Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

In yeast, the novel protein Atg40 is enriched in the cortical and cytoplasmic endoplasmic reticulum (ER), and loads these ER subdomains into autophagosomes to facilitate ER autophagy; Atg39 localizes to the perinuclear ER and induces autophagic sequestration of part of the nucleus, thus ensuring cel...

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Veröffentlicht in:	Nature (London) Jg. 522; H. 7556; S. 359 - 362
Hauptverfasser:	Mochida, Keisuke, Oikawa, Yu, Kimura, Yayoi, Kirisako, Hiromi, Hirano, Hisashi, Ohsumi, Yoshinori, Nakatogawa, Hitoshi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 18.06.2015 Nature Publishing Group
Schlagworte:	14/28 14/34 14/35 14/63 631/80/39/2346 631/80/642/1463 82/1 82/111 82/29 Amino Acid Sequence Autophagy Autophagy (Cytology) Autophagy-Related Protein 8 Family Autophagy-Related Proteins Cell Nucleus - metabolism Cellular biology Endoplasmic reticulum Endoplasmic Reticulum - metabolism Humanities and Social Sciences Kinases letter Membranes Microbial Viability Microtubule-Associated Proteins - metabolism multidisciplinary Neoplasm Proteins - metabolism Nitrogen Nitrogen - deficiency Nitrogen - metabolism Nuclear Envelope - metabolism Observations Phenotype Physiological aspects Properties Protein Binding Proteins Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - deficiency Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Science Vesicular Transport Proteins - metabolism Yeasts Yeasts (Fungi)
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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