Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder. Immunosenescence refers to disruption in the structural architecture of immune organs and dysfunction...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Immunity & ageing Ročník 17; číslo 1; s. 2 - 17
Hlavní autoři: Thomas, Rachel, Wang, Weikan, Su, Dong-Ming
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 20.01.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Adaptive immunity
Age
Age-related thymic involution
Aging
Antibodies
Antigens
Apoptosis
Atrophy
Biomedical and Life Sciences
Biomedicine
Cardiovascular diseases
Cell cycle
Central tolerance
Clinical Nutrition
Cyclin-dependent kinases
Diseases
Epigenetic inheritance
Epigenetics
Fibroblasts
Genotype & phenotype
Geriatrics/Gerontology
Homeostasis
Immune response
Immune system
Immunology
Immunosenescence
Immunosenescence and inflammaging
Inflammation
Kinases
Lymphocytes
Lymphocytes T
Molecular modelling
Money
Negative selection and regulatory T (Treg) cell generation
Phenotypes
Public Health
Recovery of function
Rejuvenation
Review
Senescence
Somatic cells
Stem cells
T cells
Thymic aging
Thymic involution
Thymus
Maryland
Negative selection and regulatory T (Treg) cell generation
Central tolerance
Thymic aging
Age-related thymic involution
Immunosenescence and inflammaging
Rejuvenation
ISSN:1742-4933, 1742-4933
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder. Immunosenescence refers to disruption in the structural architecture of immune organs and dysfunction in immune responses, resulting from both aged innate and adaptive immunity. Inflammaging, described as a chronic, sterile, systemic inflammatory condition associated with advanced age, is mainly attributed to somatic cellular senescence-associated secretory phenotype (SASP) and age-related autoimmune predisposition. However, the inability to reduce senescent somatic cells (SSCs), because of immunosenescence, exacerbates inflammaging. Age-related adaptive immune system deviations, particularly altered T cell function, are derived from age-related thymic atrophy or involution, a hallmark of thymic aging. Recently, there have been major developments in understanding how age-related thymic involution contributes to inflammaging and immunosenescence at the cellular and molecular levels, including genetic and epigenetic regulation, as well as developments of many potential rejuvenation strategies. Herein, we discuss the research progress uncovering how age-related thymic involution contributes to immunosenescence and inflammaging, as well as their intersection. We also describe how T cell adaptive immunity mediates inflammaging and plays a crucial role in the progression of age-related neurological and cardiovascular diseases, as well as cancer. We then briefly outline the underlying cellular and molecular mechanisms of age-related thymic involution, and finally summarize potential rejuvenation strategies to restore aged thymic function.
AbstractList Abstract Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder. Immunosenescence refers to disruption in the structural architecture of immune organs and dysfunction in immune responses, resulting from both aged innate and adaptive immunity. Inflammaging, described as a chronic, sterile, systemic inflammatory condition associated with advanced age, is mainly attributed to somatic cellular senescence-associated secretory phenotype (SASP) and age-related autoimmune predisposition. However, the inability to reduce senescent somatic cells (SSCs), because of immunosenescence, exacerbates inflammaging. Age-related adaptive immune system deviations, particularly altered T cell function, are derived from age-related thymic atrophy or involution, a hallmark of thymic aging. Recently, there have been major developments in understanding how age-related thymic involution contributes to inflammaging and immunosenescence at the cellular and molecular levels, including genetic and epigenetic regulation, as well as developments of many potential rejuvenation strategies. Herein, we discuss the research progress uncovering how age-related thymic involution contributes to immunosenescence and inflammaging, as well as their intersection. We also describe how T cell adaptive immunity mediates inflammaging and plays a crucial role in the progression of age-related neurological and cardiovascular diseases, as well as cancer. We then briefly outline the underlying cellular and molecular mechanisms of age-related thymic involution, and finally summarize potential rejuvenation strategies to restore aged thymic function.
Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder. Immunosenescence refers to disruption in the structural architecture of immune organs and dysfunction in immune responses, resulting from both aged innate and adaptive immunity. Inflammaging, described as a chronic, sterile, systemic inflammatory condition associated with advanced age, is mainly attributed to somatic cellular senescence-associated secretory phenotype (SASP) and age-related autoimmune predisposition. However, the inability to reduce senescent somatic cells (SSCs), because of immunosenescence, exacerbates inflammaging. Age-related adaptive immune system deviations, particularly altered T cell function, are derived from age-related thymic atrophy or involution, a hallmark of thymic aging. Recently, there have been major developments in understanding how age-related thymic involution contributes to inflammaging and immunosenescence at the cellular and molecular levels, including genetic and epigenetic regulation, as well as developments of many potential rejuvenation strategies. Herein, we discuss the research progress uncovering how age-related thymic involution contributes to immunosenescence and inflammaging, as well as their intersection. We also describe how T cell adaptive immunity mediates inflammaging and plays a crucial role in the progression of age-related neurological and cardiovascular diseases, as well as cancer. We then briefly outline the underlying cellular and molecular mechanisms of age-related thymic involution, and finally summarize potential rejuvenation strategies to restore aged thymic function.
Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder. Immunosenescence refers to disruption in the structural architecture of immune organs and dysfunction in immune responses, resulting from both aged innate and adaptive immunity. Inflammaging, described as a chronic, sterile, systemic inflammatory condition associated with advanced age, is mainly attributed to somatic cellular senescence-associated secretory phenotype (SASP) and age-related autoimmune predisposition. However, the inability to reduce senescent somatic cells (SSCs), because of immunosenescence, exacerbates inflammaging. Age-related adaptive immune system deviations, particularly altered T cell function, are derived from age-related thymic atrophy or involution, a hallmark of thymic aging. Recently, there have been major developments in understanding how age-related thymic involution contributes to inflammaging and immunosenescence at the cellular and molecular levels, including genetic and epigenetic regulation, as well as developments of many potential rejuvenation strategies. Herein, we discuss the research progress uncovering how age-related thymic involution contributes to immunosenescence and inflammaging, as well as their intersection. We also describe how T cell adaptive immunity mediates inflammaging and plays a crucial role in the progression of age-related neurological and cardiovascular diseases, as well as cancer. We then briefly outline the underlying cellular and molecular mechanisms of age-related thymic involution, and finally summarize potential rejuvenation strategies to restore aged thymic function.Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder. Immunosenescence refers to disruption in the structural architecture of immune organs and dysfunction in immune responses, resulting from both aged innate and adaptive immunity. Inflammaging, described as a chronic, sterile, systemic inflammatory condition associated with advanced age, is mainly attributed to somatic cellular senescence-associated secretory phenotype (SASP) and age-related autoimmune predisposition. However, the inability to reduce senescent somatic cells (SSCs), because of immunosenescence, exacerbates inflammaging. Age-related adaptive immune system deviations, particularly altered T cell function, are derived from age-related thymic atrophy or involution, a hallmark of thymic aging. Recently, there have been major developments in understanding how age-related thymic involution contributes to inflammaging and immunosenescence at the cellular and molecular levels, including genetic and epigenetic regulation, as well as developments of many potential rejuvenation strategies. Herein, we discuss the research progress uncovering how age-related thymic involution contributes to immunosenescence and inflammaging, as well as their intersection. We also describe how T cell adaptive immunity mediates inflammaging and plays a crucial role in the progression of age-related neurological and cardiovascular diseases, as well as cancer. We then briefly outline the underlying cellular and molecular mechanisms of age-related thymic involution, and finally summarize potential rejuvenation strategies to restore aged thymic function.
Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder. Immunosenescence refers to disruption in the structural architecture of immune organs and dysfunction in immune responses, resulting from both aged innate and adaptive immunity. Inflammaging, described as a chronic, sterile, systemic inflammatory condition associated with advanced age, is mainly attributed to somatic cellular senescence-associated secretory phenotype (SASP) and age-related autoimmune predisposition. However, the inability to reduce senescent somatic cells (SSCs), because of immunosenescence, exacerbates inflammaging. Age-related adaptive immune system deviations, particularly altered T cell function, are derived from age-related thymic atrophy or involution, a hallmark of thymic aging. Recently, there have been major developments in understanding how age-related thymic involution contributes to inflammaging and immunosenescence at the cellular and molecular levels, including genetic and epigenetic regulation, as well as developments of many potential rejuvenation strategies. Herein, we discuss the research progress uncovering how age-related thymic involution contributes to immunosenescence and inflammaging, as well as their intersection. We also describe how T cell adaptive immunity mediates inflammaging and plays a crucial role in the progression of age-related neurological and cardiovascular diseases, as well as cancer. We then briefly outline the underlying cellular and molecular mechanisms of age-related thymic involution, and finally summarize potential rejuvenation strategies to restore aged thymic function. Keywords: Thymic aging, Age-related thymic involution, Central tolerance, Negative selection and regulatory T (Treg) cell generation, Immunosenescence and inflammaging, Rejuvenation
