Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

We investigated relations between amyloid-β (Aβ) status, apolipoprotein E (APOE) ε4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau). We included 770 individuals with normal cognition, mild cognitive impairment, and Alzhei...

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Veröffentlicht in:	Alzheimer's & dementia Jg. 15; H. 5; S. 644
Hauptverfasser:	Bos, Isabelle, Vos, Stephanie, Verhey, Frans, Scheltens, Philip, Teunissen, Charlotte, Engelborghs, Sebastiaan, Sleegers, Kristel, Frisoni, Giovanni, Blin, Olivier, Richardson, Jill C, Bordet, Régis, Tsolaki, Magda, Popp, Julius, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Lleó, Alberto, Johannsen, Peter, Freund-Levi, Yvonne, Frölich, Lutz, Vandenberghe, Rik, Westwood, Sarah, Dobricic, Valerija, Barkhof, Frederik, Legido-Quigley, Cristina, Bertram, Lars, Lovestone, Simon, Streffer, Johannes, Andreasson, Ulf, Blennow, Kaj, Zetterberg, Henrik, Visser, Pieter Jelle
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.05.2019
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - physiopathology Amyloid beta-Peptides Apolipoprotein E4 - genetics Biomarkers - cerebrospinal fluid Cognitive Dysfunction - cerebrospinal fluid Cognitive Dysfunction - physiopathology Female Humans Neurofilament Proteins - cerebrospinal fluid Neurogranin - cerebrospinal fluid tau Proteins - cerebrospinal fluid Neurogranin Neurofilament light Cognition APOE Amyloid-β Cerebrospinal fluid YKL-40 Alzheimer's disease
ISSN:	1552-5279, 1552-5279
Online-Zugang:	Weitere Angaben
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