Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review

The early-life social environment can induce stable changes that influence neurodevelopment and mental health. Research focused on early-life adversity revealed that early-life experiences have a persistent impact on gene expression and behavior through epigenetic mechanisms. The hypothalamus-pituit...

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Bibliographic Details
Published in:	Biological psychiatry (1969) Vol. 79; no. 2; pp. 87 - 96
Main Authors:	Turecki, Gustavo, Meaney, Michael J.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 15.01.2016
Subjects:	Animals DNA Methylation Early-life adversity Epigenesis, Genetic Epigenetics Exons Glucocorticoid receptor Humans Hypothalamo-Hypophyseal System - metabolism Pituitary-Adrenal System - metabolism Promoter Regions, Genetic Psychiatric/Mental Health Rats Receptors, Glucocorticoid - genetics Social Environment Stress, Psychological - metabolism Systematic review Social environment DNA methylation Early-life adversity Epigenetics Systematic review Glucocorticoid receptor
ISSN:	0006-3223, 1873-2402, 1873-2402
Online Access:	Get full text
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