Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis
Background The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-...
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| Vydáno v: | BMC cancer Ročník 18; číslo 1; s. 869 - 11 |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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London
BioMed Central
03.09.2018
BioMed Central Ltd Springer Nature B.V BMC |
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| ISSN: | 1471-2407, 1471-2407 |
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| Abstract | Background
The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-protein panel of MRN complex subunits as a potential radiosensitivity marker and evaluating the prognostic and clinicopathological implications of MRN expression in rectal cancer.
Methods
Samples from 265 rectal cancer patients treated with surgery and adjuvant chemoradiotherapy, including samples from 55 patients who were treated with neoadjuvant radiotherapy between 2000 and 2011, were analyzed. Expression of MRN complex proteins in tissue samples was determined by immunohistochemistry. Univariate and multivariate analyses were carried out to identify clinicopathological characteristics that are associated with the MRN three-protein panel expression in rectal cancer samples.
Results
In Kaplan–Meier survival analyses, we found that high level expression of MRN complex proteins in postoperative samples was associated with poor disease-free (
p
= 0.021) and overall (
P
= 0.002) survival. Interestingly, high MRN expression also correlated with poor disease-free (
P
= 0.047) and overall (
P
= 0.024) survival in the neoadjuvant radiotherapy subgroup. In multivariate analysis, combined MRN expression (hazard ratio = 2.114, 95% confidence interval 1.096–4.078,
P
= 0.026) and perineural invasion (hazard ratio = 2.160, 95% confidence interval 1.209–3.859,
P
= 0.009) were significantly associated with a worse disease-free survival.
Conclusions
Expression levels of MRN complex proteins significantly predict disease-free survival in rectal cancer patients, including those treated with neoadjuvant radiotherapy, and may have value in the management of these patients. |
|---|---|
| AbstractList | Background The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-protein panel of MRN complex subunits as a potential radiosensitivity marker and evaluating the prognostic and clinicopathological implications of MRN expression in rectal cancer. Methods Samples from 265 rectal cancer patients treated with surgery and adjuvant chemoradiotherapy, including samples from 55 patients who were treated with neoadjuvant radiotherapy between 2000 and 2011, were analyzed. Expression of MRN complex proteins in tissue samples was determined by immunohistochemistry. Univariate and multivariate analyses were carried out to identify clinicopathological characteristics that are associated with the MRN three-protein panel expression in rectal cancer samples. Results In Kaplan-Meier survival analyses, we found that high level expression of MRN complex proteins in postoperative samples was associated with poor disease-free (p = 0.021) and overall (P = 0.002) survival. Interestingly, high MRN expression also correlated with poor disease-free (P = 0.047) and overall (P = 0.024) survival in the neoadjuvant radiotherapy subgroup. In multivariate analysis, combined MRN expression (hazard ratio = 2.114, 95% confidence interval 1.096-4.078, P = 0.026) and perineural invasion (hazard ratio = 2.160, 95% confidence interval 1.209-3.859, P = 0.009) were significantly associated with a worse disease-free survival. Conclusions Expression levels of MRN complex proteins significantly predict disease-free survival in rectal cancer patients, including those treated with neoadjuvant radiotherapy, and may have value in the management of these