The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production

Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement a...

Full description

Saved in:
Bibliographic Details
Published in:Veterinary research (Paris) Vol. 49; no. 1; p. 68
Main Authors: van Dijk, Albert, Hedegaard, Chris J., Haagsman, Henk P., Heegaard, Peter M. H.
Format: Journal Article
Language:English
Published: London BioMed Central 31.07.2018
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
2nd International Symposium on Alternatives to Antibiotics
acute phase proteins
adaptive immunity
animal production
Antibiotic growth promoters
Antibiotics
Antimicrobial agents
Bacterial infections
Breeding of animals
cathelicidins
Chemokines
complement
Defense mechanisms
Health aspects
Immune response
Immune system
Immunoglobulins
Immunology
Infections
Infectious diseases
innate immunity
Life Sciences
mechanism of action
Medicine
Medicine & Public Health
Microbiology
microorganisms
neonates
Neutrophils
Peptides
Review
Rodents
vaccine adjuvants
veterinary medicine
Veterinary Medicine/Veterinary Science
Virology
Yang, Cindy
Porcine Reproductive And Respiratory Syndrome Virus (PRRSV)
Cathelicidin-related Antimicrobial Peptide (CRAMP)
Indolicidin
Spray-dried Plasma (SDP)
Host Defense Peptides (HDPs)
ISSN:1297-9716, 0928-4249, 1297-9716
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
AbstractList AbstractInnate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
[...]the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described. 1 Introduction Resistance of microbes to antimicrobial agents is a global threat. [...]some cytokines show early promise (such as IL-22 [13, 14]) and some have been tested successfully for controlling infection in production animals [15]. [...]bovine G-CSF (granulocyte colony stimulating factor) was reported to have a significantly reducing effect on the number of cattle with clinical mastitis as well as on the absolute neutrophil counts in a herd investigation involving 211 periparturient Holstein cows and heifers given two doses of PEGylated (polyethylene glycol-attached) bovine G-CSF subcutaneously at day-7 and 1 after parturition [16]. For transplacentally supplied immunoglobulins this pool is simply an aliquot of the circulating pool of immunoglobulins in the maternal blood, while in mammals depending on colostrum and milk immunoglobulins the origin depends on the immunoglobulin type. [...]secretory IgA (sIgA) which is the dominating milk immunoglobulin in primates is mainly produced by local plasma cells in the lymphoid mucosal tissue of the mammary gland. [...]innate host defense mechanisms offer interesting modes of actions for new strategies for counteracting microbial infections and disease in animal husbandry.
Abstract Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
ArticleNumber 68
Audience Academic
Author Haagsman, Henk P.
van Dijk, Albert
Hedegaard, Chris J.
Heegaard, Peter M. H.
Author_xml – sequence: 1
  givenname: Albert
  surname: van Dijk
  fullname: van Dijk, Albert
  organization: Division Molecular Host Defence, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University
– sequence: 2
  givenname: Chris J.
  surname: Hedegaard
  fullname: Hedegaard, Chris J.
  organization: Innate Immunology Group, National Veterinary Institute, Technical University of Denmark
– sequence: 3
  givenname: Henk P.
  orcidid: 0000-0002-4931-5201
  surname: Haagsman
  fullname: Haagsman, Henk P.
  email: H.P.Haagsman@uu.nl
  organization: Division Molecular Host Defence, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University
– sequence: 4
  givenname: Peter M. H.
  surname: Heegaard
  fullname: Heegaard, Peter M. H.
  organization: Innate Immunology Group, National Veterinary Institute, Technical University of Denmark
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30060758$$D View this record in MEDLINE/PubMed
https://hal.science/hal-02973509$$DView record in HAL
BookMark eNqFkktv1DAUhSNURB_wA9igSGzaRYodx49skEblMZUqwaKsLY99M-MqYw92UpV_zw1p6UM8lEWSm-8cO8fnsNgLMUBRvKbklFIl3mXKuJAVoaoinKuqflYc0LqVVSup2HvwvF8c5nxFCBWMNy-KfUaIIJKrg-LmcgPlLg4QBm_6soup9NvtGOK6j6ux9yGXJrhyE_NQOuggZMRhN3gHuTxefviaT8ohlgncaKEc0GxEInaoGvzKx8HbXPqAr36L_rsUERx8DC-L553pM7y6vR8V3z59vDxbVhdfPp-fLS4qKyQZKoZrtlYZcI5QarlshGkb5yRIWxvJmKEUFGUgZcutZapRXdtaYhmz0NaOHRXns6-L5krvEm4j_dDReP1rENNam4S77EF3qhZUuhVYB40AMI1jDadAMC2zYpPX-9lrN6624CyGlkz_yPTxl-A3eh2vtSBCtE2NBiezweaJbLm40NOM4IkxTtpriuzx7WIpfh8hD3rrs4W-NwHimHVNGVVK4d7-jxJFFJe8kYi-fYJexTEFPIGJapUQXLX31NpgLj50EX_HTqZ6wRs1pVJzpE7_QOHlYOstVrXzOH8kePMwv98J3NURATkDNsWcE3Ta-sFMdUFn32tK9FR8PRdfY_H1VHw9JUufKO_M_6WpZ01GNqwh3Wfxd9FPI4cTpw
CitedBy_id crossref_primary_10_1038_s41573_019_0058_8
crossref_primary_10_1111_dth_14921
crossref_primary_10_1007_s00586_021_06826_z
crossref_primary_10_1016_j_ijbiomac_2024_132025
crossref_primary_10_1016_j_micpath_2021_104936
crossref_primary_10_3389_fvets_2025_1605215
crossref_primary_10_1080_10408398_2022_2056574
crossref_primary_10_1016_j_bbrc_2021_05_005
crossref_primary_10_3389_fmicb_2025_1590400
crossref_primary_10_3390_molecules25143219
crossref_primary_10_3390_microorganisms7080219
crossref_primary_10_1186_s40104_021_00663_2
crossref_primary_10_1016_j_dci_2020_103961
crossref_primary_10_1007_s12602_023_10155_6
crossref_primary_10_3389_fmicb_2020_01902
crossref_primary_10_3390_ani15071023
crossref_primary_10_4103_ijmr_IJMR_3514_20
