DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

Inactivation of tumour suppressor genes is central to the development of all common forms of human cancer. This inactivation often results from epigenetic silencing associated with hypermethylation rather than intragenic mutations. In human cells, the mechanisms underlying locus-specific or global m...

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Bibliographic Details
Published in:	Nature (London) Vol. 416; no. 6880; pp. 552 - 556
Main Authors:	Rhee, Ina, Bachman, Kurtis E., Park, Ben Ho, Jair, Kam-Wing, Yen, Ray-Whay Chiu, Schuebel, Kornel E., Cui, Hengmi, Feinberg, Andrew P., Lengauer, Christoph, Kinzler, Kenneth W., Baylin, Stephen B., Vogelstein, Bert
Format:	Journal Article
Language:	English
Published:	London Nature Publishing 04.04.2002 Nature Publishing Group
Subjects:	Amino Acid Sequence Biological and medical sciences Cancer Cellular biology Colorectal carcinoma Cyclin-Dependent Kinase Inhibitor p16 - genetics Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - physiology DNA Methylation DNA Methyltransferase 3B DNA, Neoplasm - metabolism DNMT1 gene DNMT3a gene Gene Expression Regulation, Neoplastic Gene Silencing Gene Targeting Gene therapy General aspects Genes, Tumor Suppressor Genomics Humans Inactivation INK4a gene Insulin-Like Growth Factor II - genetics Medical sciences Molecular Sequence Data Neoplasms - enzymology Neoplasms - genetics p16 gene Promoter Regions, Genetic Tissue Inhibitor of Metalloproteinase-3 - genetics Tumor Cells, Cultured Tumors Human Enzyme Transferases Malignant tumor Inactivation Vertebrata Specificity Mammalia Enzymatic activity Methyltransferases DNA Established cell line Methylation Tumor suppressor gene
ISSN:	0028-0836, 1476-4687
Online Access:	Get full text
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