Canine H3N8 influenza vaccines partially protect mice against the canine H3N2 strain currently circulating in the United States
•Canine H3N8 vaccines elicit antibodies that react strongly to canine H3N2 viruses.•Abs elicited by canine H3N8 vaccines bind to the HA stalk region of canine H3N2.•Canine H3N8 vaccines partially protect mice against canine H3N2 infection. Influenza A viruses infect many species and cross-species tr...
Gespeichert in:
| Veröffentlicht in: | Vaccine Jg. 34; H. 46; S. 5483 - 5487 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Netherlands
Elsevier Ltd
04.11.2016
Elsevier Limited |
| Schlagworte: | |
| ISSN: | 0264-410X, 1873-2518 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | •Canine H3N8 vaccines elicit antibodies that react strongly to canine H3N2 viruses.•Abs elicited by canine H3N8 vaccines bind to the HA stalk region of canine H3N2.•Canine H3N8 vaccines partially protect mice against canine H3N2 infection.
Influenza A viruses infect many species and cross-species transmission occurs occasionally. An equine H3N8 influenza virus began circulating in dogs in 1999 and an avian H3N2 influenza virus began circulating in dogs in 2006. The canine H3N8 (cH3N8) viral strain has become endemic in parts of the United States and there is a commercially available vaccine against this strain. The canine H3N2 (cH3N2) strain did not circulate widely in the United States until 2015. Here, we used a mouse model to determine if the cH3N8 and cH3N2 strains are antigenically related and if a commercially available cH3N8 vaccine protects animals against the cH3N2 outbreak strain. We find that the cH3N8 vaccine elicits antibodies that react to internal viral proteins and the hemagglutinin stalk region of cH3N2 viruses. These antibodies do not provide sterilizing immunity against cH3N2 infection, but these antibodies limit cH3N2 replication in the lung. |
|---|---|
| AbstractList | Highlights • Canine H3N8 vaccines elicit antibodies that react strongly to canine H3N2 viruses. • Abs elicited by canine H3N8 vaccines bind to the HA stalk region of canine H3N2. • Canine H3N8 vaccines partially protect mice against canine H3N2 infection. Influenza A viruses infect many species and cross-species transmission occurs occasionally. An equine H3N8 influenza virus began circulating in dogs in 1999 and an avian H3N2 influenza virus began circulating in dogs in 2006. The canine H3N8 (cH3N8) viral strain has become endemic in parts of the United States and there is a commercially available vaccine against this strain. The canine H3N2 (cH3N2) strain did not circulate widely in the United States until 2015. Here, we used a mouse model to determine if the cH3N8 and cH3N2 strains are antigenically related and if a commercially available cH3N8 vaccine protects animals against the cH3N2 outbreak strain. We find that the cH3N8 vaccine elicits antibodies that react to internal viral proteins and the hemagglutinin stalk region of cH3N2 viruses. These antibodies do not provide sterilizing immunity against cH3N2 infection, but these antibodies limit cH3N2 replication in the lung. •Canine H3N8 vaccines elicit antibodies that react strongly to canine H3N2 viruses.•Abs elicited by canine H3N8 vaccines bind to the HA stalk region of canine H3N2.•Canine H3N8 vaccines partially protect mice against canine H3N2 infection. Influenza A viruses infect many species and cross-species transmission occurs occasionally. An equine H3N8 influenza virus began circulating in dogs in 1999 and an avian H3N2 influenza virus began circulating in dogs in 2006. The canine H3N8 (cH3N8) viral strain has become endemic in parts of the United States and there is a commercially available vaccine against this strain. The canine H3N2 (cH3N2) strain did not circulate widely in the United States until 2015. Here, we used a mouse model to determine if the cH3N8 and cH3N2 strains are antigenically related and if a commercially available cH3N8 vaccine protects animals against the cH3N2 outbreak strain. We find that the cH3N8 vaccine elicits antibodies that react to internal viral proteins and the hemagglutinin stalk region of cH3N2 viruses. These antibodies do not provide sterilizing immunity against cH3N2 infection, but these antibodies limit cH3N2 replication in the lung. |
