-Maria (339_CR15) 2015; 112 JD Thompson (339_CR59) 1994; 22 JM Noia Di (339_CR28) 2007; 76 MJ Smyth (339_CR46) 2005; 42 G Raposo (339_CR3) 1996; 183 B Li (339_CR23) 2016; 48 B Shi (339_CR25) 2014; 11 Y Tabuchi (339_CR54) 2016; 157 D Kim (339_CR55) 2013; 14 31101897 - Nat Genet. 2019 Jun;51(6):1068 |
| References_xml | – volume: 4 start-page: e6412 year: 2009 ident: CR10 article-title: Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors publication-title: PLoS ONE doi: 10.1371/journal.pone.0006412 – volume: 168 start-page: 600 year: 2017 end-page: 612 ident: CR11 article-title: Applications of immunogenomics to cancer publication-title: Cell doi: 10.1016/j.cell.2017.01.014 – volume: 15 start-page: 160 year: 2015 end-page: 171 ident: CR2 article-title: The generation of antibody-secreting plasma cells publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3795 – volume: 103 start-page: 9190 year: 2006 end-page: 9195 ident: CR53 article-title: Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0603503103 – volume: 43 start-page: D413 year: 2015 end-page: D422 ident: CR26 article-title: IMGT(R), the international ImMunoGeneTics information system(R) 25 years on publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1056 – volume: 125 start-page: S41 year: 2010 end-page: S52 ident: CR27 article-title: Structure and function of immunoglobulins publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2009.09.046 – volume: 183 start-page: 1161 year: 1996 end-page: 1172 ident: CR3 article-title: B lymphocytes secrete antigen-presenting vesicles publication-title: J. Exp. Med. doi: 10.1084/jem.183.3.1161 – volume: 7 year: 2015 ident: CR17 article-title: Practical guidelines for B-cell receptor repertoire sequencing analysis publication-title: Genome Med. doi: 10.1186/s13073-015-0243-2 – volume: 14 start-page: 5220 year: 2008 end-page: 5227 ident: CR8 article-title: Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-08-0133 – volume: 8 start-page: 34 year: 2008 end-page: 47 ident: CR44 article-title: Fcgamma receptors as regulators of immune responses publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2206 – volume: 32 start-page: 3729 year: 2016 end-page: 3734 ident: CR19 article-title: Assembly-based inference of B-cell receptor repertoires from short read RNA sequencing data with V’DJer publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw526 – volume: 331 start-page: 1565 year: 2011 end-page: 1570 ident: CR40 article-title: Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion publication-title: Science doi: 10.1126/science.1203486 – volume: 157 start-page: 55 year: 2016 end-page: 63 ident: CR54 article-title: Protective effect of naturally occurring anti-HER2 autoantibodies on breast cancer publication-title: Breast Cancer Res. Treat. doi: 10.1007/s10549-016-3801-4 – volume: 18 start-page: 1 year: 2004 end-page: 11 ident: CR14 article-title: The generation of antibody diversity through somatic hypermutation and class switch recombination publication-title: Genes Dev. doi: 10.1101/gad.1161904 – volume: 26 start-page: 261 year: 2008 end-page: 292 ident: CR13 article-title: Mechanism and regulation of class switch recombination publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.26.021607.090248 – volume: 6 start-page: 97 year: 2015 ident: CR52 article-title: NKG2D ligands in tumor immunity: two sides of a coin publication-title: Front. Immunol. – volume: 20 start-page: 289 year: 2004 end-page: 290 ident: CR61 article-title: APE: analyses of phylogenetics and evolution in R language publication-title: Bioinformatics doi: 10.1093/bioinformatics/btg412 – volume: 90 start-page: 457 year: 2012 end-page: 467 ident: CR4 