Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

In yeast, the novel protein Atg40 is enriched in the cortical and cytoplasmic endoplasmic reticulum (ER), and loads these ER subdomains into autophagosomes to facilitate ER autophagy; Atg39 localizes to the perinuclear ER and induces autophagic sequestration of part of the nucleus, thus ensuring cel...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) Jg. 522; H. 7556; S. 359 - 362
Hauptverfasser:	Mochida, Keisuke, Oikawa, Yu, Kimura, Yayoi, Kirisako, Hiromi, Hirano, Hisashi, Ohsumi, Yoshinori, Nakatogawa, Hitoshi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 18.06.2015 Nature Publishing Group
Schlagworte:	14/28 14/34 14/35 14/63 631/80/39/2346 631/80/642/1463 82/1 82/111 82/29 Amino Acid Sequence Autophagy Autophagy (Cytology) Autophagy-Related Protein 8 Family Autophagy-Related Proteins Cell Nucleus - metabolism Cellular biology Endoplasmic reticulum Endoplasmic Reticulum - metabolism Humanities and Social Sciences Kinases letter Membranes Microbial Viability Microtubule-Associated Proteins - metabolism multidisciplinary Neoplasm Proteins - metabolism Nitrogen Nitrogen - deficiency Nitrogen - metabolism Nuclear Envelope - metabolism Observations Phenotype Physiological aspects Properties Protein Binding Proteins Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - deficiency Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Science Vesicular Transport Proteins - metabolism Yeasts Yeasts (Fungi)
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	In yeast, the novel protein Atg40 is enriched in the cortical and cytoplasmic endoplasmic reticulum (ER), and loads these ER subdomains into autophagosomes to facilitate ER autophagy; Atg39 localizes to the perinuclear ER and induces autophagic sequestration of part of the nucleus, thus ensuring cell survival under nitrogen-deprived conditions. ER-phagy receptors mapped The endoplasmic reticulum (ER) is a complex network of membranes involved in protein and lipid synthesis, ion homeostasis, protein quality control and organelle communication. It is also a source of membrane-bounded vesicles called autophagosomes, the vehicles for the self-digesting cellular process of autophagy. Two papers published online this week [in this issue of Nature] show how the ER itself is targeted for degradation by autophagy — a process that could ensure constant ER turnover in response to cellular requirements. Ivan Dikic and coworkers find the protein FAM134B is an ER-resident receptor that facilitates 'ER-phagy'. Downregulation of this protein — mutations of which can cause sensory neuropathy in humans — resulted in expanded ER structures and degeneration of mouse sensory neurons. Hitoshi Nakatogawa and colleagues show that the same phenomenon is conserved in yeast, where Atg40 is enriched in the cortical and cytoplasmic ER, loading these ER subdomains into autophagosomes. A further ER-phagy receptor, Atg39, localizes to the perinuclear ER (or the nuclear envelope) and induces autophagic sequestration of a part of the nucleus, thus ensuring cell survival under nitrogen-deprived conditions. Macroautophagy (hereafter referred to as autophagy) degrades various intracellular constituents to regulate a wide range of cellular functions, and is also closely linked to several human diseases 1 , 2 . In selective autophagy, receptor proteins recognize degradation targets and direct their sequestration by double-membrane vesicles called autophagosomes, which transport them into lysosomes or vacuoles 3 . Although recent studies have shown that selective autophagy is involved in quality/quantity control of some organelles, including mitochondria and peroxisomes 4 , it remains unclear how extensively it contributes to cellular organelle homeostasis. Here we describe selective autophagy of the endoplasmic reticulum (ER) and nucleus in the yeast Saccharomyces cerevisiae . We identify two novel proteins, Atg39 and Atg40, as receptors specific to these pathways. Atg39 localizes to the perinuclear ER (or the nuclear envelope) and induces autophagic sequestration of part of the nucleus. Atg40 is enriched in the cortical and cytoplasmic ER, and loads these ER subdomains into autophagosomes. Atg39-dependent autophagy of the perinuclear ER/nucleus is required for cell survival under nitrogen-deprivation conditions. Atg40 is probably the functional counterpart of FAM134B, an autophagy receptor for the ER in mammals that has been implicated in sensory neuropathy 5 . Our results provide fundamental insight into the pathophysiological roles and mechanisms of ‘ER-phagy’ and ‘nucleophagy’ in other organisms.
AbstractList	Macroautophagy (hereafter referred to as autophagy) degrades various intracellular constituents to regulate a wide range of cellular functions, and is also closely linked to several human diseases. In selective autophagy, receptor proteins recognize degradation targets and direct their sequestration by double-membrane vesicles called autophagosomes, which transport them into lysosomes or vacuoles. Although recent studies have shown that selective autophagy is involved in quality/quantity control of some organelles, including mitochondria and peroxisomes, it remains unclear how extensively it contributes to cellular organelle homeostasis. Here we describe selective autophagy of the endoplasmic reticulum (ER) and nucleus in the yeast Saccharomyces cerevisiae. We identify two novel proteins, Atg39 and Atg40, as receptors specific to these pathways. Atg39 localizes to the perinuclear ER (or the nuclear envelope) and induces autophagic sequestration of part of the nucleus. Atg40 is enriched in the cortical and cytoplasmic ER, and loads these ER subdomains into autophagosomes. Atg39-dependent autophagy of the perinuclear ER/nucleus is required for cell survival under nitrogen-deprivation conditions. Atg40 is probably the functional counterpart of FAM134B, an autophagy receptor for the ER in mammals that has been implicated in sensory neuropathy. Our results provide fundamental insight into the pathophysiological roles and mechanisms of 'ER-phagy' and 'nucleophagy' in other organisms. Macroautophagy (hereafter referred to as autophagy) degrades various intracellular constituents to regulate a wide range of cellular functions, and is also closely linked to several human diseases. In selective autophagy, receptor proteins recognize degradation targets and direct their sequestration by double-membrane vesicles called autophagosomes, which transport them into lysosomes or vacuoles. Although recent studies have shown that selective autophagy is involved in quality/quantity control of some organelles, including mitochondria and peroxisomes, it remains unclear how extensively it contributes to cellular organelle homeostasis. Here we describe selective autophagy of the endoplasmic reticulum (ER) and nucleus in the yeast Saccharomyces cerevisiae. We identify two novel proteins, Atg39 and Atg40, as receptors specific to these pathways. Atg39 localizes to the perinuclear ER (or the nuclear envelope) and induces autophagic sequestration of part of the nucleus. Atg40 is enriched in the cortical and cytoplasmic ER, and loads these ER subdomains into autophagosomes. Atg39-dependent autophagy of the perinuclear ER/nucleus is required for cell survival under nitrogen-deprivation conditions. Atg40 is probably the functional counterpart of FAM134B, an autophagy receptor for the ER in mammals that has been implicated in sensory neuropathy. Our results provide fundamental insight into the pathophysiological roles and mechanisms of 'ER-phagy' and 'nucleophagy' in other organisms.Macroautophagy (hereafter referred to as autophagy) degrades various intracellular constituents to regulate a wide range of cellular functions, and is also closely linked to several human diseases. In selective autophagy, receptor proteins recognize degradation targets and direct their sequestration by double-membrane vesicles called autophagosomes, which transport them into lysosomes or vacuoles. Although recent studies have shown that selective autophagy is involved in quality/quantity control of some organelles, including mitochondria and peroxisomes, it remains unclear how extensively it contributes to cellular organelle homeostasis. Here we describe selective autophagy of the endoplasmic reticulum (ER) and nucleus in the yeast Saccharomyces cerevisiae. We identify two novel proteins, Atg39 and Atg40, as receptors specific to these pathways. Atg39 localizes to the perinuclear ER (or the nuclear envelope) and induces autophagic sequestration of part of the nucleus. Atg40 is enriched in the cortical and cytoplasmic ER, and loads these ER subdomains into autophagosomes. Atg39-dependent autophagy of the perinuclear ER/nucleus is required for cell survival under nitrogen-deprivation conditions. Atg40 is probably the functional counterpart of FAM134B, an autophagy receptor for the ER in mammals that has been implicated in sensory neuropathy. Our results provide fundamental insight into the pathophysiological roles and mechanisms of 'ER-phagy' and 'nucleophagy' in other organisms. In yeast, the novel protein Atg40 is enriched in the cortical and cytoplasmic endoplasmic reticulum (ER), and loads these ER subdomains into autophagosomes to facilitate ER autophagy; Atg39 localizes to the perinuclear ER and induces autophagic sequestration of part of the nucleus, thus ensuring cell survival under nitrogen-deprived conditions. ER-phagy receptors mapped The endoplasmic reticulum (ER) is a complex network of membranes involved in protein and lipid synthesis, ion homeostasis, protein quality control and organelle communication. It is also a source of membrane-bounded vesicles called autophagosomes, the vehicles for the self-digesting cellular process of autophagy. Two papers published online this week [in this issue of Nature] show how the ER itself is targeted for degradation by autophagy — a process that could ensure constant ER turnover in response to cellular requirements. Ivan Dikic and coworkers find the protein FAM134B is an ER-resident receptor that facilitates 'ER-phagy'. Downregulation of this protein — mutations of which can cause sensory neuropathy in humans — resulted in expanded ER structures and degeneration of mouse sensory neurons. Hitoshi Nakatogawa and colleagues show that the same phenomenon is conserved in yeast, where Atg40 is enriched in the cortical and cytoplasmic ER, loading these ER subdomains into autophagosomes. A further ER-phagy receptor, Atg39, localizes to the perinuclear ER (or the nuclear envelope) and induces autophagic sequestration of a part of the nucleus, thus ensuring cell survival under nitrogen-deprived conditions. Macroautophagy (hereafter referred to as autophagy) degrades various intracellular constituents to regulate a wide range of cellular functions, and is also closely linked to several human diseases 1 , 2 . In selective autophagy, receptor proteins recognize degradation targets and direct their sequestration by double-membrane vesicles called autophagosomes, which transport them into lysosomes or vacuoles 3 . Although recent studies have shown that selective autophagy is involved in quality/quantity control of some organelles, including mitochondria and peroxisomes 4 , it remains unclear how extensively it contributes to cellular organelle homeostasis. Here we describe selective autophagy of the endoplasmic reticulum (ER) and nucleus in the yeast Saccharomyces cerevisiae . We identify two novel proteins, Atg39 and Atg40, as receptors specific to these pathways. Atg39 localizes to the perinuclear ER (or the nuclear envelope) and induces autophagic sequestration of part of the nucleus. Atg40 is enriched in the cortical and cytoplasmic ER, and loads these ER subdomains into autophagosomes. Atg39-dependent autophagy of the perinuclear ER/nucleus is required for cell survival under nitrogen-deprivation conditions. Atg40 is probably the functional counterpart of FAM134B, an autophagy receptor for the ER in mammals that has been implicated in sensory neuropathy 5 . Our results provide fundamental insight into the pathophysiological roles and mechanisms of ‘ER-phagy’ and ‘nucleophagy’ in other organisms.