patients. Keywords: DNA damage response, MRE11-RAD50-NBS1 complex, Rectal cancer, Prognosis, Biomarkers, Neoadjuvant radiotherapy The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-protein panel of MRN complex subunits as a potential radiosensitivity marker and evaluating the prognostic and clinicopathological implications of MRN expression in rectal cancer. Samples from 265 rectal cancer patients treated with surgery and adjuvant chemoradiotherapy, including samples from 55 patients who were treated with neoadjuvant radiotherapy between 2000 and 2011, were analyzed. Expression of MRN complex proteins in tissue samples was determined by immunohistochemistry. Univariate and multivariate analyses were carried out to identify clinicopathological characteristics that are associated with the MRN three-protein panel expression in rectal cancer samples. In Kaplan-Meier survival analyses, we found that high level expression of MRN complex proteins in postoperative samples was associated with poor disease-free (p = 0.021) and overall (P = 0.002) survival. Interestingly, high MRN expression also correlated with poor disease-free (P = 0.047) and overall (P = 0.024) survival in the neoadjuvant radiotherapy subgroup. In multivariate analysis, combined MRN expression (hazard ratio = 2.114, 95% confidence interval 1.096-4.078, P = 0.026) and perineural invasion (hazard ratio = 2.160, 95% confidence interval 1.209-3.859, P = 0.009) were significantly associated with a worse disease-free survival. Expression levels of MRN complex proteins significantly predict disease-free survival in rectal cancer patients, including those treated with neoadjuvant radiotherapy, and may have value in the management of these patients. Background The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-protein panel of MRN complex subunits as a potential radiosensitivity marker and evaluating the prognostic and clinicopathological implications of MRN expression in rectal cancer. Methods Samples from 265 rectal cancer patients treated with surgery and adjuvant chemoradiotherapy, including samples from 55 patients who were treated with neoadjuvant radiotherapy between 2000 and 2011, were analyzed. Expression of MRN complex proteins in tissue samples was determined by immunohistochemistry. Univariate and multivariate analyses were carried out to identify clinicopathological characteristics that are associated with the MRN three-protein panel expression in rectal cancer samples. Results In Kaplan–Meier survival analyses, we found that high level expression of MRN complex proteins in postoperative samples was associated with poor disease-free (p = 0.021) and overall (P = 0.002) survival. Interestingly, high MRN expression also correlated with poor disease-free (P = 0.047) and overall (P = 0.024) survival in the neoadjuvant radiotherapy subgroup. In multivariate analysis, combined MRN expression (hazard ratio = 2.114, 95% confidence interval 1.096–4.078, P = 0.026) and perineural invasion (hazard ratio = 2.160, 95% confidence interval 1.209–3.859, P = 0.009) were significantly associated with a worse disease-free survival. Conclusions Expression levels of MRN complex proteins significantly predict disease-free survival in rectal cancer patients, including those treated with neoadjuvant radiotherapy, and may have value in the management of these patients. Abstract Background The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-protein panel of MRN complex subunits as a potential radiosensitivity marker and evaluating the prognostic and clinicopathological implications of MRN expression in rectal cancer. Methods Samples from 265 rectal cancer patients treated with surgery and adjuvant chemoradiotherapy, including samples from 55 patients who were treated with neoadjuvant radiotherapy between 2000 and 2011, were analyzed. Expression of MRN complex proteins in