| Author | Krammer, Florian Willis, Elinor Hensley, Scott E. Parkhouse, Kaela |
| AuthorAffiliation | 4 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA 2 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 1 Wistar Institute, Philadelphia, PA 19104, USA 3 School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA |
| AuthorAffiliation_xml | – name: 2 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA – name: 1 Wistar Institute, Philadelphia, PA 19104, USA – name: 4 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA – name: 3 School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA |
| Author_xml | – sequence: 1 givenname: Elinor surname: Willis fullname: Willis, Elinor organization: Wistar Institute, Philadelphia, PA 19104, USA – sequence: 2 givenname: Kaela surname: Parkhouse fullname: Parkhouse, Kaela organization: Wistar Institute, Philadelphia, PA 19104, USA – sequence: 3 givenname: Florian surname: Krammer fullname: Krammer, Florian organization: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA – sequence: 4 givenname: Scott E. surname: Hensley fullname: Hensley, Scott E. email: hensley@mail.med.upenn.edu organization: Wistar Institute, Philadelphia, PA 19104, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27670073$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkl2LEzEUhoOsuB_6E5SAN9605mMyySCuSFFXWPRiXfAupJnTbmqaqUmmUG_862Zsd9WCdK9CyHuenPOe9xQdhS4AQk8pGVNC65eL8dpY6wKMWbmOSTMmVD5AJ1RJPmKCqiN0QlhdjSpKvh6j05QWhBDBafMIHTNZS0IkP0E_JyYUCL7gnxR2YeZ7CD8M3rETXpmYnfF-g1exy2AzXjoL2MyNCynjfAPY3hEYTjmWB2z7GCHkUmVdtL032YV5wf_WXweXocVX2WRIj9HDmfEJnuzOM3T9_t2XycXo8vOHj5O3lyNbOs0jAE6MaSogZtYYOjVqOpXAeSubmovKqKbiU9FQaZSwrKagOGNCMtHwum0U42fofMtd9dMltLZ0F43Xq-iWJm50Z5z-9yW4Gz3v1loQKQTlBfBiB4jd9x5S1kuXLHhvAnR90qy4W9OaF1cPSanikjOqKnofqRCElw0X6fM96aLrYyimDSrKacUoKapnf895N-Dtxovg1VZgY5dShJm2rmzCdcPYzmtK9JAvvdC7DOghX5o0uuSrVIu96tsPDtW92dZB2fHaQdTJOggWWhdLqHTbuYOE8z2C9S44a_w32ED644VOTBN9NWR_iP6wElUMLIDX_wfco4FfeYgWMg |
| CitedBy_id | crossref_primary_10_1155_2024_2237621 crossref_primary_10_1093_infdis_jiw620 |
| Cites_doi | 10.1128/JVI.01393-08 10.4049/jimmunol.1003057 10.4049/jimmunol.181.6.4168 10.1016/0092-8674(82)90135-0 10.1128/JVI.03146-14 10.1126/science.1117950 10.1128/JVI.00137-12 10.1007/s11262-013-0978-z 10.3390/pathogens3040845 10.1038/289373a0 10.1007/s11262-013-0882-6 10.3201/eid1405.071471 10.3390/v20801530 10.1128/JVI.00159-10 10.2460/javma.242.2.209 10.1126/scitranslmed.aab2354 10.1093/infdis/jiu334 |
| ContentType | Journal Article |
| Copyright | 2016 Elsevier Ltd Elsevier Ltd Copyright © 2016 Elsevier Ltd. All rights reserved. Copyright Elsevier Limited Nov 4, 2016 |
| Copyright_xml | – notice: 2016 Elsevier Ltd – notice: Elsevier Ltd – notice: Copyright © 2016 Elsevier Ltd. All rights reserved. – notice: Copyright Elsevier Limited Nov 4, 2016 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7RV 7T2 7T5 7U9 7X7 7XB 88C 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9- K9. KB0 LK8 M0R M0S M0T M1P M2O M7N M7P MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI Q9U 7X8 7S9 L.6 5PM |
| DOI | 10.1016/j.vaccine.2016.09.017 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Nursing & Allied Health Database Health and Safety Science Abstracts (Full archive) Immunology Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Healthcare Administration Database (Alumni) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Local Electronic Collection Information Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep (ProQuest) AIDS and Cancer Research Abstracts SciTech Premium Collection Consumer Health Database (Alumni Edition) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Biological Sciences Consumer Health Database (ProQuest) Health & Medical Collection (Alumni Edition) Healthcare Administration Database PML(ProQuest Medical Library) Research Library Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central Basic MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student ProQuest Central Essentials SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest Family Health ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Health Management (Alumni Edition) ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Family Health (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library Health & Safety Science Abstracts ProQuest Public Health ProQuest Central Basic ProQuest Health Management ProQuest Nursing & Allied Health Source ProQuest SciTech Collection ProQuest Medical Library Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts AGRICOLA MEDLINE - Academic Research Library Prep MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Veterinary Medicine Biology Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1873-2518 |
| EndPage | 5487 |
| ExternalDocumentID | PMC5075513 4225184101 27670073 10_1016_j_vaccine_2016_09_017 S0264410X16308301 1_s2_0_S0264410X16308301 |
| Genre | Journal Article |
| GeographicLocations | USA United States |
| GeographicLocations_xml | – name: USA – name: United States |
| GrantInformation_xml | – fundername: NIAID NIH HHS grantid: R01 AI108686 – fundername: NIAID NIH HHS grantid: T32 AI070077 – fundername: NIAID NIH HHS grantid: R01 AI113047 |
| GroupedDBID | --- --K --M .1- .FO .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 4.4 457 4G. 53G 5RE 5VS 7-5 71M 7RV 7X7 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8P~ 9JM AAAJQ AABNK AAEDT AAEDW AAHBH AAIKJ AAKOC AALRI AAOAW AAQFI AARKO AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABFRF ABJNI ABKYH ABMAC ABMZM ABRWV ABUWG ACDAQ ACGFO ACGFS ACIEU ACIUM ACLOT ACMHX ACPRK ACRLP ACVFH ADBBV ADCNI ADEZE ADFRT ADSLC AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEUYN AEVXI AEXOQ AFKRA AFPUW AFRAH AFRHN AFTJW AFXIZ AGEKW AGGSO AGUBO AGWPP AGYEJ AHMBA AIEXJ AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP AQUVI AXJTR AZQEC BBNVY BENPR BHPHI BKEYQ BKNYI BKOJK BLXMC BNPGV BPHCQ BVXVI CCPQU CJTIS CNWQP CS3 DWQXO EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN FYUFA G-Q GBLVA GNUQQ GUQSH HCIFZ HMCUK IHE J1W K9- KOM L7B LK8 LUGTX LW9 M0R M0T M1P M29 M2O M41 M7P MO0 N9A NAPCQ O-L O9- O9~ OAUVE OK0 OZT P-8 P-9 P2P PC. PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO Q38 ROL RPZ SAB SCC SDF SDG SDP SES SNL SPCBC SSH SSI SSZ T5K UKHRP UV1 WH7 WOW Z5R ~G- ~HD .GJ 29Q 3V. AACTN AAQXK ABWVN ABXDB ACRPL ADMUD ADNMO ADVLN AFCTW AFJKZ AFKWA AGHFR AHHHB AJOXV ALIPV AMFUW ASPBG AVWKF AZFZN FEDTE FGOYB G-2 HEJ HLV HMG HMK HMO HVGLF HX~ HZ~ R2- RIG SAE SEW SIN SVS WUQ XPP ZGI ZXP AAIAV ABLVK ABYKQ AESVU AJBFU LCYCR QYZTP 9DU AAYXX AFFHD AGQPQ AIGII CITATION AGCQF AGRNS CGR CUY CVF ECM EIF NPM 7QL 7T2 7T5 7U9 7XB 8FK C1K H94 K9. M7N MBDVC PKEHL PQEST PQUKI Q9U 7X8 PUEGO 7S9 L.6 5PM |
| ID | FETCH-LOGICAL-c670t-ee30aa94e0af9a1ba8bb7e33d796354a8943b5917a85c261e83225725936d9823 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 2 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000386988300005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0264-410X |
| IngestDate | Tue Nov 04 01:55:46 EST 2025 Sat Sep 27 18:51:17 EDT 2025 Tue Oct 07 09:52:55 EDT 2025 Wed Oct 01 13:54:41 EDT 2025 Sat Nov 29 14:32:24 EST 2025 Mon Jul 21 05:59:48 EDT 2025 Tue Nov 18 21:21:08 EST 2025 Sat Nov 29 02:25:37 EST 2025 Fri Feb 23 02:21:12 EST 2024 Tue Feb 25 20:07:28 EST 2025 Tue Oct 14 19:30:32 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 46 |
| Keywords | Antibodies Hemagglutinin Influenza |
| Language | English |
| License | Copyright © 2016 Elsevier Ltd. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c670t-ee30aa94e0af9a1ba8bb7e33d796354a8943b5917a85c261e83225725936d9823 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | http://doi.org/10.1016/j.vaccine.2016.09.017 |
| PMID | 27670073 |
| PQID | 1831314210 |
| PQPubID | 105530 |
| PageCount | 5 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5075513 proquest_miscellaneous_2000616307 proquest_miscellaneous_1837321841 proquest_miscellaneous_1835503016 proquest_journals_1831314210 pubmed_primary_27670073 crossref_citationtrail_10_1016_j_vaccine_2016_09_017 crossref_primary_10_1016_j_vaccine_2016_09_017 elsevier_sciencedirect_doi_10_1016_j_vaccine_2016_09_017 elsevier_clinicalkeyesjournals_1_s2_0_S0264410X16308301 elsevier_clinicalkey_doi_10_1016_j_vaccine_2016_09_017 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-11-04 |