Audience	Academic
Author	Ohsumi, Yoshinori Kirisako, Hiromi Mochida, Keisuke Oikawa, Yu Hirano, Hisashi Kimura, Yayoi Nakatogawa, Hitoshi
Author_xml	– sequence: 1 givenname: Keisuke surname: Mochida fullname: Mochida, Keisuke organization: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology – sequence: 2 givenname: Yu surname: Oikawa fullname: Oikawa, Yu organization: Frontier Research Center, Tokyo Institute of Technology – sequence: 3 givenname: Yayoi surname: Kimura fullname: Kimura, Yayoi organization: Advanced Medical Research Center, Yokohama City University – sequence: 4 givenname: Hiromi surname: Kirisako fullname: Kirisako, Hiromi organization: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, CREST, Japan Science and Technology Agency – sequence: 5 givenname: Hisashi surname: Hirano fullname: Hirano, Hisashi organization: Advanced Medical Research Center, Yokohama City University – sequence: 6 givenname: Yoshinori surname: Ohsumi fullname: Ohsumi, Yoshinori organization: Frontier Research Center, Tokyo Institute of Technology – sequence: 7 givenname: Hitoshi surname: Nakatogawa fullname: Nakatogawa, Hitoshi email: hnakatogawa@bio.titech.ac.jp organization: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, CREST, Japan Science and Technology Agency
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26040717$$D View this record in MEDLINE/PubMed
BookMark	eNpt0str3DAQB2BREppN2lPvxTSXltSp5IcsH0PoIxAopC30JsbS2FHwyo4epfnvq2QTuhuMDgL5mx-SZw7Jnp0sEvKG0VNGS_HJQogOWVVT_oKsWNXwvOKi2SMrSguRU1HyA3Lo_Q2ltGZN9ZIcFJxWtGHNivy-QoVzmFy-Rm0goM48jqiC-YMZxDDN1zDcZRoHBxp9Fq4xQ6uneQS_NipzGIyKY1xnYPXDVxvViNG_Ivs9jB5fP-5H5NeXzz_Pv-WX379enJ9d5orzJuSlanvVFQXWmkNVlFqwTvdAFW1Eq6HuNUKXlui1qFXBORPIuhoKjYIL7Moj8n6TO7vpNqIPcm28wnEEi1P0kvGWFrRNb0_0-Bm9maKz6XYPqmwKVrT_1QAjSmP7KThQ96HyrOKlYLxpeFL5ghrQooMx9ac36XjHv1vwaja3chudLqC0NKZ_vZj6YacgmYB_wwDRe3nx42rXvn18fexSr-XszBrcnXyahQTYBig3ee-wl8oECCZlOjCjZFTez5vcmrdUc_Ks5il2WX_caJ-UHdBtNWCB_wPyKORb
CODEN	NATUAS
CitedBy_id	crossref_primary_10_1080_27694127_2023_2236407 crossref_primary_10_3389_fncel_2022_907560 crossref_primary_10_2183_pjab_96_001 crossref_primary_10_1038_s41598_021_97640_6 crossref_primary_10_1073_pnas_2321991121 crossref_primary_10_3892_mmr_2025_13471 crossref_primary_10_1016_j_tibs_2019_11_006 crossref_primary_10_1080_19768354_2023_2285825 crossref_primary_10_3390_cells6030023 crossref_primary_10_1186_s13062_017_0174_5 crossref_primary_10_3389_fmicb_2022_822864 crossref_primary_10_1002_wdev_376 crossref_primary_10_1080_15548627_2023_2259708 crossref_primary_10_3390_ijms21103689 crossref_primary_10_1080_15548627_2024_2325297 crossref_primary_10_1083_jcb_202006007 crossref_primary_10_1016_j_livres_2018_08_004 crossref_primary_10_1002_jcp_30377 crossref_primary_10_1080_10799893_2023_2291563 crossref_primary_10_1002_1873_3468_14509 crossref_primary_10_1007_s00284_024_03838_y crossref_primary_10_1002_mrd_23235 crossref_primary_10_1016_j_brainres_2016_03_035 crossref_primary_10_1186_s13041_019_0504_x crossref_primary_10_1016_j_bbrc_2022_04_078 crossref_primary_10_1016_j_immuni_2017_08_005 crossref_primary_10_1111_imr_12613 crossref_primary_10_3389_fcell_2021_684526 crossref_primary_10_1016_j_jbc_2021_101494 crossref_primary_10_1177_25152564221136388 crossref_primary_10_1002_1873_3468_14742 crossref_primary_10_1111_febs_15031 crossref_primary_10_12688_f1000research_13968_1 crossref_primary_10_1002_adbi_201800259 crossref_primary_10_3390_genes13050748 crossref_primary_10_1007_s12253_018_0544_z crossref_primary_10_3390_biology12111426 crossref_primary_10_1016_j_ydbio_2023_12_007 crossref_primary_10_3389_fpls_2019_00280 crossref_primary_10_1002_jcp_31213 crossref_primary_10_1111_ajco_14134 crossref_primary_10_1016_j_jmb_2021_167360 crossref_primary_10_1093_jb_mvae042 crossref_primary_10_1080_15548627_2025_2455158 crossref_primary_10_4103_NRR_NRR_D_23_00995 crossref_primary_10_1038_s41467_019_12991_z crossref_primary_10_1042_BST20170354 crossref_primary_10_1016_j_tcb_2020_02_001 crossref_primary_10_1080_15548627_2019_1596477 crossref_primary_10_1083_jcb_201906047 crossref_primary_10_1080_15548627_2021_1894059 crossref_primary_10_1016_j_pharmthera_2017_04_005 crossref_primary_10_7554_eLife_58396 crossref_primary_10_1016_j_jmb_2019_09_005 crossref_primary_10_1007_s00018_024_05385_y crossref_primary_10_1016_j_tcb_2021_12_008 crossref_primary_10_1080_15548627_2024_2353502 crossref_primary_10_1016_j_ymben_2016_12_003 crossref_primary_10_1002_1873_3468_14760 crossref_primary_10_1016_j_devcel_2021_02_008 crossref_primary_10_1038_nature15548 crossref_primary_10_3389_fphar_2019_00495 crossref_primary_10_3390_cells12081132 crossref_primary_10_1177_25152564221093215 crossref_primary_10_1002_1873_3468_14418 crossref_primary_10_1016_j_molp_2022_05_006 crossref_primary_10_1038_s41467_022_30433_1 crossref_primary_10_26508_lsa_202101161 crossref_primary_10_1111_jpi_12859 crossref_primary_10_26508_lsa_202101160 crossref_primary_10_1096_fba_2024_00035 crossref_primary_10_1016_j_jgg_2019_03_008 crossref_primary_10_3390_cells11091456 crossref_primary_10_1007_s00109_016_1487_z crossref_primary_10_1016_j_jmb_2016_02_004 crossref_primary_10_1016_j_abb_2023_109766 crossref_primary_10_1002_1873_3468_14412 crossref_primary_10_1016_j_devcel_2015_11_016 crossref_primary_10_1371_journal_pone_0157960 crossref_primary_10_1093_pcp_pcac015 crossref_primary_10_1038_s41467_024_55045_9 crossref_primary_10_3390_microorganisms9102152 crossref_primary_10_1002_1873_3468_13571 crossref_primary_10_3389_fpls_2020_00477 crossref_primary_10_1016_j_devcel_2023_04_015 crossref_primary_10_1016_j_tcb_2020_11_001 crossref_primary_10_1080_15548627_2017_1314897 crossref_primary_10_1016_j_jmb_2024_168691 crossref_primary_10_1242_jcs_259778 crossref_primary_10_1242_jcs_214304 crossref_primary_10_3390_jof9121181 crossref_primary_10_1016_j_devcel_2018_01_001 crossref_primary_10_1080_15548627_2020_1725402 crossref_primary_10_1002_1873_3468_14433 crossref_primary_10_1016_j_bbr_2025_115650 crossref_primary_10_1016_j_cmet_2019_03_003 crossref_primary_10_3390_ijms20020300 crossref_primary_10_1016_j_devcel_2015_11_010 crossref_primary_10_1073_pnas_2209823119 crossref_primary_10_1016_j_devcel_2020_08_008 crossref_primary_10_1038_s41556_025_01612_1 crossref_primary_10_1016_j_tplants_2018_05_002 crossref_primary_10_7554_eLife_45284 crossref_primary_10_1038_nrm_2016_153 crossref_primary_10_1038_s41598_023_50245_7 crossref_primary_10_1111_nph_16268 crossref_primary_10_1111_tpj_15743 crossref_primary_10_1083_jcb_202108105 crossref_primary_10_1038_s41467_023_38690_4 crossref_primary_10_1038_nature14498 crossref_primary_10_1074_jbc_RA119_010295 crossref_primary_10_3389_fnins_2017_00678 crossref_primary_10_1016_j_tcb_2022_04_006 crossref_primary_10_1038_s41401_024_01423_4 crossref_primary_10_1146_annurev_genet_080320_025104 crossref_primary_10_1080_15548627_2015_1111503 crossref_primary_10_1002_jat_4282 crossref_primary_10_1016_j_devcel_2021_03_005 crossref_primary_10_1038_s41556_024_01598_2 crossref_primary_10_3390_ijms19030828 crossref_primary_10_1016_j_molcel_2019_03_034 crossref_primary_10_3389_fcell_2020_00200 crossref_primary_10_1016_j_molcel_2019_03_033 