Ipatasertib plus paclitaxel for PIK3CA/AKT1/PTEN-altered hormone receptor-positive HER2-negative advanced breast cancer: primary results from cohort B of the IPATunity130 randomized phase 3 trial

Purpose PI3K/AKT pathway alterations are frequent in hormone receptor-positive (HR+) breast cancers. IPATunity130 Cohort B investigated ipatasertib–paclitaxel in PI3K pathway-mutant HR+ unresectable locally advanced/metastatic breast cancer (aBC). Methods Cohort B of the randomized, double-blind, pl...

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Vydané v:	Breast Cancer Research and Treatment Ročník 191; číslo 3; s. 565 - 576
Hlavní autori:	Turner, Nicholas, Dent, Rebecca A., O’Shaughnessy, Joyce, Kim, Sung-Bae, Isakoff, Steven J., Barrios, Carlos, Saji, Shigehira, Bondarenko, Igor, Nowecki, Zbigniew, Lian, Qinshu, Reilly, Sarah-Jayne, Hinton, Heather, Wongchenko, Matthew J., Kovic, Bruno, Mani, Aruna, Oliveira, Mafalda
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Springer Science and Business Media LLC 01.02.2022 Springer US Springer Springer Nature B.V
Predmet:	1-Phosphatidylinositol 3-kinase AKT protein AKT1 protein Analysis Antineoplastic Combined Chemotherapy Protocols Antineoplastic Combined Chemotherapy Protocols - adverse effects Breast cancer Breast Neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cancer research Care and treatment Chemotherapy Class I Phosphatidylinositol 3-Kinases Class I Phosphatidylinositol 3-Kinases - genetics Clinical Trial Clinical trials Diarrhea Double-Blind Method Endocrine therapy ErbB-2 protein Female First-line HER2 negative Hormone receptor positive Hormones Humans Ipatasertib Leukocytes (neutrophilic) Mama - Càncer - Tractament Medicaments antineoplàstics - Efectes secundaris Medicine Medicine & Public Health Metastases NCT NCT03337724 neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES] Neoplasm Recurrence, Local Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES] Neutropenia Oncology Other subheadings::Other subheadings::/adverse effects [Other subheadings] Other subheadings::Other subheadings::/drug therapy [Other subheadings] Otros calificadores::Otros calificadores::/efectos adversos [Otros calificadores] Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores] Paclitaxel Paclitaxel - adverse effects Peripheral neuropathy Phosphatidylinositol 3-Kinases PI3K/AKT Piperazines Placebos Proto-Oncogene Proteins c-akt PTEN Phosphohydrolase PTEN Phosphohydrolase - genetics PTEN protein Pyrimidines Receptor, ErbB-2 Receptor, ErbB-2 - genetics terapéutica::terapéutica::farmacoterapia::protocolos antineoplásicos::terapéutica::farmacoterapia::protocolos de quimioterapia antineoplásica combinada [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] Therapeutics::Therapeutics::Drug Therapy::Antineoplastic Protocols::Therapeutics::Drug Therapy::Antineoplastic Combined Chemotherapy Protocols [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] Toxicity HER2 negative Ipatasertib First-line Hormone receptor positive PI3K/AKT
ISSN:	0167-6806, 1573-7217, 1573-7217
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