Expression and promotor hypermethylation of miR-34a in the various histological subtypes of ovarian cancer

Background An increasing body of evidence shows that miR-34 family has tumor suppressive properties mediating apoptosis, cell cycle arrest and senescence. In ovarian cancer, miR34 family members were found to be under expressed. Particularly miR-34a has been revealed to be a direct transcriptional t...

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Veröffentlicht in:	BMC cancer Jg. 16; H. 1; S. 102
Hauptverfasser:	Schmid, Gabriel, Notaro, Sara, Reimer, Daniel, Abdel-Azim, Samira, Duggan-Peer, Michaela, Holly, Jessica, Fiegl, Heidi, Rössler, Julia, Wiedemair, Annemarie, Concin, Nicole, Altevogt, Peter, Marth, Christian, Zeimet, Alain Gustave
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 15.02.2016 BioMed Central Ltd Springer Nature B.V
Schlagworte:	Aged Analysis Biomedical and Life Sciences Biomedicine Cancer Research DNA Methylation - genetics Female Gene expression Gene Expression Regulation, Neoplastic - genetics Gene Silencing Health Promotion and Disease Prevention Humans Medicine/Public Health Methylation MicroRNAs - analysis MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Oncology Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - mortality Ovary - chemistry Ovary - metabolism Promoter Regions, Genetic - genetics Research Article Risk factors Surgical Oncology Survival Analysis Tissue Array Analysis Translational oncology Epigenetics Promotor hypermethylation Gene-silencing miR-34a Ovarian cancer
ISSN:	1471-2407, 1471-2407
Online-Zugang:	Volltext
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