article-title: Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help publication-title: Immunol. Cell Biol. doi: 10.1038/icb.2011.64 – volume: 297 start-page: 2066 year: 2002 end-page: 2070 ident: CR38 article-title: Evolution of autoantibody responses via somatic hypermutation outside of germinal centers publication-title: Science doi: 10.1126/science.1073924 – volume: 12 year: 2011 ident: CR57 article-title: GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers publication-title: Genome Biol. doi: 10.1186/gb-2011-12-4-r41 – volume: 24 start-page: 487 year: 2005 end-page: 499 ident: CR43 article-title: Role of antibody-dependent cell-mediated cytotoxicity in the efficacy of therapeutic anti-cancer monoclonal antibodies publication-title: Cancer Metastasis Rev. doi: 10.1007/s10555-005-6192-2 – volume: 112 start-page: 4322 year: 2015 end-page: 4327 ident: CR18 article-title: Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1503587112 – volume: 48 start-page: 600 year: 2016 end-page: 606 ident: CR62 article-title: Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors publication-title: Nat. Genet. doi: 10.1038/ng.3557 – volume: 112 start-page: E862 year: 2015 end-page: E870 ident: CR15 article-title: Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1417683112 – volume: 1 start-page: 1623 year: 2012 end-page: 1625 ident: CR7 article-title: Tumor-infiltrating B cells and T cells: working together to promote patient survival publication-title: Oncoimmunology doi: 10.4161/onci.21650 – volume: 49 start-page: 482 year: 2017 end-page: 483 ident: CR24 article-title: Ultrasensitive detection of TCR hypervariable region in solid-tissue RNA-seq data publication-title: Nat. Genet. doi: 10.1038/ng.3820 – volume: 27 start-page: 5932 year: 2008 end-page: 5943 ident: CR45 article-title: NK cells and cancer immunosurveillance publication-title: Oncogene doi: 10.1038/onc.2008.267 – volume: 52 start-page: 715 year: 2003 end-page: 738 ident: CR9 article-title: Naturally occurring B-cell responses to breast cancer publication-title: Cancer Immunol. Immunother. doi: 10.1007/s00262-003-0409-4 – volume: 113 start-page: 3716 year: 2009 end-page: 3725 ident: CR47 article-title: Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses publication-title: Blood doi: 10.1182/blood-2008-09-179754 – volume: 33 start-page: 1152 year: 2015 end-page: 1158 ident: CR41 article-title: Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3344 – volume: 125 start-page: 3679 year: 2015 end-page: 3687 ident: CR21 article-title: Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing publication-title: Blood doi: 10.1182/blood-2015-03-635169 – volume: 8 start-page: 389 year: 2017 ident: CR32 article-title: Different somatic hypermutation levels among antibody subclasses disclosed by a new next-generation sequencing-based antibody repertoire analysis publication-title: Front. Immunol. doi: 10.3389/fimmu.2017.00389 – volume: 171 start-page: 6891 year: 2003 end-page: 6899 ident: CR50 article-title: Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma publication-title: J. Immunol. doi: 10.4049/jimmunol.171.12.6891 – volume: 14 year: 2013 ident: CR55 article-title: TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions publication-title: Genome Biol. doi: 10.1186/gb-2013-14-4-r36 – volume: 27 start-page: 1 year: 2013 end-page: 17 ident: CR30 article-title: Regulation of AID, the B-cell genome mutator publication-title: Genes Dev. doi: 10.1101/gad.200014.112 – volume: 6 start-page: 573 year: 2006 end-page: 583 ident: CR33 article-title: Targeting of somatic hypermutation publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1896 – volume: 4 start-page: e985082 year: 