Correlation between tumor measurement on Computed Tomography and resected specimen size in lung adenocarcinomas

To compare preoperative size of stage I and stage II lung adenocarcinoma as measured by Computed Tomography (CT) and as assessed on gross pathology specimens. 47 patients diagnosed with stage I or II lung adenocarcinoma were evaluated. Institutional Review Board permission was obtained. Tumor contou...

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Vydané v:Lung cancer (Amsterdam, Netherlands) Ročník 75; číslo 3; s. 332 - 335
Hlavní autori: Lampen-Sachar, Katharine, Zhao, Binsheng, Zheng, Junting, Moskowitz, Chaya S., Schwartz, Lawrence H., Zakowski, Maureen F., Rizvi, Naiyer A., Kris, Mark G., Ginsberg, Michelle S.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Oxford Elsevier Ireland Ltd 01.03.2012
Elsevier
Predmet:
Adenocarcinoma - diagnostic imaging
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adenocarcinoma of Lung
Algorithms
Biological and medical sciences
Computed Tomography
Hematology, Oncology and Palliative Medicine
Humans
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Medical sciences
Neoplasm Staging
Non-small cell lung cancer
Pathology measurement
Pneumology
Pulmonary/Respiratory
Staging
T descriptor
Tomography, X-Ray Computed
Tumors
Tumors of the respiratory system and mediastinum
Computed Tomography
Staging
Lung cancer
T descriptor
Non-small cell lung cancer
Pathology measurement
Lung disease
Correlation
Radiodiagnosis
Respiratory disease
Size
Malignant tumor
Bronchopulmonary adenocarcinoma
non-small cell lung carcinoma
Anatomic pathology
Cancerology
Medical imagery
Bronchus disease
Descriptor
Computerized axial tomography
Cancer
Pneumology
ISSN:0169-5002, 1872-8332, 1872-8332
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Popis
Shrnutí:To compare preoperative size of stage I and stage II lung adenocarcinoma as measured by Computed Tomography (CT) and as assessed on gross pathology specimens. 47 patients diagnosed with stage I or II lung adenocarcinoma were evaluated. Institutional Review Board permission was obtained. Tumor contours were delineated using a semi-automated segmentation algorithm and adjusted based on a radiologist's input. Based on the tumor perimeter, maximal in-plane tumor diameter was calculated automatically. The largest single diameter from the pathology gross report was utilized. A paired t-test was used to examine the measurement difference between CT and pathology. The mean largest diameter of the tumors at CT and pathology was 29.53mm and 24.04mm, respectively. There was a statistically significant difference between the mean CT measurement and mean pathology measurement of 5.49mm (standard deviation 9.08mm, p<0.001). The percent relative difference between the two measurements was 18.3% (standard deviation 28.2%). There is a statistically significant difference between the tumor diameter as measured by CT and on pathology gross specimen. These differences could have implications in the treatment and prognosis of patients with early stage lung adenocarcinoma.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0169-5002
1872-8332
1872-8332
DOI:10.1016/j.lungcan.2011.08.001