New indexes of body fat distribution and sex-specific risk of total and cause-specific mortality: a prospective cohort study

Background A number of prior studies have examined the association between anthropometric measures and mortality, but studies investigating the sex-specific predictive value of novel anthropometric measures on mortality are scarce so far. Therefore, we investigated the sex-specific relevance of the...

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Vydané v:BMC public health Ročník 18; číslo 1; s. 427 - 12
Hlavní autori: Rost, Susanne, Freuer, Dennis, Peters, Annette, Thorand, Barbara, Holle, Rolf, Linseisen, Jakob, Meisinger, Christa
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 02.04.2018
BioMed Central Ltd
Springer Nature B.V
BMC
Predmet:
Adipose tissue
All-cause mortality
Anthropometric measures
Anthropometry
Biostatistics
Body adiposity index
Body fat
Body mass index
Body measurements
Body size
Cancer
Cancer mortality
Cardiovascular diseases
Cardiovascular mortality
Chronic Disease epidemiology
Cohort analysis
Complications and side effects
Environmental Health
Epidemiology
Health risk assessment
Health risks
Hip
KORA
Medicine
Medicine & Public Health
Men
Mortality
Mortality risk
Obesity
Patient outcomes
Public Health
Regression analysis
Research Article
Risk analysis
Risk factors
Sex
Studies
Vaccine
Womens health
United States > US
KORA
Obesity
All-cause mortality
Cancer mortality
Anthropometric measures
Body adiposity index
Cardiovascular mortality
Prospective study
ISSN:1471-2458, 1471-2458
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Shrnutí:Background A number of prior studies have examined the association between anthropometric measures and mortality, but studies investigating the sex-specific predictive value of novel anthropometric measures on mortality are scarce so far. Therefore, we investigated the sex-specific relevance of the new anthropometric measures body adiposity index (BAI) and waist to height ratio (WHtR) as well as the common measures body mass index (BMI), waist circumference (WC), and waist to hip ratio (WHR) for cause-specific mortality risk. Methods The analysis was based on data from the German population based KORA (Cooperative Health Research in the Region of Augsburg) Augsburg cohort study. A total of 6670 men and 6637 women aged 25 to 74 years at baseline examination were included. During a mean follow-up period of 15.4 years, 2409 persons died. Via Cox proportional hazard regression, the associations between the different anthropometric measures and all cause-, cardiovascular disease (CVD)- and cancer mortality were assessed. Results BMI, WC, and WHR were significantly associated with all-cause and CVD-mortality in both sexes. WC and WHR were particularly associated with higher all-cause and CVD-mortality risk in women, while in men especially WHtR and BAI were strongly related to these outcomes. Females with WC, WHtR, and WHR measures in the 4th quartile compared with women in the 2nd quartile had a higher risk of death from cancer. Contrary, men in the lowest quartile of WC and WHtR in comparison to men in the 2nd quartile had a significantly elevated cancer mortality risk. BAI was no risk predictor for all-cause and cause-specific mortality in women. Conclusions Central obesity reflects higher all-cause and CVD-mortality risk particularly in women. BAI and WHtR seem to be valid as risk predictors for all-cause and especially CVD mortality in men but not women. There are marked sex-differences regarding cancer mortality risk for the different anthropometric measures.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1471-2458
1471-2458
DOI:10.1186/s12889-018-5350-8