Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer

Background Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed. Objective This study aimed to investigate the efficacy of six biomarkers for the earl...

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Veröffentlicht in:	PloS one Jg. 17; H. 8; S. e0272308
Hauptverfasser:	Ali, Fahmy T., Soliman, Reham M., Hassan, Nahla S., Ibrahim, Ahmed M., El-Gizawy, Mayada M., Mandoh, Abd Allah Y., Ibrahim, Ehab A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	San Francisco Public Library of Science 03.08.2022 Public Library of Science (PLoS)
Schlagworte:	Analysis Antigens Biological markers Biology and Life Sciences Biomarkers Breast cancer Cancer Diagnosis Disease Fatalities Gene expression Glycoproteins Gynecology Hepcidin Hospitals Liver cancer Medical diagnosis Medical prognosis Medicine and Health Sciences Microfibril-associated glycoprotein 2 MicroRNA MicroRNAs miRNA Obstetrics Ovarian cancer Ovarian carcinoma Patients Ribonucleic acid RNA Sensitivity Statistical analysis Tumors Womens health Egypt Cairo Egypt Germany
ISSN:	1932-6203, 1932-6203
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Abstract	Background Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed. Objective This study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer. Subjects & methods The study included 120 patients (benign ovarian tumors and early and late ovarian carcinoma) and 30 control healthy volunteers. MiRNA-204, CA125, CA19.9, hepcidin, microfibril-associated glycoprotein 2, and ferroportin levels were determined in all patients and control volunteers. Results The combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively. The sensitivities of miRNA-204, CA125, and CA19.9 were 98.04%, 100.00%, and 96.19% and the specificities were 58.33%, 62.50%, and 57.78%, respectively. Conclusion The positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic tool for ovarian cancer.
AbstractList	Background Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed. Objective This study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer. Subjects & methods The study included 120 patients (benign ovarian tumors and early and late ovarian carcinoma) and 30 control healthy volunteers. MiRNA-204, CA125, CA19.9, hepcidin, microfibril-associated glycoprotein 2, and ferroportin levels were determined in all patients and control volunteers. Results The combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively. The sensitivities of miRNA-204, CA125, and CA19.9 were 98.04%, 100.00%, and 96.19% and the specificities were 58.33%, 62.50%, and 57.78%, respectively. Conclusion The positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic tool for ovarian cancer. Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed. This study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer. The combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively. The sensitivities of miRNA-204, CA125, and CA19.9 were 98.04%, 100.00%, and 96.19% and the specificities were 58.33%, 62.50%, and 57.78%, respectively. The positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic tool for ovarian cancer. BackgroundOvarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed.ObjectiveThis study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer.Subjects & methodsThe study included 120 patients (benign ovarian tumors and early and late ovarian carcinoma) and 30 control healthy volunteers. MiRNA-204, CA125, CA19.9, hepcidin, microfibril-associated glycoprotein 2, and ferroportin levels were determined in all patients and control volunteers.ResultsThe combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively. The sensitivities of miRNA-204, CA125, and CA19.9 were 98.04%, 100.00%, and 96.19% and the specificities were 58.33%, 62.50%, and 57.78%, respectively.ConclusionThe positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic tool for ovarian cancer. Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed.BACKGROUNDOvarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed.This study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer.OBJECTIVEThis study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer.The study included 120 patients (benign ovarian tumors and early and late ovarian carcinoma) and 30 control healthy volunteers. MiRNA-204, CA125, CA19.9, hepcidin, microfibril-associated glycoprotein 2, and ferroportin levels were determined in all patients and control volunteers.SUBJECTS & METHODSThe study included 120 patients (benign ovarian tumors and early and late ovarian carcinoma) and 30 control healthy volunteers. MiRNA-204, CA125, CA19.9, hepcidin, microfibril-associated glycoprotein 2, and ferroportin levels were determined in all patients and control volunteers.The combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively. The sensitivities of miRNA-204, CA125, and CA19.9 were 98.04%, 100.00%, and 96.19% and the specificities were 58.33%, 62.50%, and 57.78%, respectively.RESULTSThe combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively. The sensitivities of miRNA-204, CA125, and CA19.9 were 98.04%, 100.00%, and 96.19% and the specificities were 58.33%, 62.50%, and 57.78%, respectively.The positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic tool for ovarian cancer.CONCLUSIONThe positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic tool for ovarian cancer. Background Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed. Objective This study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer. Subjects & methods The study included 120 patients (benign ovarian tumors and early and late ovarian carcinoma) and 30 control healthy volunteers. MiRNA-204, CA125, CA19.9, hepcidin, microfibril-associated glycoprotein 2, and ferroportin levels were determined in all patients and control volunteers. Results The combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively. The sensitivities of miRNA-204, CA125, and CA19.9 were 98.04%, 100.00%, and 96.19% and the specificities were 58.33%, 62.50%, and 57.78%, respectively. Conclusion The positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic tool for ovarian cancer.