2015 ident: CR37 article-title: Immune signature of tumor infiltrating immune cells in renal cancer publication-title: Oncoimmunology doi: 10.4161/2162402X.2014.985082 – volume: 11 start-page: e0160853 year: 2016 ident: CR58 article-title: A public database of memory and naive B-cell receptor sequences publication-title: PLoS ONE doi: 10.1371/journal.pone.0160853 – volume: 17 year: 2016 ident: CR36 article-title: Comprehensive analyses of tumor immunity: implications for cancer immunotherapy publication-title: Genome Biol. doi: 10.1186/s13059-016-1028-7 – volume: 76 start-page: 1 year: 2007 end-page: 22 ident: CR28 article-title: Molecular mechanisms of antibody somatic hypermutation publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.76.061705.090740 – volume: 185 start-page: 4977 year: 2010 end-page: 4982 ident: CR5 article-title: CD20 B cells: the other tumor-infiltrating lymphocytes publication-title: J. Immunol. doi: 10.4049/jimmunol.1001323 – volume: 20 start-page: 1073 year: 2017 end-page: 1087 ident: CR22 article-title: Immunogenetic profiling for gastric cancers identifies sulfated glycosaminoglycans as major and functional B cell antigens in human malignancies publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.07.016 – volume: 1171 start-page: 11 year: 1992 end-page: 18 ident: CR29 article-title: Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis publication-title: Biochim. Biophys. Acta doi: 10.1016/0167-4781(92)90134-L – volume: 92 start-page: 729 year: 2014 end-page: 733 ident: CR35 article-title: Human immunoglobulin classes and subclasses show variability in VDJ gene mutation levels publication-title: Immunol. Cell Biol. doi: 10.1038/icb.2014.44 – volume: 48 start-page: 725 year: 2016 end-page: 732 ident: CR23 article-title: Landscape of tumor-infiltrating T cell repertoire of human cancers publication-title: Nat. Genet. doi: 10.1038/ng.3581 – volume: 1 start-page: 1186 year: 2012 end-page: 1188 ident: CR6 article-title: Tumor-infiltrating B cells: the ignored players in tumor immunology publication-title: Oncoimmunology doi: 10.4161/onci.20641 – volume: 18 start-page: 22 year: 2017 end-page: 27 ident: CR20 article-title: Direct measurement of B-cell receptor repertoire’s composition and variation in systemic lupus erythematosus publication-title: Genes Immun. doi: 10.1038/gene.2016.45 – volume: 68 start-page: 6368 year: 2008 end-page: 6376 ident: CR48 article-title: Tumor-associated MICA is shed by ADAM proteases publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-6768 – ident: CR63 – volume: 38 start-page: e178 year: 2010 ident: CR56 article-title: MapSplice: accurate mapping of RNA-seq reads for splice junction discovery publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq622 – volume: 375 start-page: 819 year: 2016 end-page: 829 ident: CR42 article-title: Mutations associated with acquired resistance to PD-1 blockade in melanoma publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1604958 – volume: 42 start-page: 501 year: 2005 end-page: 510 ident: CR46 article-title: Activation of NK cell cytotoxicity publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2004.07.034 – volume: 48 start-page: 812 year: 2018 end-page: 830.e14 ident: CR1 article-title: The immune landscape of cancer publication-title: Immunity doi: 10.1016/j.immuni.2018.03.023 – volume: 31 start-page: 3997 year: 2015 end-page: 3999 ident: CR60 article-title: msa: an R package for multiple sequence alignment publication-title: Bioinformatics – volume: 45 start-page: 402 year: 2016 end-page: 414 ident: CR31 article-title: Somatically hypermutated -specific IgM(+) memory B cells are rapid, plastic, early responders upon