crossref_primary_10_1016_j_psj_2024_104758
crossref_primary_10_1016_j_rvsc_2024_105523
crossref_primary_10_1111_jpn_13198
crossref_primary_10_3390_microorganisms13071443
crossref_primary_10_3390_foods13213415
crossref_primary_10_3390_antibiotics13030251
crossref_primary_10_1371_journal_pone_0302913
crossref_primary_10_3390_antibiotics9120926
crossref_primary_10_3390_antibiotics9120903
crossref_primary_10_1111_asj_13258
crossref_primary_10_1186_s42523_024_00375_8
crossref_primary_10_3390_biom15070980
Cites_doi 10.1073/pnas.0602888103
10.4049/jimmunol.1000376
10.1016/j.ab.2009.12.002
10.1016/j.vaccine.2009.05.094
10.1002/eji.201444988
10.1016/j.micinf.2013.08.007
10.1126/science.aaf1098
10.1074/jbc.M109.001180
10.1111/imm.12418
10.1016/j.it.2015.04.005
10.1073/pnas.1301975110
10.1016/j.clnu.2015.12.004
10.1038/nchembio.1393
10.1111/j.1574-6968.1998.tb12896.x
10.1385/IR:21:1:1
10.3390/nu3040442
10.4049/jimmunol.1501242
10.1038/srep40874
10.1016/j.molimm.2017.07.005
10.4049/jimmunol.172.6.3758
10.1084/jem.192.7.1069
10.1016/j.cvfa.2007.10.005
10.1155/2013/270301
10.1038/ncb1240
10.1097/COH.0000000000000154
10.1371/journal.pone.0154546
10.1038/nri.2016.29
10.1111/1541-4337.12013
10.1203/01.PDR.0000057205.64451.B7
10.1016/j.peptides.2013.10.008
10.1126/science.286.5439.525
10.1111/wrr.12211
10.1189/jlb.6AB0914-416R
10.1038/ni.1825
10.2119/2008-00002.Steinstraesser
10.1016/j.molimm.2008.12.015
10.4049/jimmunol.163.12.6718
10.1111/j.1365-2249.2007.03587.x
10.1016/j.dci.2016.03.008
10.1046/j.1523-1747.2003.12069.x
10.1111/zph.12167
10.1016/j.chom.2014.08.017
10.4049/jimmunol.0901813
10.1371/journal.pone.0059119
10.1038/nbt1267
10.1111/j.1939-1676.2000.tb02278.x
10.1074/jbc.M007816200
10.1016/j.molimm.2013.09.003
10.1182/blood.V97.12.3951
10.1038/nri3228
10.1111/j.1365-2567.2008.02834.x
10.1371/journal.pone.0072922
10.1038/nature22058
10.1038/nature13777
10.1038/srep26622
10.4049/jimmunol.0903984
10.1007/978-1-4614-3146-6_7
10.1038/nrmicro2745
10.1136/bmj.2.1859.399
10.1016/S0161-5890(03)00161-5
10.1016/j.dci.2016.02.023
10.1172/JCI114198
10.1111/imm.12148
10.4049/jimmunol.1201648
10.1016/j.vaccine.2009.01.117
10.1111/j.1462-5822.2009.01299.x
10.1371/journal.pone.0147373
10.1128/IAI.01563-06
10.1038/nrd3591
10.1086/424463
10.1126/science.1254009
10.1016/j.dld.2004.12.008
10.1126/scitranslmed.3003515
10.1016/j.molimm.2005.09.013
10.5713/ajas.2010.70630
10.2527/2005.83122876x
10.3382/ps.2008-00366
10.1016/j.vaccine.2012.10.011
10.1007/s00253-012-4588-9
10.1021/acs.jafc.6b00968
10.2460/ajvr.76.3.231
10.1136/gut.52.5.735
10.1080/15548627.2015.1075110
10.2174/2212798410901030231
10.1016/j.vaccine.2009.01.118
10.1111/j.1462-5822.2008.01227.x
10.4049/jimmunol.172.2.1146
10.1189/jlb.0708412
10.1189/jlb.5RI0315-096R
10.3109/08820137609033871
10.1146/annurev-food-022811-101137
10.1016/j.smim.2016.05.003
10.1038/srep33274
10.1016/j.jaci.2016.06.033
10.1128/CMR.13.4.602-614.2000
10.1371/journal.pone.0020637
10.1074/jbc.274.37.26249
10.1016/j.vetimm.2016.04.007
10.1371/journal.pone.0051337
10.1111/j.1365-3083.2006.001752.x
10.1073/pnas.1202870109
10.1016/j.vetmic.2012.05.034
10.4049/jimmunol.176.4.2455
10.1039/b813787k
10.1016/j.vaccine.2014.10.075
10.1073/pnas.220424597
10.1128/AAC.35.6.1153
10.1016/j.vetimm.2017.02.001
10.1002/jlb.64.6.845
10.1016/j.peptides.2011.06.005
10.3389/fimmu.2014.00520
10.1126/science.1251086
ContentType Journal Article
Copyright The Author(s) 2018
COPYRIGHT 2018 BioMed Central Ltd.
Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License.
Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml – notice: The Author(s) 2018
– notice: COPYRIGHT 2018 BioMed Central Ltd.
– notice: Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License.
– notice: Distributed under a Creative Commons Attribution 4.0 International License
DBID C6C
AAYXX
CITATION
NPM
3V.
7X7
7XB
88E
88I
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
M0S
M1P
M2P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
7S9
L.6
1XC
VOOES
5PM
DOA
DOI 10.1186/s13567-018-0558-2
DatabaseName Springer Nature OA Free Journals
CrossRef
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central
Proquest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
Science Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList
AGRICOLA

PubMed
Publicly Available Content Database

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: PIMPY
  name: Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Veterinary Medicine
EISSN 1297-9716
EndPage 68
ExternalDocumentID oai_doaj_org_article_f82617dbecde46eea4d3451e0006ab3d
PMC6066942
oai:HAL:hal-02973509v1
A548345125
30060758
10_1186_s13567_018_0558_2
Genre Journal Article
Review
GrantInformation_xml – fundername: Immuno Valley ALTANT ASIA2 program grant of the Dutch Ministry of Economic Affairs
– fundername: ;
GroupedDBID ---
0R~
123
2WC
53G
5VS
7X7
88E
88I
8FI
8FJ
AAFWJ
AAHBH
AAJSJ
AASML
ABUWG
ACGFS
ACGOD
ADBBV
ADRAZ
ADUKV
AENEX
AFKRA
AFPKN
AHBYD
AHMBA
AHYZX
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AOIJS
AZQEC
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C6C
CCPQU
CS3
DIK
DU5
DWQXO
E3Z
EBD
EBLON
EBS
ECGQY
EJD
EMOBN
EYRJQ
F5P
FRP
FYUFA
GNUQQ
GROUPED_DOAJ
H13
HCIFZ
HMCUK
HYE
IAG
IAO
INH
INR
ITC
KQ8
M1P
M2P
M41
M48
O5R
O5S
OK1
PGMZT
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQQKQ
PROAC
PSQYO
PUEGO
RBZ
RED
RNS
ROL
RPM
RSV
SMD
SOJ
SV3
UKHRP
AAYXX
AFFHD
CITATION
-A0
3V.
