Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

We introduce an approach to identify disease-relevant tissues and cell types by analyzing gene expression data together with genome-wide association study (GWAS) summary statistics. Our approach uses stratified linkage disequilibrium (LD) score regression to test whether disease heritability is enri...

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Vydáno v:	Nature genetics Ročník 50; číslo 4; s. 621 - 629
Hlavní autoři:	Finucane, Hilary K., Reshef, Yakir A., Anttila, Verneri, Slowikowski, Kamil, Gusev, Alexander, Byrnes, Andrea, Gazal, Steven, Loh, Po-Ru, Lareau, Caleb, Shoresh, Noam, Genovese, Giulio, Saunders, Arpiar, Macosko, Evan, Pollack, Samuela, Perry, John R. B., Buenrostro, Jason D., Bernstein, Bradley E., Raychaudhuri, Soumya, McCarroll, Steven, Neale, Benjamin M., Price, Alkes L.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.04.2018 Nature Publishing Group
Témata:	631/114 631/208/199 631/208/205/2138 Agriculture Alzheimer's disease Analysis Animal Genetics and Genomics Annotations Biochemistry Biomedical and Life Sciences Biomedicine Bipolar disorder Bipolar Disorder - genetics Body Mass Index Body size Brain Brain - metabolism Cancer Research Chromatin - genetics Datasets Enrichment Epigenesis, Genetic Gene Expression Gene Expression Profiling - statistics & numerical data Gene Function Genes Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study - statistics & numerical data Genomes Genomics Heritability Human Genetics Humans Immune System Diseases - genetics Linkage Disequilibrium Mental disorders Metabolism Models, Genetic Multifactorial Inheritance Neurons Neurons - metabolism Polygenic inheritance Regression analysis Schizophrenia Schizophrenia - genetics Statistical analysis Statistical tests Statistics Tissue Distribution - genetics Tissues Tourette syndrome Type 2 diabetes
ISSN:	1061-4036, 1546-1718, 1546-1718
On-line přístup:	Získat plný text
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