malaria rechallenge publication-title: Immunity doi: 10.1016/j.immuni.2016.06.014 – volume: 184 start-page: 3346 year: 2010 end-page: 3350 ident: CR51 article-title: The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases publication-title: J. Immunol. doi: 10.4049/jimmunol.0903789 – volume: 22 start-page: 4673 year: 1994 end-page: 4680 ident: CR59 article-title: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice publication-title: Nucleic Acids Res. doi: 10.1093/nar/22.22.4673 – volume: 113 start-page: 7846 year: 2016 end-page: 7851 ident: CR16 article-title: Highly sensitive and unbiased approach for elucidating antibody repertoires publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1608649113 – volume: 3 start-page: 781 year: 2003 end-page: 790 ident: CR49 article-title: Roles of the NKG2D immunoreceptor and its ligands publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1199 – volume: 3 start-page: MDNA3-0037-2014 year: 2015 ident: CR39 article-title: Related mechanisms of antibody somatic hypermutation and class switch recombination publication-title: Microbiol. Spectr. – volume: 13 start-page: 37 year: 2000 end-page: 45 ident: CR12 article-title: Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities publication-title: Immunity doi: 10.1016/S1074-7613(00)00006-6 – volume: 11 year: 2014 ident: CR25 article-title: Comparative analysis of human and mouse immunoglobulin variable heavy regions from IMGT/LIGM-DB with IMGT/HighV-QUEST publication-title: Theor. Biol. Med. Model. doi: 10.1186/1742-4682-11-30 – volume: 112 start-page: 1570 year: 2008 end-page: 1580 ident: CR34 article-title: B lymphocytes: how they develop and function publication-title: Blood doi: 10.1182/blood-2008-02-078071 – volume: 113 start-page: 7846 year: 2016 ident: 339_CR16 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1608649113 – volume: 1171 start-page: 11 year: 1992 ident: 339_CR29 publication-title: Biochim. Biophys. Acta doi: 10.1016/0167-4781(92)90134-L – volume: 43 start-page: D413 year: 2015 ident: 339_CR26 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1056 – volume: 22 start-page: 4673 year: 1994 ident: 339_CR59 publication-title: Nucleic Acids Res. doi: 10.1093/nar/22.22.4673 – volume: 297 start-page: 2066 year: 2002 ident: 339_CR38 publication-title: Science doi: 10.1126/science.1073924 – volume: 13 start-page: 37 year: 2000 ident: 339_CR12 publication-title: Immunity doi: 10.1016/S1074-7613(00)00006-6 – volume: 3 start-page: MDNA3-0037-2014 year: 2015 ident: 339_CR39 publication-title: Microbiol. Spectr. – volume: 157 start-page: 55 year: 2016 ident: 339_CR54 publication-title: Breast Cancer Res. Treat. doi: 10.1007/s10549-016-3801-4 – volume: 27 start-page: 5932 year: 2008 ident: 339_CR45 publication-title: Oncogene doi: 10.1038/onc.2008.267 – volume: 24 start-page: 487 year: 2005 ident: 339_CR43 publication-title: Cancer Metastasis Rev. doi: 10.1007/s10555-005-6192-2 – volume: 18 start-page: 22 year: 2017 ident: 339_CR20 publication-title: Genes Immun. doi: 10.1038/gene.2016.45 – volume: 48 start-page: 600 year: 2016 ident: 339_CR62 publication-title: Nat. Genet. doi: 10.1038/ng.3557 – volume: 27 start-page: 1 year: 2013 ident: 339_CR30 publication-title: Genes Dev. doi: 10.1101/gad.200014.112 – volume: 42 start-page: 501 year: 2005 ident: 339_CR46 publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2004.07.034 – volume: 112 start-page: 4322 year: 2015 ident: 339_CR18 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1503587112 – volume: 92 start-page: 729 year: 2014 ident: 339_CR35 publication-title: Immunol. Cell Biol. doi: 10.1038/icb.2014.44 – volume: 375 start-page: 819 year: 2016 ident: 339_CR42 