Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy

A minor allele variant (rs3798220) of apolipoprotein(a) has been reported to be associated with elevated plasma lipoprotein(a) [Lp(a)] and increased cardiovascular risk. We investigated whether this allele was associated with elevated Lp(a) and cardiovascular risk in the Women's Health Study, a...

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Bibliographic Details
Published in:	Atherosclerosis Vol. 203; no. 2; pp. 371 - 376
Main Authors:	Chasman, Daniel I., Shiffman, Dov, Zee, Robert Y.L., Louie, Judy Z., Luke, May M., Rowland, Charles M., Catanese, Joseph J., Buring, Julie E., Devlin, James J., Ridker, Paul M.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ireland Ltd 01.04.2009 Elsevier
Subjects:	Alleles Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Apolipoproteins A - blood Apolipoproteins A - genetics Aspirin Aspirin - therapeutic use Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Cardiovascular Cardiovascular disease Cardiovascular Diseases - blood Cardiovascular Diseases - genetics Female Genetics Genotype Heterozygote Homozygote Humans Lipoproteins Lp(a) Medical sciences Middle Aged Pharmacology. Drug treatments Polymorphism, Genetic Proportional Hazards Models Risk Cardiovascular disease Genetics Aspirin Lipoproteins Lp(a) Prostaglandin-endoperoxide synthase Enzyme Low dose Enzyme inhibitor Acetylsalicylic acid Antiplatelet agent Lipoprotein a Vascular disease Non steroidal antiinflammatory agent Apolipoprotein A Analgesic Treatment Atherosclerosis Antipyretic Oxidoreductases Salicylates Polymorphism
ISSN:	0021-9150, 1879-1484, 1879-1484
Online Access:	Get full text
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