Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential

Pluripotency can be induced in somatic cells by overexpressing transcription factors, including POU class 5 homeobox 1 (OCT3/4), sex determining region Y-box 2 (SOX2), Krüppel-like factor 4 (KLF4), and myelocytomatosis oncogene (c-MYC). However, some induced pluripotent stem cells (iPSCs) exhibit de...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 111; H. 34; S. 12426
Hauptverfasser:	Ohnuki, Mari, Tanabe, Koji, Sutou, Kenta, Teramoto, Ito, Sawamura, Yuka, Narita, Megumi, Nakamura, Michiko, Tokunaga, Yumie, Nakamura, Masahiro, Watanabe, Akira, Yamanaka, Shinya, Takahashi, Kazutoshi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 26.08.2014
Schlagworte:	Cell Differentiation - genetics Cell Differentiation - physiology Cellular Reprogramming - genetics Cellular Reprogramming - physiology Embryonic Stem Cells - cytology Embryonic Stem Cells - physiology Embryonic Stem Cells - virology Endogenous Retroviruses - genetics Endogenous Retroviruses - physiology Epigenesis, Genetic Gene Expression Gene Knockdown Techniques Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - physiology Induced Pluripotent Stem Cells - virology Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - physiology Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - physiology Pluripotent Stem Cells - cytology Pluripotent Stem Cells - physiology Pluripotent Stem Cells - virology RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - genetics RNA, Viral - antagonists & inhibitors RNA, Viral - genetics SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - physiology retrotransposon epigenetics evolution
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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