crossref_primary_10_1002_jcp_26954 crossref_primary_10_1016_j_kint_2016_04_014 crossref_primary_10_1016_j_cellsig_2020_109884 crossref_primary_10_1016_j_cell_2023_08_008 crossref_primary_10_1016_j_jid_2016_03_016 crossref_primary_10_3390_cells11071086 crossref_primary_10_1371_journal_pgen_1009053 crossref_primary_10_7554_eLife_25555 crossref_primary_10_1080_15548627_2025_2469189 crossref_primary_10_1007_s00441_016_2472_0 crossref_primary_10_4103_AGINGADV_AGINGADV_D_24_00002 crossref_primary_10_1146_annurev_cellbio_111315_125125 crossref_primary_10_1080_15592324_2015_1101199 crossref_primary_10_1007_s11033_023_08517_y crossref_primary_10_3390_ijms23073609 crossref_primary_10_1016_j_semcdb_2018_09_013 crossref_primary_10_1073_pnas_2008923117 crossref_primary_10_1002_iub_2582 crossref_primary_10_1093_infdis_jiw270 crossref_primary_10_1016_j_molcel_2019_09_005 crossref_primary_10_1016_j_tcb_2021_10_001 crossref_primary_10_1016_j_yjmcc_2015_12_005 crossref_primary_10_1111_jcpe_13784 crossref_primary_10_1016_j_jmb_2016_02_024 crossref_primary_10_1371_journal_pbio_3002372 crossref_primary_10_1016_j_jmb_2016_02_027 crossref_primary_10_1016_j_nut_2022_111686 crossref_primary_10_3390_cells9040831 crossref_primary_10_1038_srep42591 crossref_primary_10_1083_jcb_202201068 crossref_primary_10_1111_nyas_12953 crossref_primary_10_3390_ijms21124506 crossref_primary_10_3892_ijo_2016_3450 crossref_primary_10_1016_j_isci_2021_102315 crossref_primary_10_1038_s41467_019_10345_3 crossref_primary_10_1038_s41419_022_04789_7 crossref_primary_10_1080_15548627_2016_1265192 crossref_primary_10_1016_j_arr_2025_102842 crossref_primary_10_1080_15548627_2021_1895658 crossref_primary_10_1177_15353702231220667 crossref_primary_10_1038_s41418_018_0266_5 crossref_primary_10_1074_jbc_RA118_005698 crossref_primary_10_7554_eLife_51918 crossref_primary_10_1074_jbc_M116_739821 crossref_primary_10_15252_embj_201899847 crossref_primary_10_1093_nar_gkad684 crossref_primary_10_1080_15548627_2021_1877934 crossref_primary_10_1083_jcb_202205123 crossref_primary_10_1080_14789450_2022_2052850 crossref_primary_10_1074_jbc_M117_817510 crossref_primary_10_3390_ijms19123940 crossref_primary_10_1074_jbc_M117_817999 crossref_primary_10_3390_plants9121771 crossref_primary_10_3390_cancers12010048 crossref_primary_10_1016_j_celrep_2025_115282 crossref_primary_10_1016_j_jmb_2019_12_028 crossref_primary_10_1016_j_molcel_2016_05_013 crossref_primary_10_1073_pnas_1614364114 crossref_primary_10_1186_s12933_015_0252_x crossref_primary_10_1038_ncb3423 crossref_primary_10_1080_15548627_2017_1391970 crossref_primary_10_1146_annurev_cellbio_120219_035530 crossref_primary_10_1002_1873_3468_14719 crossref_primary_10_1016_j_advms_2019_03_004 crossref_primary_10_1016_j_bbamcr_2015_09_032 crossref_primary_10_1093_jb_mvw085 crossref_primary_10_1242_jcs_194373 crossref_primary_10_1016_j_molcel_2020_10_030 crossref_primary_10_1007_s00204_018_2237_5 crossref_primary_10_1016_j_bbrc_2024_151102 crossref_primary_10_1038_ncb3430 crossref_primary_10_1111_febs_14932 crossref_primary_10_1016_j_bbagen_2021_129858 crossref_primary_10_1093_pcp_pcy096 crossref_primary_10_1080_15548627_2015_1091141 crossref_primary_10_1074_jbc_RA119_008709 crossref_primary_10_3389_fmicb_2018_00206 crossref_primary_10_26508_lsa_201900340 crossref_primary_10_1016_j_jmb_2025_169219 crossref_primary_10_1016_j_matbio_2021_02_004 crossref_primary_10_1016_j_canlet_2024_216779 crossref_primary_10_1038_s41467_023_38294_y crossref_primary_10_1038_s42003_021_01992_8 crossref_primary_10_1083_jcb_201809032 crossref_primary_10_1038_s41418_019_0444_0 crossref_primary_10_1038_s43587_021_00098_4 crossref_primary_10_1038_s41586_025_09234_1 crossref_primary_10_1371_journal_pone_0154820 crossref_primary_10_3390_cells11233813 crossref_primary_10_1016_j_jmb_2019_05_012 crossref_primary_10_1146_annurev_cellbio_100818_125300 crossref_primary_10_1016_j_jmb_2019_05_010 crossref_primary_10_1038_nrm_2016_74 crossref_primary_10_3389_fcell_2021_766142 crossref_primary_10_1016_j_molcel_2019_01_035 crossref_primary_10_1074_jbc_RA120_013565 crossref_primary_10_26508_lsa_202201640 crossref_primary_10_1016_j_devcel_2019_07_009 crossref_primary_10_1172_JCI86028 crossref_primary_10_15252_embj_201694574 crossref_primary_10_1074_jbc_M115_699124 crossref_primary_10_1080_15384101_2015_1084206 crossref_primary_10_1016_j_jjcc_2019_09_019 crossref_primary_10_1146_annurev_pharmtox_010715_103101 crossref_primary_10_1242_jcs_221747 crossref_primary_10_3390_cells11040620 crossref_primary_10_1007_s10753_024_02156_6 crossref_primary_10_1155_2019_1608787 crossref_primary_10_1016_j_cell_2024_08_020 crossref_primary_10_1007_s00401_019_02046_4 crossref_primary_10_1083_jcb_202103030 crossref_primary_10_1186_s13046_019_1048_8 crossref_primary_10_1016_j_ceb_2021_01_004 crossref_primary_10_3389_fimmu_2018_00766 crossref_primary_10_1016_j_bbrc_2024_151219 crossref_primary_10_1016_j_ceb_2022_102115 crossref_primary_10_1038_s41467_024_45863_2 crossref_primary_10_1016_j_jmb_2020_01_015 crossref_primary_10_1038_ja_2017_104 crossref_primary_10_1242_jcs_217364 crossref_primary_10_3390_cells5020024 crossref_primary_10_1038_s41467_023_40530_4 crossref_primary_10_5483_BMBRep_2016_49_2_265 crossref_primary_10_1007_s00281_024_01018_5 crossref_primary_10_1007_s00294_019_01050_1 crossref_primary_10_7554_eLife_93232_3 crossref_primary_10_1113_JP287635 crossref_primary_10_1007_s00018_024_05556_x crossref_primary_10_1042_EBC20170035 crossref_primary_10_1002_idm2_70000 crossref_primary_10_1080_15548627_2017_1380757 crossref_primary_10_1111_febs_15824 crossref_primary_10_15252_embj_2019103649 crossref_primary_10_1242_jcs_163758 crossref_primary_10_3389_fcell_2019_00373 crossref_primary_10_1091_mbc_E22_09_0432 crossref_primary_10_1016_j_bbrc_2018_05_123 crossref_primary_10_1016_j_nbd_2021_105400 crossref_primary_10_1016_j_jmb_2017_01_006 crossref_primary_10_1038_s44318_024_00091_8 crossref_primary_10_1016_j_jmb_2017_01_003 crossref_primary_10_3390_cells10092328 crossref_primary_10_3390_jof9111083 crossref_primary_10_1080_15548627_2023_2214029 crossref_primary_10_1016_j_cub_2025_03_043 crossref_primary_10_1080_15548627_2018_1467199 crossref_primary_10_1080_15548627_2019_1615302 crossref_primary_10_1002_1873_3468_12916 crossref_primary_10_1080_15548627_2024_2447207 crossref_primary_10_1038_nrgastro_2016_185 crossref_primary_10_1038_nrm4013 crossref_primary_10_1007_s10495_018_1489_0 crossref_primary_10_3892_ijmm_2015_2425 crossref_primary_10_1016_j_tcb_2016_03_006 crossref_primary_10_1080_15548627_2021_1997305 crossref_primary_10_1038_s41556_019_0459_2 crossref_primary_10_1073_pnas_1711017115 crossref_primary_10_1080_15548627_2021_1872886 crossref_primary_10_7554_eLife_71642 crossref_primary_10_1038_s41388_018_0345_6 crossref_primary_10_1111_acel_12820 crossref_primary_10_1111_tra_12805 crossref_primary_10_3390_cancers13061211 crossref_primary_10_1073_pnas_1805032115 crossref_primary_10_1111_nyas_13549 crossref_primary_10_3390_cells4040596 crossref_primary_10_1083_jcb_201602064 crossref_primary_10_1016_j_ijbiomac_2024_130379 crossref_primary_10_1080_15548627_2019_1668228 crossref_primary_10_1016_j_ejphar_2025_178007 crossref_primary_10_1016_j_tibs_2020_12_013 