Emerging role of long noncoding RNAs in lung cancer: Current status and future prospects
Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that a...
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| Vydáno v: | Respiratory medicine Ročník 110; s. 12 - 19 |
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Elsevier Ltd
01.01.2016
Elsevier Limited |
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| ISSN: | 0954-6111, 1532-3064, 1532-3064 |
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| Abstract | Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that are responsible for the development of lung cancer. Importantly, these approaches have also uncovered the widespread expression of “noncoding RNAs” including long noncoding RNAs (LncRNAs), which impact biologic responses through the regulation of mRNA transcription or translation. To date, most studies of the role of noncoding RNAs have focused on LncRNAs, which regulate mRNA translation via the RNA interference pathway. Although many of their attributes, such as patterns of expression, remain largely unknown, LncRNAs have key functions in transcriptional, post-transcriptional, and epigenetic gene regulation. Recent research showed that LncRNAs regulate flowering time in the lung cancer. In this review, we discuss these investigations into long noncoding RNAs were performed almost exclusively in lung cancer. Future work will need to extend these into lung cancer and to analyze how LncRNAs interact to regulate mRNA expression. From a clinical perspective, the targeting of LncRNAs as a novel therapeutic approach will require a deeper understanding of their function and mechanism of action.
Figure Long noncoding RNAs play a key role in the development of lung cancer. Important alterations encompassing epigenetic changes are Long noncoding RNAs. Long noncoding RNAs control gene expression in lung cancer. [Display omitted]
•LncRNAs impact on the development of lung cancer.•LncRNAs control the pathological processes of NSCLC and SCLC.•LncRNAs mediated epigenetic mechanism in lung cancer. |
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| AbstractList | Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that are responsible for the development of lung cancer. Importantly, these approaches have also uncovered the widespread expression of "noncoding RNAs" including long noncoding RNAs (LncRNAs), which impact biologic responses through the regulation of mRNA transcription or translation. To date, most studies of the role of noncoding RNAs have focused on LncRNAs, which regulate mRNA translation via the RNA interference pathway. Although many of their attributes, such as patterns of expression, remain largely unknown, LncRNAs have key functions in transcriptional, post-transcriptional, and epigenetic gene regulation. Recent research showed that LncRNAs regulate flowering time in the lung cancer. In this review, we discuss these investigations into long noncoding RNAs were performed almost exclusively in lung cancer. Future work will need to extend these into lung cancer and to analyze how LncRNAs interact to regulate mRNA expression. From a clinical perspective, the targeting of LncRNAs as a novel therapeutic approach will require a deeper understanding of their function and mechanism of action. Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that are responsible for the development of lung cancer. Importantly, these approaches have also uncovered the widespread expression of "noncoding RNAs" including long noncoding RNAs (LncRNAs), which impact biologic responses through the regulation of mRNA transcription or translation. To date, most studies of the role of noncoding RNAs have focused on LncRNAs, which regulate mRNA translation via the RNA interference pathway. Although many of their attributes, such as patterns of expression, remain largely unknown, LncRNAs have key functions in transcriptional, post-transcriptional, and epigenetic gene regulation. Recent research showed that LncRNAs regulate flowering time in the lung cancer. In this review, we discuss these investigations into long noncoding RNAs were performed almost exclusively in lung cancer. Future work will need to extend these into lung cancer and to analyze how LncRNAs interact to regulate mRNA expression. From a clinical perspective, the targeting of LncRNAs as a novel therapeutic approach will require a deeper understanding of their function and mechanism of action.Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that are responsible for the development of lung cancer. Importantly, these approaches have also uncovered the widespread expression of "noncoding RNAs" including long noncoding RNAs (LncRNAs), which impact biologic responses through the regulation of mRNA transcription or translation. To date, most studies of the role of noncoding RNAs have focused on LncRNAs, which regulate mRNA translation via the RNA interference pathway. Although many of their attributes, such as patterns of expression, remain largely unknown, LncRNAs have key functions in transcriptional, post-transcriptional, and epigenetic gene regulation. Recent research showed that LncRNAs regulate flowering time in the lung cancer. In this review, we discuss these investigations into long noncoding RNAs were performed almost exclusively in lung cancer. Future work will need to extend these into lung cancer and to analyze how LncRNAs interact to regulate mRNA expression. From a clinical perspective, the targeting of LncRNAs as a novel therapeutic approach will require a deeper understanding of their function and mechanism of action. Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that are responsible for the development of lung cancer. Importantly, these approaches have also uncovered the widespread expression of “noncoding RNAs” including long noncoding RNAs (LncRNAs), which impact biologic responses through the regulation of mRNA transcription or translation. To date, most studies of the role of noncoding RNAs have focused on LncRNAs, which regulate mRNA translation via the RNA interference pathway. Although many of their attributes, such as patterns of expression, remain largely unknown, LncRNAs have key functions in transcriptional, post-transcriptional, and epigenetic gene regulation. Recent research showed that LncRNAs regulate flowering time in the lung cancer. In this review, we discuss these investigations into long noncoding RNAs were performed almost exclusively in lung cancer. Future work will need to extend these into lung cancer and to analyze how LncRNAs interact to regulate mRNA expression. From a clinical perspective, the targeting of LncRNAs as a novel therapeutic approach will require a deeper understanding of their function and mechanism of action. Figure Long noncoding RNAs play a key role in the development of lung cancer. Important alterations encompassing epigenetic changes are Long noncoding RNAs. Long noncoding RNAs control gene expression in lung cancer. [Display omitted] •LncRNAs impact on the development of lung cancer.•LncRNAs control the pathological processes of NSCLC and SCLC.•LncRNAs mediated epigenetic mechanism in lung cancer. Abstract Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that are responsible for the development of lung cancer. Importantly, these approaches have also uncovered the widespread expression of “noncoding RNAs” including long noncoding RNAs (LncRNAs), which impact biologic responses through the regulation of mRNA transcription or translation. To date, most studies of the role of noncoding RNAs have focused on LncRNAs, which regulate mRNA translation via the RNA interference pathway. Although many of their attributes, such as patterns of expression, remain largely unknown, LncRNAs have key functions in transcriptional, post-transcriptional, and epigenetic gene regulation. Recent research showed that LncRNAs regulate flowering time in the lung cancer. In this review, we discuss these investigations into long noncoding RNAs were performed almost exclusively in lung cancer. Future work will need to extend these into lung cancer and to analyze how LncRNAs interact to regulate mRNA expression. From a clinical perspective, the targeting of LncRNAs as a novel therapeutic approach will require a deeper understanding of their function and mechanism of action. |
| Author | Li, Jun Tao, Hui Zhou, Xiao Shi, Kai-Hu Yang, Jing-Jing Deng, Zi-Yu |
| Author_xml | – sequence: 1 givenname: Hui surname: Tao fullname: Tao, Hui organization: Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei 230601, China – sequence: 2 givenname: Jing-Jing surname: Yang fullname: Yang, Jing-Jing organization: Department of Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China – sequence: 3 givenname: Xiao surname: Zhou fullname: Zhou, Xiao email: 13905601531@139.com organization: Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei 230601, China – sequence: 4 givenname: Zi-Yu surname: Deng fullname: Deng, Zi-Yu organization: Department of Scientific and Educational, The Second Hospital of Anhui Medical University, China – sequence: 5 givenname: Kai-Hu surname: Shi fullname: Shi, Kai-Hu email: ayskh3@hotmail.com organization: Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei 230601, China – sequence: 6 givenname: Jun surname: Li fullname: Li, Jun organization: School of Pharmacy, Anhui Medical University, Hefei 230032, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26603340$$D View this record in MEDLINE/PubMed |
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| Keywords | Epigenetic Transcriptional regulation Lung cancer LncRNAs |
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| Snippet | Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both... Abstract Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both... |
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| SubjectTerms | Biomarkers Cancer therapies Deoxyribonucleic acid DNA DNA methylation Epigenetic Epigenetics Gene expression Gene Expression Regulation Humans LncRNAs Lung cancer Lung Neoplasms - genetics Medical prognosis Metastasis Protein Biosynthesis - genetics Proteins Pulmonary/Respiratory RNA polymerase RNA, Long Noncoding - genetics Transcription, Genetic Transcriptional regulation |
| Title | Emerging role of long noncoding RNAs in lung cancer: Current status and future prospects |
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