tissue samples was determined by immunohistochemistry. Univariate and multivariate analyses were carried out to identify clinicopathological characteristics that are associated with the MRN three-protein panel expression in rectal cancer samples. Results In Kaplan–Meier survival analyses, we found that high level expression of MRN complex proteins in postoperative samples was associated with poor disease-free (p = 0.021) and overall (P = 0.002) survival. Interestingly, high MRN expression also correlated with poor disease-free (P = 0.047) and overall (P = 0.024) survival in the neoadjuvant radiotherapy subgroup. In multivariate analysis, combined MRN expression (hazard ratio = 2.114, 95% confidence interval 1.096–4.078, P = 0.026) and perineural invasion (hazard ratio = 2.160, 95% confidence interval 1.209–3.859, P = 0.009) were significantly associated with a worse disease-free survival. Conclusions Expression levels of MRN complex proteins significantly predict disease-free survival in rectal cancer patients, including those treated with neoadjuvant radiotherapy, and may have value in the management of these patients. The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-protein panel of MRN complex subunits as a potential radiosensitivity marker and evaluating the prognostic and clinicopathological implications of MRN expression in rectal cancer.BACKGROUNDThe MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-protein panel of MRN complex subunits as a potential radiosensitivity marker and evaluating the prognostic and clinicopathological implications of MRN expression in rectal cancer.Samples from 265 rectal cancer patients treated with surgery and adjuvant chemoradiotherapy, including samples from 55 patients who were treated with neoadjuvant radiotherapy between 2000 and 2011, were analyzed. Expression of MRN complex proteins in tissue samples was determined by immunohistochemistry. Univariate and multivariate analyses were carried out to identify clinicopathological characteristics that are associated with the MRN three-protein panel expression in rectal cancer samples.METHODSSamples from 265 rectal cancer patients treated with surgery and adjuvant chemoradiotherapy, including samples from 55 patients who were treated with neoadjuvant radiotherapy between 2000 and 2011, were analyzed. Expression of MRN complex proteins in tissue samples was determined by immunohistochemistry. Univariate and multivariate analyses were carried out to identify clinicopathological characteristics that are associated with the MRN three-protein panel expression in rectal cancer samples.In Kaplan-Meier survival analyses, we found that high level expression of MRN complex proteins in postoperative samples was associated with poor disease-free (p = 0.021) and overall (P = 0.002) survival. Interestingly, high MRN expression also correlated with poor disease-free (P = 0.047) and overall (P = 0.024) survival in the neoadjuvant radiotherapy subgroup. In multivariate analysis, combined MRN expression (hazard ratio = 2.114, 95% confidence interval 1.096-4.078, P = 0.026) and perineural invasion (hazard ratio = 2.160, 95% confidence interval 1.209-3.859, P = 0.009) were significantly associated with a worse disease-free survival.RESULTSIn Kaplan-Meier survival analyses, we found that high level expression of MRN complex proteins in postoperative samples was associated with poor disease-free (p = 0.021) and overall (P = 0.002) survival. Interestingly, high MRN expression also correlated with poor disease-free (P = 0.047) and overall (P = 0.024) survival in the neoadjuvant radiotherapy subgroup. In multivariate analysis, combined MRN expression (hazard ratio = 2.114, 95% confidence interval 1.096-4.078, P = 0.026) and perineural invasion (hazard ratio = 2.160, 95% confidence interval 1.209-3.859, P = 0.009) were significantly associated with a