Role of HDACs in normal and malignant hematopoiesis

Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of gene expression at each stage of development, and epigenetic regulators play a vital role. Disordered epigenetic regulation has emerged as a key mechanism contributing to hematological malignancies. Histone deac...

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Bibliographic Details
Published in:	Molecular cancer Vol. 19; no. 1; pp. 5 - 21
Main Authors:	Wang, Pan, Wang, Zi, Liu, Jing
Format:	Journal Article
Language:	English
Published:	London BioMed Central 07.01.2020 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Aging Amino acids Animals Biomedical and Life Sciences Biomedicine Bone marrow Cancer Research Cell cycle Cell Differentiation Cofactors Deacetylation Deoxyribonucleic acid Development and progression DNA Drug development Drug resistance Enzymes Epigenesis, Genetic Epigenetic inheritance Epigenetics Etiology Gene expression Genes Genetic aspects Genetic transcription Granulocytes HDAC inhibitor Hematological malignancy Hematology Hematopoiesis Histone deacetylase Histone Deacetylase Inhibitors - therapeutic use Histone deacetylases Histone Deacetylases - chemistry Histone Deacetylases - metabolism Histones - genetics Histones - metabolism Homeostasis Humans Kinases Localization Lysine Molecular Targeted Therapy Mutation Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - etiology Neoplasms - pathology Nonhistone proteins Oncology Physiological aspects Proteins Review Reviews Stem cells Therapeutic applications Transcription Transcription factors HDAC inhibitor Histone deacetylases Drug resistance Hematopoiesis Hematological malignancy
ISSN:	1476-4598, 1476-4598
Online Access:	Get full text
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