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1604958 – volume: 4 start-page: e985082 year: 2015 ident: 339_CR37 publication-title: Oncoimmunology doi: 10.4161/2162402X.2014.985082 – volume: 48 start-page: 725 year: 2016 ident: 339_CR23 publication-title: Nat. Genet. doi: 10.1038/ng.3581 – volume: 26 start-page: 261 year: 2008 ident: 339_CR13 publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.26.021607.090248 – volume: 15 start-page: 160 year: 2015 ident: 339_CR2 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3795 – volume: 20 start-page: 289 year: 2004 ident: 339_CR61 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btg412 – volume: 125 start-page: S41 year: 2010 ident: 339_CR27 publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2009.09.046 – volume: 14 year: 2013 ident: 339_CR55 publication-title: Genome Biol. doi: 10.1186/gb-2013-14-4-r36 – volume: 6 start-page: 573 year: 2006 ident: 339_CR33 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1896 – volume: 125 start-page: 3679 year: 2015 ident: 339_CR21 publication-title: Blood doi: 10.1182/blood-2015-03-635169 – volume: 38 start-page: e178 year: 2010 ident: 339_CR56 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq622 – volume: 18 start-page: 1 year: 2004 ident: 339_CR14 publication-title: Genes Dev. doi: 10.1101/gad.1161904 – volume: 112 start-page: 1570 year: 2008 ident: 339_CR34 publication-title: Blood doi: 10.1182/blood-2008-02-078071 – volume: 113 start-page: 3716 year: 2009 ident: 339_CR47 publication-title: Blood doi: 10.1182/blood-2008-09-179754 – volume: 12 year: 2011 ident: 339_CR57 publication-title: Genome Biol. doi: 10.1186/gb-2011-12-4-r41 – volume: 49 start-page: 482 year: 2017 ident: 339_CR24 publication-title: Nat. Genet. doi: 10.1038/ng.3820 – volume: 112 start-page: E862 year: 2015 ident: 339_CR15 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1417683112 – volume: 45 start-page: 402 year: 2016 ident: 339_CR31 publication-title: Immunity doi: 10.1016/j.immuni.2016.06.014 – volume: 3 start-page: 781 year: 2003 ident: 339_CR49 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1199 – volume: 48 start-page: 812 year: 2018 ident: 339_CR1 publication-title: Immunity doi: 10.1016/j.immuni.2018.03.023 – volume: 8 start-page: 34 year: 2008 ident: 339_CR44 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2206 – volume: 8 start-page: 389 year: 2017 ident: 339_CR32 publication-title: Front. Immunol. doi: 10.3389/fimmu.2017.00389 – volume: 4 start-page: e6412 year: 2009 ident: 339_CR10 publication-title: PLoS ONE doi: 10.1371/journal.pone.0006412 – volume: 11 year: 2014 ident: 339_CR25 publication-title: Theor. Biol. Med. Model. doi: 10.1186/1742-4682-11-30 – volume: 14 start-page: 5220 year: 2008 ident: 339_CR8 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-08-0133 – volume: 31 start-page: 3997 year: 2015 ident: 339_CR60 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv494 – volume: 52 start-page: 715 year: 2003 ident: 339_CR9 publication-title: Cancer Immunol. Immunother. doi: 10.1007/s00262-003-0409-4 – volume: 184 start-page: 3346 year: 2010 ident: 339_CR51 publication-title: J. Immunol. doi: 10.4049/jimmunol.0903789 – volume: 1 start-page: 1186 year: 2012 ident: 339_CR6 publication-title: Oncoimmunology doi: 10.4161/onci.20641 – volume: 331 start-page: 1565 year: 2011 ident: 339_CR40 publication-title: Science doi: 10.1126/science.1203486 – ident: 339_CR63 – volume: 185 start-page: 4977 year: 2010 ident: 339_CR5 publication-title: J. Immunol. doi: 10.4049/jimmunol.1001323 – volume: 68 start-page: 6368 year: 2008 ident: 339_CR48 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-6768 – volume: 7 year: 2015 