worse disease-free survival.Expression levels of MRN complex proteins significantly predict disease-free survival in rectal cancer patients, including those treated with neoadjuvant radiotherapy, and may have value in the management of these patients.CONCLUSIONSExpression levels of MRN complex proteins significantly predict disease-free survival in rectal cancer patients, including those treated with neoadjuvant radiotherapy, and may have value in the management of these patients. The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-protein panel of MRN complex subunits as a potential radiosensitivity marker and evaluating the prognostic and clinicopathological implications of MRN expression in rectal cancer. In Kaplan-Meier survival analyses, we found that high level expression of MRN complex proteins in postoperative samples was associated with poor disease-free (p = 0.021) and overall (P = 0.002) survival. Interestingly, high MRN expression also correlated with poor disease-free (P = 0.047) and overall (P = 0.024) survival in the neoadjuvant radiotherapy subgroup. In multivariate analysis, combined MRN expression (hazard ratio = 2.114, 95% confidence interval 1.096-4.078, P = 0.026) and perineural invasion (hazard ratio = 2.160, 95% confidence interval 1.209-3.859, P = 0.009) were significantly associated with a worse disease-free survival. Expression levels of MRN complex proteins significantly predict disease-free survival in rectal cancer patients, including those treated with neoadjuvant radiotherapy, and may have value in the management of these patients. Background The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-protein panel of MRN complex subunits as a potential radiosensitivity marker and evaluating the prognostic and clinicopathological implications of MRN expression in rectal cancer. Methods Samples from 265 rectal cancer patients treated with surgery and adjuvant chemoradiotherapy, including samples from 55 patients who were treated with neoadjuvant radiotherapy between 2000 and 2011, were analyzed. Expression of MRN complex proteins in tissue samples was determined by immunohistochemistry. Univariate and multivariate analyses were carried out to identify clinicopathological characteristics that are associated with the MRN three-protein panel expression in rectal cancer samples. Results In Kaplan–Meier survival analyses, we found that high level expression of MRN complex proteins in postoperative samples was associated with poor disease-free ( p = 0.021) and overall ( P = 0.002) survival. Interestingly, high MRN expression also correlated with poor disease-free ( P = 0.047) and overall ( P = 0.024) survival in the neoadjuvant radiotherapy subgroup. In multivariate analysis, combined MRN expression (hazard ratio = 2.114, 95% confidence interval 1.096–4.078, P = 0.026) and perineural invasion (hazard ratio = 2.160, 95% confidence interval 1.209–3.859, P = 0.009) were significantly associated with a worse disease-free survival. Conclusions Expression levels of MRN complex proteins significantly predict disease-free survival in rectal cancer patients, including those treated with neoadjuvant radiotherapy, and may have value in the management of these patients. |
| ArticleNumber | 869 |
| Audience | Academic |
| Author | Lee, Mark Lea, Vivienne Chung, Liping Lim, Stephanie H. Abubakar, Askar Ng, Weng de Souza, Paul Lee, Cheok Soon Ho, Vincent Singh, Amandeep Shin, Joo-Shik |
