Effect of Continuous Glucose Monitoring on Hypoglycemia in Type 1 Diabetes

OBJECTIVE: To assess the impact of continuous glucose monitoring on hypoglycemia in people with type 1 diabetes. RESEARCH DESIGN AND METHODS: In this randomized, controlled, multicenter study, 120 children and adults on intensive therapy for type 1 diabetes and a screening level of glycated hemoglob...

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Published in:Diabetes care Vol. 34; no. 4; pp. 795 - 800
Main Authors: Battelino, Tadej, Phillip, Moshe, Bratina, Natasa, Nimri, Revital, Oskarsson, Per, Bolinder, Jan
Format: Journal Article
Language:English
Published: United States American Diabetes Association 01.04.2011
Subjects:
Adolescent
Adult
adults
Aged
blood
blood glucose
Blood Glucose - metabolism
Blood Glucose Self-Monitoring
Blood sugar
Blood sugar monitoring
Care and treatment
Child
children
Clinical medicine
Design
Diabetes
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - metabolism
Diabetes Mellitus, Type 1 - physiopathology
Diabetes therapy
Diabetics
diagnosis
Female
glucose
Glycated Hemoglobin
Glycated Hemoglobin A - metabolism
glycohemoglobin
Glycosylated hemoglobin
Grants
Humans
Hypoglycemia
Hypoglycemia - diagnosis
Hypoglycemia - pathology
insulin-dependent diabetes mellitus
Male
metabolism
Middle Aged
monitoring
Monitoring systems
Original Research
pathology
Patient monitoring equipment
patients
people
physiopathology
screening
Statistical analysis
therapeutics
Type 1 diabetes
Young Adult
ISSN:0149-5992, 1935-5548, 1935-5548
Online Access:Get full text
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Summary:OBJECTIVE: To assess the impact of continuous glucose monitoring on hypoglycemia in people with type 1 diabetes. RESEARCH DESIGN AND METHODS: In this randomized, controlled, multicenter study, 120 children and adults on intensive therapy for type 1 diabetes and a screening level of glycated hemoglobin A₁c (HbA₁c) <7.5% were randomly assigned to a control group performing conventional home monitoring with a blood glucose meter and wearing a masked continuous glucose monitor every second week for five days or to a group with real-time continuous glucose monitoring. The primary outcome was the time spent in hypoglycemia (interstitial glucose concentration <63 mg/dL) over a period of 26 weeks. Analysis was by intention to treat for all randomized patients. RESULTS: The time per day spent in hypoglycemia was significantly shorter in the continuous monitoring group than in the control group (mean ± SD 0.48 ± 0.57 and 0.97 ± 1.55 h/day, respectively; ratio of means 0.49; 95% CI 0.26-0.76; P = 0.03). HbA₁c at 26 weeks was lower in the continuous monitoring group than in the control group (difference -0.27%; 95% CI -0.47 to -0.07; P = 0.008). Time spent in 70 to 180 mg/dL normoglycemia was significantly longer in the continuous glucose monitoring group compared with the control group (mean hours per day, 17.6 vs. 16.0, P = 0.009). CONCLUSIONS: Continuous glucose monitoring was associated with reduced time spent in hypoglycemia and a concomitant decrease in HbA₁c in children and adults with type 1 diabetes.
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ISSN:0149-5992
1935-5548
1935-5548
DOI:10.2337/dc10-1989