| PublicationDateYYYYMMDD | 2016-11-04 |
| PublicationDate_xml | – month: 11 year: 2016 text: 2016-11-04 day: 04 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands – name: Kidlington |
| PublicationTitle | Vaccine |
| PublicationTitleAlternate | Vaccine |
| PublicationYear | 2016 |
| Publisher | Elsevier Ltd Elsevier Limited |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier Limited |
| References | Keleta, Ibricevic, Bovin, Brody, Brown (b0080) 2008; 82 Krammer, Palese, Steel (b0055) 2015; 386 Crawford, Dubovi, Castleman, Stephenson, Gibbs, Chen (b0010) 2005; 310 Govorkova, Gambaryan, Claas, Smirnov (b0085) 2000; 44 Su, Yuan, Chen, Xie, Li, Huang (b0035) 2013; 46 LaMere, Lam, Moquin, Haynes, Lund, Randall (b0065) 2011; 186 Carragher, Kaminski, Moquin, Hartson, Randall (b0070) 2008; 181 Song, Kang, Lee, Jung, Ha, Kang (b0025) 2008; 14 Parrish, Murcia, Holmes (b0005) 2015; 89 Bunpapong, Nonthabenjawan, Chaiwong, Tangwangvivat, Boonyapisitsopa, Jairak (b0030) 2014; 48 Wiley, Wilson, Skehel (b0040) 1981; 289 Hai, Krammer, Tan, Pica, Eggink, Maamary (b0050) 2012; 86 Jegaskanda, Vandenberg, Laurie, Loh, Kramski, Winnall (b0060) 2014; 210 Caton, Brownlee, Yewdell, Gerhard (b0075) 1982; 31 Ahmed, Volkmuth, Duca, Corti, Pallaoro, Pezzicoli (b0045) 2015; 7 Bouvier, Lowen (b0095) 2010; 2 Deshpande, Jirjis, Tubbs, Jayappa, Sweeney, Spencer (b0020) 2009; 10 Ilyushina, Khalenkov, Seiler, Forrest, Bovin, Marjuki (b0090) 2010; 84 Margine, Krammer (b0100) 2014; 3 Anderson, Crawford, Dubovi, Gibbs, Hernandez (b0015) 2013; 242 Carragher (10.1016/j.vaccine.2016.09.017_b0070) 2008; 181 Keleta (10.1016/j.vaccine.2016.09.017_b0080) 2008; 82 Govorkova (10.1016/j.vaccine.2016.09.017_b0085) 2000; 44 Parrish (10.1016/j.vaccine.2016.09.017_b0005) 2015; 89 Bunpapong (10.1016/j.vaccine.2016.09.017_b0030) 2014; 48 Krammer (10.1016/j.vaccine.2016.09.017_b0055) 2015; 386 Jegaskanda (10.1016/j.vaccine.2016.09.017_b0060) 2014; 210 Crawford (10.1016/j.vaccine.2016.09.017_b0010) 2005; 310 Su (10.1016/j.vaccine.2016.09.017_b0035) 2013; 46 LaMere (10.1016/j.vaccine.2016.09.017_b0065) 2011; 186 Hai (10.1016/j.vaccine.2016.09.017_b0050) 2012; 86 Ilyushina (10.1016/j.vaccine.2016.09.017_b0090) 2010; 84 Margine (10.1016/j.vaccine.2016.09.017_b0100) 2014; 3 Deshpande (10.1016/j.vaccine.2016.09.017_b0020) 2009; 10 Ahmed (10.1016/j.vaccine.2016.09.017_b0045) 2015; 7 Song (10.1016/j.vaccine.2016.09.017_b0025) 2008; 14 Anderson (10.1016/j.vaccine.2016.09.017_b0015) 2013; 242 Caton (10.1016/j.vaccine.2016.09.017_b0075) 1982; 31 Bouvier (10.1016/j.vaccine.2016.09.017_b0095) 2010; 2 Wiley (10.1016/j.vaccine.2016.09.017_b0040) 1981; 289 24101341 - Virus Genes. 2014 Feb;48(1):56-63 23276098 - J Am Vet Med Assoc. 2013 Jan 15;242(2):209-16 25007847 - Curr Top Microbiol Immunol. 2015;386:301-21 22398287 - J Virol. 2012 May;86(10):5774-81 18439355 - Emerg Infect Dis. 2008 May;14(5):741-6 6162101 - Nature. 1981 Jan 29;289(5796):373-8 20037964 - Vet Ther. 2009 Fall;10(3):103-12 6186384 - Cell. 1982 Dec;31(2 Pt 1):417-27 26136476 - Sci Transl Med. 2015 Jul 1;7(294):294ra105 24916185 - J Infect Dis. 2014 Dec 1;210(11):1811-22 18768874 - J Immunol. 2008 Sep 15;181(6):4168-76 23355070 - Virus Genes. 2013 Jun;46(3):554-7 21357542 - J Immunol. 2011 Apr 1;186(7):4331-9 25436508 - Pathogens. 2014 Oct 21;3(4):845-74 11252668 - Acta Virol. 2000 Oct;44(5):241-8 20592084 - J Virol. 2010 Sep;84(17):8607-16 25540375 - J Virol. 2015 Mar;89(6):2990-4 16186182 - Science. 2005 Oct 21;310(5747):482-5 18829764 - J Virol. 2008 Dec;82(23):11599-608 21442033 - Viruses. 2010;2(8):1530-1563 |
