Base editing: precision chemistry on the genome and transcriptome of living cells

RNA-guided programmable nucleases from CRISPR systems generate precise breaks in DNA or RNA at specified positions. In cells, this activity can lead to changes in DNA sequence or RNA transcript abundance. Base editing is a newer genome-editing approach that uses components from CRISPR systems togeth...

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Bibliographic Details
Published in:	Nature reviews. Genetics Vol. 19; no. 12; pp. 770 - 788
Main Authors:	Rees, Holly A, Liu, David R
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.12.2018
Subjects:	Animals CRISPR CRISPR-Cas Systems Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA damage DNA glycosylase Double-stranded RNA Editing Endonucleases Gene Editing - methods Gene expression Genome editing Genomes Humans Mutation Nuclease Nucleotide sequence Ribonucleic acid RNA RNA editing Therapeutic applications Transcription Transcriptome
ISSN:	1471-0056, 1471-0064, 1471-0064
Online Access:	Get full text
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