Anticancer effect of berberine based on experimental animal models of various cancers: a systematic review and meta-analysis

Background Numerous studies have explored the anti-tumor effect of berberine (BBR), but little clinical evidence guides the use of BBR in cancer patients. Objectives Our aim was to investigate the impact of BBR on various cancers in healthy animals to promote the transformation from bench to bed. Se...

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Published in:	BMC cancer Vol. 19; no. 1; pp. 589 - 20
Main Authors:	Xu, Jianhao, Long, Yuming, Ni, Liwei, Yuan, Xuya, Yu, Na, Wu, Runhong, Tao, Jialong, Zhang, Yusong
Format:	Journal Article
Language:	English
Published:	London BioMed Central 17.06.2019 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Analysis Angiogenesis Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - adverse effects Angiogenesis Inhibitors - therapeutic use Animal models Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Berberine Berberine - administration & dosage Berberine - adverse effects Berberine - therapeutic use Berberis - chemistry Bias Biliary tract cancer Biomedical and Life Sciences Biomedicine Body Weight Breast cancer Cancer Cancer patients Cancer Research Cancer treatment Carcinoma Care and treatment Cholangiocarcinoma Colorectal cancer Colorectal carcinoma Cricetinae Disease Models, Animal Dogs Dose-Response Relationship, Drug Endometrial cancer Endometrium Esophageal cancer Esophagus Experimental animals Gastric cancer Gastrointestinal diseases Guinea Pigs Haplorhini Health aspects Health Promotion and Disease Prevention Horses Humans Liver Liver cancer Lung cancer Lung carcinoma Medical and radiation oncology Medical research Medicine/Public Health Meta-analysis Mice Nasopharyngeal carcinoma Neoplasms - drug therapy Neoplasms - metabolism Nutrition research Oncology Oral cancer Phytotherapy Plant Extracts - therapeutic use Practice guidelines (Medicine) Rabbits Rats Research Article Sarcoma Sheep Software Statistical analysis Studies Surgical Oncology Systematic review Throat cancer Tongue cancer Traditional Chinese medicine Tumor Burden Tumors Uterine cancer Berberine Experimental animals Cancer Meta-analysis
ISSN:	1471-2407, 1471-2407
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Summary:	Background Numerous studies have explored the anti-tumor effect of berberine (BBR), but little clinical evidence guides the use of BBR in cancer patients. Objectives Our aim was to investigate the impact of BBR on various cancers in healthy animals to promote the transformation from bench to bed. Search methods PubMed, Embase, Springer, and Cochrane databases were searched from January 2000 to October 2018 for relevant articles. Selection criteria Only published studies focusing on the relationship between BBR and various cancers in vivo were qualified. Two review authors independently assessed the risk of bias for each study, and any disagreement was resolved by discussion or by involving a third assessor. Results A total of 26 studies from 2000 to 2018, focusing on various cancer types, including breast cancer, liver cancer, colorectal cancer, nasopharyngeal carcinoma, lung cancer, gastric cancer, neuroepithelial cancer, endometrial carcinoma, esophageal cancer, tongue cancer, cholangiocarcinoma, and sarcoma were included. Overall, BBR reduced tumor volume (SMD =3.72, 95% CI: 2.89, 4.56, Z = 8.73, p < 0.00001) and tumor weight (SMD =2.35, 95% CI: 1.51, 3.19, Z = 5.50, p < 0.00001) in a linear The dose–response relationship (Pearson r = − 0.6717, p < 0.0001 in tumor volume analysis; Pearson r = − 0.7704, p < 0.0005 in tumor weight analysis). BBR inhibited angiogenesis in tumor tissues (SMD = 4.29, 95% CI: 2.14, 6.44, Z = 3.92, p < 0.00001), but it had no significant effect on the body weight of experimental animals (SMD = 0.11, 95% CI: − 0.70, 0.92, Z = 0.27, p = 0.78). Publication bias was not detected. Conclusion BBR exerted anti-tumor effects in a variety of tumors in vivo, especially breast cancer and lung cancer, and the evidence was still insufficient in colorectal cancer and gastric cancer.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1471-2407 1471-2407
DOI:	10.1186/s12885-019-5791-1