ident: 339_CR17 publication-title: Genome Med. doi: 10.1186/s13073-015-0243-2 – volume: 168 start-page: 600 year: 2017 ident: 339_CR11 publication-title: Cell doi: 10.1016/j.cell.2017.01.014 – volume: 90 start-page: 457 year: 2012 ident: 339_CR4 publication-title: Immunol. Cell Biol. doi: 10.1038/icb.2011.64 – volume: 103 start-page: 9190 year: 2006 ident: 339_CR53 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0603503103 – volume: 32 start-page: 3729 year: 2016 ident: 339_CR19 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw526 – volume: 6 start-page: 97 year: 2015 ident: 339_CR52 publication-title: Front. Immunol. – volume: 171 start-page: 6891 year: 2003 ident: 339_CR50 publication-title: J. Immunol. doi: 10.4049/jimmunol.171.12.6891 – volume: 1 start-page: 1623 year: 2012 ident: 339_CR7 publication-title: Oncoimmunology doi: 10.4161/onci.21650 – volume: 17 year: 2016 ident: 339_CR36 publication-title: Genome Biol. doi: 10.1186/s13059-016-1028-7 – volume: 20 start-page: 1073 year: 2017 ident: 339_CR22 publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.07.016 – volume: 33 start-page: 1152 year: 2015 ident: 339_CR41 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3344 – volume: 183 start-page: 1161 year: 1996 ident: 339_CR3 publication-title: J. Exp. Med. doi: 10.1084/jem.183.3.1161 – volume: 76 start-page: 1 year: 2007 ident: 339_CR28 publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.76.061705.090740 – volume: 11 start-page: e0160853 year: 2016 ident: 339_CR58 publication-title: PLoS ONE doi: 10.1371/journal.pone.0160853 – reference: 31101897 - Nat Genet. 2019 Jun;51(6):1068 |
| SSID | ssj0014408 |
| Score | 2.5993729 |
| Snippet | Tumor-infiltrating B cells are an important component in the microenvironment but have unclear anti-tumor effects. We enhanced our previous computational... Tumor-infiltrating B cells are an important component in the microenvironment with unclear anti-tumor impacts. We enhanced our previous computational algorithm... |
| SourceID | pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 560 |
| SubjectTerms | 45/91 631/114/2164 631/114/794 631/250/580 631/67/327 631/67/580 Agriculture Algorithms Analysis Animal Genetics and Genomics Antibodies Antibody-dependent cell-mediated cytotoxicity Anticancer properties Antigens B cells B-Lymphocytes - immunology Base Sequence Bioinformatics Biomedical and Life Sciences Biomedicine Breast cancer Cancer Cancer genetics Cancer Research Care and treatment Cloning Complementarity Complementarity Determining Regions - immunology Complementarity-determining region Complementarity-determining region 3 Computer applications Copy number Cytotoxicity Gene Function Gene sequencing Genes Genomes Genomics Heavy chains Human Genetics Humans Immune evasion Immune Evasion - immunology Immunity Immunity (Disease) Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin Heavy Chains - immunology Immunoglobulin Variable Region - immunology Immunoglobulins Immunotherapy Ligands Lymphocytes B Major histocompatibility complex Medical schools Mutation Neoplasms - immunology Novels Performance evaluation Ribonucleic acid Risk factors RNA RNA sequencing Sequence Analysis, RNA - methods Somatic Hypermutation, Immunoglobulin - immunology Toxicity Tumors |
| Title | Landscape of B cell immunity and related immune evasion in human cancers |
| URI | https://link.springer.com/article/10.1038/s41588-018-0339-x https://www.ncbi.nlm.nih.gov/pubmed/30742113 https://www.proquest.com/docview/2188533257 https://www.proquest.com/docview/2187534950 https://pubmed.ncbi.nlm.nih.gov/PMC6773274 |
| Volume | 51 |
