The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production

Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement a...

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Vydané v:Veterinary research (Paris) Ročník 49; číslo 1; s. 68
Hlavní autori: van Dijk, Albert, Hedegaard, Chris J., Haagsman, Henk P., Heegaard, Peter M. H.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 31.07.2018
BioMed Central Ltd
Springer Nature B.V
BMC
Predmet:
2nd International Symposium on Alternatives to Antibiotics
acute phase proteins
adaptive immunity
animal production
Antibiotic growth promoters
Antibiotics
Antimicrobial agents
Bacterial infections
Breeding of animals
cathelicidins
Chemokines
complement
Defense mechanisms
Health aspects
Immune response
Immune system
Immunoglobulins
Immunology
Infections
Infectious diseases
innate immunity
Life Sciences
mechanism of action
Medicine
Medicine & Public Health
Microbiology
microorganisms
neonates
Neutrophils
Peptides
Review
Rodents
vaccine adjuvants
veterinary medicine
Veterinary Medicine/Veterinary Science
Virology
Yang, Cindy
Porcine Reproductive And Respiratory Syndrome Virus (PRRSV)
Cathelicidin-related Antimicrobial Peptide (CRAMP)
Indolicidin
Spray-dried Plasma (SDP)
Host Defense Peptides (HDPs)
ISSN:1297-9716, 0928-4249, 1297-9716
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Abstract Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
AbstractList AbstractInnate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
[...]the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described. 1 Introduction Resistance of microbes to antimicrobial agents is a global threat. [...]some cytokines show early promise (such as IL-22 [13, 14]) and some have been tested successfully for controlling infection in production animals [15]. [...]bovine G-CSF (granulocyte colony stimulating factor) was reported to have a significantly reducing effect on the number of cattle with clinical mastitis as well as on the absolute neutrophil counts in a herd investigation involving 211 periparturient Holstein cows and heifers given two doses of PEGylated (polyethylene glycol-attached) bovine G-CSF subcutaneously at day-7 and 1 after parturition [16]. For transplacentally supplied immunoglobulins this pool is simply an aliquot of the circulating pool of immunoglobulins in the maternal blood, while in mammals depending on colostrum and milk immunoglobulins the origin depends on the immunoglobulin type. [...]secretory IgA (sIgA) which is the dominating milk immunoglobulin in primates is mainly produced by local plasma cells in the lymphoid mucosal tissue of the mammary gland. [...]innate host defense mechanisms offer interesting modes of actions for new strategies for counteracting microbial infections and disease in animal husbandry.
Abstract Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
ArticleNumber 68
Audience Academic
Author Haagsman, Henk P.
van Dijk, Albert
Hedegaard, Chris J.
Heegaard, Peter M. H.
Author_xml – sequence: 1
  givenname: Albert
  surname: van Dijk
  fullname: van Dijk, Albert
  organization: Division Molecular Host Defence, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University
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  surname: Hedegaard
  fullname: Hedegaard, Chris J.
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  givenname: Henk P.
  orcidid: 0000-0002-4931-5201
  surname: Haagsman
  fullname: Haagsman, Henk P.
  email: H.P.Haagsman@uu.nl
  organization: Division Molecular Host Defence, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University
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  givenname: Peter M. H.
  surname: Heegaard
  fullname: Heegaard, Peter M. H.
  organization: Innate Immunology Group, National Veterinary Institute, Technical University of Denmark
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Keywords Porcine Reproductive And Respiratory Syndrome Virus (PRRSV)
Cathelicidin-related Antimicrobial Peptide (CRAMP)
Indolicidin
Spray-dried Plasma (SDP)
Host Defense Peptides (HDPs)
Language English
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  year: 2018
  text: 2018-07-31
  day: 31
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Veterinary research (Paris)
PublicationTitleAbbrev Vet Res
PublicationTitleAlternate Vet Res
PublicationYear 2018
Publisher BioMed Central
BioMed Central Ltd
Springer Nature B.V
BMC
Publisher_xml – name: BioMed Central
– name: BioMed Central Ltd
– name: Springer Nature B.V
– name: BMC
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RelatedPersons Yang, Cindy
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Snippet Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation,...
[...]the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described. 1...
AbstractInnate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation,...
Abstract Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation,...
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SubjectTerms 2nd International Symposium on Alternatives to Antibiotics
acute phase proteins
adaptive immunity
animal production
Antibiotic growth promoters
Antibiotics
Antimicrobial agents
Bacterial infections
Breeding of animals
cathelicidins
Chemokines
complement
Defense mechanisms
Health aspects
Immune response
Immune system
Immunoglobulins
Immunology
Infections
Infectious diseases
innate immunity
Life Sciences
mechanism of action
Medicine
Medicine & Public Health
Microbiology
microorganisms
neonates
Neutrophils
Peptides
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Rodents
vaccine adjuvants
veterinary medicine
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Title The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production
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