| References_xml | – volume: 86 start-page: 5774 year: 2012 end-page: 5781 ident: b0050 article-title: Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes publication-title: J Virol – volume: 310 start-page: 482 year: 2005 end-page: 485 ident: b0010 article-title: Transmission of equine influenza virus to dogs publication-title: Science – volume: 242 start-page: 209 year: 2013 end-page: 216 ident: b0015 article-title: Prevalence of and exposure factors for seropositivity to H3N8 canine influenza virus in dogs with influenza-like illness in the United States publication-title: J Am Vet Med Assoc – volume: 181 start-page: 4168 year: 2008 end-page: 4176 ident: b0070 article-title: A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus publication-title: J Immunol – volume: 3 start-page: 845 year: 2014 end-page: 874 ident: b0100 article-title: Animal models for influenza viruses: implications for universal vaccine development publication-title: Pathogens – volume: 210 start-page: 1811 year: 2014 end-page: 1822 ident: b0060 article-title: Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity in intravenous immunoglobulin as a potential therapeutic against emerging influenza viruses publication-title: J Infect Dis – volume: 31 start-page: 417 year: 1982 end-page: 427 ident: b0075 article-title: The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype) publication-title: Cell – volume: 82 start-page: 11599 year: 2008 end-page: 11608 ident: b0080 article-title: Experimental evolution of human influenza virus H3 hemagglutinin in the mouse lung identifies adaptive regions in HA1 and HA2 publication-title: J Virol – volume: 10 start-page: 103 year: 2009 end-page: 112 ident: b0020 article-title: Evaluation of the efficacy of a canine influenza virus (H3N8) vaccine in dogs following experimental challenge publication-title: Vet Ther – volume: 48 start-page: 56 year: 2014 end-page: 63 ident: b0030 article-title: Genetic characterization of canine influenza A virus (H3N2) in Thailand publication-title: Virus Genes – volume: 386 start-page: 301 year: 2015 end-page: 321 ident: b0055 article-title: Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin publication-title: Curr Top Microbiol Immunol – volume: 186 start-page: 4331 year: 2011 end-page: 4339 ident: b0065 article-title: Contributions of antinucleoprotein IgG to heterosubtypic immunity against influenza virus publication-title: J Immunol – volume: 7 start-page: 294ra105 year: 2015 ident: b0045 article-title: Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2 publication-title: Sci Transl Med – volume: 46 start-page: 554 year: 2013 end-page: 557 ident: b0035 article-title: Short communication: isolation and phylogenetic analysis of an avian-origin H3N2 canine influenza virus in dog shelter, China publication-title: Virus Genes – volume: 89 start-page: 2990 year: 2015 end-page: 2994 ident: b0005 article-title: Influenza virus reservoirs and intermediate hosts: dogs, horses, and new possibilities for influenza virus exposure of humans publication-title: J Virol – volume: 84 start-page: 8607 year: 2010 end-page: 8616 ident: b0090 article-title: Adaptation of pandemic H1N1 influenza viruses in mice publication-title: J Virol – volume: 2 start-page: 1530 year: 2010 end-page: 1563 ident: b0095 article-title: Animal models for influenza virus pathogenesis and transmission publication-title: Viruses – volume: 289 start-page: 373 year: 1981 end-page: 378 ident: b0040 article-title: Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation publication-title: Nature – volume: 14 start-page: 741 year: 2008 end-page: 746 ident: b0025 article-title: Transmission of avian influenza virus (H3N2) to dogs publication-title: Emerg Infect Dis – volume: 44 start-page: 241 year: 2000 end-page: 248 ident: b0085 article-title: Amino acid changes in the hemagglutinin and matrix proteins of influenza a (H2) viruses adapted to mice publication-title: Acta Virol – volume: 82 start-page: 11599 year: 2008 ident: 10.1016/j.vaccine.2016.09.017_b0080 article-title: Experimental evolution of human influenza virus H3 hemagglutinin in the mouse lung identifies adaptive regions in HA1 and HA2 publication-title: J Virol doi: 10.1128/JVI.01393-08 – volume: 186 start-page: 4331 year: 2011 ident: 10.1016/j.vaccine.2016.09.017_b0065 article-title: Contributions of antinucleoprotein IgG to heterosubtypic immunity against influenza virus publication-title: J Immunol doi: 10.4049/jimmunol.1003057 – volume: 10 start-page: 103 year: 2009 ident: 10.1016/j.vaccine.2016.09.017_b0020 article-title: Evaluation of the efficacy of a canine influenza virus (H3N8) vaccine in dogs following experimental challenge publication-title: Vet Ther – volume: 181 start-page: 4168 year: 2008 ident: 