crossref_primary_10_1126_science_aau9263 crossref_primary_10_1371_journal_pgen_1009255 crossref_primary_10_1038_s41598_024_64493_8 crossref_primary_10_1016_j_tibs_2024_10_012 crossref_primary_10_1083_jcb_201706164 crossref_primary_10_1096_fj_201701253R crossref_primary_10_1016_j_molcel_2015_07_021 crossref_primary_10_1016_j_tcb_2022_08_006 crossref_primary_10_1016_j_devcel_2017_11_024 crossref_primary_10_1111_1462_2920_15753 crossref_primary_10_1016_j_bbrc_2018_04_114 crossref_primary_10_1038_s41467_020_17163_y crossref_primary_10_1093_abbs_gmw057 crossref_primary_10_1080_15548627_2018_1539590 crossref_primary_10_1093_mam_ozae102 crossref_primary_10_1074_jbc_RA118_002829 crossref_primary_10_1146_annurev_arplant_042817_040606 crossref_primary_10_1002_med_21662 crossref_primary_10_3390_cells8091071 crossref_primary_10_1083_jcb_201910063 crossref_primary_10_1080_15548627_2018_1507440 crossref_primary_10_3390_ijms19103020 crossref_primary_10_3389_fmolb_2019_00040 crossref_primary_10_15252_embj_2019102586 crossref_primary_10_1016_j_bbrc_2015_09_153 crossref_primary_10_3389_fpls_2022_835738 crossref_primary_10_1007_s12268_017_0868_3 crossref_primary_10_1016_j_bbamcr_2017_07_008 crossref_primary_10_1016_j_molcel_2023_04_022 crossref_primary_10_1016_j_ceb_2023_102257 crossref_primary_10_1083_jcb_201806127 crossref_primary_10_1165_rcmb_2016_0045PS crossref_primary_10_3390_diseases7010015 crossref_primary_10_1080_27694127_2023_2188523 crossref_primary_10_7554_eLife_93232 crossref_primary_10_1016_j_mcn_2018_04_009 crossref_primary_10_1083_jcb_201804185 crossref_primary_10_1038_s41598_021_91480_0 crossref_primary_10_3389_fpls_2019_01192 crossref_primary_10_1038_s41467_018_05278_2 crossref_primary_10_1242_dev_203046 crossref_primary_10_1016_j_chemphyslip_2018_11_001 crossref_primary_10_1186_s12943_024_01934_y crossref_primary_10_1038_s41467_018_06115_2 crossref_primary_10_1016_j_molp_2018_11_011 crossref_primary_10_12677_bp_2025_152019 crossref_primary_10_1016_j_devcel_2017_02_016 crossref_primary_10_1016_j_molcel_2022_02_018 crossref_primary_10_1083_jcb_202408061 crossref_primary_10_1002_2211_5463_12355 crossref_primary_10_1016_j_bbrc_2022_05_021 crossref_primary_10_1083_jcb_202407193 crossref_primary_10_1242_jcs_255802 crossref_primary_10_1007_s00018_015_2034_8 crossref_primary_10_3390_cells12060956 crossref_primary_10_1038_s41572_022_00365_7 crossref_primary_10_1007_s10495_021_01687_9 crossref_primary_10_1016_j_bioactmat_2021_02_015 crossref_primary_10_1002_jnr_25309 crossref_primary_10_1038_s41419_023_06154_8 crossref_primary_10_15252_embj_2019102608 crossref_primary_10_1007_s13277_015_4125_4 crossref_primary_10_1080_15548627_2019_1646540 crossref_primary_10_1111_febs_14589 crossref_primary_10_1016_j_molcel_2019_06_028 crossref_primary_10_3389_fimmu_2022_842077 crossref_primary_10_1002_1873_3468_14589 crossref_primary_10_1093_pcp_pcaa162 crossref_primary_10_1073_pnas_1701030114 crossref_primary_10_1016_j_ceb_2016_03_009 crossref_primary_10_1016_j_jbc_2025_108493 crossref_primary_10_3390_cells8020103 crossref_primary_10_1016_j_cub_2018_01_073 crossref_primary_10_1002_mbo3_359 crossref_primary_10_1177_15593258221100593 crossref_primary_10_1080_15548627_2019_1646552 crossref_primary_10_1016_j_devcel_2019_06_016 crossref_primary_10_1016_j_tcb_2015_08_010 crossref_primary_10_1007_s00018_016_2224_z crossref_primary_10_1038_s41586_023_06090_9 crossref_primary_10_1038_s41556_018_0037_z crossref_primary_10_1002_jcp_26137 crossref_primary_10_1074_jbc_R117_804641 crossref_primary_10_1016_j_bbrc_2019_09_002 crossref_primary_10_1016_j_lfs_2022_120491 crossref_primary_10_3390_cells9112349 crossref_primary_10_1016_j_jhep_2019_08_026 crossref_primary_10_1073_pnas_2117554119 crossref_primary_10_3389_fcell_2021_814955 crossref_primary_10_3390_ijms241310499 crossref_primary_10_1080_15548627_2020_1719746 crossref_primary_10_1016_j_devcel_2024_05_004 crossref_primary_10_1111_febs_16986 crossref_primary_10_3390_ijms24129829 crossref_primary_10_1111_febs_14448 crossref_primary_10_1016_j_bbrc_2024_150628 crossref_primary_10_1016_j_pbi_2021_102106 crossref_primary_10_1016_j_prostaglandins_2015_12_006 crossref_primary_10_3390_molecules25102352 crossref_primary_10_1016_j_bbrc_2019_02_084 crossref_primary_10_1016_j_bbrc_2021_02_141 crossref_primary_10_1172_JCI163584 crossref_primary_10_1002_wrna_1522 crossref_primary_10_1080_15548627_2016_1222992 crossref_primary_10_1038_s41419_022_04824_7 crossref_primary_10_1002_jcp_27329 crossref_primary_10_1242_jcs_189332 crossref_primary_10_1080_15548627_2022_2063494 crossref_primary_10_1007_s41048_020_00113_y crossref_primary_10_1016_j_cell_2022_03_005 crossref_primary_10_1016_j_rechem_2025_102601 crossref_primary_10_1080_15548627_2020_1783118 crossref_primary_10_1007_s10555_018_9727_z crossref_primary_10_1242_jcs_237156 crossref_primary_10_1016_j_scitotenv_2020_142355 crossref_primary_10_1016_j_tibs_2020_07_006 crossref_primary_10_3390_ijms22126200 crossref_primary_10_1089_ars_2020_8176 crossref_primary_10_1042_EBC20170092 crossref_primary_10_1016_j_toxlet_2022_05_010 crossref_primary_10_3389_fcell_2020_00090 crossref_primary_10_1016_j_celrep_2024_114255 crossref_primary_10_1080_15548627_2021_1971380 crossref_primary_10_3389_fmolb_2022_912848 crossref_primary_10_15252_embj_201796697 crossref_primary_10_3389_fcell_2021_771353 crossref_primary_10_1007_s12010_023_04464_3 crossref_primary_10_1080_15548627_2016_1207015 crossref_primary_10_1002_pro_3623 crossref_primary_10_1038_s44319_024_00275_7 crossref_primary_10_15252_embr_202255192 crossref_primary_10_1080_15548627_2016_1217381 crossref_primary_10_1016_j_molcel_2020_07_019 crossref_primary_10_1074_jbc_M117_783126 crossref_primary_10_1016_j_aquatox_2017_12_014 crossref_primary_10_1002_2211_5463_13340 crossref_primary_10_3390_antiox10111736 crossref_primary_10_3390_ijms19113466 crossref_primary_10_1016_j_bbrc_2021_03_033 crossref_primary_10_4254_wjh_v13_i1_6 crossref_primary_10_1007_s00253_021_11394_9 crossref_primary_10_1080_15548627_2020_1725377 crossref_primary_10_1371_journal_pgen_1005390 crossref_primary_10_1073_pnas_2020215118 crossref_primary_10_1083_jcb_202103178 crossref_primary_10_1073_pnas_2221929120 crossref_primary_10_1038_nature14532 crossref_primary_10_1097_CM9_0000000000002263 crossref_primary_10_3390_cells9030553 crossref_primary_10_1016_j_ceb_2020_01_011 crossref_primary_10_1016_j_bbrc_2017_12_163 crossref_primary_10_1007_s12264_023_01120_y
Cites_doi	10.1083/jcb.201402054 10.1371/journal.pone.0015650 10.1038/ncb2979 10.4161/auto.8901 10.1016/j.febslet.2014.09.032 10.1083/jcb.147.2.435 10.4161/auto.8.2.18373 10.1006/bbrc.1995.1636 10.1111/j.1600-0854.2004.00245.x 10.1016/j.cell.2005.11.047 10.1038/nrm2708 10.1002/yea.1142 10.1242/jcs.154716 10.1074/jbc.273.7.3963 10.1111/j.1365-2443.2008.01238.x 10.1016/0014-5793(93)80398-E 10.1016/j.tcb.2011.07.004 10.1016/j.gde.2014.04.003 10.1371/journal.pone.0017412 10.1038/embor.2013.40 10.1242/jcs.133090 10.1002/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2-2 10.1016/j.febslet.2010.01.018 10.1128/MCB.8.11.4936 10.1016/j.cell.2014.05.048 10.1083/jcb.119.2.301 10.1083/jcb.201402128 10.4161/auto.3586 10.1093/genetics/144.4.1425 10.1093/genetics/102.4.665 10.1038/nature14498 10.1093/genetics/122.1.19