ArticleNumber 2
Audience Academic
Author Thomas, Rachel
Wang, Weikan
Su, Dong-Ming
Author_xml – sequence: 1
  givenname: Rachel
  surname: Thomas
  fullname: Thomas, Rachel
  organization: Cell Biology, Immunology, and Microbiology Graduate Program, Graduate School of Biomedical Sciences
– sequence: 2
  givenname: Weikan
  surname: Wang
  fullname: Wang, Weikan
  organization: Cell Biology, Immunology, and Microbiology Graduate Program, Graduate School of Biomedical Sciences
– sequence: 3
  givenname: Dong-Ming
  orcidid: 0000-0002-3326-4753
  surname: Su
  fullname: Su, Dong-Ming
  email: dongming.su@unthsc.edu
  organization: Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31988649$$D View this record in MEDLINE/PubMed
BookMark eNp9kktr3DAUhU1JaR7tD-imGLrpxqle1mNTGIYmHQgU2nQtZFlyNNhSatmB_PtcZ9IkE9rihY383XN8j89xcRBTdEXxHqNTjCX_nDFRQlWIoAphQSv5qjjCgpGKKUoPnj0fFsc5bxGiTHH2pjikWEnJmToqfq5TnMbQzFNIMZfJl6vOVT9cbybXlpdXt0Ow5SbepP6eKKdUboZhjim76LJ10brSxBYQ35thMF2I3dvitTd9du8e7ifFr7Ovl-tv1cX38816dVFZztVUMcQZM621TthaMiO8N6YxLXXMUoJ8bZAlqOZGIt4C1CruVUM5ronBXrb0pNjsdNtktvp6DIMZb3UyQd8fpLHTZpyC7Z12tsHM8raR1jIwaoSQjlqIjzsucQNaX3Za13MzOLCDVEy_J7r_JoYr3aUbzZXAiiAQ-PQgMKbfs8uTHgLk0_cmujRnTSgTNWaESkA_vkC3aR4jRAVULTDnXPAnqjOwQIg-ga9dRPWKYykIYmixPf0LBVfr4M9BXXyA872BD88XfdzwTyUAwDvAjinn0flHBCO91E7vaqehdnqpnV42Ei9mbJjMUhj4mtD_d5LsJjO4xM6NT1n8e-gO4TTrjQ
CitedBy_id crossref_primary_10_1093_ckj_sfae235
crossref_primary_10_1016_j_intimp_2023_109996
crossref_primary_10_3389_fimmu_2023_1154699
crossref_primary_10_1016_j_jtho_2025_08_017
crossref_primary_10_1038_s43587_025_00939_6
crossref_primary_10_1007_s00281_020_00804_1
crossref_primary_10_1111_imcb_12825
crossref_primary_10_3390_cancers15061836
crossref_primary_10_3390_jpm10030102
crossref_primary_10_3390_vaccines12121389
crossref_primary_10_1016_j_smim_2023_101816
crossref_primary_10_1186_s13578_022_00815_5
crossref_primary_10_1155_2023_5517445
crossref_primary_10_15252_embr_202357925
crossref_primary_10_3390_cells10030628
crossref_primary_10_1007_s11033_020_05988_1
crossref_primary_10_3390_ijms222212539
crossref_primary_10_3390_cells10102562
crossref_primary_10_3390_ijms242015468
crossref_primary_10_3390_medicina60091523
crossref_primary_10_1016_j_arr_2025_102786
crossref_primary_10_1186_s12979_023_00333_z
crossref_primary_10_1186_s13287_020_01849_7
crossref_primary_10_4049_jimmunol_2100677
crossref_primary_10_1016_j_vetvac_2025_100120
crossref_primary_10_1016_j_autrev_2025_103875
crossref_primary_10_1038_s41467_024_52522_z
crossref_primary_10_3389_fimmu_2024_1285798
crossref_primary_10_3390_nu14030616
crossref_primary_10_2337_dbi21_0013
crossref_primary_10_1186_s12929_025_01146_6
crossref_primary_10_3390_antiox11112242
crossref_primary_10_3389_fimmu_2021_738511
crossref_primary_10_1007_s10522_022_09969_8
crossref_primary_10_3390_vaccines9020136
crossref_primary_10_1093_nutrit_nuae169
crossref_primary_10_3389_fimmu_2021_717850
crossref_primary_10_1016_j_jtcvs_2024_09_004
crossref_primary_10_3389_fcell_2022_835675
crossref_primary_10_1177_1073858420987224
crossref_primary_10_1097_MD_0000000000036045
crossref_primary_10_1016_j_bbadis_2022_166393
crossref_primary_10_3390_ijms21124346
crossref_primary_10_1016_j_autrev_2021_102893
crossref_primary_10_1016_j_jot_2025_06_015
crossref_primary_10_3389_fimmu_2021_799380
crossref_primary_10_3390_ijms22115749
crossref_primary_10_1016_j_biopha_2023_114476
crossref_primary_10_1016_j_cytogfr_2024_07_009
crossref_primary_10_1002_jcp_31327
crossref_primary_10_1186_s12979_023_00371_7
crossref_primary_10_1093_nutrit_nuaf027
crossref_primary_10_1016_j_imlet_2021_08_003
crossref_primary_10_1186_s12979_023_00334_y
crossref_primary_10_3389_fimmu_2025_1616531
crossref_primary_10_1016_j_mehy_2020_110392
crossref_primary_10_1016_j_exger_2021_111377
crossref_primary_10_3390_ijms25020753
crossref_primary_10_1111_acel_13700
crossref_primary_10_3390_cells13090749
crossref_primary_10_1126_science_adh8967
crossref_primary_10_1177_17455057231155286
crossref_primary_10_1016_j_ebiom_2025_105900
crossref_primary_10_3389_fimmu_2022_920306
crossref_primary_10_1007_s00281_020_00818_9
crossref_primary_10_1186_s12979_022_00313_9
crossref_primary_10_1186_s40001_023_01604_7
crossref_primary_10_3390_ijms25126444
crossref_primary_10_36290_vnl_2020_101
crossref_primary_10_1002_aac2_12032
crossref_primary_10_1136_jitc_2024_009258
crossref_primary_10_1007_s11914_022_00745_8
crossref_primary_10_1038_s43587_024_00724_x
crossref_primary_10_1007_s40266_024_01100_5
crossref_primary_10_1007_s00281_020_00821_0
crossref_primary_10_1161_CIRCRESAHA_125_325496
crossref_primary_10_1111_imm_13333
crossref_primary_10_3390_ijms24065708
crossref_primary_10_3390_biomedicines12071408
crossref_primary_10_1002_cmdc_202400672
crossref_primary_10_3390_biom13071085
crossref_primary_10_1186_s12877_021_02128_7
crossref_primary_10_3389_fnagi_2022_909273
crossref_primary_10_1038_s43587_024_00801_1
crossref_primary_10_1186_s12979_024_00492_7
crossref_primary_10_3389_fmed_2021_675573
crossref_primary_10_1016_j_arr_2021_101410
crossref_primary_10_1097_CM9_0000000000003410
crossref_primary_10_3389_fncel_2021_811852
crossref_primary_10_1038_s41408_024_01071_1
crossref_primary_10_3389_fimmu_2021_706244
crossref_primary_10_1016_j_stem_2024_03_012
crossref_primary_10_1007_s00018_022_04520_x
crossref_primary_10_1038_s41467_024_45984_8
crossref_primary_10_3390_biomedicines12050956
crossref_primary_10_1007_s00011_023_01791_3
crossref_primary_10_1111_imcb_12645
crossref_primary_10_1111_acel_13219
crossref_primary_10_3389_fimmu_2020_585655
crossref_primary_10_1016_j_cyto_2020_155314
crossref_primary_10_1016_j_heliyon_2023_e15668
crossref_primary_10_1200_EDBK_25_473856
crossref_primary_10_3389_fimmu_2025_1608206
crossref_primary_10_1007_s11357_023_00947_7
crossref_primary_10_1007_s11914_024_00896_w
crossref_primary_10_1007_s12011_020_02437_9
crossref_primary_10_1016_j_heliyon_2023_e22645
crossref_primary_10_3389_fimmu_2020_01745
crossref_primary_10_3389_fimmu_2021_752330
crossref_primary_10_3390_molecules30061251
crossref_primary_10_1016_j_beha_2024_101558
crossref_primary_10_1016_j_semcancer_2023_04_008
crossref_primary_10_1186_s12979_023_00351_x
crossref_primary_10_3390_biomedicines12081890
crossref_primary_10_1093_infdis_jiae603
crossref_primary_10_3389_fneur_2023_1197212
crossref_primary_10_1016_j_bbi_2023_05_004
crossref_primary_10_3389_fimmu_2020_00773
crossref_primary_10_3389_fimmu_2025_1589513
crossref_primary_10_3390_toxins12040224
crossref_primary_10_1016_j_exger_2023_112184
crossref_primary_10_1038_s41435_021_00126_8
crossref_primary_10_3390_biom14101217
crossref_primary_10_1016_j_neurobiolaging_2024_10_001
crossref_primary_10_1186_s12979_020_00204_x
crossref_primary_10_1016_j_lanwpc_2025_101615
crossref_primary_10_3389_fimmu_2023_1132653
crossref_primary_10_3389_fimmu_2024_1393324
crossref_primary_10_1038_s41392_025_02371_z
crossref_primary_10_1016_j_clicom_2023_02_005
crossref_primary_10_1016_j_ebiom_2022_104179
crossref_primary_10_1186_s12979_023_00340_0
crossref_primary_10_1182_bloodadvances_2022008071
crossref_primary_10_1038_s41586_024_07701_9
crossref_primary_10_3389_fcvm_2024_1384996
crossref_primary_10_3389_fphys_2020_584248
crossref_primary_10_3390_vaccines8040636
crossref_primary_10_1101_gad_352644_125
crossref_primary_10_3389_fimmu_2024_1421858
crossref_primary_10_3390_ijms23179797
crossref_primary_10_3389_fphys_2021_668327
crossref_primary_10_1186_s12879_022_07609_7
crossref_primary_10_1093_mr_road030
crossref_primary_10_1186_s12979_024_00480_x
crossref_primary_10_1097_ID9_0000000000000134
crossref_primary_10_3389_fnagi_2021_685863
crossref_primary_10_1016_j_exger_2022_111931
crossref_primary_10_26599_NR_2025_94907609
crossref_primary_10_3390_life10100246
crossref_primary_10_3390_ijms24065862
crossref_primary_10_3389_fnagi_2021_648662
crossref_primary_10_1097_RCT_0000000000001425
crossref_primary_10_1186_s12979_022_00323_7
crossref_primary_10_3389_fimmu_2020_579972
crossref_primary_10_1111_imr_13306
crossref_primary_10_1155_2021_9919024
crossref_primary_10_3390_nu13020665
crossref_primary_10_1016_j_devcel_2024_09_011
crossref_primary_10_3389_fmed_2022_1083879
crossref_primary_10_1016_j_semcancer_2025_01_007
crossref_primary_10_1016_j_jgo_2024_101789
crossref_primary_10_1097_JP9_0000000000000133
crossref_primary_10_1038_s41392_023_01451_2
crossref_primary_10_3389_fcell_2022_882211
crossref_primary_10_1016_j_ejphar_2025_177960
crossref_primary_10_1186_s13045_020_00986_z
crossref_primary_10_1038_s41423_020_00530_6
crossref_primary_10_1016_j_arr_2025_102715
crossref_primary_10_3390_cancers14153796
crossref_primary_10_1002_alz_14173
crossref_primary_10_1016_j_semcancer_2025_02_012
crossref_primary_10_1007_s00281_021_00842_3
crossref_primary_10_1007_s00391_025_02496_4
crossref_primary_10_3389_fimmu_2023_1233870
crossref_primary_10_1038_s41590_021_00927_z
crossref_primary_10_3389_fimmu_2022_1059173
crossref_primary_10_1016_j_exger_2022_112009
crossref_primary_10_1016_j_mad_2022_111739
crossref_primary_10_1177_15353702221121635
crossref_primary_10_7554_eLife_90091
crossref_primary_10_3389_fimmu_2025_1655819
crossref_primary_10_1093_jleuko_qiae180
crossref_primary_10_1038_s41419_021_04289_0
crossref_primary_10_1155_2021_5593584
crossref_primary_10_1096_fj_202400622RR
crossref_primary_10_3389_fimmu_2024_1338680
crossref_primary_10_1186_s12950_025_00460_y
crossref_primary_10_1093_ageing_afad127
crossref_primary_10_1007_s10534_020_00279_5
crossref_primary_10_1186_s12979_022_00317_5
crossref_primary_10_3389_fmed_2023_1258037
crossref_primary_10_3390_v15010155
crossref_primary_10_4049_jimmunol_2000171
crossref_primary_10_4093_dmj_2024_0140
crossref_primary_10_1212_WNL_0000000000209482
crossref_primary_10_1080_14712598_2020_1761322
crossref_primary_10_1093_jleuko_qiae231