10.1016/j.vaccine.2016.09.017_b0070 article-title: A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus publication-title: J Immunol doi: 10.4049/jimmunol.181.6.4168 – volume: 31 start-page: 417 year: 1982 ident: 10.1016/j.vaccine.2016.09.017_b0075 article-title: The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype) publication-title: Cell doi: 10.1016/0092-8674(82)90135-0 – volume: 89 start-page: 2990 year: 2015 ident: 10.1016/j.vaccine.2016.09.017_b0005 article-title: Influenza virus reservoirs and intermediate hosts: dogs, horses, and new possibilities for influenza virus exposure of humans publication-title: J Virol doi: 10.1128/JVI.03146-14 – volume: 310 start-page: 482 year: 2005 ident: 10.1016/j.vaccine.2016.09.017_b0010 article-title: Transmission of equine influenza virus to dogs publication-title: Science doi: 10.1126/science.1117950 – volume: 86 start-page: 5774 year: 2012 ident: 10.1016/j.vaccine.2016.09.017_b0050 article-title: Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes publication-title: J Virol doi: 10.1128/JVI.00137-12 – volume: 48 start-page: 56 year: 2014 ident: 10.1016/j.vaccine.2016.09.017_b0030 article-title: Genetic characterization of canine influenza A virus (H3N2) in Thailand publication-title: Virus Genes doi: 10.1007/s11262-013-0978-z – volume: 386 start-page: 301 year: 2015 ident: 10.1016/j.vaccine.2016.09.017_b0055 article-title: Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin publication-title: Curr Top Microbiol Immunol – volume: 3 start-page: 845 year: 2014 ident: 10.1016/j.vaccine.2016.09.017_b0100 article-title: Animal models for influenza viruses: implications for universal vaccine development publication-title: Pathogens doi: 10.3390/pathogens3040845 – volume: 289 start-page: 373 year: 1981 ident: 10.1016/j.vaccine.2016.09.017_b0040 article-title: Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation publication-title: Nature doi: 10.1038/289373a0 – volume: 44 start-page: 241 year: 2000 ident: 10.1016/j.vaccine.2016.09.017_b0085 article-title: Amino acid changes in the hemagglutinin and matrix proteins of influenza a (H2) viruses adapted to mice publication-title: Acta Virol – volume: 46 start-page: 554 year: 2013 ident: 10.1016/j.vaccine.2016.09.017_b0035 article-title: Short communication: isolation and phylogenetic analysis of an avian-origin H3N2 canine influenza virus in dog shelter, China publication-title: Virus Genes doi: 10.1007/s11262-013-0882-6 – volume: 14 start-page: 741 year: 2008 ident: 10.1016/j.vaccine.2016.09.017_b0025 article-title: Transmission of avian influenza virus (H3N2) to dogs publication-title: Emerg Infect Dis doi: 10.3201/eid1405.071471 – volume: 2 start-page: 1530 year: 2010 ident: 10.1016/j.vaccine.2016.09.017_b0095 article-title: Animal models for influenza virus pathogenesis and transmission publication-title: Viruses doi: 10.3390/v20801530 – volume: 84 start-page: 8607 year: 2010 ident: 10.1016/j.vaccine.2016.09.017_b0090 article-title: Adaptation of pandemic H1N1 influenza viruses in mice publication-title: J Virol doi: 10.1128/JVI.00159-10 – volume: 242 start-page: 209 year: 2013 ident: 10.1016/j.vaccine.2016.09.017_b0015 article-title: Prevalence of and exposure factors for seropositivity to H3N8 canine influenza virus in dogs with influenza-like illness in the United States publication-title: J Am Vet Med Assoc doi: 10.2460/javma.242.2.209 – volume: 7 start-page: 294ra105 year: 2015 ident: 10.1016/j.vaccine.2016.09.017_b0045 article-title: Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aab2354 – volume: 210 start-page: 1811 year: 2014 ident: 10.1016/j.vaccine.2016.09.017_b0060 article-title: Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity in intravenous immunoglobulin as a potential therapeutic against emerging influenza viruses publication-title: J Infect Dis doi: 10.1093/infdis/jiu334 – reference: 6186384 - Cell. 1982 Dec;31(2 Pt 1):417-27 – reference: 11252668 - Acta Virol. 2000 Oct;44(5):241-8 – reference: 18829764 - J Virol. 2008 Dec;82(23):11599-608 – reference: 18439355 - Emerg Infect Dis. 2008 May;14(5):741-6 – reference: 24916185 - J Infect Dis. 2014 Dec 1;210(11):1811-22 – reference: 18768874 - J Immunol. 