The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production

Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement a...

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Published in:Veterinary research (Paris) Vol. 49; no. 1; p. 68
Main Authors: van Dijk, Albert, Hedegaard, Chris J., Haagsman, Henk P., Heegaard, Peter M. H.
Format: Journal Article
Language:English
Published: London BioMed Central 31.07.2018
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
2nd International Symposium on Alternatives to Antibiotics
acute phase proteins
adaptive immunity
animal production
Antibiotic growth promoters
Antibiotics
Antimicrobial agents
Bacterial infections
Breeding of animals
cathelicidins
Chemokines
complement
Defense mechanisms
Health aspects
Immune response
Immune system
Immunoglobulins
Immunology
Infections
Infectious diseases
innate immunity
Life Sciences
mechanism of action
Medicine
Medicine & Public Health
Microbiology
microorganisms
neonates
Neutrophils
Peptides
Review
Rodents
vaccine adjuvants
veterinary medicine
Veterinary Medicine/Veterinary Science
Virology
Yang, Cindy
Porcine Reproductive And Respiratory Syndrome Virus (PRRSV)
Cathelicidin-related Antimicrobial Peptide (CRAMP)
Indolicidin
Spray-dried Plasma (SDP)
Host Defense Peptides (HDPs)
ISSN:1297-9716, 0928-4249, 1297-9716
Online Access:Get full text
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Summary:Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
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ISSN:1297-9716
0928-4249
1297-9716
DOI:10.1186/s13567-018-0558-2