Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Background Preeclampsia is a pregnancy-specific hypertensive disorder characterized by impaired angiogenesis. We postulate that senescence of mesenchymal stem cells (MSC), multipotent cells with pro-angiogenic activities, is one of the mechanisms by which systemic inflammation exerts inhibitory effe...

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Veröffentlicht in:	Biology of sex differences Jg. 10; H. 1; S. 49 - 13
Hauptverfasser:	Suvakov, Sonja, Cubro, Hajrunisa, White, Wendy M., Butler Tobah, Yvonne S., Weissgerber, Tracey L., Jordan, Kyra L., Zhu, Xiang Y., Woollard, John R., Chebib, Fouad T., Milic, Natasa M., Grande, Joseph P., Xu, Ming, Tchkonia, Tamara, Kirkland, James L., Lerman, Lilach O., Garovic, Vesna D.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 14.09.2019 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	Adipose tissue Adipose Tissue - cytology Adult Angiogenesis Angiogenesis, Senolytics, Dasatinib Apoptosis Biomedical and Life Sciences Biomedicine Cell adhesion & migration Cell Movement Cell Proliferation Cell Survival Cellular Senescence Cesarean section Complications and side effects Dasatinib Dasatinib - pharmacology Endocrinology Experiments Explants Female Fetuses Gene expression Genes Genotype & phenotype Health aspects Human Physiology Humans Hypertension Inflammation Interleukin 6 Interleukin 8 Interleukins Leukocyte migration Medical research Mesenchymal stem cells Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - physiology Mesenchyme Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Necrosis Neovascularization Phenotypes Pre-Eclampsia Preeclampsia Pregnancy Protein Kinase Inhibitors - pharmacology Proteins renal and cardiovascular disease in pregnancy Risk factors Senescence Stem cells Tumor necrosis factor Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors β-Galactosidase Angiogenesis, Senolytics, Dasatinib Senescence Preeclampsia Mesenchymal stem cells
ISSN:	2042-6410, 2042-6410
Online-Zugang:	Volltext
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