ContentType	Journal Article
Copyright	Springer Nature Limited 2015 COPYRIGHT 2015 Nature Publishing Group Copyright Nature Publishing Group Jun 18, 2015
Copyright_xml	– notice: Springer Nature Limited 2015 – notice: COPYRIGHT 2015 Nature Publishing Group – notice: Copyright Nature Publishing Group Jun 18, 2015
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7X8
DOI	10.1038/nature14506
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection (ProQuest) ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database (ProQuest) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Technology Collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database ProQuest Health & Medical Collection Medical Database Psychology Database Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database (ProQuest) Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) University of Michigan Technology Collection Technology Research Database ProQuest One Academic Middle East (New) SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic Agricultural Science Database
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PATMY name: Environmental Science Database url: http://search.proquest.com/environmentalscience sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Physics
EISSN	1476-4687
EndPage	362
ExternalDocumentID	3722901191 A463816776 26040717 10_1038_nature14506
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- --Z -DZ -ET -~X .55 .CO .XZ 00M 07C 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 3V. 4.4 41X 53G 5RE 6TJ 70F 7RV 7X2 7X7 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z A8Z AAEEF AAHBH AAHTB AAIKC AAKAB AAKAS AAMNW AASDW AAYEP AAYZH AAZLF ABAWZ ABDBF ABDQB ABFSI ABIVO ABJCF ABJNI ABLJU ABOCM ABPEJ ABPPZ ABUWG ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACUHS ACWUS ADBBV ADFRT ADUKH ADYSU ADZCM AENEX AEUYN AFFNX AFKRA AFLOW AFRAH AFSHS AGAYW AGHSJ AGHTU AGNAY AGSOS AHMBA AHSBF AIDAL AIDUJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH APEBS ARAPS ARMCB ARTTT ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN AZQEC B0M BBNVY BCU BDKGC BEC BENPR BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BLC BPHCQ BVXVI CCPQU CJ0 CS3 D1I D1J D1K DO4 DU5 DWQXO E.- E.L EAD EAP EAS EAZ EBC EBD EBO EBS ECC EE. EJD EMB EMF EMH EMK EMOBN EPL EPS ESE ESN ESX EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH HCIFZ HG6 HMCUK HVGLF HZ~ I-F IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR ITC K6- KB. KOO L6V L7B LK5 LK8 LSO M0K M0L M1P M2M M2O M2P M7P M7R M7S N9A NAPCQ NEJ NEPJS O9- OBC OES OHH OMK OVD P-O P2P P62 PATMY PCBAR PDBOC PKN PM3 PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SOJ SV3 TAE TAOOD TBHMF TDRGL TEORI TH9 TN5 TSG TUS TWZ U5U UIG UKHRP UKR UMD UQL VQA VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YCJ YFH YIF YIN YNT YOC YQT YR2 YR5 YXB YZZ Z5M ZCA ZE2 ZKB ~02 ~7V ~88 ~8M ~KM AARCD AAYXX ABFSG ABUFD ACSTC ADXHL AETEA AFANA AFFHD ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB ADGHP CGR CUY CVF ECM EIF NPM ACMFV AEIIB PMFND 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 SOI 7X8 ESTFP
ID	FETCH-LOGICAL-c667t-3c9fcb22e5d6a423d81bdfa0c0789da5fdeababa8fd85c26618e1b5a2de868eb3
IEDL.DBID	P5Z
ISICitedReferencesCount	500
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000356425400057&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0028-0836 1476-4687
IngestDate	Sun Nov 09 10:15:20 EST 2025 Sat Nov 29 15:03:35 EST 2025 Sat Nov 29 13:11:31 EST 2025 Sat Nov 29 11:27:21 EST 2025 Tue Jun 10 15:33:04 EDT 2025 Sun Nov 23 09:05:09 EST 2025 Wed Nov 26 09:41:38 EST 2025 Mon Jul 21 06:03:32 EDT 2025 Tue Nov 18 21:58:02 EST 2025 Sat Nov 29 05:17:52 EST 2025 Fri Feb 21 02:37:35 EST 2025
IsPeerReviewed	true
IsScholarly	true
Issue	7556
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c667t-3c9fcb22e5d6a423d81bdfa0c0789da5fdeababa8fd85c26618e1b5a2de868eb3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
PMID	26040717
PQID	1690372129
PQPubID	40569
PageCount	4
ParticipantIDs	proquest_miscellaneous_1690209000 proquest_journals_1690372129 gale_infotracmisc_A463816776 gale_infotracgeneralonefile_A463816776 gale_infotraccpiq_463816776 gale_infotracacademiconefile_A463816776 gale_incontextgauss_ISR_A463816776 pubmed_primary_26040717 crossref_citationtrail_10_1038_nature14506 crossref_primary_10_1038_nature14506 springer_journals_10_1038_nature14506
PublicationCentury	2000
PublicationDate	2015-06-18
PublicationDateYYYYMMDD	2015-06-18
PublicationDate_xml	– month: 06 year: 2015 text: 2015-06-18 day: 18
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationSubtitle	International weekly journal of science
PublicationTitle	Nature (London)
PublicationTitleAbbrev	Nature
PublicationTitleAlternate	Nature
PublicationYear	2015
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Voeltz, Prinz, Shibata, Rist, Rapoport (CR13) 2006; 124 Friedman, Voeltz (CR12) 2011; 21 James, Halladay, Craig (CR27) 1996; 144 Tanaka (CR31) 2014; 207 Noda, Ohsumi (CR8) 1998; 273 Mijaljica, Devenish (CR19) 2013; 126 Stolz, Ernst, Dikic (CR3) 2014; 16 Noda, Ohsumi, Inagaki (CR6) 2010; 584 Takeshige, Baba, Tsuboi, Noda, Ohsumi (CR14) 1992; 119 Nakatogawa, Suzuki, Kamada, Ohsumi (CR1) 2009; 10 Okamoto (CR4) 2014; 205 Nakatogawa, Ishii, Asai, Ohsumi (CR25) 2012; 8 Sikorski, Hieter (CR26) 1989; 122 Noda (CR30) 2008; 13 Hamasaki, Noda, Baba, Ohsumi (CR9) 2005; 6 Shoji, Kikuma, Arioka, Kitamoto (CR18) 2010; 5 Robinson, Klionsky, Banta, Emr (CR23) 1988; 8 Farré, Burkenroad, Burnett, Subramani (CR7) 2013; 14 Park (CR17) 2009; 5 Noda, Matsuura, Wada, Ohsumi (CR32) 1995; 210 Janke (CR24) 2004; 21 CR5 Schneider, Cuervo (CR2) 2014; 26 Jones, Zubenko, Parker (CR22) 1982; 102 Schuck, Gallagher, Walter (CR10) 2014; 127 Tsukada, Ohsumi (CR16) 1993; 333 Brachmann (CR21) 1998; 14 Mochida, Ohsumi, Nakatogawa (CR28) 2014; 588 Suzuki, Onodera, Ohsumi (CR29) 2011; 6 Lu, Psakhye, Jentsch (CR20) 2014; 158 Kirisako (CR11) 1999; 147 Kvam, Goldfarb (CR15) 2007; 3 GK Voeltz (BFnature14506_CR13) 2006; 124 CB Brachmann (BFnature14506_CR21) 1998; 14 JS Robinson (BFnature14506_CR23) 1988; 8 T Noda (BFnature14506_CR32) 1995; 210 SW Suzuki (BFnature14506_CR29) 2011; 6 JY Shoji (BFnature14506_CR18) 2010; 5 T Kirisako (BFnature14506_CR11) 1999; 147 K Okamoto (BFnature14506_CR4) 2014; 205 K Lu (BFnature14506_CR20) 2014; 158 K Takeshige (BFnature14506_CR14) 1992; 119 D Mijaljica (BFnature14506_CR19) 2013; 126 H Nakatogawa (BFnature14506_CR1) 2009; 10 T Noda (BFnature14506_CR8) 1998; 273 JL Schneider (BFnature14506_CR2) 2014; 26 YE Park (BFnature14506_CR17) 2009; 5 C Tanaka (BFnature14506_CR31) 2014; 207 E Kvam (BFnature14506_CR15) 2007; 3 M Tsukada (BFnature14506_CR16) 1993; 333 S Schuck (BFnature14506_CR10) 2014; 127 JC Farré (BFnature14506_CR7) 2013; 14 M Hamasaki (BFnature14506_CR9) 2005; 6 JR Friedman (BFnature14506_CR12) 2011; 21 K Mochida (BFnature14506_CR28) 2014; 588 RS Sikorski (BFnature14506_CR26) 1989; 122 A Stolz (BFnature14506_CR3) 2014; 16 NN Noda (BFnature14506_CR30) 2008; 13 H Nakatogawa (BFnature14506_CR25) 2012; 8 BFnature14506_CR5 NN Noda (BFnature14506_CR6) 2010; 584 EW Jones (BFnature14506_CR22) 1982; 102 P James (BFnature14506_CR27) 1996; 144 C Janke (BFnature14506_CR24) 2004; 21 22240591 - Autophagy. 