2008 Sep 15;181(6):4168-76 – reference: 25436508 - Pathogens. 2014 Oct 21;3(4):845-74 – reference: 25540375 - J Virol. 2015 Mar;89(6):2990-4 – reference: 20037964 - Vet Ther. 2009 Fall;10(3):103-12 – reference: 25007847 - Curr Top Microbiol Immunol. 2015;386:301-21 – reference: 21442033 - Viruses. 2010;2(8):1530-1563 – reference: 23355070 - Virus Genes. 2013 Jun;46(3):554-7 – reference: 24101341 - Virus Genes. 2014 Feb;48(1):56-63 – reference: 16186182 - Science. 2005 Oct 21;310(5747):482-5 – reference: 21357542 - J Immunol. 2011 Apr 1;186(7):4331-9 – reference: 22398287 - J Virol. 2012 May;86(10):5774-81 – reference: 20592084 - J Virol. 2010 Sep;84(17):8607-16 – reference: 26136476 - Sci Transl Med. 2015 Jul 1;7(294):294ra105 – reference: 6162101 - Nature. 1981 Jan 29;289(5796):373-8 – reference: 23276098 - J Am Vet Med Assoc. 2013 Jan 15;242(2):209-16 |
| SSID | ssj0005319 |
| Score | 2.1996758 |
| Snippet | •Canine H3N8 vaccines elicit antibodies that react strongly to canine H3N2 viruses.•Abs elicited by canine H3N8 vaccines bind to the HA stalk region of canine... Highlights • Canine H3N8 vaccines elicit antibodies that react strongly to canine H3N2 viruses. • Abs elicited by canine H3N8 vaccines bind to the HA stalk... Influenza A viruses infect many species and cross-species transmission occurs occasionally. An equine H3N8 influenza virus began circulating in dogs in 1999... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 5483 |
| SubjectTerms | Allergy and Immunology Amino acids animal models Animals Antibodies Antibodies, Viral - blood birds Cross Protection Disease Models, Animal Dog Diseases - epidemiology Dog Diseases - prevention & control Dog Diseases - virology Dogs Experiments Hemagglutinin Hemagglutinin Glycoproteins, Influenza Virus - immunology hemagglutinins horses Immunoglobulins Infections Influenza Influenza A virus Influenza A Virus, H3N2 Subtype - genetics Influenza A Virus, H3N2 Subtype - immunology Influenza A Virus, H3N8 Subtype - genetics Influenza A Virus, H3N8 Subtype - immunology influenza vaccines Influenza Vaccines - immunology Laboratories Licenses Lung - virology Mice Orthomyxoviridae Orthomyxoviridae Infections - epidemiology Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - veterinary Phylogenetics Proteins sterilizing immunity Studies United States United States - epidemiology Vaccines viral proteins Viruses |
| Title | Canine H3N8 influenza vaccines partially protect mice against the canine H3N2 strain currently circulating in the United States |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0264410X16308301 https://www.clinicalkey.es/playcontent/1-s2.0-S0264410X16308301 https://dx.doi.org/10.1016/j.vaccine.2016.09.017 https://www.ncbi.nlm.nih.gov/pubmed/27670073 https://www.proquest.com/docview/1831314210 https://www.proquest.com/docview/1835503016 https://www.proquest.com/docview/1837321841 https://www.proquest.com/docview/2000616307 https://pubmed.ncbi.nlm.nih.gov/PMC5075513 |
| Volume | 34 |
| WOSCitedRecordID | wos000386988300005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-2518 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005319 issn: 0264-410X databaseCode: AIEXJ dateStart: 20091030 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVPQU databaseName: AUTh Library subscriptions: ProQuest Central customDbUrl: eissn: 1873-2518 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0005319 issn: 0264-410X databaseCode: BENPR dateStart: 20020101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1873-2518 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0005319 issn: 0264-410X databaseCode: M7P dateStart: 20020101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Consumer Health Database customDbUrl: eissn: 1873-2518 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0005319 issn: 0264-410X databaseCode: M0R dateStart: 20020101 isFulltext: true titleUrlDefault: https://search.proquest.com/familyhealth providerName: ProQuest – providerCode: PRVPQU databaseName: Health Medical collection customDbUrl: eissn: 1873-2518 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0005319 issn: 0264-410X databaseCode: 7X7 dateStart: 20020101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Healthcare