Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with a 382-nucleotide deletion (∆382) in the open reading frame 8 (ORF8) region of the genome have been detected in Singapore and other countries. We investigated the effect of this deletion on the clinical features of infection....

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 396; no. 10251; pp. 603 - 611
Main Authors:	Young, Barnaby E, Fong, Siew-Wai, Chan, Yi-Hao, Mak, Tze-Minn, Ang, Li Wei, Anderson, Danielle E, Lee, Cheryl Yi-Pin, Amrun, Siti Naqiah, Lee, Bernett, Goh, Yun Shan, Su, Yvonne C F, Wei, Wycliffe E, Kalimuddin, Shirin, Chai, Louis Yi Ann, Pada, Surinder, Tan, Seow Yen, Sun, Louisa, Parthasarathy, Purnima, Chen, Yuan Yi Constance, Barkham, Timothy, Lin, Raymond Tzer Pin, Maurer-Stroh, Sebastian, Leo, Yee-Sin, Wang, Lin-Fa, Renia, Laurent, Lee, Vernon J, Smith, Gavin J D, Lye, David Chien, Ng, Lisa F P
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 29.08.2020 Elsevier Limited
Subjects:	Adult Aged Betacoronavirus Binding sites Clinical outcomes Cohort analysis Coronavirus Infections - complications Coronavirus Infections - epidemiology Coronavirus Infections - virology Coronaviruses COVID-19 Cytokines Disease transmission Electronic health records Electronic medical records Epidemics Gene Deletion Genome, Viral - genetics Genomes Glycoproteins Hospitals Humans Hypoxia Hypoxia - etiology Hypoxia - therapy Identification methods Infections Infectious diseases Inflammation Inflammatory response Medical research Middle Aged Nucleotides Observational studies Open Reading Frames Oxygen Pandemics Patients Pneumonia, Viral - complications Pneumonia, Viral - epidemiology Pneumonia, Viral - virology Prospective Studies Proteins Respiratory diseases Respiratory Therapy SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Singapore - epidemiology Vaccines Viral diseases Virus Replication Viruses Singapore Bangladesh Australia United States > US Taiwan Spain
ISSN:	0140-6736, 1474-547X, 1474-547X
Online Access:	Get full text
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