An energetic tale of AMPK-independent effects of metformin

Metformin has become a mainstay in the modest therapeutic armamentarium for the treatment of the insulin resistance of type 2 diabetes mellitus. Although metformin functions primarily by reducing hepatic glucose output, the molecular mechanism mediating this effect had remained elusive until recentl...

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Vydáno v:	The Journal of clinical investigation Ročník 120; číslo 7; s. 2267 - 2270
Hlavní autoři:	Miller, Russell A., Birnbaum, Morris J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States American Society for Clinical Investigation 01.07.2010
Témata:	AMP-Activated Protein Kinases Biomedical research Carbohydrate Metabolism Care and treatment Cyclic adenylic acid Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Gene expression Gene Expression - drug effects Genetic aspects Health aspects Hepatocytes - drug effects Hepatocytes - metabolism Humans Hypoglycemic Agents - metabolism Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin Resistance Liver - drug effects Liver - metabolism Metformin Metformin - metabolism Metformin - pharmacology Metformin - therapeutic use Physiological aspects Protein kinases Protein Kinases - metabolism Protein Kinases - pharmacology Signal Transduction - drug effects Type 2 diabetes United States
ISSN:	0021-9738, 1558-8238, 1558-8238
On-line přístup:	Získat plný text
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