Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells

Cell-cell interactions mediated by Notch are critical for the maintenance of skeletal muscle stem cells. However, dynamics, cellular source and identity of functional Notch ligands during expansion of the stem cell pool in muscle growth and regeneration remain poorly characterized. Here we demonstra...

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Veröffentlicht in:	Nature communications Jg. 12; H. 1; S. 1318 - 16
Hauptverfasser:	Zhang, Yao, Lahmann, Ines, Baum, Katharina, Shimojo, Hiromi, Mourikis, Philippos, Wolf, Jana, Kageyama, Ryoichiro, Birchmeier, Carmen
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 26.02.2021 Nature Publishing Group Nature Portfolio
Schlagworte:	13/100 13/31 13/44 13/89 13/95 14/19 14/5 38/32 38/70 45/15 45/70 631/136 631/208 631/532 631/553 631/80 64/110 64/60 9/10 Animals Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cell differentiation Cell Differentiation - physiology Cell interactions Cell self-renewal DELTA protein Female Gene Expression Regulation, Developmental HEK293 Cells Humanities and Social Sciences Humans Life Sciences Ligands Maintenance Mathematical models Mice Mice, Knockout multidisciplinary Muscle Development - genetics Muscle Development - physiology Muscle regulatory factor Muscles Muscles - metabolism Mutation MyoD protein MyoD Protein - genetics MyoD Protein - metabolism Oscillations Pacemakers Regeneration Robustness (mathematics) Science Science (multidisciplinary) Signal Transduction - physiology Skeletal muscle Stem cell transplantation Stem cells Stem Cells - physiology Surgical implants Transcription Transcription Factor HES-1 - metabolism Transcriptome
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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