Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease

Endothelial protein C receptor (EPCR) and thrombomodulin (TM) are expressed at high levels in the resting microvasculature and convert protein C (PC) into its activated form, which is a potent anticoagulant and antiinflammatory molecule. Here we provide evidence that in Crohn disease (CD) and ulcera...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 117; no. 7; pp. 1951 - 1960
Main Authors:	Scaldaferri, Franco, Sans, Miquel, Vetrano, Stefania, Graziani, Cristina, De Cristofaro, Raimondo, Gerlitz, Bruce, Repici, Alessandro, Arena, Vincenzo, Malesci, Alberto, Panes, Julian, Grinnell, Brian W., Danese, Silvio
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.07.2007
Subjects:	Animals Antigens, CD - metabolism Biomedical research Cell Adhesion - drug effects Cells, Cultured Chemokines - biosynthesis Colorectal diseases Down-Regulation Endothelial Protein C Receptor Endothelium - pathology Gastrointestinal diseases Humans Immunohistochemistry Inflammation Inflammation - metabolism Inflammation - pathology Inflammatory bowel disease Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology Intercellular Adhesion Molecule-1 - metabolism Leukocytes - cytology Mice Microcirculation - metabolism Microcirculation - pathology Protein C Protein C - metabolism Protein C - pharmacology Receptors, Cell Surface - metabolism Signal Transduction - drug effects Thrombomodulin - metabolism Tumor Necrosis Factor-alpha - pharmacology Vascular Cell Adhesion Molecule-1 - metabolism United States
ISSN:	0021-9738, 1558-8238
Online Access:	Get full text
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