ACRMQ
ADINQ
ALIPV
C24
M~E
NPM
7XB
8FK
K9.
PKEHL
PQEST
PQUKI
PRINS
Q9U
7X8
7S9
L.6
--K
1B1
1XC
2VQ
4.4
AAOTM
ABUBZ
AHSBF
GI~
IHE
IPNFZ
NQ-
RIG
RPZ
TR2
VOOES
5PM
ID FETCH-LOGICAL-c670t-3efe9c8aedd011c5746a94dd7e7c2a733a11e813e7795cc3848f99c0c33ce92d3
IEDL.DBID DOA
ISICitedReferencesCount 39
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000440478400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1297-9716
0928-4249
IngestDate Fri Oct 03 12:41:56 EDT 2025
Tue Nov 04 02:00:54 EST 2025
Tue Oct 14 20:03:28 EDT 2025
Thu Oct 02 11:12:17 EDT 2025
Sun Nov 09 10:00:09 EST 2025
Sun Oct 19 01:28:18 EDT 2025
Tue Nov 11 09:53:59 EST 2025
Tue Nov 04 17:25:41 EST 2025
Wed Feb 19 02:42:45 EST 2025
Tue Nov 18 19:42:09 EST 2025
Sat Nov 29 06:05:07 EST 2025
Sat Sep 06 07:20:50 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Porcine Reproductive And Respiratory Syndrome Virus (PRRSV)
Cathelicidin-related Antimicrobial Peptide (CRAMP)
Indolicidin
Spray-dried Plasma (SDP)
Host Defense Peptides (HDPs)
Language English
License Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c670t-3efe9c8aedd011c5746a94dd7e7c2a733a11e813e7795cc3848f99c0c33ce92d3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-4931-5201
OpenAccessLink https://doaj.org/article/f82617dbecde46eea4d3451e0006ab3d
PMID 30060758
PQID 2089866589
PQPubID 2040250
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_f82617dbecde46eea4d3451e0006ab3d
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6066942
hal_primary_oai_HAL_hal_02973509v1
proquest_miscellaneous_2131888006
proquest_miscellaneous_2080857547
proquest_journals_2089866589
gale_infotracmisc_A548345125
gale_infotracacademiconefile_A548345125
pubmed_primary_30060758
crossref_citationtrail_10_1186_s13567_018_0558_2
crossref_primary_10_1186_s13567_018_0558_2
springer_journals_10_1186_s13567_018_0558_2
PublicationCentury 2000
PublicationDate 2018-07-31
PublicationDateYYYYMMDD 2018-07-31
PublicationDate_xml – month: 07
  year: 2018
  text: 2018-07-31
  day: 31
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Veterinary research (Paris)
PublicationTitleAbbrev Vet Res
PublicationTitleAlternate Vet Res
PublicationYear 2018
Publisher BioMed Central
BioMed Central Ltd
Springer Nature B.V
BMC
Publisher_xml – name: BioMed Central
– name: BioMed Central Ltd
– name: Springer Nature B.V
– name: BMC
References M Akdis (558_CR11) 2016; 138
J Kovacs-Nolan (558_CR113) 2009; 27
LT Sunkara (558_CR83) 2014; 57
AH Achtman (558_CR118) 2012; 4
A Al-Mamun (558_CR79) 2013; 15
RP Darveau (558_CR117) 1991; 35
OE Sorensen (558_CR63) 2001; 97
A Gronberg (558_CR95) 2014; 22
RL Hassfurther (558_CR16) 2015; 76
D Carlander (558_CR37) 2000; 21
A Calmette (558_CR26) 1896; 2
558_CR2
558_CR3
VK Lishko (558_CR104) 2016; 2016
M Schlee (558_CR87) 2007; 75
A Dijk van (558_CR42) 2009; 46
A Dijk van (558_CR94) 2012; 160
J Kovacs-Nolan (558_CR112) 2009; 27
CJ Hedegaard (558_CR39) 2016; 11
K Chakraborty (558_CR84) 2009; 284
558_CR1
AL Hilchie (558_CR96) 2013; 9
F Nimmerjahn (558_CR22) 2015; 36
JB Schaal (558_CR49) 2012; 7
X Zeng (558_CR74) 2013; 8
R Fisher (558_CR30) 2016
JH Es van (558_CR58) 2005; 7
RI Lehrer (558_CR64) 1989; 84
V Virdi (558_CR34) 2013; 110
A Nijnik (558_CR110) 2010; 184
MD Kraaij (558_CR100) 2017; 90
N Mookherjee (558_CR50) 2006; 176
TA Pham (558_CR13) 2014; 16
H Sherman (558_CR73) 2006; 43
RE Hancock (558_CR41) 2006; 24
DM Weaver (558_CR19) 2000; 14
MJ Alam (558_CR82) 2015; 33
RE Hancock (558_CR97) 2012; 10
MA Keller (558_CR27) 2000; 13
NH Salzman (558_CR70) 2010; 11
CJ Hedegaard (558_CR40) 2017; 186
G Vidarsson (558_CR23) 2014; 5
J Kindrachuk (558_CR114) 2009; 27
S Caro Di (558_CR86) 2005; 37
D Yang (558_CR47) 2000; 192
R Ramos (558_CR106) 2011; 32
NY Yount (558_CR62) 1999; 274
G Marano (558_CR29) 2016; 14
RA Dorschner (558_CR68) 2003; 53
DA O’Neil (558_CR66) 1999; 163
V Petrov (558_CR43) 2013; 140
CSF Bah (558_CR35) 2013; 12
CJ Hedegaard (558_CR18) 2016; 174
X Qiu (558_CR28) 2014; 514
J Rohrl (558_CR48) 2010; 184
M Schwab (558_CR80) 2008; 125
L Bandholtz (558_CR98) 2006; 63
R Nocerino (558_CR89) 2017; 36
J Kleinnijenhuis (558_CR7) 2012; 109
K Moor (558_CR21) 2017; 544
R Raqib (558_CR77) 2006; 103
M Coorens (558_CR51) 2017; 7
RS Rekha (558_CR75) 2015; 11
M Cappelletti (558_CR103) 2015; 144
A Lihme (558_CR38) 2010; 399
T Cuperus (558_CR108) 2016; 6
Y Goto (558_CR14) 2014; 345
T Cuperus (558_CR57) 2016; 61
P Sarker (558_CR78) 2011; 6
M Coorens (558_CR53) 2015; 195
K Chakraborty (558_CR85) 2008; 10
JL Pierce (558_CR33) 2005; 83
DA O’Neil (558_CR60) 2003; 40
AS Ferreira (558_CR31) 2009; 1
N Mookherjee (558_CR44) 2009; 5
DC Speksnijder (558_CR4) 2015; 62
U Gerstel (558_CR67) 2009; 11
RJ Arts (558_CR8) 2015; 98
P Presicce (558_CR102) 2009; 86
D Torrallardona (558_CR32) 2010; 23
A Kalita (558_CR116) 2004; 190
S Saeed (558_CR9) 2014; 345
CD Fjell (558_CR93) 2011; 11
MG Netea (558_CR5) 2016; 352
DJ Davidson (558_CR99) 2004; 172
J Schauber (558_CR71) 2003; 52
S Godden (558_CR20) 2008; 24
E Miraglia (558_CR81) 2016; 6
W Jiang (558_CR72) 2013; 50
RL Gallo (558_CR65) 2012; 12
L Kannan (558_CR56) 2009; 88
MM Rahman (558_CR15) 2012; 30
H Liu (558_CR52) 2013; 97
MA Hamon (558_CR10) 2016; 28
DM Bowdish (558_CR45) 2004; 172
P Fehlbaum (558_CR90) 2000; 97
E Tourneur (558_CR69) 2013; 2013
BA Blok (558_CR6) 2015; 98
