Synthetic carbohydrate-based vaccines: challenges and opportunities

Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial fermentation, the quality and length of glycans...

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Published in:Journal of biomedical science Vol. 27; no. 1; pp. 9 - 22
Main Authors: Mettu, Ravinder, Chen, Chiang-Yun, Wu, Chung-Yi
Format: Journal Article
Language:English
Published: London BioMed Central 03.01.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Antibiotics
Antigenicity
Antigens
Antimicrobial agents
Bacteria
Bacterial diseases
Bacterial infections
Bacterial vaccines
Biomedical and Life Sciences
Biomedicine
Cancer
Capsular polysaccharides
Carbohydrates
Chemical synthesis
Chemistry
Clinical trials
Fermentation
Glycan
Health aspects
Immunogenicity
Infection
Licenses
Medical research
Pathogens
Pneumonia
Polysaccharides
Proteins
Researchers
Review
Saccharides
Salmonella
Streptococcus infections
Success
Translating innovative biomedical research in disease treatments
Vaccines
Vaccines and Cancer
United States > US
Carbohydrates
Polysaccharides
Immunogenicity
Antigenicity
Vaccines and Cancer
ISSN:1423-0127, 1021-7770, 1423-0127
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Abstract Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial fermentation, the quality and length of glycans are always inconsistent. Such kind of situation make the CMC of glycoconjugate vaccines are difficult to well control. Thanks to the advantage of synthetic methods for carbohydrates syntheses. The well controlled glycan antigens are more easily to obtain, and them are conjugated to carrier protein to from the so-call homogeneous fully synthetic glycoconjugate vaccines. Several fully glycoconjugate vaccines are in different phases of clinical trial for bacteria or cancers. The review will introduce the recent development of fully synthetic glycoconjugate vaccine.
AbstractList Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial fermentation, the quality and length of glycans are always inconsistent. Such kind of situation make the CMC of glycoconjugate vaccines are difficult to well control. Thanks to the advantage of synthetic methods for carbohydrates syntheses. The well controlled glycan antigens are more easily to obtain, and them are conjugated to carrier protein to from the so-call homogeneous fully synthetic glycoconjugate vaccines. Several fully glycoconjugate vaccines are in different phases of clinical trial for bacteria or cancers. The review will introduce the recent development of fully synthetic glycoconjugate vaccine.
Abstract Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial fermentation, the quality and length of glycans are always inconsistent. Such kind of situation make the CMC of glycoconjugate vaccines are difficult to well control. Thanks to the advantage of synthetic methods for carbohydrates syntheses. The well controlled glycan antigens are more easily to obtain, and them are conjugated to carrier protein to from the so-call homogeneous fully synthetic glycoconjugate vaccines. Several fully glycoconjugate vaccines are in different phases of clinical trial for bacteria or cancers. The review will introduce the recent development of fully synthetic glycoconjugate vaccine.
Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial fermentation, the quality and length of glycans are always inconsistent. Such kind of situation make the CMC of glycoconjugate vaccines are difficult to well control. Thanks to the advantage of synthetic methods for carbohydrates syntheses. The well controlled glycan antigens are more easily to obtain, and them are conjugated to carrier protein to from the so-call homogeneous fully synthetic glycoconjugate vaccines. Several fully glycoconjugate vaccines are in different phases of clinical trial for bacteria or cancers. The review will introduce the recent development of fully synthetic glycoconjugate vaccine.Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial fermentation, the quality and length of glycans are always inconsistent. Such kind of situation make the CMC of glycoconjugate vaccines are difficult to well control. Thanks to the advantage of synthetic methods for carbohydrates syntheses. The well controlled glycan antigens are more easily to obtain, and them are conjugated to carrier protein to from the so-call homogeneous fully synthetic glycoconjugate vaccines. Several fully glycoconjugate vaccines are in different phases of clinical trial for bacteria or cancers. The review will introduce the recent development of fully synthetic glycoconjugate vaccine.
Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial fermentation, the quality and length of glycans are always inconsistent. Such kind of situation make the CMC of glycoconjugate vaccines are difficult to well control. Thanks to the advantage of synthetic methods for carbohydrates syntheses. The well controlled glycan antigens are more easily to obtain, and them are conjugated to carrier protein to from the so-call homogeneous fully synthetic glycoconjugate vaccines. Several fully glycoconjugate vaccines are in different phases of clinical trial for bacteria or cancers. The review will introduce the recent development of fully synthetic glycoconjugate vaccine. Keywords: Carbohydrates, Immunogenicity, Antigenicity, Polysaccharides, Vaccines and Cancer
ArticleNumber 9
Audience Academic
Author Chen, Chiang-Yun
Mettu, Ravinder
Wu, Chung-Yi
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  email: cyiwu@gate.sinica.edu.tw
  organization: Genomics Research Center, Academia Sinica
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31900143$$D View this record in MEDLINE/PubMed
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ISSN 1423-0127
1021-7770
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Issue 1
Keywords Carbohydrates
Polysaccharides
Immunogenicity
Antigenicity
Vaccines and Cancer
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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PublicationTitle Journal of biomedical science
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Snippet Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan...
Abstract Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The...
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SubjectTerms Antibiotics
Antigenicity
Antigens
Antimicrobial agents
Bacteria
Bacterial diseases
Bacterial infections
Bacterial vaccines
Biomedical and Life Sciences
Biomedicine
Cancer
Capsular polysaccharides
Carbohydrates
Chemical synthesis
Chemistry
Clinical trials
Fermentation
Glycan
Health aspects
Immunogenicity
Infection
Licenses
Medical research
Pathogens
Pneumonia
Polysaccharides
Proteins
Researchers
Review
Saccharides
Salmonella
Streptococcus infections
Success
Translating innovative biomedical research in disease treatments
Vaccines
Vaccines and Cancer
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Title Synthetic carbohydrate-based vaccines: challenges and opportunities
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Volume 27
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