Audience	Academic
Author	Ibrahim, Ehab A. Ibrahim, Ahmed M. Soliman, Reham M. El-Gizawy, Mayada M. Ali, Fahmy T. Hassan, Nahla S. Mandoh, Abd Allah Y.
AuthorAffiliation	4 Department of Molecular Biology and Cytogenics, Armed Forces Central Laboratory and Blood Bank, Cairo, Egypt 1 Faculty of Science, Department of Biochemistry, Ain Shams University, Cairo, Egypt 2 Faculty of Medicine, Department of Medicine, Ain Shams University, Cairo, Egypt 3 Medical Physiology Department, Medical Division, National Research Center, Giza, Egypt Peter MacCallum Cancer Institute, AUSTRALIA
AuthorAffiliation_xml	– name: 3 Medical Physiology Department, Medical Division, National Research Center, Giza, Egypt – name: 4 Department of Molecular Biology and Cytogenics, Armed Forces Central Laboratory and Blood Bank, Cairo, Egypt – name: Peter MacCallum Cancer Institute, AUSTRALIA – name: 2 Faculty of Medicine, Department of Medicine, Ain Shams University, Cairo, Egypt – name: 1 Faculty of Science, Department of Biochemistry, Ain Shams University, Cairo, Egypt
Author_xml	– sequence: 1 givenname: Fahmy T. surname: Ali fullname: Ali, Fahmy T. – sequence: 2 givenname: Reham M. surname: Soliman fullname: Soliman, Reham M. – sequence: 3 givenname: Nahla S. orcidid: 0000-0002-9530-0828 surname: Hassan fullname: Hassan, Nahla S. – sequence: 4 givenname: Ahmed M. surname: Ibrahim fullname: Ibrahim, Ahmed M. – sequence: 5 givenname: Mayada M. surname: El-Gizawy fullname: El-Gizawy, Mayada M. – sequence: 6 givenname: Abd Allah Y. surname: Mandoh fullname: Mandoh, Abd Allah Y. – sequence: 7 givenname: Ehab A. orcidid: 0000-0003-0520-7169 surname: Ibrahim fullname: Ibrahim, Ehab A.
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Snippet	Background Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific... Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for... BackgroundOvarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific... Background Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific...
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SubjectTerms	Analysis Antigens Biological markers Biology and Life Sciences Biomarkers Breast cancer Cancer Diagnosis Disease Fatalities Gene expression Glycoproteins Gynecology Hepcidin Hospitals Liver cancer Medical diagnosis Medical prognosis Medicine and Health Sciences Microfibril-associated glycoprotein 2 MicroRNA MicroRNAs miRNA Obstetrics Ovarian cancer Ovarian carcinoma Patients Ribonucleic acid RNA Sensitivity Statistical analysis Tumors Womens health
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Title	Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer
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