M Ren (558_CR91) 2016; 64
AM Does van der (558_CR101) 2010; 185
WL Hurley (558_CR17) 2011; 3
BS Graham (558_CR25) 2015; 10
D Yang (558_CR46) 1999; 286
K Putsep (558_CR59) 2000; 275
RE Hancock (558_CR55) 2016; 16
L Steinstraesser (558_CR105) 2008; 14
VA Schneider (558_CR109) 2016; 60
C Subbalakshmi (558_CR92) 1998; 160
SH Kim (558_CR115) 2015; 45
M Schlee (558_CR88) 2008; 151
B Rivas-Santiago (558_CR111) 2013; 8
M Ohno (558_CR12) 2012; 746
I Nagaoka (558_CR61) 1998; 64
L Zhang (558_CR76) 2016; 11
TJ Newby (558_CR24) 1976; 5
P Tewary (558_CR54) 2013; 191
JD Heilborn (558_CR107) 2003; 120
J Kovacs-Nolan (558_CR36) 2012; 3
References_xml – volume: 103
  start-page: 9178
  year: 2006
  ident: 558_CR77
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0602888103
– volume: 185
  start-page: 1442
  year: 2010
  ident: 558_CR101
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1000376
– volume: 399
  start-page: 102
  year: 2010
  ident: 558_CR38
  publication-title: Anal Biochem
  doi: 10.1016/j.ab.2009.12.002
– volume: 27
  start-page: 4662
  year: 2009
  ident: 558_CR114
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2009.05.094
– volume: 45
  start-page: 1402
  year: 2015
  ident: 558_CR115
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201444988
– volume: 15
  start-page: 939
  year: 2013
  ident: 558_CR79
  publication-title: Microbes Infect
  doi: 10.1016/j.micinf.2013.08.007
– volume: 352
  start-page: aaf1098
  year: 2016
  ident: 558_CR5
  publication-title: Science
  doi: 10.1126/science.aaf1098
– volume: 284
  start-page: 21810
  year: 2009
  ident: 558_CR84
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.001180
– volume: 144
  start-page: 661
  year: 2015
  ident: 558_CR103
  publication-title: Immunology
  doi: 10.1111/imm.12418
– volume: 36
  start-page: 325
  year: 2015
  ident: 558_CR22
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2015.04.005
– volume: 110
  start-page: 11809
  year: 2013
  ident: 558_CR34
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1301975110
– volume: 36
  start-page: 118
  year: 2017
  ident: 558_CR89
  publication-title: Clin Nutr
  doi: 10.1016/j.clnu.2015.12.004
– volume: 9
  start-page: 761
  year: 2013
  ident: 558_CR96
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.1393
– volume: 160
  start-page: 91
  year: 1998
  ident: 558_CR92
  publication-title: FEMS Microbiol Lett
  doi: 10.1111/j.1574-6968.1998.tb12896.x
– volume: 21
  start-page: 1
  year: 2000
  ident: 558_CR37
  publication-title: Immunol Res
  doi: 10.1385/IR:21:1:1
– volume: 3
  start-page: 442
  year: 2011
  ident: 558_CR17
  publication-title: Nutrients
  doi: 10.3390/nu3040442
– volume: 195
  start-page: 3970
  year: 2015
  ident: 558_CR53
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1501242
– volume: 7
  start-page: 40874
  year: 2017
  ident: 558_CR51
  publication-title: Sci Rep
  doi: 10.1038/srep40874
– volume: 90
  start-page: 118
  year: 2017
  ident: 558_CR100
  publication-title: Mol Immunol
  doi: 10.1016/j.molimm.2017.07.005
– volume: 172
  start-page: 3758
  year: 2004
  ident: 558_CR45
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.6.3758
– volume: 192
  start-page: 1069
  year: 2000
  ident: 558_CR47
  publication-title: J Exp Med
  doi: 10.1084/jem.192.7.1069
– volume: 24
  start-page: 19
  year: 2008
  ident: 558_CR20
  publication-title: Vet Clin North Am Food Anim Pract
  doi: 10.1016/j.cvfa.2007.10.005
– volume: 2013
  start-page: 270301
  year: 2013
  ident: 558_CR69
  publication-title: Clin Dev Immunol
  doi: 10.1155/2013/270301
– volume: 7
  start-page: 381
  year: 2005
  ident: 558_CR58
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1240
– volume: 10
  start-page: 129
  year: 2015
  ident: 558_CR25
  publication-title: Curr Opin HIV AIDS
  doi: 10.1097/COH.0000000000000154
– volume: 11
  start-page: e0154546
  year: 2016
  ident: 558_CR76
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0154546
– volume: 16
  start-page: 321
  year: 2016
  ident: 558_CR55
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri.2016.29
– ident: 558_CR3
– volume: 12
  start-page: 314
  year: 2013
  ident: 558_CR35
  publication-title: Compr Rev Food Sci Food Saf
  doi: 10.1111/1541-4337.12013
– volume: 53
  start-page: 566
  year: 2003
  ident: 558_CR68
  publication-title: Pediatr Res
  doi: 10.1203/01.PDR.0000057205.64451.B7
– volume: 50
  start-page: 129
  year: 2013
  ident: 558_CR72
  publication-title: Peptides
  doi: 10.1016/j.peptides.2013.10.008
– volume: 286
  start-page: 525
  year: 1999
  ident: 558_CR46
  publication-title: Science
  doi: 10.1126/science.286.5439.525
– volume: 22
  start-page: 613
  year: 2014
  ident: 558_CR95
  publication-title: Wound Repair Regen
  doi: 10.1111/wrr.12211
– volume-title: Emerging infections, Chapter 3
  year: 2016
  ident: 558_CR30
– volume: 98
  start-page: 129
  year: 2015
  ident: 558_CR8
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.6AB0914-416R
– volume: 11
  start-page: 76
  year: 2010
  ident: 558_CR70
  publication-title: Nat Immunol
  doi: 10.1038/ni.1825
– volume: 14
  start-page: 528
  year: 2008
  ident: 558_CR105
  publication-title: Mol Med
  doi: 10.2119/2008-00002.Steinstraesser
– volume: 46
  start-page: 1517
  year: 2009
