Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism and promotes hepatitis C virus (HCV) replication. Reduced miR-122 expression in hepatocellular carcinoma (HCC) correlates with metastasis and poor prognosis. Nevertheless, the consequences of sustained loss of fun...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 122; no. 8; pp. 2871 - 2883
Main Authors:	Hsu, Shu-hao, Wang, Bo, Kota, Janaiah, Yu, Jianhua, Costinean, Stefan, Kutay, Huban, Yu, Lianbo, Bai, Shoumei, La Perle, Krista, Chivukula, Raghu R., Mao, Hsiaoyin, Wei, Min, Clark, K. Reed, Mendell, Jerry R., Caligiuri, Michael A., Jacob, Samson T., Mendell, Joshua T., Ghoshal, Kalpana
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.08.2012
Subjects:	3' Untranslated Regions Animals Anti-inflammatory drugs Base Sequence Biomedical research Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - therapy Cell Proliferation Cell Survival - genetics Cholesterol Cytokines Cytokines - biosynthesis Fatty Liver - etiology Fatty Liver - genetics Fatty Liver - metabolism Fatty Liver - pathology Gene Expression Genes Genes, myc Genes, Tumor Suppressor Genotype & phenotype Hepatitis C Hepatitis C virus Humans Lipid Metabolism - genetics Lipids - blood Liver - immunology Liver - metabolism Liver - pathology Liver cancer Liver diseases Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - therapy Liver Neoplasms, Experimental - etiology Liver Neoplasms, Experimental - genetics Liver Neoplasms, Experimental - metabolism Metabolism Metabolites Metastasis Mice Mice, 129 Strain Mice, Knockout MicroRNA MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism MicroRNAs - therapeutic use Monocytes - immunology Monocytes - pathology Neutrophils - immunology Neutrophils - pathology Physiological aspects RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Tumor necrosis factor Tumors
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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