| Author_xml | – sequence: 1 givenname: Vincent orcidid: 0000-0003-3127-2933 surname: Ho fullname: Ho, Vincent email: v.ho@westernsydney.edu.au organization: MBBS FRACP, School of Medicine, Western Sydney University – sequence: 2 givenname: Liping surname: Chung fullname: Chung, Liping organization: MBBS FRACP, School of Medicine, Western Sydney University, Ingham Institute for Applied Medical Research – sequence: 3 givenname: Amandeep surname: Singh fullname: Singh, Amandeep organization: Department of Anatomical Pathology, Liverpool Hospital – sequence: 4 givenname: Vivienne surname: Lea fullname: Lea, Vivienne organization: Department of Anatomical Pathology, Liverpool Hospital – sequence: 5 givenname: Askar surname: Abubakar fullname: Abubakar, Askar organization: MBBS FRACP, School of Medicine, Western Sydney University, Ingham Institute for Applied Medical Research – sequence: 6 givenname: Stephanie H. surname: Lim fullname: Lim, Stephanie H. organization: Ingham Institute for Applied Medical Research, Macarthur Cancer Therapy Centre, Campbelltown Hospital, Discipline of Medical Oncology, School of Medicine, Western Sydney University – sequence: 7 givenname: Weng surname: Ng fullname: Ng, Weng organization: Department of Medical Oncology, Liverpool Hospital – sequence: 8 givenname: Mark surname: Lee fullname: Lee, Mark organization: Department of Radiation Oncology, Liverpool Hospital – sequence: 9 givenname: Paul surname: de Souza fullname: de Souza, Paul organization: MBBS FRACP, School of Medicine, Western Sydney University, Ingham Institute for Applied Medical Research, Department of Medical Oncology, Liverpool Hospital, Discipline of Medical Oncology, School of Medicine, Western Sydney University – sequence: 10 givenname: Joo-Shik surname: Shin fullname: Shin, Joo-Shik organization: Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital – sequence: 11 givenname: Cheok Soon surname: Lee fullname: Lee, Cheok Soon organization: MBBS FRACP, School of Medicine, Western Sydney University, Ingham Institute for Applied Medical Research, Department of Anatomical Pathology, Liverpool Hospital, Discipline of Pathology, School of Medicine, Western Sydney University, Faculty of Medicine, South Western Sydney Clinical School, The University of New South Wales |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30176843$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1245/s10434-013-3198-9 10.1126/science.8484122 10.1111/j.1463-1318.2008.01599.x 10.1016/j.ctrv.2015.06.007 10.1080/02841860701348670 10.1158/0008-5472.CAN-10-1202 10.1007/s10350-004-6545-x 10.1186/bcr3676 10.1371/journal.pone.0167675 10.1016/S0140-6736(01)06409-1 10.1002/cncr.22625 10.1200/JCO.2005.02.9017 10.1186/s12885-016-2190-8 10.1038/nchembio.63 10.1186/s12916-017-0929-y 10.1093/embo-reports/kvf044 10.3322/caac.21395 10.1146/annurev.genet.34.1.359 10.3349/ymj.2015.56.6.1461 10.1016/j.ijrobp.2006.12.005 10.1245/s10434-010-0985-4 10.1016/j.ijrobp.2009.05.056 10.1371/journal.pone.0078709 10.3390/biom5042877 10.1056/NEJMoa010580 10.1038/sj.embor.embor925 10.3390/cancers9120163 10.1001/jama.284.8.1008 10.1016/j.canlet.2014.12.038 10.1186/s12935-017-0419-5 10.21873/anticanres.11094 10.1016/j.cllc.2017.05.008 10.1080/02656730902747919 10.1200/JCO.2005.08.144 10.3390/ijms18030573 10.1111/j.1464-410X.2012.11564.x 10.18632/oncotarget.5437 10.1667/RR2594.1 10.3322/caac.20107 10.1038/nchembio0309-129 |
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| Keywords | MRE11-RAD50-NBS1 complex Biomarkers Prognosis Neoadjuvant radiotherapy Rectal cancer DNA damage response |
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| References | S Eschrich (4776_CR15) 2009; 75 L Chung (4776_CR27) 2014; 16 KM Garner (4776_CR37) 2009; 5 P Das (4776_CR11) 2007; 109 O Reerink (4776_CR29) 2004; 24 J Folkesson (4776_CR6) 2005; 23 A Choudhury (4776_CR31) 2010; 70 B Altan (4776_CR39) 2016; 36 A Jemal (4776_CR2) 2011; 61 RL Siegel (4776_CR1) 2017; 67 J Zhao (4776_CR21) 2017; 17 4776_CR28 J Lindebjerg (4776_CR33) 2009; 11 KA Ahmed (4776_CR16) 2015; 6 V Ho (4776_CR24) 2016; 11 4776_CR25 BD Harfe (4776_CR19) 2000; 34 G Giannini (4776_CR35) 2002; 3 JR Dynlacht (4776_CR42) 2011; 176 L Chang (4776_CR40) 2016; 16 A Dupre (4776_CR36) 2008; 4 SN Thibodeau (4776_CR20) 1993; 260 NK Kim (4776_CR14) 2015; 56 YC Lee (4776_CR4) 2013; 8 C Camma (4776_CR9) 2000; 284 Colorectal Cancer Collaborative Group (4776_CR8) 2001; 358 MF Lavin (4776_CR23) 2015; 5 JR Laurberg (4776_CR32) 2012; 110 E Kapiteijn (4776_CR5) 2001; 345 H Tian (4776_CR18) 2015; 358 S Kuroda (4776_CR38) 2012; 66 A Quintanal-Villalonga (4776_CR34) 2017; 18 NN Rahbari (4776_CR7) 2013; 20 JP Foy (4776_CR17) 2017; 15 M van den Bosch (4776_CR22) 2003; 4 SB Edge (4776_CR26) 2010; 17 K Tamas (4776_CR3) 2015; 41 H Birgisson (4776_CR12) 2005; 23 K Soderlund (4776_CR30) 2007; 68 H Birgisson (4776_CR13) 2007; 46 WC Dewey (4776_CR41) 2009; 25 J Garcia-Aguilar (4776_CR10) 2003; 46 |
| References_xml | – volume: 20 start-page: 4169 issue: 13 year: 2013 ident: 4776_CR7 publication-title: Ann Surg Oncol doi: 10.1245/s10434-013-3198-9 – volume: 260 start-page: 816 issue: 5109 year: 1993 ident: 4776_CR20 publication-title: Science (New York, NY) doi: 10.1126/science.8484122 – volume: 11 start-page: 264 issue: 3 year: 2009 ident: 4776_CR33 publication-title: Colorectal Dis doi: 10.1111/j.1463-1318.2008.01599.x – volume: 41 start-page: 671 issue: 8 year: 2015 ident: 4776_CR3 publication-title: Cancer Treat Rev doi: 10.1016/j.ctrv.2015.06.007 – volume: 24 start-page: 1217 issue: 2c year: 2004 ident: 4776_CR29 publication-title: Anticancer Res – volume: 46 start-page: 504 issue: 4 year: 2007 ident: 4776_CR13 publication-title: Acta Oncol doi: 10.1080/02841860701348670 – volume: 70 start-page: 7017 issue: 18 year: 2010 ident: 4776_CR31 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-10-1202 – volume: 46 start-page: 298 issue: 3 year: 2003 ident: 4776_CR10 publication-title: Dis Colon Rectum doi: 10.1007/s10350-004-6545-x – volume: 16 start-page: R63 issue: 3 year: 2014 ident: 4776_CR27 publication-title: Breast Cancer Res : BCR doi: 10.1186/bcr3676 – volume: 11 start-page: e0167675 issue: 12 year: 2016 ident: 4776_CR24 publication-title: PLoS One doi: 10.1371/journal.pone.0167675 – volume: 358 start-page: 1291 issue: 9290 year: 2001 ident: 4776_CR8 publication-title: Lancet doi: 10.1016/S0140-6736(01)06409-1 – volume: 109 start-page: 1750 issue: 9 year: 2007 ident: 4776_CR11 publication-title: Cancer doi: 10.1002/cncr.22625 – volume: 23 start-page: 8697 issue: 34 year: 2005 ident: 4776_CR12 publication-title: J Clin Oncol doi: 10.1200/JCO.2005.02.9017 – volume: 16 start-page: 190 year: 2016 ident: 4776_CR40 publication-title: BMC Cancer doi: 10.1186/s12885-016-2190-8 – volume: 4 start-page: 119 issue: 2 year: 2008 ident: 4776_CR36 publication-title: Nat Chem Biol doi: 10.1038/nchembio.63 – volume: 15 start-page: 165 issue: 1 year: 2017 ident: 4776_CR17 publication-title: BMC Med doi: 10.1186/s12916-017-0929-y – volume: 3 start-page: 248 issue: 3 year: 2002 ident: 4776_CR35 publication-title: EMBO Rep doi: 10.1093/embo-reports/kvf044 – volume: 67 start-page: 177 issue: 3 year: 2017 ident: 4776_CR1 publication-title: CA Cancer J Clin doi: 10.3322/caac.21395 – volume: 34 start-page: 359 year: 2000 ident: 4776_CR19 publication-title: Annu Rev Genet doi: 10.1146/annurev.genet.34.1.359 – volume: 56 start-page: 1461 issue: 6 year: 2015 ident: 4776_CR14 publication-title: Yonsei Med J doi: 10.3349/ymj.2015.56.6.1461 – volume: 68 start-page: 50 issue: 1 year: 2007 ident: 4776_CR30 publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2006.12.005 – volume: 17 start-page: 1471 issue: 6 year: 2010 ident: 4776_CR26 publication-title: Ann Surg Oncol doi: 10.1245/s10434-010-0985-4 – volume: 75 start-page: 497 issue: 2 year: 2009 ident: 4776_CR15 publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2009.05.056 – volume: 8 start-page: e78709 issue: 11 year: 2013 ident: 4776_CR4 publication-title: PLoS One doi: 10.1371/journal.pone.0078709 – volume: 5 start-page: 2877 issue: 4 year: 2015 ident: 4776_CR23 publication-title: Biomolecules doi: 10.3390/biom5042877 – volume: 345 start-page: 638 issue: 9 