  ident: 558_CR42
  publication-title: Mol Immunol
  doi: 10.1016/j.molimm.2008.12.015
– volume: 163
  start-page: 6718
  year: 1999
  ident: 558_CR66
  publication-title: J Immunol
  doi: 10.4049/jimmunol.163.12.6718
– volume: 151
  start-page: 528
  year: 2008
  ident: 558_CR88
  publication-title: Clin Exp Immunol
  doi: 10.1111/j.1365-2249.2007.03587.x
– volume: 61
  start-page: 48
  year: 2016
  ident: 558_CR57
  publication-title: Dev Comp Immunol
  doi: 10.1016/j.dci.2016.03.008
– volume: 120
  start-page: 379
  year: 2003
  ident: 558_CR107
  publication-title: J Invest Dermatol
  doi: 10.1046/j.1523-1747.2003.12069.x
– volume: 62
  start-page: 79
  issue: Suppl 1
  year: 2015
  ident: 558_CR4
  publication-title: Zoonoses Public Health
  doi: 10.1111/zph.12167
– volume: 16
  start-page: 504
  year: 2014
  ident: 558_CR13
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2014.08.017
– volume: 184
  start-page: 2539
  year: 2010
  ident: 558_CR110
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0901813
– volume: 8
  start-page: e59119
  year: 2013
  ident: 558_CR111
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0059119
– volume: 24
  start-page: 1551
  year: 2006
  ident: 558_CR41
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt1267
– volume: 14
  start-page: 569
  year: 2000
  ident: 558_CR19
  publication-title: J Vet Intern Med
  doi: 10.1111/j.1939-1676.2000.tb02278.x
– volume: 275
  start-page: 40478
  year: 2000
  ident: 558_CR59
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M007816200
– volume: 57
  start-page: 171
  year: 2014
  ident: 558_CR83
  publication-title: Mol Immunol
  doi: 10.1016/j.molimm.2013.09.003
– volume: 14
  start-page: 152
  year: 2016
  ident: 558_CR29
  publication-title: Blood Transfus
– volume: 97
  start-page: 3951
  year: 2001
  ident: 558_CR63
  publication-title: Blood
  doi: 10.1182/blood.V97.12.3951
– volume: 12
  start-page: 503
  year: 2012
  ident: 558_CR65
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3228
– volume: 2016
  start-page: 39
  year: 2016
  ident: 558_CR104
  publication-title: Res Rep Biochem
– volume: 125
  start-page: 241
  year: 2008
  ident: 558_CR80
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2008.02834.x
– volume: 8
  start-page: e72922
  year: 2013
  ident: 558_CR74
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0072922
– volume: 544
  start-page: 498
  year: 2017
  ident: 558_CR21
  publication-title: Nature
  doi: 10.1038/nature22058
– volume: 514
  start-page: 47
  year: 2014
  ident: 558_CR28
  publication-title: Nature
  doi: 10.1038/nature13777
– volume: 6
  start-page: 26622
  year: 2016
  ident: 558_CR108
  publication-title: Sci Rep
  doi: 10.1038/srep26622
– volume: 184
  start-page: 6688
  year: 2010
  ident: 558_CR48
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0903984
– volume: 746
  start-page: 86
  year: 2012
  ident: 558_CR12
  publication-title: Adv Exp Med Biol
  doi: 10.1007/978-1-4614-3146-6_7
– volume: 10
  start-page: 243
  year: 2012
  ident: 558_CR97
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro2745
– volume: 2
  start-page: 399
  year: 1896
  ident: 558_CR26
  publication-title: Br Med J
  doi: 10.1136/bmj.2.1859.399
– volume: 40
  start-page: 445
  year: 2003
  ident: 558_CR60
  publication-title: Mol Immunol
  doi: 10.1016/S0161-5890(03)00161-5
– volume: 60
  start-page: 108
  year: 2016
  ident: 558_CR109
  publication-title: Dev Comp Immunol
  doi: 10.1016/j.dci.2016.02.023
– volume: 84
  start-page: 553
  year: 1989
  ident: 558_CR64
  publication-title: J Clin Invest
  doi: 10.1172/JCI114198
– volume: 140
  start-page: 413
  year: 2013
  ident: 558_CR43
  publication-title: Immunology
  doi: 10.1111/imm.12148
– volume: 191
  start-page: 865
  year: 2013
  ident: 558_CR54
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1201648
– volume: 27
  start-page: 2048
  year: 2009
  ident: 558_CR113
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2009.01.117
– volume: 11
  start-page: 842
  year: 2009
  ident: 558_CR67
  publication-title: Cell Microbiol
  doi: 10.1111/j.1462-5822.2009.01299.x
– ident: 558_CR2
– volume: 11
  start-page: e0147373
  year: 2016
  ident: 558_CR39
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0147373
– volume: 75
  start-page: 2399
  year: 2007
  ident: 558_CR87
  publication-title: Infect Immun
  doi: 10.1128/IAI.01563-06
– volume: 11
  start-page: 37
  year: 2011
  ident: 558_CR93
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd3591
– volume: 190
  start-page: 1476
  year: 2004
  ident: 558_CR116
  publication-title: J Infect Dis
  doi: 10.1086/424463
– volume: 345
  start-page: 1254009
  year: 2014
  ident: 558_CR14
  publication-title: Science
  doi: 10.1126/science.1254009
– volume: 37
  start-page: 320
  year: 2005
  ident: 558_CR86
  publication-title: Dig Liver Dis
  doi: 10.1016/j.dld.2004.12.008
– volume: 4
  start-page: 135ra164
  year: 2012
  ident: 558_CR118
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3003515
– volume: 43
  start-page: 1617
  year: 2006
  ident: 558_CR73
  publication-title: Mol Immunol
  doi: 10.1016/j.molimm.2005.09.013
– volume: 23
  start-page: 131
  year: 2010
  ident: 558_CR32
  publication-title: Asian-Austr J Anim Sci
