Arsenic exposure and respiratory outcomes during childhood in the INMA study

Ingested inorganic arsenic (iAs) is a human carcinogen that is also linked to other adverse health effects, such as respiratory outcomes. Yet, among populations consuming low-arsenic drinking water, the impact of iAs exposure on childhood respiratory health is still uncertain. For a Spanish child st...

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Vydáno v:PloS one Ročník 17; číslo 9; s. e0274215
Hlavní autoři: Signes-Pastor, Antonio J., Díaz-Coto, Susana, Martinez-Camblor, Pablo, Carey, Manus, Soler-Blasco, Raquel, García-Villarino, Miguel, Fernández-Somoano, Ana, Julvez, Jordi, Carrasco, Paula, Lertxundi, Aitana, Santa Marina, Loreto, Casas, Maribel, Meharg, Andrew A., Karagas, Margaret R., Vioque-Lopez, Jesús
Médium: Journal Article
Jazyk:angličtina
Vydáno: San Francisco Public Library of Science 09.09.2022
Public Library of Science (PLoS)
Témata:
Acids
Arsenic
Asthma
Asthma in children
Biology and Life Sciences
Biomarkers
Carcinogens
Childhood
Children
Cohort analysis
Confidence intervals
Diagnosis
Dimethylarsinic acid
Drinking water
Eczema
Exposure
Food
Health aspects
Health risks
Hospitals
Ingestion
Medicine and Health Sciences
Metabolites
Pediatrics
People and Places
Physical Sciences
Poisson density functions
Population
Populations
Questionnaires
Regression analysis
Regression models
Rice
Risk factors
Seafood
Skin diseases
Spline functions
Statistical analysis
Urine
Spain
ISSN:1932-6203, 1932-6203
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Popis
Shrnutí:Ingested inorganic arsenic (iAs) is a human carcinogen that is also linked to other adverse health effects, such as respiratory outcomes. Yet, among populations consuming low-arsenic drinking water, the impact of iAs exposure on childhood respiratory health is still uncertain. For a Spanish child study cohort (INfancia y Medio Ambiente—INMA), low-arsenic drinking water is usually available and ingestion of iAs from food is considered the major source of exposure. Here, we explored the association between iAs exposure and children’s respiratory outcomes assessed at 4 and 7 years of age ( n = 400). The summation of 4-year-old children’s urinary iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) was used as a biomarker of iAs exposure (∑As) (median of 4.92 μg/L). Children’s occurrence of asthma, eczema, sneeze, wheeze, and medication for asthma and wheeze at each assessment time point (i.e., 4- and 7-year) was assessed with maternal interviewer-led questionnaires. Crude and adjusted Poisson regression models using Generalized Estimating Equation (GEE) were performed to account for the association between natural logarithm transformed (ln) urinary ∑As in μg/L at 4 years and repeated assessments of respiratory symptoms at 4 and 7 years of age. The covariates included in the models were child sex, maternal smoking status, maternal level of education, sub-cohort, and children’s consumption of vegetables, fruits, and fish/seafood. The GEE—splines function using Poisson regression showed an increased trend of the overall expected counts of respiratory symptoms with high urinary ∑As. The adjusted expected counts (95% confidence intervals) at ln-transformed urinary ∑As 1.57 (average concentration) and 4.00 (99 th percentile concentration) were 0.63 (0.36, 1.10) and 1.33 (0.61, 2.89), respectively. These exploratory findings suggest that even relatively low-iAs exposure levels, relevant to the Spanish and other populations, may relate to an increased number of respiratory symptoms during childhood.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0274215