Influence of antibiotic exposure in the early postnatal period on the development of intestinal microbiota

The influence of antibiotic exposure in the early postnatal period on the development of intestinal microbiota was monitored in 26 infants including five antibiotic-treated (AT) subjects orally administered a broad-spectrum antibiotic for the first 4 days of life and three caesarean-delivered (CD) s...

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Vydané v:	FEMS immunology and medical microbiology Ročník 56; číslo 1; s. 80 - 87
Hlavní autori:	Tanaka, Shigemitsu, Kobayashi, Takako, Songjinda, Prapa, Tateyama, Atsushi, Tsubouchi, Mina, Kiyohara, Chikako, Shirakawa, Taro, Sonomoto, Kenji, Nakayama, Jiro
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.06.2009 Blackwell Publishing Ltd Blackwell
Predmet:	administration & dosage analysis Anti-Bacterial Agents Anti-Bacterial Agents - administration & dosage antibiotics Bacteria Bacteria - drug effects Bacteria - genetics Bacteria - isolation & purification Bifidobacterium Bifidobacterium - drug effects Bifidobacterium - genetics Bifidobacterium - isolation & purification Biological and medical sciences caesarian delivery Cesarean Section DNA, Bacterial DNA, Bacterial - analysis DNA, Bacterial - isolation & purification drug effects Enterobacteriaceae Enterobacteriaceae - drug effects Enterobacteriaceae - genetics Enterobacteriaceae - isolation & purification Enterococcus Feces Feces - microbiology Female Fundamental and applied biological sciences. Psychology genetics Humans Infant Infant, Newborn Intestinal Mucosa Intestinal Mucosa - microbiology Intestines Intestines - microbiology isolation & purification Microbiology neonatal intestinal microbiota Polymorphism, Restriction Fragment Length Pregnancy quantitative real-time PCR Reverse Transcriptase Polymerase Chain Reaction RNA, Bacterial RNA, Bacterial - analysis RNA, Bacterial - isolation & purification terminal restriction fragment length polymorphism neonatal intestinal microbiota quantitative real-time PCR antibiotics terminal restriction fragment length polymorphism caesarian delivery Microbiology Digestive system Gut Genotype Microflora Real time Postnatal development Polymerase chain reaction Antibiotic Immunology Restriction fragment length polymorphism Quantitative analysis
ISSN:	0928-8244, 1574-695X, 1574-695X
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Shrnutí:	The influence of antibiotic exposure in the early postnatal period on the development of intestinal microbiota was monitored in 26 infants including five antibiotic-treated (AT) subjects orally administered a broad-spectrum antibiotic for the first 4 days of life and three caesarean-delivered (CD) subjects whose mothers were intravenously injected by the similar type of antibiotics in the same period. The faecal bacterial composition was analysed daily for the first 5 days and monthly for the first 2 months. Terminal restriction fragment length polymor-phisms in the AT subjects showed less diversity with the attenuation of the colonization of some bacterial groups, especially in Bifidobacterium and unusual colonization of Enterococcus in the first week than the control antibiotic-free infants (AF, n=18). Quantitative real-time PCR showed overgrowth of enterococci (day 3, P=0.01; day 5, P=0.003; month 1, P=0.01) and arrested growth of Bifidobacterium (day 3, P=0.03) in the AT group. Furthermore, after 1 month, the Enterobacteriaceae population was markedly higher in the AT group than in the AF group (month 1, P=0.02; month 2, P=0.02). CD infants sustained similar, although relatively weaker, alteration in the developing microbiota. These results indicate that antibiotic exposure at the beginning of life greatly influences the development of neonatal intestinal microbiota.
Bibliografia:	http://dx.doi.org/10.1111/j.1574-695X.2009.00553.x Editor: Jacques Schrenzel Shigemitsu Tanaka, Division of Microbial Technology, Ariake Sea Research Project, Saga University, 1 Honjo‐cho, Saga 840‐8502, Japan. Present address ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0928-8244 1574-695X 1574-695X
DOI:	10.1111/j.1574-695X.2009.00553.x