  doi: 10.5713/ajas.2010.70630
– volume: 83
  start-page: 2876
  year: 2005
  ident: 558_CR33
  publication-title: J Anim Sci
  doi: 10.2527/2005.83122876x
– volume: 88
  start-page: 372
  year: 2009
  ident: 558_CR56
  publication-title: Poult Sci
  doi: 10.3382/ps.2008-00366
– volume: 30
  start-page: 7165
  year: 2012
  ident: 558_CR15
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2012.10.011
– volume: 97
  start-page: 3395
  year: 2013
  ident: 558_CR52
  publication-title: Appl Microbiol Biotechnol
  doi: 10.1007/s00253-012-4588-9
– volume: 64
  start-page: 3371
  year: 2016
  ident: 558_CR91
  publication-title: J Agric Food Chem
  doi: 10.1021/acs.jafc.6b00968
– volume: 76
  start-page: 231
  year: 2015
  ident: 558_CR16
  publication-title: Am J Vet Res
  doi: 10.2460/ajvr.76.3.231
– volume: 52
  start-page: 735
  year: 2003
  ident: 558_CR71
  publication-title: Gut
  doi: 10.1136/gut.52.5.735
– volume: 11
  start-page: 1688
  year: 2015
  ident: 558_CR75
  publication-title: Autophagy
  doi: 10.1080/15548627.2015.1075110
– volume: 1
  start-page: 231
  year: 2009
  ident: 558_CR31
  publication-title: Recent Pat Food Nutr Agric
  doi: 10.2174/2212798410901030231
– volume: 27
  start-page: 2055
  year: 2009
  ident: 558_CR112
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2009.01.118
– volume: 10
  start-page: 2520
  year: 2008
  ident: 558_CR85
  publication-title: Cell Microbiol
  doi: 10.1111/j.1462-5822.2008.01227.x
– volume: 172
  start-page: 1146
  year: 2004
  ident: 558_CR99
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.2.1146
– volume: 86
  start-page: 941
  year: 2009
  ident: 558_CR102
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.0708412
– volume: 98
  start-page: 347
  year: 2015
  ident: 558_CR6
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.5RI0315-096R
– volume: 5
  start-page: 631
  year: 1976
  ident: 558_CR24
  publication-title: Immunol Commun
  doi: 10.3109/08820137609033871
– volume: 3
  start-page: 163
  year: 2012
  ident: 558_CR36
  publication-title: Annu Rev Food Sci Technol
  doi: 10.1146/annurev-food-022811-101137
– volume: 28
  start-page: 351
  year: 2016
  ident: 558_CR10
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2016.05.003
– volume: 6
  start-page: 33274
  year: 2016
  ident: 558_CR81
  publication-title: Sci Rep
  doi: 10.1038/srep33274
– volume: 138
  start-page: 984
  year: 2016
  ident: 558_CR11
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2016.06.033
– volume: 13
  start-page: 602
  year: 2000
  ident: 558_CR27
  publication-title: Clin Microbiol Rev
  doi: 10.1128/CMR.13.4.602-614.2000
– volume: 6
  start-page: e20637
  year: 2011
  ident: 558_CR78
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0020637
– volume: 274
  start-page: 26249
  year: 1999
  ident: 558_CR62
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.37.26249
– volume: 174
  start-page: 50
  year: 2016
  ident: 558_CR18
  publication-title: Vet Immunol Immunopathol
  doi: 10.1016/j.vetimm.2016.04.007
– volume: 7
  start-page: e51337
  year: 2012
  ident: 558_CR49
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0051337
– volume: 63
  start-page: 410
  year: 2006
  ident: 558_CR98
  publication-title: Scand J Immunol
  doi: 10.1111/j.1365-3083.2006.001752.x
– volume: 109
  start-page: 17537
  year: 2012
  ident: 558_CR7
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1202870109
– volume: 160
  start-page: 347
  year: 2012
  ident: 558_CR94
  publication-title: Vet Microbiol
  doi: 10.1016/j.vetmic.2012.05.034
– volume: 176
  start-page: 2455
  year: 2006
  ident: 558_CR50
  publication-title: J Immunol
  doi: 10.4049/jimmunol.176.4.2455
– volume: 5
  start-page: 483
  year: 2009
  ident: 558_CR44
  publication-title: Mol BioSyst
  doi: 10.1039/b813787k
– volume: 33
  start-page: 18
  year: 2015
  ident: 558_CR82
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2014.10.075
– volume: 97
  start-page: 12723
  year: 2000
  ident: 558_CR90
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.220424597
– volume: 35
  start-page: 1153
  year: 1991
  ident: 558_CR117
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.35.6.1153
– volume: 186
  start-page: 9
  year: 2017
  ident: 558_CR40
  publication-title: Vet Immunol Immunopathol
  doi: 10.1016/j.vetimm.2017.02.001
– volume: 64
  start-page: 845
  year: 1998
  ident: 558_CR61
  publication-title: J Leukoc Biol
  doi: 10.1002/jlb.64.6.845
– volume: 32
  start-page: 1469
  year: 2011
  ident: 558_CR106
  publication-title: Peptides
  doi: 10.1016/j.peptides.2011.06.005
– volume: 5
  start-page: 520
  year: 2014
  ident: 558_CR23
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2014.00520
– volume: 345
  start-page: 1251086
  year: 2014
  ident: 558_CR9
  publication-title: Science
  doi: 10.1126/science.1251086
– ident: 558_CR1
RelatedPersons Yang, Cindy
RelatedPersons_xml – fullname: Yang, Cindy
SSID ssj0016354
Score 2.421551
SecondaryResourceType review_article
Snippet Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation,...
[...]the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described. 1...
AbstractInnate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation,...
Abstract Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation,...