Administration Database customDbUrl: eissn: 1873-2518 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0005319 issn: 0264-410X databaseCode: M0T dateStart: 20020101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthmanagement providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1873-2518 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0005319 issn: 0264-410X databaseCode: 7RV dateStart: 20020101 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1873-2518 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0005319 issn: 0264-410X databaseCode: 8C1 dateStart: 20020101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1873-2518 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0005319 issn: 0264-410X databaseCode: M2O dateStart: 20020101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELfYBogXPspXYVRGQntatjhx4vQJQbVpD6xUo0x9sxzHG51KWppuUnnhX-fOdlIGY0PixWoVX1K758vv7LvfEfImQY49lRhYSKkJeM6LANxmFhjOc6bZiVE2ePz4g-j3s9GoO_AbbpUPq6xtojXUxVTjHvkuqB6LGQcP5e3sW4BVo_B01ZfQWCMbyJIQ2dC9wSrEI7aFPcDN4AFn4WiVwbN7tnOhNB5dY3RXaqlObc2yK99Nf2LP30Mof3kn7T_439E8JPc9GqXvnPo8IrdM2SJ3XH3KZYvcPfQn7y2yNXAc18ttOlylbFXbdIsOVuzXINM6xgAbm-VLa_HH5EdPlfCBHsT9jI5dYZTvivrZqegMNVhNJkvqiSPoV7BgVJ2qMeBXCiiV6uYOEa1sZQuqHbkUSOnxXNtCZOUp3N72d2iaOjT9hHze3xv2DgJf-yHQqQgXgTFxqFSXm1CddBXLVZbnwsRxIcBiJFwhbXyegK-pskSDF2isZRIRFigsulkUPyXr5bQ0zwkFVFIkAJRUGmmemVzpOCqQyU5r8OaKok14_a9L7YnRcRQTWUfAnUk_HRKVRYZdCcrSJjuN2Mwxg9wkkNYqJeu0VzDUEt5dNwmKqwRN5c1NJZmsIhnKT6GFt-EIQDZA65C1SdZIekTlkNK_PHSz1ly5ek6jtm3yurkMBglPmVRppue2D3i98PD02j4ixs0F9vc-NocMBwI_5ZlbbM08RwKzy0QMM3NpGTYdkDT98pVy_MWSp4P_gzWNXlw_vJfkHs6FTTrlm2R9MT83r8htfbEYV_MOWRNHx9iOhG0zaLMe65CN93v9wRF8OwxdO8Q2-tixdukn9ZWOpA |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB5V5XnhEV6BAosEPdWtH-tHDgihQtWqSRSJUOW2Xa-3JVVwQpwWhQv_iN_IzK7tUCgtlx64RfKOnV3PzM7nnfkG4GVIHHsy1GhIkXZ4yjMHYbPnaM5TT3kHWprk8b123O0mg0GrtwQ_qloYSqusfKJx1NlY0TfyDVQ9L_A4IpQ3ky8OdY2i09WqhYZVi109_4qQrXi98w7f7yvf33rf39x2yq4Cjopid-ZoHbhStrh25UFLeqlM0jTWQZDFqIshl0RInoaIYmQSKsQX2uh87FPru6yVENEBuvwrxKtHXP0dt79IKQlMIxGENdzhnjtYVAxtHK2fSEVH5ZRNFhlqVdMj7cy98M9Y9_eUzV_2wK3b_9vq3YFbZbTN3lrzuAtLOm_ANdt_c96A650ys6ABqz3L4T1fY_1FSVqxxlZZb8HujTKNPUogMlXMrBK_B983ZY4_2HbQTdjQNn75Jln5Ngo2IQuVo9GclcQY7DN6aCYP5RDjc4ZROFP1HXxWmM4dTFnyLJRSw6kyjdbyQ7y9GW_RArNo4T58vJR1fADL-TjXj4Bh1JWFGAjKyFc80alUgZ8RU59SiFazrAm80jKhSuJ3msVIVBl-R6JcDkHKKdyWQOVswnotNrHMJxcJRJUKi6qsFzcigXvzRYLxWYK6KN1pITxR-MIVH1wTvrsDBBEIHVyvCUktWUaMNhL8l4euVJYiFs-pzaQJL-rL6HDpFE3menxsxiCqx4dH546JA_p44v19jKmRo4ngX3lojbteZz-m6rk4wJU5Zfb1ACKFP30lH34y5PCI76hn0-Pzp_ccbmz3O23R3unuPoGbtC6mwJavwPJseqyfwlV1MhsW02fGwzHYv2yn8BOtt-Eo |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB5VBSouPMIrUGCRoKe69WP9yAEh1BK1ahtFUKrctuv1pqQKTojTonDhf_HrmNm1HQql5dIDt0jesbPj2dn5vDPfALwMiWNPhhoXUqQdnvLMQdjsOZrz1FNeX0uTPH6wG3c6Sa_X6i7Aj6oWhtIqK59oHHU2UvSNfB1Nzws8ThUn_TItorvZfjP-4lAHKTpprdppWBPZ0bOvCN-K19ub-K5f-X773f7GllN2GHBUFLtTR-vAlbLFtSv7LemlMknTWAdBFqNdhlwSOXkaIqKRSagQa2hj_7FPbfCyVkKkB-j-r8U89Im3f899P08vCUxTEYQ43OGe25tXD60fr51KRcfmlFkWGZpV0y_t3H3xz7j39_TNX_bD9u3_WZN34FYZhbO3dtnchQWdN-CG7cs5a8DSXplx0ICVruX2nq2y_XmpWrHKVlh3zvqNMo0DSiwy1c2sEr8H3zdkjj_YVtBJ2MA2hPkmWflmCjamlSuHwxkrCTPYZ_TcTB7JAcbtDKNzpuo7-KwwHT2YsqRaKKUGE2UasOVHeHsz3qIIZlHEffh4JXp8AIv5KNePgGE0loUYIMrIVzzRqVSBnxGDn1KIYrOsCbyyOKFKQniaxVBUmX_HolSHIEMVbkugoTZhrRYbW0aUywSiypxFVe6LG5TAPfsywfg8QV2UbrYQnih84YoPrgnr3R6CC4QUrteEpJYsI0kbIf7LQ5erVSPmz6mXTBNe1JfREdPpmsz16MSMQbSPD48uHBMH9FHF-_sYUztHE8G_8tAu9FrPfkxVdXGAmjnjAuoBRBZ_9ko--GRI4xH3US-nxxdP7zksoS8Qu9udnSdwk9Ri6m75MixOJyf6KVxXp9NBMXlmnB2Dw6v2CT8BZSHp6A |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Canine+H3N8+influenza+vaccines+partially+protect+mice+against+the+canine+H3N2+strain+currently+circulating+in+the+United+States&rft.jtitle=Vaccine&rft.au=Willis%2C+Elinor&rft.au=Parkhouse%2C+Kaela&rft.au=Krammer%2C+Florian&rft.au=Hensley%2C+Scott+E.&rft.date=2016-11-04&rft.issn=0264-410X&rft.volume=34&rft.issue=46&rft.spage=5483&rft.epage=5487&rft_id=info:doi/10.1016%2Fj.vaccine.2016.09.017&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_vaccine_2016_09_017 |
| thumbnail_m | http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F0264410X%2FS0264410X16X00461%2Fcov150h.gif |