A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

Background Renin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). We postulated that repleting ACE2 using GSK2586881, a recombinant form of human angiotensin-converting enzyme 2 (rhAC...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 21; no. 1; pp. 234 - 9
Main Authors:	Khan, Akram, Benthin, Cody, Zeno, Brian, Albertson, Timothy E., Boyd, John, Christie, Jason D., Hall, Richard, Poirier, Germain, Ronco, Juan J., Tidswell, Mark, Hardes, Kelly, Powley, William M., Wright, Tracey J., Siederer, Sarah K., Fairman, David A., Lipson, David A., Bayliffe, Andrew I., Lazaar, Aili L.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 07.09.2017 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Acute lung injury Acute respiratory distress syndrome Acute respiratory failure Adult Analysis Angiotensin Angiotensin-converting enzyme 2 Clinical trials Critical care Critical Care Medicine Drug dosages Emergency Medicine Enzymes Genetic aspects Human subjects Intensive Medicine Medicine & Public Health Patients Physiological aspects Physiology Proteins Renin-angiotensin system Respiratory distress syndrome Risk factors Rodents Sepsis Surfactants Ventilators Acute lung injury Angiotensin-converting enzyme 2 Respiratory distress syndrome Humans Adult Acute respiratory failure Renin-angiotensin system Interleukin-6
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X, 1366-609X
Online Access:	Get full text
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