Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer

Background Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed. Objective This study aimed to investigate the efficacy of six biomarkers for the earl...

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Veröffentlicht in:PloS one Jg. 17; H. 8; S. e0272308
Hauptverfasser: Ali, Fahmy T., Soliman, Reham M., Hassan, Nahla S., Ibrahim, Ahmed M., El-Gizawy, Mayada M., Mandoh, Abd Allah Y., Ibrahim, Ehab A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: San Francisco Public Library of Science 03.08.2022
Public Library of Science (PLoS)
Schlagworte:
Analysis
Antigens
Biological markers
Biology and Life Sciences
Biomarkers
Breast cancer
Cancer
Diagnosis
Disease
Fatalities
Gene expression
Glycoproteins
Gynecology
Hepcidin
Hospitals
Liver cancer
Medical diagnosis
Medical prognosis
Medicine and Health Sciences
Microfibril-associated glycoprotein 2
MicroRNA
MicroRNAs
miRNA
Obstetrics
Ovarian cancer
Ovarian carcinoma
Patients
Ribonucleic acid
RNA
Sensitivity
Statistical analysis
Tumors
Womens health
Egypt
Cairo Egypt
Germany
ISSN:1932-6203, 1932-6203
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Zusammenfassung:Background Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed. Objective This study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer. Subjects & methods The study included 120 patients (benign ovarian tumors and early and late ovarian carcinoma) and 30 control healthy volunteers. MiRNA-204, CA125, CA19.9, hepcidin, microfibril-associated glycoprotein 2, and ferroportin levels were determined in all patients and control volunteers. Results The combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively. The sensitivities of miRNA-204, CA125, and CA19.9 were 98.04%, 100.00%, and 96.19% and the specificities were 58.33%, 62.50%, and 57.78%, respectively. Conclusion The positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic tool for ovarian cancer.
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0272308