2012 Feb 1;8(2):177-86 3062374 - Mol Cell Biol. 1988 Nov;8(11):4936-48 21900009 - Trends Cell Biol. 2011 Dec;21(12):709-17 19550147 - Autophagy. 2009 Aug;5(6):795-804 19491929 - Nat Rev Mol Cell Biol. 2009 Jul;10 (7):458-67 24013549 - J Cell Sci. 2013 Oct 1;126(Pt 19):4325-30 17204844 - Autophagy. 2007 Mar-Apr;3(2):85-92 8978031 - Genetics. 1996 Dec;144(4):1425-36 15334558 - Yeast. 2004 Aug;21(11):947-62 25281559 - FEBS Lett. 2014 Nov 3;588(21):3862-9 2659436 - Genetics. 1989 May;122(1):19-27 10525546 - J Cell Biol. 1999 Oct 18;147(2):435-46 25042851 - Cell. 2014 Jul 31;158(3):549-63 24875736 - Nat Cell Biol. 2014 Jun;16(6):495-501 25052096 - J Cell Sci. 2014 Sep 15;127(Pt 18):4078-88 7741731 - Biochem Biophys Res Commun. 1995 May 5;210(1):126-32 26040720 - Nature. 2015 Jun 18;522(7556):354-8 16469703 - Cell. 2006 Feb 10;124(3):573-86 23559066 - EMBO Rep. 2013 May;14 (5):441-9 6764901 - Genetics. 1982 Dec;102(4):665-77 9483801 - Yeast. 1998 Jan 30;14(2):115-32 20083108 - FEBS Lett. 2010 Apr 2;584(7):1379-85 8224160 - FEBS Lett. 1993 Oct 25;333(1-2):169-74 21364763 - PLoS One. 2011 Feb 25;6(2):e17412 19021777 - Genes Cells. 2008 Dec;13(12 ):1211-8 15569245 - Traffic. 2005 Jan;6(1):56-65 21187926 - PLoS One. 2010 Dec 20;5(12):e15650 24862571 - J Cell Biol. 2014 May 26;205(4):435-45 9461583 - J Biol Chem. 1998 Feb 13;273(7):3963-6 26040721 - Nature. 2015 Jun 18;522(7556):291-2 1400575 - J Cell Biol. 1992 Oct;119(2):301-11 24907664 - Curr Opin Genet Dev. 2014 Jun;26:16-23 25287303 - J Cell Biol. 2014 Oct 13;207 (1):91-105
References_xml	– volume: 205 start-page: 435 year: 2014 end-page: 445 ident: CR4 article-title: Organellophagy: eliminating cellular building blocks via selective autophagy publication-title: J. Cell Biol. doi: 10.1083/jcb.201402054 – volume: 5 start-page: e15650 year: 2010 ident: CR18 article-title: Macroautophagy-mediated degradation of whole nuclei in the filamentous fungus publication-title: PLoS ONE doi: 10.1371/journal.pone.0015650 – volume: 16 start-page: 495 year: 2014 end-page: 501 ident: CR3 article-title: Cargo recognition and trafficking in selective autophagy publication-title: Nature Cell Biol. doi: 10.1038/ncb2979 – volume: 5 start-page: 795 year: 2009 end-page: 804 ident: CR17 article-title: Autophagic degradation of nuclear components in mammalian cells publication-title: Autophagy doi: 10.4161/auto.8901 – volume: 588 start-page: 3862 year: 2014 end-page: 3869 ident: CR28 article-title: Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of α-mannosidase under nitrogen starvation conditions publication-title: FEBS Lett. doi: 10.1016/j.febslet.2014.09.032 – volume: 147 start-page: 435 year: 1999 end-page: 446 ident: CR11 article-title: Formation process of autophagosome is traced with Apg8/Aut7p in yeast publication-title: J. Cell Biol. doi: 10.1083/jcb.147.2.435 – volume: 8 start-page: 177 year: 2012 end-page: 186 ident: CR25 article-title: Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis publication-title: Autophagy doi: 10.4161/auto.8.2.18373 – volume: 210 start-page: 126 year: 1995 end-page: 132 ident: CR32 article-title: Novel system for monitoring autophagy in the yeast publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1995.1636 – volume: 6 start-page: 56 year: 2005 end-page: 65 ident: CR9 article-title: Starvation triggers the delivery of the endoplasmic reticulum to the vacuole via autophagy in yeast publication-title: Traffic doi: 10.1111/j.1600-0854.2004.00245.x – volume: 124 start-page: 573 year: 2006 end-page: 586 ident: CR13 article-title: A class of membrane proteins shaping the tubular endoplasmic reticulum publication-title: Cell doi: 10.1016/j.cell.2005.11.047 – volume: 10 start-page: 458 year: 2009 end-page: 467 ident: CR1 article-title: Dynamics and diversity in autophagy mechanisms: lessons from yeast publication-title: Nature Rev. Mol. Cell Biol. doi: 10.1038/nrm2708 – volume: 21 start-page: 947 year: 2004 end-page: 962 ident: CR24 article-title: A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes publication-title: Yeast doi: 10.1002/yea.1142 – volume: 127 start-page: 4078 year: 2014 end-page: 4088 ident: CR10 article-title: ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery publication-title: J. Cell Sci. doi: 10.1242/jcs.154716 – volume: 273 start-page: 3963 year: 1998 end-page: 3966 ident: CR8 article-title: Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.7.3963 – volume: 144 start-page: 1425 year: 1996 end-page: 1436 ident: CR27 article-title: Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast publication-title: Genetics – volume: 13 start-page: 1211 year: 2008 end-page: 1218 ident: CR30 article-title: Structural basis of target recognition by Atg8/LC3 during selective autophagy publication-title: Genes Cells doi: 10.1111/j.1365-2443.2008.01238.x – volume: 333 start-page: 169 year: 1993 end-page: 174 ident: CR16 article-title: Isolation and characterization of autophagy-defective mutants of publication-title: FEBS Lett. doi: 10.1016/0014-5793(93)80398-E – volume: 21 start-page: 709 year: 2011 end-page: 717 ident: CR12 article-title: The ER in 3D: a multifunctional dynamic membrane network publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2011.07.004 – volume: 122 start-page: 19 year: 1989 end-page: 27 ident: CR26 article-title: A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in publication-title: Genetics – volume: 26 start-page: 16 year: 2014 end-page: 23 ident: CR2 article-title: Autophagy and human disease: emerging themes publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2014.04.003 – volume: 6 start-page: e17412 year: 2011 ident: CR29 article-title: Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction publication-title: PLoS ONE doi: 10.1371/journal.pone.0017412 – volume: 102 start-page: 665 year: 1982 end-page: 677 ident: CR22 article-title: gene function is required for expression of several vacuolar hydrolases in publication-title: Genetics – volume: 14 start-page: 441 year: 2013 end-page: 449 ident: CR7 article-title: Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11 publication-title: EMBO Rep. doi: 10.1038/embor.2013.40 – volume: 126 start-page: 4325 year: 2013 end-page: 4330 ident: CR19 article-title: Nucleophagy at a glance publication-title: J. Cell Sci. doi: 10.1242/jcs.133090 – volume: 14 start-page: 115 year: 1998 end-page: 132 ident: CR21 article-title: Designer deletion strains derived from S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications publication-title: Yeast doi: 10.1002/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2-2 – volume: 584 start-page: 1379 year: 2010 end-page: 1385 ident: CR6 article-title: Atg8-family interacting motif crucial for selective autophagy publication-title: FEBS Lett. doi: 10.1016/j.febslet.2010.01.018 – volume: 8 start-page: 4936 year: 1988 end-page: 4948 ident: CR23 article-title: Protein sorting in : isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.8.11.4936 – ident: CR5 – volume: 158 start-page: 