Genomic subtyping and therapeutic targeting of acute erythroleukemia

Acute erythroid leukemia (AEL) is a high-risk leukemia of poorly understood genetic basis, with controversy regarding diagnosis in the spectrum of myelodysplasia and myeloid leukemia. We compared genomic features of 159 childhood and adult AEL cases with non-AEL myeloid disorders and defined five ag...

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Bibliographic Details
Published in:	Nature genetics Vol. 51; no. 4; pp. 694 - 704
Main Authors:	Iacobucci, Ilaria, Wen, Ji, Meggendorfer, Manja, Choi, John K., Shi, Lei, Pounds, Stanley B., Carmichael, Catherine L., Masih, Katherine E., Morris, Sarah M., Lindsley, R. Coleman, Janke, Laura J., Alexander, Thomas B., Song, Guangchun, Qu, Chunxu, Li, Yongjin, Payne-Turner, Debbie, Tomizawa, Daisuke, Kiyokawa, Nobutaka, Valentine, Marcus, Valentine, Virginia, Basso, Giuseppe, Locatelli, Franco, Enemark, Eric J., Kham, Shirley K. Y., Yeoh, Allen E. J., Ma, Xiaotu, Zhou, Xin, Sioson, Edgar, Rusch, Michael, Ries, Rhonda E., Stieglitz, Elliot, Hunger, Stephen P., Wei, Andrew H., To, L Bik, Lewis, Ian D., D’Andrea, Richard J., Kile, Benjamin T., Brown, Anna L., Scott, Hamish S., Hahn, Christopher N., Marlton, Paula, Pei, Deqing, Cheng, Cheng, Loh, Mignon L., Ebert, Benjamin L., Meshinchi, Soheil, Haferlach, Torsten, Mullighan, Charles G.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.04.2019 Nature Publishing Group
Subjects:	631/67/1990/283 631/67/1990/283/1897 Acute leukemia Adolescent Adult Adults Age Agriculture Animal Genetics and Genomics Bioinformatics Biomedical and Life Sciences Biomedicine Bone marrow Cancer genetics Cancer Research Cancer therapies Care and treatment Cell cycle Child Child, Preschool Children Classification Deoxyribonucleic acid Diagnosis DNA DNA methylation Epigenetics Erythroleukemia Female fms-Like Tyrosine Kinase 3 - genetics Gene Function Genes Genetic aspects Genomes Genomics Genomics - methods Homeodomain Proteins - genetics Human Genetics Humans Infant Infant, Newborn Leukemia Leukemia, Erythroblastic, Acute - genetics Leukemogenesis Male Medical prognosis Medical schools Mutation Mutation - genetics Myelodysplastic syndrome Myeloid leukemia Myeloid-Lymphoid Leukemia Protein - genetics Nuclear Proteins - genetics Nucleophosmin p53 Protein Pediatrics Prognosis Risk Subgroups Therapeutic targets Transcription Tumor proteins Tumor Suppressor Protein p53 - genetics Tumors Young Adult
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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