| WOSCitedRecordID | wos000459947200023&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1546-1718 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: M7P dateStart: 20000101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1546-1718 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: 7X7 dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1546-1718 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: BENPR dateStart: 20000101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1546-1718 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: 8C1 dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1546-1718 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: M2O dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR1da9sw8FjbDfay73Xe2qCNwWDD1JEcy34abWnpoEtDt5W8CVmW18Cwuzgp7b_fnfzROtC-7MEGWydj6U463TfAR55wmWdG-FoY7oc6yH2NfMYXKTd5GAmpXY2ls2M5HsfTaTJpFG5V41bZ7oluo85KQzryHWRFyFkEUtjXi78-VY0i62pTQmMNNihLAneue5POikDVlJ21MyI5SUStVVPEOxUyrpjcuCjATCT-VY8vre7Ot9jTquvkiv3UsaXDp_87oGfwpDmQst2agp7DA1u8gEd1icrrl3B0TLHA5CXFypztMVL0s5kLKllcM2xjLhrGZvVLy-ylJgUcmxXM1f9jhuhqXr2CX4cHP_eP_Kb6gm8iOVz4KQ-zRGvK9qKp4luMYnRkpM6lSPGMh1jNkdGNEh2kNoujNMbLRIYbGWg8NozEa1gvysK-AYZkYJNcjIRJwjALEy2wW2oD_Aae4FLuQdDOvTJNanKqkPFHORO5iFWNLoXoUoQudeXB567LRZ2X4z7gD4RQRfkuCnKo-a2XVaW-nZypXZS3CJzLu4B-nPaAPjVAeYl_aHQTxIDjpDxaPcitHiSuWtNvbqlCNbtGpW5IwoP3XTP1JE-4wpZLB4MSJoq1gQebNS12EyBI0TEcCg9kj0o7AMol3m8pZucup3gkpeAy9OBLS883v3XnvL69fxDv4DEu-6T22NuC9cV8abfhoblczKr5ANbkVLp7jPd4fziAjb2D8eQUn77zk4Fbyv8ANLFHWQ |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB5VBUQvvKGBAgaBkEBRs3YaJweEyqPaVZelglL1ZhzHgZVQUja7pfun-I3MOMmWrNTeeuCQSzyObGc84_E8PoBnPOEyz4zwtTDcD3WQ-xr1jC9SbvIwElI7jKWDoRyN4sPDZG8F_rS5MBRW2cpEJ6iz0tAd-SaqItQsAjnszdEvn1CjyLvaQmjUbLFr57_RZKteD97j_33O-c6H_Xd9v0EV8E0ke1M_5WGWaE1VTDQhmcVoHkZG6lyKFM8uONocBfhWooPUZnGUxviYyHAjA43qkFAiUORfwmME5y5UcG_htSD0ZuddjcguE1HrRRXxZoWKMqawMUpoE4l_0tGDy9rgH3W4HKq55K91anDn-v-2gDfgWnPgZtv1DrkJK7a4BVdqCM75begPKdeZosBYmbO3jBwZbOySZqZzhm3MZfvYrH5pmT3WdMHIxgVz-IbM0L6ZVHfg64VM4y6sFmVh14Ehm9skF1vCJGGYhYkW2C21AX4DT6gp9yBo_7UyTel1QgD5qVwIgIhVzR4K2UMRe6gTD14uuhzVdUfOI35KDKSonkdBAUPf9ayq1ODTgdpGe5LIuTyL6MvnDtGLhigvcYRGN0kaOE-qE9ah3OhQolQy3eaWC1UjFSt1yoIePFk0U0-K9CtsOXM0aEGj2R54cK_m_cUCCLrI6fWEB7KzKxYEVCu921KMf7ia6ZGUgsvQg1ft_jkd1pnrev_8STyGq_39j0M1HIx2H8Aairikjk7cgNXpZGYfwmVzPB1Xk0dOTDD4dtHb6i87K53N |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3LbtNAcFSVh3rhTTEUWBAICWTF2XW99gGhQokaNQoR0Kq3Zb1eQyTklDgpza_xdcys7RRHam89cMjFMxvtYx47Oy-AFzzhMs-M8LUw3A91kPsa9YwvUm7yMBJSux5LhwM5HMZHR8loDf40uTAUVtnIRCeos4mhN_IOqiLULAIprJPXYRGj3d67418-dZAiT2vTTqMikX27-I3mW_m2v4tn_ZLz3sevH_b8usOAbyLZnfkpD7NEa6pooqmrWYymYmSkzqVI8R6DM89RmG8nOkhtFkdpjD8TGW5koFE1UscIFP9XZBgFoQsbHC09GNTJ2XlaI7LRRNR4VEXcKVFpxhRCRsltIvFPWzpxVTP8oxpXwzZXfLdOJfZu_s-beQtu1BdxtlNxzm1Ys8UduFa15lzchb0B5UBTdBib5Ow9IwcHG7tkmtmCIYy5LCCbVR8tsyeaHh7ZuGCu7yEzxE_T8h4cXMoy7sN6MSnsA2BI_jbJxbYwSRhmYaIFDkttgP-BN9eUexA0565MXZKdOoP8VC40QMSqIhWFpKKIVNSpB6-XQ46reiQXIT8nYlJU56OgQ_6u52Wp-p8O1Q7amYTO5XlIXz63kF7VSPkEZ2h0nbyB66T6YS3MrRYmSivTBjcUqWppWaozcvTg2RJMIykCsLCTucNByxrN-cCDzYoPlhsg6IGn2xUeyBaHLBGohnobUox_uFrqkZSCy9CDNw0vnU3r3H19ePEinsJ15CY16A_3H8EGSr6kClrcgvXZdG4fw1VzMhuX0ydOYjD4dtlc9ReYr6aT |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Landscape+of+B+cell+immunity+and+related+immune+evasion+in+human+cancers&rft.jtitle=Nature+genetics&rft.au=Hu%2C+Xihao&rft.au=Zhang%2C+Jian&rft.au=Wang%2C+Jin&rft.au=Fu%2C+Jingxin&rft.date=2019-03-01&rft.issn=1546-1718&rft.eissn=1546-1718&rft.volume=51&rft.issue=3&rft.spage=560&rft_id=info:doi/10.1038%2Fs41588-018-0339-x&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1061-4036&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1061-4036&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1061-4036&client=summon |