549 year: 2014 end-page: 563 ident: CR20 article-title: Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family publication-title: Cell doi: 10.1016/j.cell.2014.05.048 – volume: 119 start-page: 301 year: 1992 end-page: 311 ident: CR14 article-title: Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction publication-title: J. Cell Biol. doi: 10.1083/jcb.119.2.301 – volume: 207 start-page: 91 year: 2014 end-page: 105 ident: CR31 article-title: Hrr25 triggers selective autophagy-related pathways by phosphorylating receptor proteins publication-title: J. Cell Biol. doi: 10.1083/jcb.201402128 – volume: 3 start-page: 85 year: 2007 end-page: 92 ident: CR15 article-title: Nucleus-vacuole junctions and piecemeal microautophagy of the nucleus in publication-title: Autophagy doi: 10.4161/auto.3586 – volume: 158 start-page: 549 year: 2014 ident: BFnature14506_CR20 publication-title: Cell doi: 10.1016/j.cell.2014.05.048 – volume: 119 start-page: 301 year: 1992 ident: BFnature14506_CR14 publication-title: J. Cell Biol. doi: 10.1083/jcb.119.2.301 – volume: 6 start-page: e17412 year: 2011 ident: BFnature14506_CR29 publication-title: PLoS ONE doi: 10.1371/journal.pone.0017412 – volume: 144 start-page: 1425 year: 1996 ident: BFnature14506_CR27 publication-title: Genetics doi: 10.1093/genetics/144.4.1425 – volume: 102 start-page: 665 year: 1982 ident: BFnature14506_CR22 publication-title: Genetics doi: 10.1093/genetics/102.4.665 – ident: BFnature14506_CR5 doi: 10.1038/nature14498 – volume: 147 start-page: 435 year: 1999 ident: BFnature14506_CR11 publication-title: J. Cell Biol. doi: 10.1083/jcb.147.2.435 – volume: 16 start-page: 495 year: 2014 ident: BFnature14506_CR3 publication-title: Nature Cell Biol. doi: 10.1038/ncb2979 – volume: 6 start-page: 56 year: 2005 ident: BFnature14506_CR9 publication-title: Traffic doi: 10.1111/j.1600-0854.2004.00245.x – volume: 207 start-page: 91 year: 2014 ident: BFnature14506_CR31 publication-title: J. Cell Biol. doi: 10.1083/jcb.201402128 – volume: 14 start-page: 115 year: 1998 ident: BFnature14506_CR21 publication-title: Yeast doi: 10.1002/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2-2 – volume: 13 start-page: 1211 year: 2008 ident: BFnature14506_CR30 publication-title: Genes Cells doi: 10.1111/j.1365-2443.2008.01238.x – volume: 124 start-page: 573 year: 2006 ident: BFnature14506_CR13 publication-title: Cell doi: 10.1016/j.cell.2005.11.047 – volume: 126 start-page: 4325 year: 2013 ident: BFnature14506_CR19 publication-title: J. Cell Sci. doi: 10.1242/jcs.133090 – volume: 127 start-page: 4078 year: 2014 ident: BFnature14506_CR10 publication-title: J. Cell Sci. doi: 10.1242/jcs.154716 – volume: 8 start-page: 177 year: 2012 ident: BFnature14506_CR25 publication-title: Autophagy doi: 10.4161/auto.8.2.18373 – volume: 3 start-page: 85 year: 2007 ident: BFnature14506_CR15 publication-title: Autophagy doi: 10.4161/auto.3586 – volume: 584 start-page: 1379 year: 2010 ident: BFnature14506_CR6 publication-title: FEBS Lett. doi: 10.1016/j.febslet.2010.01.018 – volume: 588 start-page: 3862 year: 2014 ident: BFnature14506_CR28 publication-title: FEBS Lett. doi: 10.1016/j.febslet.2014.09.032 – volume: 210 start-page: 126 year: 1995 ident: BFnature14506_CR32 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1995.1636 – volume: 14 start-page: 441 year: 2013 ident: BFnature14506_CR7 publication-title: EMBO Rep. doi: 10.1038/embor.2013.40 – volume: 205 start-page: 435 year: 2014 ident: BFnature14506_CR4 publication-title: J. Cell Biol. doi: 10.1083/jcb.201402054 – volume: 8 start-page: 4936 year: 1988 ident: BFnature14506_CR23 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.8.11.4936 – volume: 21 start-page: 947 year: 2004 ident: BFnature14506_CR24 publication-title: Yeast doi: 10.1002/yea.1142 – volume: 5 start-page: 795 year: 2009 ident: BFnature14506_CR17 publication-title: Autophagy doi: 10.4161/auto.8901 – volume: 21 start-page: 709 year: 2011 ident: BFnature14506_CR12 publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2011.07.004 – volume: 122 start-page: 19 year: 1989 ident: BFnature14506_CR26 publication-title: Genetics doi: 10.1093/genetics/122.1.19 – volume: 273 start-page: 3963 year: 1998 ident: BFnature14506_CR8 publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.7.3963 – volume: 5 start-page: e15650 year: 2010 ident: BFnature14506_CR18 publication-title: PLoS ONE doi: 10.1371/journal.pone.0015650 – volume: 10 start-page: 458 year: 2009 ident: BFnature14506_CR1 publication-title: Nature Rev. Mol. Cell Biol. doi: 10.1038/nrm2708 – volume: 333 start-page: 169 year: 1993 ident: BFnature14506_CR16 publication-title: FEBS Lett. doi: 10.1016/0014-5793(93)80398-E – volume: 26 start-page: 16 year: 2014 ident: BFnature14506_CR2 publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2014.04.003 – reference: 23559066 - EMBO Rep. 2013 May;14 (5):441-9 – reference: 20083108 - FEBS Lett. 2010 Apr 2;584(7):1379-85 – reference: 17204844 - Autophagy. 2007 Mar-Apr;3(2):85-92 – reference: 21187926 - PLoS One. 2010 Dec 20;5(12):e15650 – reference: 8224160 - FEBS Lett. 1993 Oct 25;333(1-2):169-74 – reference: 21900009 - Trends Cell Biol. 2011 Dec;21(12):709-17 – reference: 15569245 - Traffic. 2005 Jan;6(1):56-65 – reference: 26040721 - Nature. 2015 Jun 18;522(7556):291-2 – reference: 24013549 - J Cell Sci. 2013 Oct 1;126(Pt 19):4325-30 – reference: 21364763 - PLoS One. 2011 Feb 25;6(2):e17412 – reference: 22240591 - Autophagy. 2012 Feb 1;8(2):177-86 – reference: 3062374 - Mol Cell Biol. 1988 Nov;8(11):4936-48 – reference: 25287303 - J Cell Biol. 2014 Oct 13;207 (1):91-105 – reference: 9483801 - Yeast. 1998 Jan 30;14(2):115-32 – reference: 10525546 - J Cell Biol. 1999 Oct 18;147(2):435-46 – reference: 7741731 - Biochem Biophys Res Commun. 1995 May 5;210(1):126-32 – reference: 9461583 - J Biol Chem. 1998 Feb 13;273(7):3963-6 – reference: 25281559 - FEBS Lett. 2014 Nov 3;588(21):3862-9 – reference: 24862571 - J Cell Biol. 2014 May 26;205(4):435-45 – reference: 25042851 - Cell. 2014 Jul 31;158(3):549-63 – reference: 16469703 - Cell. 2006 Feb 10;124(3):573-86 – reference: 24907664 - Curr Opin Genet Dev. 2014 Jun;26:16-23 – reference: 15334558 - Yeast. 2004 Aug;21(11):947-62 – reference: 26040720 - Nature. 2015 Jun 18;522(7556):354-8 – reference: 6764901 - Genetics. 1982 Dec;102(4):665-77 – reference: 25052096 - J Cell Sci. 2014 Sep 15;127(Pt 18):4078-88 – reference: 2659436 - Genetics. 1989 May;122(1):19-27 – reference: 19491929 - Nat Rev Mol Cell Biol. 2009 Jul;10 (7):458-67 – reference: 24875736 - Nat Cell Biol. 2014 Jun;16(6):495-501 – reference: 19550147 - Autophagy. 2009 Aug;5(6):795-804 – reference: 1400575 - J Cell Biol. 1992 Oct;119(2):301-11 – reference: 8978031 - Genetics. 1996 Dec;144(4):1425-36 – reference: 19021777 - Genes Cells. 2008 Dec;13(12 ):1211-8
SSID	ssj0005174
Score	2.6371522
Snippet	In yeast, the novel protein Atg40 is enriched in the cortical and cytoplasmic endoplasmic reticulum (ER), and loads these ER subdomains into autophagosomes to... Macroautophagy (hereafter referred to as autophagy) degrades various intracellular constituents to regulate a wide range of cellular functions, and is also...
