Inflammatory signaling in human tuberculosis granulomas is spatially organized

Using proteomic analyses, Eric Rubin, Véronique Dartois and colleagues show that tuberculosis granulomas have spatially segregated protein compositions that compartmentalize pro- and anti-inflammatory responses to distinct regions. Granulomas are the pathological hallmark of tuberculosis (TB). Howev...

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Bibliographic Details
Published in:	Nature medicine Vol. 22; no. 5; pp. 531 - 538
Main Authors:	Marakalala, Mohlopheni J, Raju, Ravikiran M, Sharma, Kirti, Zhang, Yanjia J, Eugenin, Eliseo A, Prideaux, Brendan, Daudelin, Isaac B, Chen, Pei-Yu, Booty, Matthew G, Kim, Jin Hee, Eum, Seok Yong, Via, Laura E, Behar, Samuel M, Barry, Clifton E, Mann, Matthias, Dartois, Véronique, Rubin, Eric J
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.05.2016 Nature Publishing Group
Subjects:	13/51 14/19 14/63 631/1647/2067 631/1647/664/1257 631/1647/767/1424 692/699/255/1856 82/80 Animals Arachidonic Acid - metabolism Biomedicine Cancer Research Cellular signal transduction Development and progression Eicosanoids - immunology Eicosanoids - metabolism Genetic aspects Granuloma Granuloma - immunology Granuloma - metabolism Granuloma - pathology Health aspects Humans Immunohistochemistry Infectious Diseases Inflammation Inflammation - immunology Inflammation - metabolism Inflammation - pathology Laser Capture Microdissection Lesions Mass Spectrometry Metabolic Diseases Microscopy Microscopy, Confocal Molecular Medicine Mycobacterium Neurosciences Pathology Peptides Properties Proteomics Rabbits Reactive Oxygen Species - immunology Reactive Oxygen Species - metabolism Signal Transduction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tuberculosis Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - metabolism Tuberculosis, Pulmonary - pathology Tumor proteins
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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