Quantitative SARS-CoV-2 subgenomic RNA as a surrogate marker for viral infectivity: Comparison between culture isolation and direct sgRNA quantification

Detection of subgenomic (sg) SARS-CoV-2 RNAs are frequently used as a correlate of viral infectiousness, but few data about correlation between sg load and viable virus are available. Here, we defined concordance between culture isolation and E and N sgRNA quantification by ddPCR assays in 51 nasoph...

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Bibliographic Details
Published in:	PloS one Vol. 18; no. 9; p. e0291120
Main Authors:	Scutari, Rossana, Renica, Silvia, Cento, Valeria, Nava, Alice, Sammartino, Josè Camilla, Ferrari, Alessandro, Pani, Arianna, Merli, Marco, Fanti, Diana, Vismara, Chiara, Scaglione, Francesco, Puoti, Massimo, Bandera, Alessandra, Gori, Andrea, Piralla, Antonio, Baldanti, Fausto, Perno, Carlo Federico, Alteri, Claudia
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 01.09.2023 Public Library of Science (PLoS)
Subjects:	Analysis Assaying Asymptomatic Biology and life sciences Correlation COVID-19 Disease susceptibility Genetic aspects Infectivity Medicine and health sciences Patients RNA Severe acute respiratory syndrome coronavirus 2 Viral diseases Viruses Italy
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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