SourceID doaj
pubmedcentral
hal
proquest
gale
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 68
SubjectTerms 2nd International Symposium on Alternatives to Antibiotics
acute phase proteins
adaptive immunity
animal production
Antibiotic growth promoters
Antibiotics
Antimicrobial agents
Bacterial infections
Breeding of animals
cathelicidins
Chemokines
complement
Defense mechanisms
Health aspects
Immune response
Immune system
Immunoglobulins
Immunology
Infections
Infectious diseases
innate immunity
Life Sciences
mechanism of action
Medicine
Medicine & Public Health
Microbiology
microorganisms
neonates
Neutrophils
Peptides
Review
Rodents
vaccine adjuvants
veterinary medicine
Veterinary Medicine/Veterinary Science
Virology
Yang, Cindy
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LbxMxELZoyoELj_JaKMggJF5aEcf22j6hFFrlUKIIAerN2tgOjQS7IZtU_HxmHGerpSIXjtkdO_Z6ZjzjGX9DyIuBQrxTVuZ8xkOOgbMcdJ7MwROYyVAKb1zEmT1V47E-OzOTdODWpLTKrU6MitrXDs_IwUnXBrHZtHm_-JVj1SiMrqYSGntkH5HKRI_sHx2PJ5_bOAJspxFAyuAZEngaKa7JdPGuYVwWmHap876UwC6dnSkC-Ldqeu8csySvmqBXMyn_CqfGXerk1v_O7za5mexTOtww1B1yLVQH5OAbJs3Em7v0UwrG3yW_gcXool5hvhE0AeuXzvG2SY0gI5jg3tCy8hSvkVAfZuAvAzkm0fjQ0Fejj5PmNV3VdIngsYGCIUrXQFHPoBVeZKkRQJrOK_g5_wn9LzbYtMBH98jXk-MvH0Z5KuSQu0L1VzmH_zBOl8F7UCdOKlGURnivgnKDUnFeMhY040EpI53jGhjFGNd3nLtgBp7fJ72qrsJDQplgU3CyBCtVKQKf6iI4zaehL91UCKky0t8uonUJ5RyLbfyw0dvRhd2su4V1t7judpCRN22TxQbiYxfxEXJGS4jo3PFBvfxuk7DbmUacew_i4YMoArI8F5IFtA3KKfcZeYl8ZVGHwOBcma5CwBQRjcsOJR7xgikmM3LYoQTZd53Xz4EzO4MZDU8tPotFycAavGDQx5bjbFJQjb1kt4w8a19j95h0V4V6HWliAVehdtAw2BRgD-gXGXmwkYV2OBzBfsAfzYjqSElnvN031fw8QpyjW20EfO23W3m6HPo_1-bR7ok-JjcGUdrxYP6Q9FbLdXhCrruL1bxZPk2a4w_29HPR
  priority: 102
  providerName: ProQuest
– databaseName: Springer Journals
  dbid: RSV
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfYQGgvfBQYgYEMQgKGIpLYju3H8jH1YUwTH9PeLNd2WSVIqqad-PO5c5OgMJgEj3XOrmPfne9ydz8T8qyQiHea25TNWEgxcJaCzhMpeAIzESz32kWc2UN5dKROT_VxW8fddNnuXUgyauoo1qp83eRMlJgmqdJMCNjeLXIVTjuF0vjx00kfOoATlLfhyz92GxxAEae_18ZbZ5gMedHSvJgw-VvUNB5GBzf_6zVukRut7UnHG2a5Ta6EakSuf2ij6yMyOsHcmFigS7vWO-QHcBJd1CtMK4LeYOTSORaV1IglgnnsDbWVp1gtQn2YgVsM5Jgr40NDX0zeHTcv6aqmS8SIDRTsTboGinoGvbBepUacaDqv4Of8O4y_2EDQArvcJV8O3n9-O0nb-xpSV8pslTL4D-2UDd6D1nBC8tJq7r0M0hVWMmbzPKicBSm1cI4p4AetXeYYc0EXnt0j21VdhfuE5jyfgi_FcystD2yqyuAUm4ZMuCnnQiYk6zbRuBbMHO_U-GaiU6NKs1lnA-tscJ1NkZD9vstig-RxGfEb5IyeEEG4Y0O9_GpamTYzhXD2HqTAB14G5GzGRR7QBLBT5hPyHPnKoKqAyTnbVjzAKyLolhkL_JILFpdIyN6AEkTcDR4_Bc4cTGYyPjTYFu8eAzE4z2GMjnFNq4caU2RKI6Kh0gl50j_G4TG3rgr1OtLEe1q5vIQmB90Pqj4rE7K7kYV-OgwxfcDtTIgcSMlgvsMn1fwsIpmj96w5rParTlZ-Tf2ve_Pgn6gfkp0iCht-jt8j26vlOjwi19z5at4sH0fV8RNA_Wk1
  priority: 102
  providerName: Springer Nature
Title The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production
URI https://link.springer.com/article/10.1186/s13567-018-0558-2
https://www.ncbi.nlm.nih.gov/pubmed/30060758
https://www.proquest.com/docview/2089866589
https://www.proquest.com/docview/2080857547
https://www.proquest.com/docview/2131888006
https://hal.science/hal-02973509
https://pubmed.ncbi.nlm.nih.gov/PMC6066942
https://doaj.org/article/f82617dbecde46eea4d3451e0006ab3d
Volume 49
WOSCitedRecordID wos000440478400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVADU
  databaseName: BioMed Central Open Access Free
  customDbUrl:
  eissn: 1297-9716
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0016354
  issn: 1297-9716
  databaseCode: RBZ
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://www.biomedcentral.com/search/
  providerName: BioMedCentral
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1297-9716
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0016354
  issn: 1297-9716
  databaseCode: DOA
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1297-9716
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0016354
  issn: 1297-9716
  databaseCode: 7X7
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1297-9716
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0016354
  issn: 1297-9716
  databaseCode: BENPR
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 1297-9716
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0016354
  issn: 1297-9716
  databaseCode: PIMPY