crossref_primary_10_1002_mco2_542
crossref_primary_10_1016_j_jvacx_2025_100662
crossref_primary_10_3390_tropicalmed6030153
crossref_primary_10_1016_j_jacadv_2025_102116
crossref_primary_10_1126_sciimmunol_ado4720
crossref_primary_10_1016_j_cpt_2023_08_001
crossref_primary_10_1016_j_lfs_2024_123366
crossref_primary_10_1038_s41467_023_43456_z
crossref_primary_10_3389_fimmu_2024_1386856
crossref_primary_10_3390_biology11111678
crossref_primary_10_1002_ncp_11036
crossref_primary_10_1016_j_jaut_2025_103433
crossref_primary_10_1016_j_semcancer_2024_10_003
crossref_primary_10_1016_j_arr_2024_102204
crossref_primary_10_3389_fimmu_2023_1298004
crossref_primary_10_3390_sclerosis3020019
crossref_primary_10_1056_NEJMoa2302892
crossref_primary_10_3389_fimmu_2024_1478777
crossref_primary_10_3389_fimmu_2020_585168
crossref_primary_10_1080_1744666X_2022_2106217
crossref_primary_10_1016_j_bbrc_2023_149201
crossref_primary_10_3389_fimmu_2021_652538
crossref_primary_10_3389_fimmu_2022_956919
crossref_primary_10_1038_s41598_024_70300_1
crossref_primary_10_1002_adfm_202509165
crossref_primary_10_3389_fimmu_2023_1102517
crossref_primary_10_1002_advs_202502013
crossref_primary_10_1186_s12979_021_00215_2
crossref_primary_10_1097_jagr_0000000000000021
crossref_primary_10_1016_j_archger_2020_104174
crossref_primary_10_3389_fvets_2025_1609405
crossref_primary_10_1038_s41568_024_00714_6
crossref_primary_10_1134_S2079057021040068
crossref_primary_10_3389_fimmu_2024_1464728
crossref_primary_10_1016_j_mad_2022_111710
crossref_primary_10_1016_j_mad_2020_111357
crossref_primary_10_3389_fcell_2022_1083743
crossref_primary_10_1002_bies_202000024
crossref_primary_10_3390_ijms232314984
crossref_primary_10_1016_j_tig_2022_02_014
crossref_primary_10_3390_cells11030359
crossref_primary_10_1038_s41591_021_01581_6
crossref_primary_10_1038_s41577_022_00809_x
crossref_primary_10_1080_01635581_2025_2474263
crossref_primary_10_1038_s43587_025_00908_z
crossref_primary_10_3390_cancers15245765
crossref_primary_10_1016_j_arr_2020_101097
crossref_primary_10_1016_j_exger_2022_112040
crossref_primary_10_1210_endrev_bnae010
crossref_primary_10_3390_pathogens14010041
crossref_primary_10_3390_medsci13030100
crossref_primary_10_1093_jleuko_qiaf115
crossref_primary_10_3390_cells11233818
Cites_doi 10.1016/j.gde.2010.10.005
10.1016/j.clim.2005.08.015
10.1016/j.tcb.2018.02.001
10.1038/nri3155
10.3389/fimmu.2019.01099
10.1038/nature04850
10.1093/intimm/dxw025
10.18632/oncotarget.12572
10.1016/j.pneurobio.2017.07.006
10.1038/ni1033
10.5966/sctm.2012-0033
10.1034/j.1600-065X.2002.18902.x
10.1038/ncb3023
10.1016/j.stemcr.2014.04.009
10.1189/jlb.3RI0716-335R
10.1073/pnas.1714478115
10.1038/35095500
10.4049/jimmunol.1001668
10.15252/embr.201948678
10.1016/j.exger.2006.11.016
10.4049/jimmunol.1500082
10.4049/jimmunol.181.3.1835
10.1016/j.molmed.2010.03.003
10.1111/j.0105-2896.2006.00348.x
10.1126/science.1251141
10.1056/NEJMoa1200690
10.1016/j.redox.2012.11.004
10.1093/brain/awt259
10.1016/j.cell.2017.05.015
10.1038/onc.2012.206
10.1016/S0140-6736(00)04046-0
10.1161/CIRCULATIONAHA.117.031420
10.1038/217370a0
10.1097/01.tp.0000183962.64777.da
10.1038/nri.2016.26
10.1038/s41590-017-0006-x
10.1152/ajpendo.00484.2005
10.1016/j.coi.2012.04.005
10.1053/j.seminhematol.2016.10.001
10.1016/j.it.2016.01.006
10.1016/j.arr.2018.02.001
10.3389/fcvm.2018.00012
10.1124/pr.117.014647
10.1017/S0016672300010168
10.1016/j.immuni.2016.02.009
10.1002/ijc.2910600624
10.1161/CIRCRESAHA.111.246876
10.1038/nri1779
10.1126/science.1110542
10.1016/j.smim.2019.04.003
10.1016/j.coi.2012.12.003
10.3389/fimmu.2017.00095
10.1155/2014/149185
10.1046/j.1365-3083.2002.01077.x
10.1126/science.1252945
10.1038/nature03260
10.1002/(SICI)1097-0045(19980915)37:1<19::AID-PROS4>3.0.CO;2-3
10.1111/j.1365-2567.2007.02555.x
10.1161/CIR.0b013e31820a55f5
10.4049/jimmunol.1502010
10.1210/endo.142.3.8032
10.1084/jem.192.9.1273
10.1016/S0531-5565(01)00212-1
10.1126/science.272.5263.886
10.1038/ncomms8967
10.1111/acel.12750
10.3390/ijms20143561
10.1371/journal.pone.0057114
10.1155/1998/89782
10.1038/sj.embor.7400922
10.1146/annurev-immunol-020711-075035
10.1073/pnas.0601040103
10.1007/s11357-013-9564-5
10.1097/CCO.0000000000000500
10.14336/AD.2016.1230
10.1084/jem.190.2.153
10.1016/S0301-472X(03)00196-6
10.1016/0024-3205(91)90147-4
10.1172/JCI81894
10.1182/blood-2011-03-342097
10.1038/nature10357
10.7150/ijms.27238
10.1016/j.cell.2008.05.009
10.1007/s13277-016-5098-7
10.1016/j.coi.2009.05.002
10.1186/s12916-015-0470-9
10.1038/s41577-019-0177-9
10.1126/science.1218004
10.1016/j.smim.2012.04.008
10.1073/pnas.0910139106
10.4049/jimmunol.1301600
10.1186/s41232-018-0082-9
10.4049/jimmunol.0801752
10.1038/s41577-018-0083-6
10.1182/blood-2002-04-1036
10.1158/1541-7786.MCR-05-0261
10.1038/nri2318
10.3389/fimmu.2013.00316
10.1046/j.1365-2249.2002.01736.x
10.1038/nrc2734
10.1089/rej.2012.1331
10.1159/000478044
10.1159/000355303
10.1016/j.cjca.2012.06.023
10.1016/j.stem.2013.04.004
10.1016/j.nbd.2008.12.015
10.1016/j.atherosclerosis.2019.03.004
10.1038/nri2970
10.1016/j.clim.2013.11.002
10.1182/blood-2006-02-004531
10.1016/j.smim.2018.10.008
10.3389/fimmu.2018.01701
10.1016/j.smim.2018.09.003
10.1172/JCI86800
10.1371/journal.pone.0069129
10.1097/RTI.0000000000000349
10.1016/j.mad.2006.11.016
10.4049/jimmunol.1001505
10.1038/nri3667
10.1016/j.immuni.2016.04.018
10.1111/j.1474-9726.2011.00773.x
10.1016/S0531-5565(99)00068-6
10.1371/journal.pbio.2003352
10.1038/ni.1874
10.4049/jimmunol.118.3.846
10.18632/aging.100487
10.1146/annurev.immunol.25.022106.141623
10.1111/j.1474-9728.2004.00102.x
10.18632/oncotarget.4970
10.1073/pnas.0610155104
10.1146/annurev-pathol-121808-102144
10.1016/j.autrev.2012.10.014
10.1371/journal.pone.0151666
10.1016/j.smim.2005.05.007
10.1007/s10238-015-0376-z
10.1016/j.smim.2012.04.007
10.1016/0014-4827(61)90192-6
10.1139/apnm-2017-0775
10.1084/jem.177.5.1391
10.1182/blood-2012-06-437236
10.15252/embr.201847379
10.1023/A:1006611518223
10.1016/j.smim.2012.04.005
10.1016/j.coi.2013.05.018
10.1016/j.nbd.2016.07.007
10.1002/eji.201545814
10.1038/ncomms11762
10.1242/dev.103614
10.1093/intimm/dxm095
10.1126/science.1221677
10.1016/j.febslet.2005.02.055
10.1101/gad.10.17.2212
10.1111/j.1474-9726.2012.00812.x
10.1007/s10522-017-9682-z
10.1038/nature01322
10.4049/jimmunol.175.5.2982
10.1111/acel.12191
10.1073/pnas.1211270110
10.4049/jimmunol.1200947
10.1113/jphysiol.1904.sp001062
10.1084/jem.20081359
10.1038/icb.2010.123
10.1002/eji.201444823
10.1111/imr.12398
10.1371/journal.pbio.0060301
10.1158/1541-7786.MCR-18-0308
10.1016/j.exger.2014.01.005
10.1002/eji.201646553
10.1038/nri1085
10.1073/pnas.0808493106
10.1111/acel.12552
10.1152/ajpgi.00079.2004
10.4049/jimmunol.1500609
10.1016/j.cell.2014.10.039
10.1016/S0065-2776(06)90001-7
10.1016/j.smim.2018.10.011
10.1111/imr.12418
10.1111/j.1749-6632.2000.tb06651.x
10.7150/ijbs.5033
10.1111/j.1474-9726.2010.00559.x
10.1016/S0264-410X(99)00498-3
10.1038/nrendo.2015.168
10.4161/onci.24898
10.1038/nm0996-1011
10.1016/j.mad.2004.07.007
10.1016/S0531-5565(99)00002-9
10.1016/j.immuni.2004.05.004
10.1016/j.cell.2013.04.015
10.1074/jbc.M109.072124
10.1016/j.stem.2011.11.019
10.1111/acel.12675
10.1016/j.exger.2013.09.011
10.1158/0008-5472.CAN-04-3232
10.3390/ijms19123701
10.1186/s12979-017-0111-6
10.1371/journal.pone.0075786
10.4049/jimmunol.1403158
10.4049/jimmunol.1801403
10.1016/j.coi.2009.05.023
10.1186/s12979-018-0117-8
10.1007/s00330-015-3796-y
10.1126/science.1144090
10.4049/jimmunol.173.3.1604
10.1007/s00011-005-1377-2
10.1016/j.ejca.2005.08.016
10.1172/JCI64098
10.1016/S0047-6374(00)00210-4
10.1007/s00401-018-1807-1
10.1034/j.1600-0625.2001.100501.x
10.1038/nrc1256
10.1038/nm.3569
10.1038/nature12079
10.1007/s10522-015-9590-z
10.1016/j.jacc.2007.06.040
10.1371/journal.pone.0173048
10.4049/jimmunol.176.11.6586
10.1002/path.2104
10.1007/s00018-019-03132-2
10.4049/jimmunol.169.5.2756
10.1016/j.jacc.2017.01.064
10.1101/gad.284851.116
10.1161/xJAHA.111.000125
10.1084/jem.180.5.1955
10.4049/jimmunol.175.6.4112
10.3389/fimmu.2016.00502
10.1084/jem.190.10.1375
10.3389/fimmu.2017.01960
10.1073/pnas.1116110108
10.1016/j.exger.2017.10.024
10.1038/372103a0
10.1016/j.stem.2013.06.014
10.1084/jem.20131289
10.1016/j.cell.2010.09.043
10.4049/jimmunol.173.1.245
10.1093/intimm/dxf042
10.1016/j.arr.2010.08.003
10.1111/j.0105-2896.2005.00263.x
10.1111/j.1474-9726.2007.00325.x
10.4049/jimmunol.175.4.2741
10.3389/fimmu.2013.00231
10.1038/s41590-017-0022-x
10.1111/j.0105-2896.2005.00262.x
10.1182/blood-2005-07-2831
10.1038/nri.2016.80
ContentType Journal Article
Copyright The Author(s). 2020
The Author(s). 2020.
COPYRIGHT 2020 BioMed Central Ltd.
2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s). 2020
– notice: The Author(s). 2020.
– notice: COPYRIGHT 2020 BioMed Central Ltd.
– notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
NPM
3V.
7T5
7X7
7XB
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
H94
K9.
M0S
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1186/s12979-020-0173-8
DatabaseName Springer Nature OA/Free Journals
CrossRef
PubMed
ProQuest Central (Corporate)
Immunology Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Immunology Abstracts
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList

PubMed
Publicly Available Content Database
CrossRef

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals (DOAJ)
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: PIMPY
  name: Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Public Health
Biology
Social Welfare & Social Work
EISSN 1742-4933
EndPage 17
ExternalDocumentID oai_doaj_org_article_ecb14c6db8cc47ffb778e3c2976e681b
PMC6971920
A618720400
31988649
10_1186_s12979_020_0173_8
Genre Journal Article
Review
GeographicLocations Maryland
GeographicLocations_xml – name: Maryland
GrantInformation_xml – fundername: National Institute of Allergy and Infectious Diseases
  grantid: R01AI121147
  funderid: http://dx.doi.org/10.13039/100000060
– fundername: ;
  grantid: R01AI121147
GroupedDBID ---
0R~
29I
2WC
53G
5GY
5VS
7X7
8FI
8FJ
AAFWJ
AAJSJ
AASML
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACPRK
ACUHS
ADBBV
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AHBYD
AHMBA
AHYZX
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C6C
CCPQU
CS3
DIK
E3Z
EBD
EBLON
EBS
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HMCUK
HYE
IAO
IHR
ITC
KQ8
M48
M~E
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PUEGO
RBZ
RNS
ROL
RPM
RSV
SBL
SOJ
TR2
TUS
UKHRP
WOQ
WOW
XSB
~8M
AAYXX
AFFHD
CITATION
-56
-5G
-A0
-BR
2VQ
3V.