year: 2001 ident: 4776_CR5 publication-title: N Engl J Med doi: 10.1056/NEJMoa010580 – volume: 4 start-page: 844 issue: 9 year: 2003 ident: 4776_CR22 publication-title: EMBO Rep doi: 10.1038/sj.embor.embor925 – ident: 4776_CR25 doi: 10.3390/cancers9120163 – volume: 284 start-page: 1008 issue: 8 year: 2000 ident: 4776_CR9 publication-title: Jama doi: 10.1001/jama.284.8.1008 – volume: 358 start-page: 8 issue: 1 year: 2015 ident: 4776_CR18 publication-title: Cancer Lett doi: 10.1016/j.canlet.2014.12.038 – volume: 17 start-page: 49 year: 2017 ident: 4776_CR21 publication-title: Cancer Cell Int doi: 10.1186/s12935-017-0419-5 – volume: 36 start-page: 5237 issue: 10 year: 2016 ident: 4776_CR39 publication-title: Anticancer Res doi: 10.21873/anticanres.11094 – volume: 18 start-page: 667 issue: 6 year: 2017 ident: 4776_CR34 publication-title: Clin Lung Cancer doi: 10.1016/j.cllc.2017.05.008 – volume: 25 start-page: 3 issue: 1 year: 2009 ident: 4776_CR41 publication-title: Int J Hyperthermia doi: 10.1080/02656730902747919 – volume: 23 start-page: 5644 issue: 24 year: 2005 ident: 4776_CR6 publication-title: J Clin Oncol doi: 10.1200/JCO.2005.08.144 – ident: 4776_CR28 doi: 10.3390/ijms18030573 – volume: 66 start-page: 83 issue: 2 year: 2012 ident: 4776_CR38 publication-title: Acta Med Okayama – volume: 110 start-page: E1228 issue: 11 Pt C year: 2012 ident: 4776_CR32 publication-title: BJU Int doi: 10.1111/j.1464-410X.2012.11564.x – volume: 6 start-page: 34414 issue: 33 year: 2015 ident: 4776_CR16 publication-title: Oncotarget doi: 10.18632/oncotarget.5437 – volume: 176 start-page: 323 issue: 3 year: 2011 ident: 4776_CR42 publication-title: Radiat Res doi: 10.1667/RR2594.1 – volume: 61 start-page: 69 issue: 2 year: 2011 ident: 4776_CR2 publication-title: CA Cancer J Clin doi: 10.3322/caac.20107 – volume: 5 start-page: 129 issue: 3 year: 2009 ident: 4776_CR37 publication-title: Nat Chem Biol doi: 10.1038/nchembio0309-129 |
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The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11,... The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and... Background The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11,... Abstract Background The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles... |
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| SubjectTerms | Acid Anhydride Hydrolases Adult Aged Aged, 80 and over Analysis Biomarkers Biomedical and Life Sciences Biomedicine Bladder cancer Cancer Cancer patients Cancer recurrence Cancer Research Cancer therapies Care and treatment Cell and molecular biology Cell cycle Cell Cycle Proteins - genetics Chemoradiotherapy Colorectal cancer Confidence intervals Deoxyribonucleic acid Diagnosis Disease-Free Survival DNA DNA Breaks, Double-Stranded - radiation effects DNA damage DNA damage response DNA Repair Enzymes - genetics DNA-Binding Proteins - genetics Female Gene Expression Regulation, Neoplastic - radiation effects Genes Health aspects Health Promotion and Disease Prevention Health risk assessment Humans Immunohistochemistry Kaplan-Meier Estimate Kinases Lymphatic system Male Medical prognosis Medicine/Public Health Middle Aged Mortality MRE11 Homologue Protein - genetics MRE11 protein MRE11-RAD50-NBS1 complex Multiprotein Complexes - genetics Multivariate analysis Mutation Neoadjuvant radiotherapy Neoadjuvant therapy Neoadjuvant Therapy - adverse effects Nuclear Proteins - genetics Oncology Patients Prevention Prognosis Proteins Radiation therapy Radiosensitivity Rectal cancer Rectal Neoplasms - genetics Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Rectum Research Article Surgery Surgical Oncology Survival Tissue Array Analysis Treatment outcome |
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| Title | Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis |
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