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Science Database
  customDbUrl:
  eissn: 1297-9716
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0016354
  issn: 1297-9716
  databaseCode: M2P
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/sciencejournals
  providerName: ProQuest
– providerCode: PRVAVX
  databaseName: SpringerLINK Contemporary 1997-Present
  customDbUrl:
  eissn: 1297-9716
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0016354
  issn: 1297-9716
  databaseCode: RSV
  dateStart: 20111201
  isFulltext: true
  titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22
  providerName: Springer Nature
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELfY4IEXBOMrMCqDkPhStDi2Y-exg01FWqtowDSerNR2tUqQVE078edz56SFMDFeeIkU--xccufzXXz-mZCXqUK8U1bGfMZ9jAtnMdg8GUMkMJO-FC63AWf2RE0m-vw8L3476gtzwlp44PbDHcw0YoY7eJTzIvPYnAvJPNrZcsodWl_wejbBVLd-ANOo6NYwmc4OGsZlhimWOk6kBNXozUIBrH9rkncuMCPyqrt5NWvyj6XTMCMd3yV3OleSDttXuEdu-GqP7J1hfkvYZEvH3br5ffIDtIEu6hWmBkETcFTpHDeG1IgHgrnoDS0rR3HHB3V-BqEtkGO-i_MNfT36UDRv6KqmS8R59RR8RroGinoGrXDPSY1Yz3Rewe38O_S_aGFkQeQPyJfjo8_vR3F35kJsM5WsYg7PyK0uvXMw8q1UIitz4Zzyyqal4rxkzGvGvVK5tJZrkGme28Rybn2eOv6Q7FZ15R8TygSbQjwkWKlK4flUZ95qPvWJtFMhpIpIspGBsR0gOZ6L8c2EwERnphWbAbEZFJtJI_J222TRonFcR3yIgt0SIpB2KAD1Mp16mX-pV0ReoVoYHO7AnC27XQvwigicZYYS_8aC1yQjst-jhGFqe9UvQLF6zIyGJwbLwvlh4LhdMuhjo3emsyWNAfXOEZVQ5xF5vq3G7jE_rvL1OtCEs1aFuoaGgf0Gc51kEXnUqvKWHY64PBA6RkT1lLzHb7-mml8ENHKMgHMBX_vdZjj8Yv2vsnnyP2TzlNxOw5DGP-37ZHe1XPtn5Ja9XM2b5YDsqHMVrnpAbh4eTYrTQTAScB2nBZQVH8fFV7g7_XT2E7kqapE
linkProvider Directory of Open Access Journals
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELbaggQXHuUVKGAQiJcikjiO7QNCC6XaqttVDwXtzWRtL10JkmWzW-BP8RuZcZKtQkVvPXBMPLYmzsx4xh5_Q8iTRCDeaZyHbMJciAdnIdg8HkIkMOEuT60yHmd2IIZDORqpgzXyu70Lg2mVrU30htqWBvfIIUiXCrHZpHo7-x5i1Sg8XW1LaNRised-_YCQrXqzuw3_92mS7Hw4fN8Pm6oCoclEtAiZmzhlZO6sBdk2XKRZrlJrhRMmyQVjeRw7GTMnhOLGMAlcK2Uiw5hxKrEMxl0nF8COC0whE6NVgAeuja-6FincsYK4pjlFjWX2uooZzzDJU4YR5yCcnXXQlwtYLQrrR5iTedrhPZ23-dfhrV8Td67-b7N5jVxpvG_aq9XlOllzxSbZ_IQpQf5eMt1vUg1ukJ-gQHRWLjCbCrqAb0-neJemRAgVTN-vaF5YipdkqAX2igrIMUXIuoo-728fVC_ooqRzhMZ1FNxsugSKcgK98JpOifDYdFrA4_QbjD-rkXdBS26Sj-cyBbfIRlEW7g6hcRqPIYRM41zkqWNjmTkj2dhF3IzTlIuARK3QaNNguGMpka_ax3Iy07WcaZAzjXKmk4C8XHWZ1QAmZxG_Q0lcESL2uH9Rzr_oxpTpiUQUfwvKb12aOVRolvLYoeeTj5kNyDOUY40WEpgzeXPRAz4RscZ0j-MGNjiaPCBbHUqwbKbT_Bg0ocNMvzfQ-M6XXANf9ziGMVoJ1435rfSJeAfk0aoZh8eUwsKVS0_jy9Om4gyaGJY8WOGiLCC3a91bscMQygii7YCIjlZ2-O22FNMjD-COmwYqhdl-1ervCev__Dd3z_7Qh-RS_3B_oAe7w7175HLiLQ0eQWyRjcV86e6Ti-Z4Ma3mD7zNouTzeav1HzBQ0HA
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3rb9MwELfYQBNfeJRXYIBBSLwULYnt2PlYGFURpZoETPtmpbbDKkFSNe3En8-d80BhMAnxMfbZcew7-y539zMhzxKJeKdxHrKCuRAdZyHseSIES6AQLuc2Mx5ndibnc3Vykh2195zWXbR755JschoQpancHKxs0Yi4Sg_qmIkUQyZVGAkBS71DLnO8MwjN9U_HvRsBTlPeujL_2GxwGHnM_n5n3jnFwMjzWuf54MnfPKj-YJpc_-9PukGutTopHTdMdJNccuWI7H1sve4jMjrGmBmfuEu70lvkB3AYXVX4CuBhCsovXWKySYUYIxjfXtO8tBSzSKh1BZjLQI4xNNbV9MX08Kh-STcVXSN2rKOgh9ItUFQFtMI8lgrxo-myhMfld-h_1UDTAhvdJl8m7z6_nYbtPQ6hSWW0CRm8IzMqd9bCbmKE5GmecWulkybJJWN5HDsVMydlJoxhCvgky0xkGDMuSyy7Q3bLqnT3CI15vAAbi8e5zLljC5U6o9jCRcIsOBcyIFG3oNq0IOd418Y37Y0dlepmnjXMs8Z51klAXvVNVg3Cx0XEb5BLekIE5_YF1fqrbmVdFwph7i1Ih3U8dcjxjIvYoWqQL5gNyHPkMY1bCAzO5G0mBHwignHpscA_vKCJiYDsDyhB9M2g-ilw6WAw0_FMY5m_kwyUwbMY-uiYWLf7U62TSGWIdKiygDzpq7F7jLkrXbX1NP7-Vi4voInhTIAjIEoDcreRi344DLF-wBwNiBxIzGC8w5pyeeoRztGqzjjM9utObn4N_a9rc_-fqB-TvaPDiZ69n394QK4mXu7wj_0-2d2st-4huWLONst6_cjvKD8B6ml0_Q
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+potential+for+immunoglobulins+and+host+defense+peptides+%28HDPs%29+to+reduce+the+use+of+antibiotics+in+animal+production&rft.jtitle=Veterinary+research+%28Paris%29&rft.au=van+Dijk%2C+Albert&rft.au=Hedegaard%2C+Chris+J.&rft.au=Haagsman%2C+Henk+P.&rft.au=Heegaard%2C+Peter+M.+H.&rft.date=2018-07-31&rft.pub=BioMed+Central&rft.issn=0928-4249&rft.eissn=1297-9716&rft.volume=49&rft.issue=1&rft_id=info:doi/10.1186%2Fs13567-018-0558-2&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=oai%3AHAL%3Ahal-02973509v1
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1297-9716&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1297-9716&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1297-9716&client=summon