SourceID	proquest gale pubmed crossref springer
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	359
SubjectTerms	14/28 14/34 14/35 14/63 631/80/39/2346 631/80/642/1463 82/1 82/111 82/29 Amino Acid Sequence Autophagy Autophagy (Cytology) Autophagy-Related Protein 8 Family Autophagy-Related Proteins Cell Nucleus - metabolism Cellular biology Endoplasmic reticulum Endoplasmic Reticulum - metabolism Humanities and Social Sciences Kinases letter Membranes Microbial Viability Microtubule-Associated Proteins - metabolism multidisciplinary Neoplasm Proteins - metabolism Nitrogen Nitrogen - deficiency Nitrogen - metabolism Nuclear Envelope - metabolism Observations Phenotype Physiological aspects Properties Protein Binding Proteins Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - deficiency Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Science Vesicular Transport Proteins - metabolism Yeasts Yeasts (Fungi)
Title	Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
URI	https://link.springer.com/article/10.1038/nature14506 https://www.ncbi.nlm.nih.gov/pubmed/26040717 https://www.proquest.com/docview/1690372129 https://www.proquest.com/docview/1690209000
Volume	522
WOSCitedRecordID	wos000356425400057&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAQT databaseName: Nature customDbUrl: eissn: 1476-4687 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: RNT dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.nature.com providerName: Nature Publishing – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: P5Z dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agriculture Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M0K dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database (ProQuest) customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7P dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Earth, Atmospheric & Aquatic Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PCBAR dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/eaasdb providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7S dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PATMY dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7X7 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: KB. dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: BENPR dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Nursing & Allied Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7RV dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2M dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 8C1 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2O dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database (ProQuest) customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2P dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED-xDSRegI2vslEFND6lsCR1EucJddMm0NRSdRsqvESO7VSVIM2WBon_njvH7doy8YIqnVT5nFjx-e7sO_8OYF8w4WVZwFwm_NBlaDEJAzJ0ladYrNDf8JU0xSbifp-PRsnAHrhVNq1yrhONolZTSWfkBxTO6eB2JUg-lpcuVY2i6KotobEBW4SSQAtzEH6_TvFYQ2G29_O8Dj9oYDN9FlKpoyWLtK6XlwzTWqTUGKCT-_879Adwz7qeTreRlW24pYsduGNSQGW1A9t2mVfOW4tF_e4hjNCt1CXuy11zxQTdU6cylXNQSTqiJlQCMf7tKIKcUNgV3UlHF2paolP-cyIdc0eSDhgdUSjTWhCAcl09gouT4_OjT64txuDKKIpnbkcmucyCQIcqEuiDKfR3VS48SXj1SoS50iLDH88VDyWZfa79LBSB0jziuGV_DJvFtNBPwQkiyRlaxUyjQDDBEqlizROWBx10P0TUgvfzCUmlRSqnghk_UhMx7_B0afZasL9gLhuAjpvZXtLMpgR5UVBOzVjUVZV-PhumXRZR9DSOkemNZcqn-EIp7BUFHDahZK1w7q5wynJymS61vl5pHTezdtNj9lYYcWnL1ea5QKVWtVTptTS14MWimXpSulyhp3XDE3hUD7YFTxr5XXwc3MCaTXwLXs0Feunhf3-5Z_8exC7cRR8ypOw5n-_B5uyq1s_htvw1m1RXbdiIh1-JjmJDOVJ-5Ldh6_C4Pxjiv9PDD0h73inRoGfoF0MHROOGnrXNysZ-g-5579sfC2VL6Q
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db5RAEJ_UqtEXtfULWxVNq9WElIMFlgdjGrXppfVibE3ujS67y-USBXrcafpP-Tc6s8CVOxvf-mB4nGGBZXY-dmd-A7AlmHDT1GMOE73AYWgxCQMycJSrWKTQ3-gpaZpNRIMBHw7jLyvwu62FobTKVicaRa0KSXvku3Sc42O44sXvyzOHukbR6WrbQqMWi0N9_gtDtupd_yP-323P2_908uHAaboKODIMo6njyziTqefpQIUCnQmFjpvKhCsJeF2JIFNapHjxTPFAkv3iupcGwlOahxxjTxz3GlxHPR5RClk0jC5SSpZQn5t6QNfnuzVMZ48F1FqpYwGX7UDHEC6dzBqDt3_3f5uqe3Cnca3tvXotrMGKztfhpklxldU6rDVqrLJ3GqztN_dhiG6zLqfFxDElNOh-25XpDIRGwBYzQl0Qo3NbEaSGwlvRXbZ1rooSg44fY2mbGlDaQLVFrgw1J4DoWfUAvl3Jtz6E1bzI9WOwvVByhlY_1SjwTLBYqkjzmGWej-6VCC142wpAIhskdmoI8j0xGQE-TzrSYsHWnLmsAUguZ3tJkpQQpEdOOUMjMauqpH_8NdljIZ0ORxEyvW6YsgIfKEVTgoGvTShgC5wbC5yyHJ8lHeqrBeqo_muXDbO5wIiqSy6SWwFOGtVZJRfSa8GLOZnupHTAXBezmsdzqd-tBY_q9TKfHAzQzSaFBdvtAuoM_vfMPfn3SzyHWwcnn4-So_7gcANuo78cUKZgj2_C6nQy00_hhvw5HVeTZ0YX2HB61SvqD8pBoBg
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6V8hAXoOUVWsCgFgqSFcde25sDQhUlIiqKIh5SxMVd766jSGCncQzqX-PXMbO2UztU3HpAOc54Y-_Oc3f2G4A9wYQTxy6zmej5NkOPSRiQvq0cxUKF8UZPSdNsIhyN-GTSH2_A7_ouDJVV1jbRGGqVSdoj79JxjofpitvvJlVZxPho8HZ-alMHKTpprdtplCJyrM9-YfqWvxke4Vrvu-7g_Zd3H-yqw4AtgyBc2p7sJzJ2Xe2rQGBgoTCIU4lwJIGwK-EnSosYfzxR3Jfky7juxb5wleYBxzwUx70CV0PMMSnxG_vfzstL1hCgq7uBjse7JWRnj_nUZqnhDdd9QsMprp3SGuc3uP0_T9sduFWF3NZhqSNbsKHTbbhuSl9lvg1blXnLrYMKg_vVXZhgOK3ny2xhm6s1GJZbuekYhM7BEgWhMYjpmaUIakPhoxhGWzpV2RyTkR8zaZm7obSxaolUGWpKwNFFfg--Xsq33ofNNEv1Q7DcQHKG0UCsURGYYH2pQs37LHE9DLtE0IHXtTBEskJop0Yh3yNTKeDxqCE5HdhbMc9LYJKL2Z6TVEUE9ZHS6k9FkefR8POn6JAFdGochsj0smJKMvxDKaqrGfjahA7W4txpccr57DRqUF-0qNNy1S4aZrfFiCZNtsm1MEeVSc2jc0nuwLMVmZ6kMsFUZ0XJ4zrUB7cDD0rdWU0OJu5m86ID-7UyNQb_e-Ye_fslnsINVKTo43B0vAM3MYz2qYCwx3dhc7ko9GO4Jn8uZ_niiTELFpxctkL9AcJdqQs
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Receptor-mediated+selective+autophagy+degrades+the+endoplasmic+reticulum+and+the+nucleus&rft.jtitle=Nature+%28London%29&rft.au=Mochida%2C+Keisuke&rft.au=Oikawa%2C+Yu&rft.au=Kimura%2C+Yayoi&rft.au=Kirisako%2C+Hiromi&rft.date=2015-06-18&rft.pub=Nature+Publishing+Group&rft.issn=0028-0836&rft.volume=522&rft.issue=7556&rft.spage=359&rft_id=info:doi/10.1038%2Fnature14506&rft.externalDocID=A463816776
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon