Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires

The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abun...

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Veröffentlicht in:	PLoS computational biology Jg. 13; H. 7; S. e1005572
Hauptverfasser:	Pogorelyy, Mikhail V., Elhanati, Yuval, Marcou, Quentin, Sycheva, Anastasiia L., Komech, Ekaterina A., Nazarov, Vadim I., Britanova, Olga V., Chudakov, Dmitriy M., Mamedov, Ilgar Z., Lebedev, Yury B., Mora, Thierry, Walczak, Aleksandra M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.07.2017 PLOS Public Library of Science (PLoS)
Schlagworte:	Age Aging - genetics Aging - immunology Base Sequence Bioinformatics Biology and Life Sciences Cells, Cultured Cloning Cord blood Data analysis Decay rate Fetuses Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - immunology Gene Rearrangement, T-Lymphocyte - genetics Genetic Variation - genetics Humans Immune system Leukemia Life Sciences Lymphocytes Lymphocytes T Medical research Medicine and Health Sciences Molecular Sequence Data Nucleotides Pathogens Peptides Physiological aspects Receptors Receptors, Antigen, T-Cell - physiology Recombination Recombination, Genetic Research and Analysis Methods Stochastic processes Stochasticity T cell antigen receptors T cell receptors T-Cell Antigen Receptor Specificity - genetics T-cell receptor Twins Twins, Monozygotic - genetics
ISSN:	1553-7358, 1553-734X, 1553-7358
Online-Zugang:	Volltext
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