4.4
ACRMQ
ADINQ
AHSBF
ALIPV
C1A
C24
EJD
H13
ICW
IPNFZ
NPM
RIG
7T5
7XB
8FK
AZQEC
DWQXO
H94
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c669t-40644adcce7c584a7ffaabad3e4c320f5a0c2056a806dce7d96f9b36152a1f8d3
IEDL.DBID DOA
ISICitedReferencesCount 302
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000513663100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1742-4933
IngestDate Fri Oct 03 12:49:29 EDT 2025
Tue Nov 04 01:45:57 EST 2025
Wed Oct 01 17:15:31 EDT 2025
Wed Oct 15 14:26:11 EDT 2025
Tue Nov 11 10:41:08 EST 2025
Tue Nov 04 17:53:26 EST 2025
Thu Jan 02 22:59:49 EST 2025
Tue Nov 18 21:41:21 EST 2025
Sat Nov 29 03:39:04 EST 2025
Sat Sep 06 07:19:21 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Negative selection and regulatory T (Treg) cell generation
Central tolerance
Thymic aging
Age-related thymic involution
Immunosenescence and inflammaging
Rejuvenation
Language English
License The Author(s). 2020.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c669t-40644adcce7c584a7ffaabad3e4c320f5a0c2056a806dce7d96f9b36152a1f8d3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-3326-4753
OpenAccessLink https://doaj.org/article/ecb14c6db8cc47ffb778e3c2976e681b
PMID 31988649
PQID 2357166676
PQPubID 54869
PageCount 17
ParticipantIDs doaj_primary_oai_doaj_org_article_ecb14c6db8cc47ffb778e3c2976e681b
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6971920
proquest_miscellaneous_2347514238
proquest_journals_2357166676
gale_infotracmisc_A618720400
gale_infotracacademiconefile_A618720400
pubmed_primary_31988649
crossref_primary_10_1186_s12979_020_0173_8
crossref_citationtrail_10_1186_s12979_020_0173_8
springer_journals_10_1186_s12979_020_0173_8
PublicationCentury 2000
PublicationDate 2020-01-20
PublicationDateYYYYMMDD 2020-01-20
PublicationDate_xml – month: 01
  year: 2020
  text: 2020-01-20
  day: 20
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Immunity & ageing
PublicationTitleAbbrev Immun Ageing
PublicationTitleAlternate Immun Ageing
PublicationYear 2020
Publisher BioMed Central
BioMed Central Ltd
Springer Nature B.V
BMC
Publisher_xml – name: BioMed Central
– name: BioMed Central Ltd
– name: Springer Nature B.V
– name: BMC
References DH Gray (173_CR233) 2006; 108
H Yang (173_CR116) 2013; 8
JF Ghersi-Egea (173_CR120) 2018; 135
PA Heidenreich (173_CR127) 2011; 123
T Matsuda (173_CR200) 2007; 104
J Xia (173_CR12) 2012; 3
JD Hudson (173_CR165) 1999; 190
F Veglia (173_CR176) 2018; 19
DM Su (173_CR39) 2013; 25
SE Prockop (173_CR188) 2004; 173
CA Chougnet (173_CR75) 2011; 186
SA Villeda (173_CR249) 2011; 477
D Conze (173_CR159) 2001; 61
X Sun (173_CR207) 2013; 13
G Liuzzo (173_CR138) 2007; 50
R Aspinall (173_CR70) 2000; 20
G Pawelec (173_CR140) 2017; 18
I Rode (173_CR197) 2015; 195
SH Itzkowitz (173_CR162) 2004; 287
S Malchow (173_CR97) 2016; 44
W Wang (173_CR251) 2018; 1
J Fessler (173_CR79) 2013; 4
AV Parent (173_CR206) 2013; 13
W Savino (173_CR222) 2002; 55
F Balkwill (173_CR160) 2001; 357
J Crespo (173_CR54) 2013; 25
J Lara (173_CR65) 2015; 13
K Baruch (173_CR123) 2014; 346
A Wilson (173_CR187) 2006; 6
CL Soh (173_CR208) 2014; 2
MU Chupel (173_CR110) 2018; 43
A Bektas (173_CR68) 2017; 102
CS Hsieh (173_CR31) 2012; 12
S He (173_CR47) 2017; 169
J Nikolich-Zugich (173_CR5) 2018; 19
BK Kennedy (173_CR44) 2014; 159
CL Mackall (173_CR219) 2011; 11
DR Hodge (173_CR168) 2005; 41
AS Brack (173_CR245) 2007; 317
PF Hou (173_CR152) 2017; 12
E Ban (173_CR227) 1991; 48
EH Bent (173_CR154) 2016; 30
AM Gallegos (173_CR33) 2006; 209
R Del Pinto (173_CR129) 2018; 19
G Pawelec (173_CR3) 2007; 8
L Xie (173_CR126) 2015; 45
J Campisi (173_CR49) 2011; 21
S Sakaguchi (173_CR125) 2008; 133
PJ Linton (173_CR179) 2004; 5
Michael J. Drabkin (173_CR8) 2018; 33
T Kimura (173_CR134) 2018; 138
MJ Machiela (173_CR7) 2019; 31
C Ferreira (173_CR81) 2014; 192
NJ Olsen (173_CR234) 2001; 142
T Fulop (173_CR27) 2016; 68
J Gui (173_CR76) 2007; 19
Y Takeuchi (173_CR146) 2016; 28
EM Pantelouris (173_CR195) 1968; 217
G Pawelec (173_CR1) 2018; 105
S Swain (173_CR77) 2005; 17
CS Lages (173_CR100) 2008; 181
MA Perales (173_CR221) 2012; 120
Q Qi (173_CR143) 2014; 54
P Orosz (173_CR167) 1995; 60
E Kieback (173_CR99) 2016; 44
F Paneni (173_CR102) 2017; 69
C Franceschi (173_CR72) 1999; 34
O Sizova (173_CR155) 2018; 16
DE Speiser (173_CR147) 2016; 16
L Sun (173_CR38) 2012; 4
H Tsukamoto (173_CR73) 2009; 106
E Velardi (173_CR235) 2014; 211
Saul A Villeda (173_CR248) 2014; 20
MJ Kim (173_CR210) 2015; 194
Z Zhang (173_CR199) 2012; 8
L Klein (173_CR41) 2014; 14
AL Fletcher (173_CR86) 2009; 182
HC Chen (173_CR145) 2019; 20
A Sagiv (173_CR58) 2013; 32
A Waterstrat (173_CR172) 2009; 21
V Geenen (173_CR226) 1993; 21
JS Sutherland (173_CR231) 2005; 175
C Franceschi (173_CR16) 2000; 908
J Gui (173_CR25) 2012; 3
SZ Josefowicz (173_CR83) 2012; 30
M Sandmand (173_CR124) 2002; 127
ML Tyan (173_CR180) 1977; 118
MK Shaw (173_CR133) 2017; 8
M Fann (173_CR135) 2005; 205
L Klein (173_CR87) 2019; 19
B Coder (173_CR14) 2015; 6
J Oh (173_CR85) 2017; 15
L Cheng (173_CR198) 2010; 285
P Bakhru (173_CR240) 2016; 126
A Jagger (173_CR93) 2014; 60
JL Brissette (173_CR193) 1996; 10
LA Ormandy (173_CR150) 2005; 65
J Pohar (173_CR88) 2018; 9
Z Liang (173_CR112) 2017; 157
BW Wong (173_CR104) 2012; 28
LA Gilbert (173_CR153) 2010; 143
KE O’Neill (173_CR205) 2016; 11
A Wikby (173_CR67) 2002; 37
GL Stritesky (173_CR82) 2012; 30
G Accardi (173_CR45) 2018; 15
M Nehls (173_CR191) 1996; 272
ML Leon (173_CR137) 2005; 54
LM Coussens (173_CR161) 2002; 420
HT Yu (173_CR130) 2016; 16
KA Moore (173_CR186) 2006; 311
C Falci (173_CR141) 2013; 48
I Pishel (173_CR243) 2012; 15
SJ Morrison (173_CR171) 1996; 2
LV Kovtonyuk (173_CR36) 2016; 7
AV Griffith (173_CR237) 2012; 11
N Bredenkamp (173_CR204) 2014; 141
A Zinger (173_CR6) 2017; 8
HT Petrie (173_CR69) 2002; 189
C Cao (173_CR118) 2009; 34
TC Browne (173_CR114) 2013; 190
O Alpdogan (173_CR213) 2006; 107
H Min (173_CR181) 2005; 205
G Anderson (173_CR40) 2001; 1
S Palmer (173_CR26) 2018; 115
SK Garg (173_CR96) 2014; 13
R Aspinall (173_CR189) 2000; 18
I Prinz (173_CR144) 2019; 20
A Bhandoola (173_CR214) 2012; 336
L Katsimpardi (173_CR247) 2014; 344
SL Topalian (173_CR55) 2012; 366
T Nishioka (173_CR94) 2006; 176
S Malchow (173_CR98) 2013; 2
HJ Vaidya (173_CR42) 2016; 46
YY Sanders (173_CR51) 2013; 1
F Sanada (173_CR103) 2018; 5
E Zenaro (173_CR109) 2017; 107
CL Ortman (173_CR196) 2002; 14
A Hernandez-Segura (173_CR48) 2018; 28
G Pawelec (173_CR175) 2019; 10
NA Duggal (173_CR254) 2019; 19
M De Martinis (173_CR15) 2005; 579
TS Heng (173_CR230) 2005; 175
T Fulop (173_CR23) 2018; 40
R Marcotte (173_CR50) 2004; 125
N Bredenkamp (173_CR211) 2014; 16
R Aspinall (173_CR43) 2018; 15
AL Gruver (173_CR108) 2007; 211
Rashmi Das (173_CR113) 2019; 76
M Barsanti (173_CR209) 2017; 47
R Rezzani (173_CR10) 2014; 36
K Baruch (173_CR117) 2015; 6
X Zhu (173_CR182) 2007; 6
MS Chaudhry (173_CR216) 2016; 271
IK Chinn (173_CR173) 2012; 24
M Nehls (173_CR190) 1994; 372
C Franceschi (173_CR62) 2018; 40
AA Okoye (173_CR218) 2015; 195
M Erickson (173_CR212) 2002; 100
LA Callender (173_CR20) 2018; 17
VI Summerhill (173_CR132) 2019; 20
L Sun (173_CR184) 2012; 11
N Dragin (173_CR241) 2016; 126
G Wirnsberger (173_CR90) 2011; 89
H Tsukamoto (173_CR74) 2010; 185
HE Porritt (173_CR185) 2004; 20
N Kurd (173_CR29) 2016; 271
MO Li (173_CR84) 2016; 16
P Orosz (173_CR166) 1993; 177
UK Liyanage (173_CR149) 2002; 169
J Plowden (173_CR59) 2004; 3
CC Bleul (173_CR201) 2006; 441
B Suarez-Alvarez (173_CR136) 2017; 16
J Raynor (173_CR92) 2012; 24
B Bottazzi (173_CR106) 2018; 40
H Min (173_CR236) 2006; 118
S Brunner (173_CR17) 2011; 10
JJ Peschon (173_CR183) 1994; 180
JP Chou (173_CR52) 2013; 19
T Schlake (173_CR192) 2001; 10
SP Flanagan (173_CR194) 1966; 8
Larissa G.P. Langhi Prata (173_CR56) 2018; 40
JS Hale (173_CR9) 2006; 103
EC Zook (173_CR203) 2011; 118
JA Dudakov (173_CR215) 2012; 336
D Aw (173_CR107) 2007; 120
JM Ruckh (173_CR244) 2012; 10
A Cebula (173_CR32) 2013; 497
C Franceschi (173_CR19) 2007; 128
T Fulop (173_CR24) 2017; 8
173_CR101
G Pawelec (173_CR4) 1999; 34
A Freund (173_CR18) 2010; 16
M Hinterberger (173_CR91) 2010; 11
B Pan (173_CR217) 2014; 150
F Ichihara (173_CR148) 2003; 9
ST Page (173_CR238) 2006; 290
DB Palmer (173_CR11) 2013; 4
H Yu (173_CR156) 2009; 9
W Savino (173_CR228) 2016; 12
J Darrigues (173_CR95) 2018; 64
L Sun (173_CR202) 2010; 9
MA Brown (173_CR239) 2019; 202
DGA Burton (173_CR57) 2018; 43
MA Erickson (173_CR111) 2018; 70
P Wikstrom (173_CR169) 1998; 37
JE McElhaney (173_CR2) 2009; 21
K Sudo (173_CR34) 2000; 192
H Lu (173_CR163) 2006; 4
A Deczkowska (173_CR121) 2016; 37
SM Henson (173_CR220) 2005; 175
E Palmer (173_CR30) 2003; 3
SK Lathrop (173_CR89) 2008; 205
X Dai (173_CR28) 2018; 15
K Hirokawa (173_CR223) 2016; 17
N Kumari (173_CR158) 2016; 37
MK Ruhland (173_CR177) 2016; 7
GL Goldberg (173_CR232) 2005; 80
JP Coppe (173_CR21) 2008; 6
IM Conboy (173_CR242) 2005; 433
DN Paton (173_CR229) 1904; 32
JP Coppe (173_CR22) 2010; 5
G Kunis (173_CR122) 2013; 136
JW Pollard (173_CR164) 2004; 4
EY Woo (173_CR151) 2001; 61
BJ Chen (173_CR224) 2003; 31
J Olsson (173_CR66) 2000; 121
FS Loffredo (173_CR246) 2013; 153
JJ Goronzy (173_CR78) 2007; 42
V De Mello-Coelho (173_CR225) 1998; 6
KP High (173_CR64) 2012; 24
T Araki (173_CR252) 2016; 26
SE Latchney (173_CR37) 2017; 54
B Zhang (173_CR174) 2013; 8
L Hayflick (173_CR46) 1961; 25
BD Coder (173_CR13) 2015; 194
BJ North (173_CR128) 2012; 110
J Stock (173_CR131) 2019; 284
H Min (173_CR35) 2004; 173
WW Pang (173_CR170) 2011; 108
NA Duggal (173_CR253) 2018; 17
J Nikolich-Zugich (173_CR63) 2008; 8
G Van Zant (173_CR178) 2012; 1
G Landskron (173_CR142) 2014; 2014
C Ferreira (173_CR80) 2009; 106
K Baruch (173_CR119) 2013; 110
SA Villeda (173_CR250) 2013; 12
J Zhang (173_CR115) 2013; 8
E Costantini (173_CR105) 2018; 2018
E Ammirati (173_CR139) 2012; 1
RJ Hodes (173_CR71) 1999; 190
MJ Smyth (173_CR157) 2006; 90
T Tchkonia (173_CR61) 2013; 123
R Solana (173_CR60) 2012; 24
Y Fukushima (173_CR53) 2018; 38
References_xml – volume: 21
  start-page: 107
  issue: 1
  year: 2011
  ident: 173_CR49
  publication-title: Curr Opin Genet Dev
  doi: 10.1016/j.gde.2010.10.005
– volume: 118
  start-page: 117
  issue: 1
  year: 2006
  ident: 173_CR236
  publication-title: Clin Immunol
  doi: 10.1016/j.clim.2005.08.015
– volume: 28
  start-page: 436
  issue: 6
  year: 2018
  ident: 173_CR48
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2018.02.001
– volume: 68
  start-page: 84
  issue: 2
  year: 2016
  ident: 173_CR27
  publication-title: Rev Investig Clin
– volume: 12
  start-page: 157
  issue: 3
  year: 2012
  ident: 173_CR31
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3155
– volume: 10
  start-page: 1099
  year: 2019
  ident: 173_CR175
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2019.01099
– volume: 441
  start-page: 992
  issue: 7096
  year: 2006
  ident: 173_CR201
  publication-title: Nature
  doi: 10.1038/nature04850
– volume: 28
  start-page: 401
  issue: 8
  year: 2016
  ident: 173_CR146
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxw025
– ident: 173_CR101
  doi: 10.18632/oncotarget.12572
– volume: 157
  start-page: 2
  year: 2017
  ident: 173_CR112
  publication-title: Prog Neurobiol
  doi: 10.1016/j.pneurobio.2017.07.006
– volume: 5
  start-page: 133
  issue: 2
  year: 2004
  ident: 173_CR179
  publication-title: Nat Immun
  doi: 10.1038/ni1033
– volume: 1
  start-page: 651
  issue: 9
  year: 2012
  ident: 173_CR178
  publication-title: Stem Cells Transl Med
  doi: 10.5966/sctm.2012-0033
– volume: 189
  start-page: 8
  year: 2002
  ident: 173_CR69
  publication-title: Immunol Rev
  doi: 10.1034/j.1600-065X.2002.18902.x
– volume: 16
  start-page: 902
  issue: 9
  year: 2014
  ident: 173_CR211
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb3023
– volume: 2
  start-page: 925
  issue: 6
  year: 2014
  ident: 173_CR208
  publication-title: Stem Cell Rep
  doi: 10.1016/j.stemcr.2014.04.009
– volume: 102
  start-page: 977
  issue: 4
  year: 2017
  ident: 173_CR68
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.3RI0716-335R
– volume: 115
  start-page: 1883
  issue: 8
  year: 2018
  ident: 173_CR26
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1714478115
– volume: 1
  start-page: 31
  issue: 1
  year: 2001
  ident: 173_CR40
  publication-title: Nat Rev Immunol
  doi: 10.1038/35095500
– volume: 185
  start-page: 4535
  issue: 8
  year: 2010
  ident: 173_CR74
  publication-title: J Immunol (Baltimore, Md : 1950)
  doi: 10.4049/jimmunol.1001668
– volume: 20
  start-page: e48678
  issue: 8
  year: 2019
  ident: 173_CR144
  publication-title: EMBO Rep
  doi: 10.15252/embr.201948678
– volume: 42
  start-page: 400
  issue: 5
  year: 2007
  ident: 173_CR78
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2006.11.016
– volume: 194
  start-page: 5825
  issue: 12
  year: 2015
  ident: 173_CR13
  publication-title: J Immunol (Baltimore, Md : 1950)
  doi: 10.4049/jimmunol.1500082
– volume: 181
  start-page: 1835
  issue: 3
  year: 2008
  ident: 173_CR100
  publication-title: J Immunol (Baltimore, Md : 1950)
  doi: 10.4049/jimmunol.181.3.1835
– volume: 16
  start-page: 238
  issue: 5
  year: 2010
  ident: 173_CR18
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2010.03.003
– volume: 209
  start-page: 290
  year: 2006
  ident: 173_CR33
  publication-title: Immunol Rev
  doi: 10.1111/j.0105-2896.2006.00348.x
– volume: 344
  start-page: 630
  issue: 6184
  year: 2014
  ident: 173_CR247
  publication-title: Science
  doi: 10.1126/science.1251141
– volume: 366
  start-page: 2443
  issue: 26
  year: 2012
  ident: 173_CR55
  publication-title: New Engl J Med
  doi: 10.1056/NEJMoa1200690
– volume: 1
  start-page: 8
  year: 2013
  ident: 173_CR51
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2012.11.004
– volume: 2018
  start-page: 6039171
  year: 2018
  ident: 173_CR105
  publication-title: Mediat Inflamm
– volume: 136
  start-page: 3427
  issue: Pt 11
  year: 2013
  ident: 173_CR122
  publication-title: Brain
  doi: 10.1093/brain/awt259
– volume: 169
  start-page: 1000
  issue: 6
  year: 2017
  ident: 173_CR47
  publication-title: Cell
  doi: 10.1016/j.cell.2017.05.015
– volume: 32
  start-page: 1971
  issue: 15
  year: 2013
  ident: 173_CR58
  publication-title: Oncogene
  doi: 10.1038/onc.2012.206
– volume: 357
  start-page: 539
  issue: 9255
  year: 2001
  ident: 173_CR160
  publication-title: Lancet
  doi: 10.1016/S0140-6736(00)04046-0
– volume: 138
  start-page: 1130
  issue: 11
  year: 2018
  ident: 173_CR134
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.117.031420
– volume: 217
  start-page: 370
  issue: 5126
  year: 1968
  ident: 173_CR195
  publication-title: Nature
  doi: 10.1038/217370a0
– volume: 80
  start-page: 1604
  issue: 11
  year: 2005
  ident: 173_CR232
  publication-title: Transplantation
  doi: 10.1097/01.tp.0000183962.64777.da
– volume: 16
  start-page: 220
  issue: 4
  year: 2016
  ident: 173_CR84
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri.2016.26
– volume: 19
  start-page: 10
  issue: 1
  year: 2018
  ident: 173_CR5
  publication-title: Nat Immun
  doi: 10.1038/s41590-017-0006-x
– volume: 290
  start-page: E856
  issue: 5
  year: 2006
  ident: 173_CR238
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00484.2005
– volume: 21
  start-page: 115
  issue: 2
  year: 1993
  ident: 173_CR226
  publication-title: Thymus
– volume: 3
  start-page: 280
  issue: 3
  year: 2012
  ident: 173_CR25
  publication-title: Aging Dis
– volume: 24
  start-page: 482
  issue: 4
  year: 2012
  ident: 173_CR92
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2012.04.005
– volume: 54
  start-page: 25
  issue: 1
  year: 2017
  ident: 173_CR37
  publication-title: Semin Hematol
  doi: 10.1053/j.seminhematol.2016.10.001
– volume: 37
  start-page: 181
  issue: 3
  year: 2016
  ident: 173_CR121
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2016.01.006
– volume: 43
  start-page: 17
  year: 2018
  ident: 173_CR57
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2018.02.001
– volume: 5
  start-page: 12
  year: 2018
  ident: 173_CR103
  publication-title: Front Cardiovasc Med
  doi: 10.3389/fcvm.2018.00012
– volume: 70
  start-page: 278
  issue: 2
  year: 2018
  ident: 173_CR111
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.117.014647
– volume: 8
  start-page: 295
  issue: 3
  year: 1966
  ident: 173_CR194
  publication-title: Genet Res
  doi: 10.1017/S0016672300010168
– volume: 44
  start-page: 1102
  issue: 5
  year: 2016
  ident: 173_CR97
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.02.009
– volume: 60
  start-page: 867
  issue: 6
  year: 1995
  ident: 173_CR167
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910600624
– volume: 110
  start-page: 1097
  issue: 8
  year: 2012
  ident: 173_CR128
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.111.246876
– volume: 6
  start-page: 93
  issue: 2
  year: 2006
  ident: 173_CR187
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri1779
– volume: 311
  start-page: 1880
  issue: 5769
  year: 2006
  ident: 173_CR186
  publication-title: Science
  doi: 10.1126/science.1110542
– volume: 40
  start-page: 101275
  year: 2018
  ident: 173_CR56
  publication-title: Seminars in Immunology
  doi: 10.1016/j.smim.2019.04.003
– volume: 25
  start-page: 214
  issue: 2
  year: 2013
  ident: 173_CR54
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2012.12.003
– volume: 8
  start-page: 95
  year: 2017
  ident: 173_CR133
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2017.00095
– volume: 2014
  start-page: 149185
  year: 2014
  ident: 173_CR142
  publication-title: J Immunol Res
  doi: 10.1155/2014/149185
– volume: 55
  start-page: 442
  issue: 5
  year: 2002
  ident: 173_CR222
  publication-title: Scand J Immunol
  doi: 10.1046/j.1365-3083.2002.01077.x
– volume: 346
  start-page: 89
  issue: 6205
  year: 2014
  ident: 173_CR123
  publication-title: Science
  doi: 10.1126/science.1252945
– volume: 433
  start-page: 760
  issue: 7027
  year: 2005
  ident: 173_CR242
  publication-title: Nature
  doi: 10.1038/nature03260
– volume: 37
  start-page: 19
  issue: 1
  year: 1998
  ident: 173_CR169
  publication-title: Prostate
  doi: 10.1002/(SICI)1097-0045(19980915)37:1<19::AID-PROS4>3.0.CO;2-3
– volume: 120
  start-page: 435
  issue: 4
  year: 2007
  ident: 173_CR107
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2007.02555.x
– volume: 123
  start-page: 933
  issue: 8
  year: 2011
  ident: 173_CR127
  publication-title: Circulation
  doi: 10.1161/CIR.0b013e31820a55f5
– volume: 195
  start-page: 5678
  issue: 12
  year: 2015
  ident: 173_CR197
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1502010
– volume: 142
  start-page: 1278
  issue: 3
  year: 2001
  ident: 173_CR234
  publication-title: Endocrinology
  doi: 10.1210/endo.142.3.8032
– volume: 192
  start-page: 1273
  issue: 9
  year: 2000
  ident: 173_CR34
  publication-title: J Exp Med
  doi: 10.1084/jem.192.9.1273
– volume: 37
  start-page: 445
  issue: 2-3
  year: 2002
  ident: 173_CR67
  publication-title: Exp Gerontol
  doi: 10.1016/S0531-5565(01)00212-1
– volume: 272
  start-page: 886
  issue: 5263
  year: 1996
  ident: 173_CR191
  publication-title: Science
  doi: 10.1126/science.272.5263.886
– volume: 6
  start-page: 7967
  year: 2015
  ident: 173_CR117
  publication-title: Nat Commun
  doi: 10.1038/ncomms8967
– volume: 17
  start-page: 2
  year: 2018
  ident: 173_CR253
  publication-title: Aging Cell
  doi: 10.1111/acel.12750
– volume: 20
  start-page: 14
  year: 2019
  ident: 173_CR132
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20143561
– volume: 8
  start-page: e57114
  issue: 2
  year: 2013
  ident: 173_CR174
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0057114
– volume: 6
  start-page: 317
  issue: 3-4
  year: 1998
  ident: 173_CR225
  publication-title: Dev Immunol
  doi: 10.1155/1998/89782
– volume: 8
  start-page: 220
  issue: 3
  year: 2007
  ident: 173_CR3
  publication-title: EMBO Rep
  doi: 10.1038/sj.embor.7400922
– volume: 30
  start-page: 95
  year: 2012
  ident: 173_CR82
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev-immunol-020711-075035
– volume: 103
  start-page: 8447
  issue: 22
  year: 2006
  ident: 173_CR9
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0601040103
– volume: 36
  start-page: 313
  issue: 1
  year: 2014
  ident: 173_CR10
  publication-title: Age (Dordr)
  doi: 10.1007/s11357-013-9564-5
– volume: 31
  start-page: 108
  issue: 2
  year: 2019
  ident: 173_CR7
  publication-title: Curr Opin Oncol
  doi: 10.1097/CCO.0000000000000500
– volume: 8
  start-page: 611
  issue: 5
  year: 2017
  ident: 173_CR6
  publication-title: Aging Dis
  doi: 10.14336/AD.2016.1230
– volume: 190
  start-page: 153
  issue: 2
  year: 1999
  ident: 173_CR71
  publication-title: J Exp Med
  doi: 10.1084/jem.190.2.153
– volume: 31
  start-page: 953
  issue: 10
  year: 2003
  ident: 173_CR224
  publication-title: Exp Hematol
  doi: 10.1016/S0301-472X(03)00196-6
– volume: 48
  start-page: 2141
  issue: 22
  year: 1991
  ident: 173_CR227
  publication-title: Life Sci
  doi: 10.1016/0024-3205(91)90147-4
– volume: 126
  start-page: 1525
  issue: 4
  year: 2016
  ident: 173_CR241
  publication-title: J Clin Invest
  doi: 10.1172/JCI81894
– volume: 118
  start-page: 5723
  issue: 22
  year: 2011
  ident: 173_CR203
  publication-title: Blood
  doi: 10.1182/blood-2011-03-342097
– volume: 477
  start-page: 90
  issue: 7362
  year: 2011
  ident: 173_CR249
  publication-title: Nature
  doi: 10.1038/nature10357
– volume: 15
  start-page: 1555
  issue: 13
  year: 2018
  ident: 173_CR28
  publication-title: Int J Med Sci
  doi: 10.7150/ijms.27238
– volume: 133
  start-page: 775
  issue: 5
  year: 2008
  ident: 173_CR125
  publication-title: Cell
  doi: 10.1016/j.cell.2008.05.009
– volume: 37
  start-page: 11553
  issue: 9
  year: 2016
  ident: 173_CR158
  publication-title: Tumour Biol
  doi: 10.1007/s13277-016-5098-7
– volume: 21
  start-page: 408
  issue: 4
  year: 2009
  ident: 173_CR172
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2009.05.002
– volume: 13
  start-page: 222
  year: 2015
  ident: 173_CR65
  publication-title: BMC Med
  doi: 10.1186/s12916-015-0470-9
– volume: 19
  start-page: 563
  issue: 9
  year: 2019
  ident: 173_CR254
  publication-title: Nat Rev Immunol
  doi: 10.1038/s41577-019-0177-9
– volume: 336
  start-page: 91
  issue: 6077
  year: 2012
  ident: 173_CR215
  publication-title: Science
  doi: 10.1126/science.1218004
– volume: 24
  start-page: 331
  issue: 5
  year: 2012
  ident: 173_CR60
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2012.04.008
– volume: 106
  start-page: 18333
  issue: 43
  year: 2009
  ident: 173_CR73
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0910139106
– volume: 192
  start-page: 4145
  issue: 9
  year: 2014
  ident: 173_CR81
  publication-title: J Immunol (Baltimore, Md : 1950)
  doi: 10.4049/jimmunol.1301600
– volume: 38
  start-page: 24
  year: 2018
  ident: 173_CR53
  publication-title: Inflamm Regen
  doi: 10.1186/s41232-018-0082-9
– volume: 182
  start-page: 2690
  issue: 5
  year: 2009
  ident: 173_CR86
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0801752
– volume: 19
  start-page: 7
  issue: 1
  year: 2019
  ident: 173_CR87
  publication-title: Nat Rev Immunol
  doi: 10.1038/s41577-018-0083-6
– volume: 100
  start-page: 3269
  issue: 9
  year: 2002
  ident: 173_CR212
  publication-title: Blood
  doi: 10.1182/blood-2002-04-1036
– volume: 4
  start-page: 221
  issue: 4
  year: 2006
  ident: 173_CR163
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-05-0261
– volume: 8
  start-page: 512
  issue: 7
  year: 2008
  ident: 173_CR63
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2318
– volume: 4
  start-page: 316
  year: 2013
  ident: 173_CR11
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2013.00316
– volume: 127
  start-page: 107
  issue: 1
  year: 2002
  ident: 173_CR124
  publication-title: Clin Exp Immunol
  doi: 10.1046/j.1365-2249.2002.01736.x
– volume: 9
  start-page: 798
  issue: 11
  year: 2009
  ident: 173_CR156
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc2734
– volume: 15
  start-page: 239
  issue: 2
  year: 2012
  ident: 173_CR243
  publication-title: Rejuvenation Res
  doi: 10.1089/rej.2012.1331
– volume: 64
  start-page: 28
  issue: 1
  year: 2018
  ident: 173_CR95
  publication-title: Gerontology
  doi: 10.1159/000478044
– volume: 60
  start-page: 130
  issue: 2
  year: 2014
  ident: 173_CR93
  publication-title: Gerontology
  doi: 10.1159/000355303
– volume: 28
  start-page: 631
  issue: 6
  year: 2012
  ident: 173_CR104
  publication-title: Can J Cardiol
  doi: 10.1016/j.cjca.2012.06.023
– volume: 13
  start-page: 219
  issue: 2
  year: 2013
  ident: 173_CR206
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.04.004
– volume: 34
  start-page: 63
  issue: 1
  year: 2009
  ident: 173_CR118
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2008.12.015
– volume: 284
  start-page: 221
  year: 2019
  ident: 173_CR131
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2019.03.004
– volume: 11
  start-page: 330
  issue: 5
  year: 2011
  ident: 173_CR219
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2970
– volume: 3
  start-page: 248
  issue: 3
  year: 2012
  ident: 173_CR12
  publication-title: Aging Dis
– volume: 150
  start-page: 101
  issue: 1
  year: 2014
  ident: 173_CR217
  publication-title: Clin Immunol (Orlando, Fla)
  doi: 10.1016/j.clim.2013.11.002
– volume: 108
  start-page: 3777
  issue: 12
  year: 2006
  ident: 173_CR233
  publication-title: Blood
  doi: 10.1182/blood-2006-02-004531
– volume: 40
  start-page: 1
  year: 2018
  ident: 173_CR62
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2018.10.008
– volume: 9
  start-page: 1701
  year: 2018
  ident: 173_CR88
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.01701
– volume: 40
  start-page: 17
  year: 2018
  ident: 173_CR23
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2018.09.003
– volume: 126
  start-page: 1239
  issue: 4
  year: 2016
  ident: 173_CR240
  publication-title: J Clin Invest
  doi: 10.1172/JCI86800
– volume: 8
  start-page: e69129
  issue: 7
  year: 2013
  ident: 173_CR116
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0069129
– volume: 33
  start-page: 409
  issue: 6
  year: 2018
  ident: 173_CR8
  publication-title: Journal of Thoracic Imaging
  doi: 10.1097/RTI.0000000000000349
– volume: 128
  start-page: 92
  issue: 1
  year: 2007
  ident: 173_CR19
  publication-title: Mech Ageing Dev
  doi: 10.1016/j.mad.2006.11.016
– volume: 186
  start-page: 156
  issue: 1
  year: 2011
  ident: 173_CR75
  publication-title: J Immunol (Baltimore, Md : 1950)
  doi: 10.4049/jimmunol.1001505
– volume: 14
  start-page: 377
  issue: 6
  year: 2014
  ident: 173_CR41
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3667
– volume: 44
  start-page: 1114
  issue: 5
  year: 2016
  ident: 173_CR99
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.04.018
– volume: 11
  start-page: 169
  issue: 1
  year: 2012
  ident: 173_CR237
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2011.00773.x
– volume: 34
  start-page: 911
  issue: 8
  year: 1999
  ident: 173_CR72
  publication-title: Exp Gerontol
  doi: 10.1016/S0531-5565(99)00068-6
– volume: 15
  start-page: e2003352
  issue: 11
  year: 2017
  ident: 173_CR85
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.2003352
– volume: 11
  start-page: 512
  issue: 6
  year: 2010
  ident: 173_CR91
  publication-title: Nat Immun
  doi: 10.1038/ni.1874
– volume: 118
  start-page: 846
  issue: 3
  year: 1977
  ident: 173_CR180
  publication-title: J Immunol (Baltimore, Md : 1950)
  doi: 10.4049/jimmunol.118.3.846
– volume: 4
  start-page: 606
  issue: 9
  year: 2012
  ident: 173_CR38
  publication-title: Aging
  doi: 10.18632/aging.100487
– volume: 30
  start-page: 531
  year: 2012
  ident: 173_CR83
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev.immunol.25.022106.141623
– volume: 3
  start-page: 161
  issue: 4
  year: 2004
  ident: 173_CR59
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9728.2004.00102.x
– volume: 61
  start-page: 8851
  issue: 24
  year: 2001
  ident: 173_CR159
  publication-title: Cancer Res
– volume: 6
  start-page: 21777
  issue: 26
  year: 2015
  ident: 173_CR14
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.4970
– volume: 1
  start-page: fj201800059R
  year: 2018
  ident: 173_CR251
  publication-title: FASEB J
– volume: 104
  start-page: 1027
  issue: 3
  year: 2007
  ident: 173_CR200
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0610155104
– volume: 5
  start-page: 99
  year: 2010
  ident: 173_CR22
  publication-title: Annu Rev Pathol
  doi: 10.1146/annurev-pathol-121808-102144
– volume: 12
  start-page: 674
  issue: 6
  year: 2013
  ident: 173_CR250
  publication-title: Autoimmun Rev
  doi: 10.1016/j.autrev.2012.10.014
– volume: 11
  start-page: e0151666
  issue: 3
  year: 2016
  ident: 173_CR205
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0151666
– volume: 17
  start-page: 370
  issue: 5
  year: 2005
  ident: 173_CR77
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2005.05.007
– volume: 16
  start-page: 257
  issue: 3
  year: 2016
  ident: 173_CR130
  publication-title: Clin Exp Med
  doi: 10.1007/s10238-015-0376-z
– volume: 24
  start-page: 373
  issue: 5
  year: 2012
  ident: 173_CR64
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2012.04.007
– volume: 25
  start-page: 585
  year: 1961
  ident: 173_CR46
  publication-title: Exp Cell Res
  doi: 10.1016/0014-4827(61)90192-6
– volume: 43
  start-page: 733
  issue: 7
  year: 2018
  ident: 173_CR110
  publication-title: Appl Physiol Nutr Metab
  doi: 10.1139/apnm-2017-0775
– volume: 177
  start-page: 1391
  issue: 5
  year: 1993
  ident: 173_CR166
  publication-title: J Exp Med
  doi: 10.1084/jem.177.5.1391
– volume: 120
  start-page: 4882
  issue: 24
  year: 2012
  ident: 173_CR221
  publication-title: Blood
  doi: 10.1182/blood-2012-06-437236
– volume: 20
  start-page: e47379
  issue: 8
  year: 2019
  ident: 173_CR145
  publication-title: EMBO Rep
  doi: 10.15252/embr.201847379
– volume: 20
  start-page: 250
  issue: 4
  year: 2000
  ident: 173_CR70
  publication-title: J Clin Immunol
  doi: 10.1023/A:1006611518223
– volume: 24
  start-page: 309
  issue: 5
  year: 2012
  ident: 173_CR173
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2012.04.005
– volume: 25
  start-page: 498
  issue: 4
  year: 2013
  ident: 173_CR39
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2013.05.018
– volume: 107
  start-page: 41
  year: 2017
  ident: 173_CR109
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2016.07.007
– volume: 46
  start-page: 1826
  issue: 8
  year: 2016
  ident: 173_CR42
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201545814
– volume: 7
  start-page: 11762
  year: 2016
  ident: 173_CR177
  publication-title: Nat Commun
  doi: 10.1038/ncomms11762
– volume: 141
  start-page: 1627
  issue: 8
  year: 2014
  ident: 173_CR204
  publication-title: Development (Cambridge, England)
  doi: 10.1242/dev.103614
– volume: 19
  start-page: 1201
  issue: 10
  year: 2007
  ident: 173_CR76
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxm095
– volume: 336
  start-page: 40
  issue: 6077
  year: 2012
  ident: 173_CR214
  publication-title: Science
  doi: 10.1126/science.1221677
– volume: 579
  start-page: 2035
  issue: 10
  year: 2005
  ident: 173_CR15
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2005.02.055
– volume: 10
  start-page: 2212
  issue: 17
  year: 1996
  ident: 173_CR193
  publication-title: Genes Dev
  doi: 10.1101/gad.10.17.2212
– volume: 11
  start-page: 509
  issue: 3
  year: 2012
  ident: 173_CR184
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2012.00812.x
– volume: 18
  start-page: 717
  issue: 4
  year: 2017
  ident: 173_CR140
  publication-title: Biogerontology
  doi: 10.1007/s10522-017-9682-z
– volume: 420
  start-page: 860
  issue: 6917
  year: 2002
  ident: 173_CR161
  publication-title: Nature
  doi: 10.1038/nature01322
– volume: 175
  start-page: 2982
  issue: 5
  year: 2005
  ident: 173_CR230
  publication-title: J Immunol
  doi: 10.4049/jimmunol.175.5.2982
– volume: 13
  start-page: 441
  issue: 3
  year: 2014
  ident: 173_CR96
  publication-title: Aging Cell
  doi: 10.1111/acel.12191
– volume: 61
  start-page: 4766
  issue: 12
  year: 2001
  ident: 173_CR151
  publication-title: Cancer Res
– volume: 110
  start-page: 2264
  issue: 6
  year: 2013
  ident: 173_CR119
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1211270110
– volume: 190
  start-page: 2241
  issue: 5
  year: 2013
  ident: 173_CR114
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1200947
– volume: 32
  start-page: 28
  issue: 1
  year: 1904
  ident: 173_CR229
  publication-title: J Physiol
  doi: 10.1113/jphysiol.1904.sp001062
– volume: 205
  start-page: 3105
  issue: 13
  year: 2008
  ident: 173_CR89
  publication-title: J Exp Med
  doi: 10.1084/jem.20081359
– volume: 89
  start-page: 45
  issue: 1
  year: 2011
  ident: 173_CR90
  publication-title: Immunol Cell Biol
  doi: 10.1038/icb.2010.123
– volume: 45
  start-page: 180
  issue: 1
  year: 2015
  ident: 173_CR126
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201444823
– volume: 271
  start-page: 114
  issue: 1
  year: 2016
  ident: 173_CR29
  publication-title: Immunol Rev
  doi: 10.1111/imr.12398
– volume: 6
  start-page: 2853
  issue: 12
  year: 2008
  ident: 173_CR21
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0060301
– volume: 16
  start-page: 1652
  issue: 11
  year: 2018
  ident: 173_CR155
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-18-0308
– volume: 54
  start-page: 71
  year: 2014
  ident: 173_CR143
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2014.01.005
– volume: 47
  start-page: 291
  issue: 2
  year: 2017
  ident: 173_CR209
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201646553
– volume: 3
  start-page: 383
  issue: 5
  year: 2003
  ident: 173_CR30
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri1085
– volume: 106
  start-page: 8320
  issue: 20
  year: 2009
  ident: 173_CR80
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0808493106
– volume: 9
  start-page: 4404
  issue: 12
  year: 2003
  ident: 173_CR148
  publication-title: Clin Cancer Res
– volume: 16
  start-page: 293
  issue: 2
  year: 2017
  ident: 173_CR136
  publication-title: Aging Cell
  doi: 10.1111/acel.12552
– volume: 287
  start-page: G7
  issue: 1
  year: 2004
  ident: 173_CR162
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.00079.2004
– volume: 195
  start-page: 4292
  issue: 9
  year: 2015
  ident: 173_CR218
  publication-title: J Immunol (Baltimore, Md : 1950)
  doi: 10.4049/jimmunol.1500609
– volume: 19
  start-page: 1680
  issue: 9
  year: 2013
  ident: 173_CR52
  publication-title: Curr Pharm Des
– volume: 159
  start-page: 709
  issue: 4
  year: 2014
  ident: 173_CR44
  publication-title: Cell
  doi: 10.1016/j.cell.2014.10.039
– volume: 90
  start-page: 1
  year: 2006
  ident: 173_CR157
  publication-title: Adv Immunol
  doi: 10.1016/S0065-2776(06)90001-7
– volume: 40
  start-page: 74
  year: 2018
  ident: 173_CR106
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2018.10.011
– volume: 271
  start-page: 56
  issue: 1
  year: 2016
  ident: 173_CR216
  publication-title: Immunol Rev
  doi: 10.1111/imr.12418
– volume: 908
  start-page: 244
  year: 2000
  ident: 173_CR16
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2000.tb06651.x
– volume: 8
  start-page: 1156
  issue: 8
  year: 2012
  ident: 173_CR199
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.5033
– volume: 9
  start-page: 347
  issue: 3
  year: 2010
  ident: 173_CR202
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2010.00559.x
– volume: 18
  start-page: 1629
  issue: 16
  year: 2000
  ident: 173_CR189
  publication-title: Vaccine
  doi: 10.1016/S0264-410X(99)00498-3
– volume: 12
  start-page: 77
  issue: 2
  year: 2016
  ident: 173_CR228
  publication-title: Nat Rev Endocrinol
  doi: 10.1038/nrendo.2015.168
– volume: 2
  start-page: e24898
  issue: 7
  year: 2013
  ident: 173_CR98
  publication-title: Oncoimmunology
  doi: 10.4161/onci.24898
– volume: 2
  start-page: 1011
  issue: 9
  year: 1996
  ident: 173_CR171
  publication-title: Nat Med
  doi: 10.1038/nm0996-1011
– volume: 125
  start-page: 777
  issue: 10-11
  year: 2004
  ident: 173_CR50
  publication-title: Mech Ageing Dev
  doi: 10.1016/j.mad.2004.07.007
– volume: 34
  start-page: 419
  issue: 3
  year: 1999
  ident: 173_CR4
  publication-title: Exp Gerontol
  doi: 10.1016/S0531-5565(99)00002-9
– volume: 20
  start-page: 735
  issue: 6
  year: 2004
  ident: 173_CR185
  publication-title: Immunity
  doi: 10.1016/j.immuni.2004.05.004
– volume: 153
  start-page: 828
  issue: 4
  year: 2013
  ident: 173_CR246
  publication-title: Cell
  doi: 10.1016/j.cell.2013.04.015
– volume: 285
  start-page: 5836
  issue: 8
  year: 2010
  ident: 173_CR198
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.072124
– volume: 10
  start-page: 96
  issue: 1
  year: 2012
  ident: 173_CR244
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2011.11.019
– volume: 17
  start-page: 1
  year: 2018
  ident: 173_CR20
  publication-title: Aging Cell
  doi: 10.1111/acel.12675
– volume: 48
  start-page: 1436
  issue: 12
  year: 2013
  ident: 173_CR141
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2013.09.011
– volume: 65
  start-page: 2457
  issue: 6
  year: 2005
  ident: 173_CR150
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-04-3232
– volume: 19
  start-page: 12
  year: 2018
  ident: 173_CR129
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms19123701
– volume: 15
  start-page: 5
  year: 2018
  ident: 173_CR43
  publication-title: Immun Ageing
  doi: 10.1186/s12979-017-0111-6
– volume: 8
  start-page: e75786
  issue: 10
  year: 2013
  ident: 173_CR115
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0075786
– volume: 194
  start-page: 4784
  issue: 10
  year: 2015
  ident: 173_CR210
  publication-title: J Immunol (Baltimore, Md : 1950)
  doi: 10.4049/jimmunol.1403158
– volume: 202
  start-page: 1927
  issue: 7
  year: 2019
  ident: 173_CR239
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1801403
– volume: 21
  start-page: 418
  issue: 4
  year: 2009
  ident: 173_CR2
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2009.05.023
– volume: 15
  start-page: 11
  year: 2018
  ident: 173_CR45
  publication-title: Immun Ageing
  doi: 10.1186/s12979-018-0117-8
– volume: 26
  start-page: 15
  issue: 1
  year: 2016
  ident: 173_CR252
  publication-title: Eur Radiol
  doi: 10.1007/s00330-015-3796-y
– volume: 317
  start-page: 807
  issue: 5839
  year: 2007
  ident: 173_CR245
  publication-title: Science
  doi: 10.1126/science.1144090
– volume: 173
  start-page: 1604
  issue: 3
  year: 2004
  ident: 173_CR188
  publication-title: J Immunol
  doi: 10.4049/jimmunol.173.3.1604
– volume: 54
  start-page: 395
  issue: 10
  year: 2005
  ident: 173_CR137
  publication-title: Inflamm Res
  doi: 10.1007/s00011-005-1377-2
– volume: 41
  start-page: 2502
  issue: 16
  year: 2005
  ident: 173_CR168
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2005.08.016
– volume: 123
  start-page: 966
  issue: 3
  year: 2013
  ident: 173_CR61
  publication-title: J Clin Invest
  doi: 10.1172/JCI64098
– volume: 121
  start-page: 187
  issue: 1-3
  year: 2000
  ident: 173_CR66
  publication-title: Mech Ageing Dev
  doi: 10.1016/S0047-6374(00)00210-4
– volume: 135
  start-page: 337
  issue: 3
  year: 2018
  ident: 173_CR120
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-018-1807-1
– volume: 10
  start-page: 293
  issue: 5
  year: 2001
  ident: 173_CR192
  publication-title: Exp Dermatol
  doi: 10.1034/j.1600-0625.2001.100501.x
– volume: 4
  start-page: 71
  issue: 1
  year: 2004
  ident: 173_CR164
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc1256
– volume: 20
  start-page: 659
  issue: 6
  year: 2014
  ident: 173_CR248
  publication-title: Nature Medicine
  doi: 10.1038/nm.3569
– volume: 497
  start-page: 258
  issue: 7448
  year: 2013
  ident: 173_CR32
  publication-title: Nature
  doi: 10.1038/nature12079
– volume: 17
  start-page: 55
  issue: 1
  year: 2016
  ident: 173_CR223
  publication-title: Biogerontology
  doi: 10.1007/s10522-015-9590-z
– volume: 50
  start-page: 1450
  issue: 15
  year: 2007
  ident: 173_CR138
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2007.06.040
– volume: 12
  start-page: e0173048
  issue: 3
  year: 2017
  ident: 173_CR152
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0173048
– volume: 176
  start-page: 6586
  issue: 11
  year: 2006
  ident: 173_CR94
  publication-title: J Immunol (Baltimore, Md : 1950)
  doi: 10.4049/jimmunol.176.11.6586
– volume: 211
  start-page: 144
  issue: 2
  year: 2007
  ident: 173_CR108
  publication-title: J Pathol
  doi: 10.1002/path.2104
– volume: 76
  start-page: 3681
  issue: 19
  year: 2019
  ident: 173_CR113
  publication-title: Cellular and Molecular Life Sciences
  doi: 10.1007/s00018-019-03132-2
– volume: 169
  start-page: 2756
  issue: 5
  year: 2002
  ident: 173_CR149
  publication-title: J Immunol
  doi: 10.4049/jimmunol.169.5.2756
– volume: 69
  start-page: 1952
  issue: 15
  year: 2017
  ident: 173_CR102
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2017.01.064
– volume: 30
  start-page: 1811
  issue: 16
  year: 2016
  ident: 173_CR154
  publication-title: Genes Dev
  doi: 10.1101/gad.284851.116
– volume: 1
  start-page: 27
  issue: 1
  year: 2012
  ident: 173_CR139
  publication-title: J Am Heart Assoc
  doi: 10.1161/xJAHA.111.000125
– volume: 180
  start-page: 1955
  issue: 5
  year: 1994
  ident: 173_CR183
  publication-title: J Exp Med
  doi: 10.1084/jem.180.5.1955
– volume: 175
  start-page: 4112
  issue: 6
  year: 2005
  ident: 173_CR220
  publication-title: J Immunol (Baltimore, Md : 1950)
  doi: 10.4049/jimmunol.175.6.4112
– volume: 7
  start-page: 502
  year: 2016
  ident: 173_CR36
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2016.00502
– volume: 190
  start-page: 1375
  issue: 10
  year: 1999
  ident: 173_CR165
  publication-title: J Exp Med
  doi: 10.1084/jem.190.10.1375
– volume: 8
  start-page: 1960
  year: 2017
  ident: 173_CR24
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2017.01960
– volume: 108
  start-page: 20012
  issue: 50
  year: 2011
  ident: 173_CR170
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1116110108
– volume: 105
  start-page: 4
  year: 2018
  ident: 173_CR1
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2017.10.024
– volume: 372
  start-page: 103
  issue: 6501
  year: 1994
  ident: 173_CR190
  publication-title: Nature
  doi: 10.1038/372103a0
– volume: 13
  start-page: 230
  issue: 2
  year: 2013
  ident: 173_CR207
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.06.014
– volume: 211
  start-page: 2341
  issue: 12
  year: 2014
  ident: 173_CR235
  publication-title: J Exp Med
  doi: 10.1084/jem.20131289
– volume: 143
  start-page: 355
  issue: 3
  year: 2010
  ident: 173_CR153
  publication-title: Cell
  doi: 10.1016/j.cell.2010.09.043
– volume: 173
  start-page: 245
  issue: 1
  year: 2004
  ident: 173_CR35
  publication-title: J Immunol (Baltimore, Md : 1950)
  doi: 10.4049/jimmunol.173.1.245
– volume: 14
  start-page: 813
  issue: 7
  year: 2002
  ident: 173_CR196
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxf042
– volume: 10
  start-page: 362
  issue: 3
  year: 2011
  ident: 173_CR17
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2010.08.003
– volume: 205
  start-page: 7
  year: 2005
  ident: 173_CR181
  publication-title: Immunol Rev
  doi: 10.1111/j.0105-2896.2005.00263.x
– volume: 6
  start-page: 663
  issue: 5
  year: 2007
  ident: 173_CR182
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2007.00325.x
– volume: 175
  start-page: 2741
  issue: 4
  year: 2005
  ident: 173_CR231
  publication-title: J Immunol
  doi: 10.4049/jimmunol.175.4.2741
– volume: 4
  start-page: 231
  year: 2013
  ident: 173_CR79
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2013.00231
– volume: 19
  start-page: 108
  issue: 2
  year: 2018
  ident: 173_CR176
  publication-title: Nat Immun
  doi: 10.1038/s41590-017-0022-x
– volume: 205
  start-page: 190
  year: 2005
  ident: 173_CR135
  publication-title: Immunol Rev
  doi: 10.1111/j.0105-2896.2005.00262.x
– volume: 107
  start-page: 2453
  issue: 6
  year: 2006
  ident: 173_CR213
  publication-title: Blood
  doi: 10.1182/blood-2005-07-2831
– volume: 16
  start-page: 599
  issue: 10
  year: 2016
  ident: 173_CR147
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri.2016.80
SSID ssj0034964
Score 2.6154919
SecondaryResourceType review_article
Snippet Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the...
Abstract Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 2
SubjectTerms Adaptive immunity
Age
Age-related thymic involution
Aging
Antibodies
Antigens
Apoptosis
Atrophy
Biomedical and Life Sciences
Biomedicine
Cardiovascular diseases
Cell cycle
Central tolerance
Clinical Nutrition
Cyclin-dependent kinases
Diseases
Epigenetic inheritance
Epigenetics
Fibroblasts
Genotype & phenotype
Geriatrics/Gerontology
Homeostasis
Immune response
Immune system
Immunology
Immunosenescence
Immunosenescence and inflammaging
Inflammation
Kinases
Lymphocytes
Lymphocytes T
Molecular modelling
Money
Negative selection and regulatory T (Treg) cell generation
Phenotypes
Public Health
Recovery of function
Rejuvenation
Review
Senescence
Somatic cells
Stem cells
T cells
Thymic aging
Thymic involution
Thymus
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZgC4gLj-UVWJCREEhUUfNw_TihLWpFJVhVUERvlmM77Yo2KZttpf57ZhJnS4rohdsqHq888efxTMb-hpA3yBejlJGx2bQiZk7BL5mVsbcu577l4G8p8z-L2UweHKi98MGtCccqe5vYGmpXW_xGvoG0LJjiEvzD6a8Yq0ZhdjWU0LhJ1pCpjI3I2tb2bO9rb4uRDZ2FXGYq-UYDu5tQMYZMgMQ8loPdqCXt_9s0_7E3XT03eSV52u5JO_f_V5sH5F7wRum0g89DcsNXY3K7q095MSZ3voTM-5hMunu89Ic_Ls3C07e0f1Avfj4i35Dlqq-d1dC6pNNDH7cn7byj-0cXJ3NLd6vzAHS6rOku3kypG7S1Fs0LNZUDkRIgetKWTnpMvu9s73_8FId6DbHlXC0hFAXnyjhrvbDg1xhRlsYUxuWe2TxLyk2T2AwcLiMTDu9QOMVLVeTgU2UmLaXLn5BRVVf-GaFJakRmjPSlYUyl0jhWpMJlzPhCWicjkvTzpm0gM8eaGse6DWok191Ua5hqjVOtocv7VZfTjsnjOuEtBMNKEEm42wf14lCHNa29LVJmuYMRWQbKFkJIn1v4K-45hAMReYdQ0mgqYHDWhBsPoCKSbukpTyXWCEqSiEwGkrDE7bC5R5EOJqbRlxCKyOtVM_bEY3OVr89QhgnwiMEti8jTDrsrlcD2SsmZiogYoHqg87Clmh-1BORcCQgMYFjrPf4vh_XPV_r8eiVekLtZty7BcE_IaLk48y_JLXu-nDeLV2Fd_wYqcVXs
  priority: 102
  providerName: ProQuest
– databaseName: SpringerLink Contemporary (1997 - Present)
  dbid: RSV
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3raxQxEB-0PhDEx_laPSWCKCiL-0jz-HiKxYIWsVX7LWSTbFtsd2X3Wuh_7ySbPd36AP12bCZLZu43k8km-Q3AE88XI6UWqV43PKVW4i9R1KkztmQucPAHyvx3fGtL7O7KD_Eedz-edh-3JEOkDm4t2MseZyYuU7_cQRSVqTgPF3C2E94bP25_HsOvJ0Cncfvyt90mE1Dg6f81Gv80HZ09KnlmvzRMQxvX_0uBG3AtZp1kMcDkJpxzzQwuDXUoT2dw-X3cYZ_B1eE7HhmuJ81gPtzfJV_cYa07R56S8UHbfb0F257daqyZ1ZO2Jos9l4YTds6Snf3TI3zXZnMSAU6WLdn0N1La3sdY48MK0Y1FkRqheRRKJt2GTxtvdl6_TWOdhtQwJpe4BMWkSltjHDeYz2he11pX2paOmrLI6nWdmQITLS0yhobkVrJaViXmUoXOa2HLO7DWtI27ByTLNS-0Fq7WlMpcaEurnNuCalcJY0UC2fjnKRNJzH0tjUMVFjOCqcHKCq2svJUVdnm-6vJtYPD4m_Arj4iVoCffDg_abk9FX1bOVDk1zOKIDEVlK86FKw2-ijmGy4AEnnk8KR8icHBGx5sOqKIn21ILlgtfGyjLEphPJNG1zbR5RKSKoaVXnp_I7_VylsDjVbPv6Y_LNa499jKUYyaM6VgCdwcAr1TCmCsEozIBPoH2ROdpS3OwH4jHmeS4IMBhvRgB_mNYfzTp_X-SfgBXisFDMH7PYW3ZHbuHcNGcLA_67lHw9O_0sk8M
  priority: 102
  providerName: Springer Nature
Title Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
URI https://link.springer.com/article/10.1186/s12979-020-0173-8
https://www.ncbi.nlm.nih.gov/pubmed/31988649
https://www.proquest.com/docview/2357166676
https://www.proquest.com/docview/2347514238
https://pubmed.ncbi.nlm.nih.gov/PMC6971920
https://doaj.org/article/ecb14c6db8cc47ffb778e3c2976e681b
Volume 17
WOSCitedRecordID wos000513663100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVADU
  databaseName: BioMedCentral
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: RBZ
  dateStart: 20040101
  isFulltext: true
  titleUrlDefault: https://www.biomedcentral.com/search/
  providerName: BioMedCentral
– providerCode: PRVAON
  databaseName: Directory of Open Access Journals (DOAJ)
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: DOA
  dateStart: 20040101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: M~E
  dateStart: 20040101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: 7X7
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: BENPR
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: PIMPY
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVAVX
  databaseName: SpringerLINK Contemporary 1997-Present
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: RSV
  dateStart: 20041201
  isFulltext: true
  titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22
  providerName: Springer Nature
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwED_B-BAvCAqDQKmMhEACRcuH54_HDm1iEquqbUB5shzbYRVbgtpu0v57zk5SliHghZcoic-Sfffz-SzbvwN45flipNQi1tuGx9RKfBNZGTtjc-YCB3-gzP_IJxMxm8nplVRf_kxYQw_cKG7LmSKlhtlCGEN5WRacC5ebDKdRxzDm8t4Xo55uMdX4YM-CTts9zFSwrSXOalzGfqmECMxj0ZuFAln_7y75ypx0_bzktU3TMBftPYD7bRBJxk3jH8INVw3gTpNW8nIAdw_aDfMBDJvrt-SLOy31wpHXpPtRL74_giNPTtWlvFqSuiTjby4OB-ScJccnl2dzQ_arixafZFWTfX-hpF56F2m8VyC6sihSIrLOQsajx_Bpb_f4_Ye4TbMQG8bkCleQGBNpa4zjBsMRjUrWutA2d9TkWVJu68RkGCdpkTBUAbeSlbLIMRTKdFoKm2_CRlVX7imQJNU801q4UlMqU6EtLVJuM6od2s-KCJJO7cq0HOQ-FcapCmsRwVRjKYWWUt5SCqu8XVf50RBw_E14x9tyLei5s8MPRJRqEaX-hagI3ngkKD_CsXFGtxcVsIueK0uNWSp8ap8kiWDYk8SRafrFHZZU6xmWytML-a1aziJ4uS72Nf1pt8rV516GcgxkMZqK4EkDvXWX0GUKwaiMgPdA2etzv6SanwTecCY5xvPYrHcdfH81648qffY_VPoc7mXN4EOvPISN1eLcvYDb5mI1Xy5GcJPPeHiKEdza2Z1MD0dhOOPXdP9g-hW_Do8-_wQ5nE4C
linkProvider Directory of Open Access Journals
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Zb9QwEB6VLdcLR7kCCxiJQwJFzVXbeUBoOaquurtaia0oT8axnXZFm5TNtmj_FL-RcY4tKaJvfeAtiseRJ_lmxhPb3wA8t3wxcSy5KzcUcyMd4xUPUtcoHVJTcvCXlPkDNhrx3d14vAK_mrMwdltl4xNLR61zZf-Rr1taFrvExei7ox-urRplV1ebEhoVLLbN4iembMXb_kf8vi-CYPPT5MOWW1cVcBWl8RwTJpwCSK2UYQqjr2RpKmUidWgiFQZeuiE9FeC0QHKPahTSMU3jJMTIH0g_5TrE516C1QjBzjuwOu4Px18b32_Z16N67dTndL3AaMpi16ZoiPzQ5a3oVxYJ-DsU_BELz-7TPLNYW8bAzZv_29u7BTfq2TbpVeZxG1ZMtgZXqvqbizW4Oqx3FqxBtzqnTL6Yg1TODHlJmhv57Psd-GxZvJraYAXJU9LbM265k9BoMtlfHE4V6WcntSGTeU769uRNXthYoqz7JDLTKJKiCR6WpaHuws6F6H4POlmemQdAPF-yQEpuUhlFsc-ljhKf6SCSJuFKcwe8BidC1WTttmbIgSiTNk5FBS2B0BIWWgK7vF52OaqYSs4Tfm_BtxS0JOPljXy2J2qfJYxK_EhRjSNSESqbMMZNqPBR1FBMdxx4ZaErrCvEwSlZn-hAFS2pmOhRn9saSJ7nQLcliS5MtZsb1IrahRbiFLIOPFs22552W2Bm8mMrEzGc8eO004H7la0sVcLYwjmNYgdYy4paOrdbsul-SbBOY4aJDw7rTWNvp8P65yt9eL4ST-Ha1mQ4EIP-aPsRXA8qn4BBqgud-ezYPIbL6mQ-LWZPap9C4NtFG-JvH821dg
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3rb9QwDLdgwISEeByvwgFBQiCBqvWRJenH4zFxYpwmbbB9i9Ik3Sa2drreJu2_x-7joOMhIb6dGqeKfY5j1_HPAC8ILybLjArNupUhdxn-UkkReutS4RsM_gYyf1POZmpvL9vq-pzW_W33PiXZ1jQQSlO5WDtxRbvFlVir8ZSSWUihD2pUGqrLcIVTzyAK17e_9qaYwNB5l8r87bTBYdRg9v9qmX86mi5em7yQO22OpI1b_83MbbjZeaNs0qrPHbjkyxFca_tTno9g9XOXeR_Bjfb7HmvLlkYwbut62a4_Kszcs5esf1DNv92FbUK96ntp1awq2GTfh83NO-_YzsH5Mb5rWp51is8WFZtSpUpVk-21ZG6YKR2SFKiyx00rpXvwZePDzruPYde_IbRCZAsMTdHZMs5aLy36OUYWhTG5cannNk2iYt1ENkEHzKhIoFCly0SR5Sn6WImJC-XS-7BSVqV_CCyKjUyMUb4wnGexMo7nsXQJNz5X1qkAov6P1LYDN6ceG0e6CXKU0K2UNUpZk5Q1Tnm9nHLSInv8jfgtaceSkEC5mwfVfF93e1x7m8fcCocrshyZzaVUPrX4KuEFhgcBvCLd0mQ6cHHWdBUQyCKBcOmJiBX1DIqiAMYDStzydjjca6fuTE6tCbeIcsBSBPB8OUwz6Rpd6atTouESPWR00wJ40CrzkiW0xUoJngUgB2o-4Hk4Uh4eNIDkIpMYKOCy3vTK_mNZfxTpo3-ifgarW-839OZ09ukxXE_azYImfgwri_mpfwJX7dnisJ4_bQzAd7CDWtQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Contributions+of+Age-Related+Thymic+Involution+to+Immunosenescence+and+Inflammaging&rft.jtitle=Immunity+%26+ageing&rft.au=Thomas%2C+Rachel&rft.au=Wang%2C+Weikan&rft.au=Su%2C+Dong-Ming&rft.date=2020-01-20&rft.pub=BioMed+Central&rft.eissn=1742-4933&rft.volume=17&rft_id=info:doi/10.1186%2Fs12979-020-0173-8&rft_id=info%3Apmid%2F31988649&rft.externalDocID=PMC6971920
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1742-4933&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1742-4933&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1742-4933&client=summon