Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

Cancer-associated systemic inflammation is strongly linked to poor disease outcome in patients with cancer 1 , 2 . For most human epithelial tumour types, high systemic neutrophil-to-lymphocyte ratios are associated with poor overall survival 3 , and experimental studies have demonstrated a causal r...

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Veröffentlicht in:	Nature (London) Jg. 572; H. 7770; S. 538 - 542
Hauptverfasser:	Wellenstein, Max D., Coffelt, Seth B., Duits, Danique E. M., van Miltenburg, Martine H., Slagter, Maarten, de Rink, Iris, Henneman, Linda, Kas, Sjors M., Prekovic, Stefan, Hau, Cheei-Sing, Vrijland, Kim, Drenth, Anne Paulien, de Korte-Grimmerink, Renske, Schut, Eva, van der Heijden, Ingrid, Zwart, Wilbert, Wessels, Lodewyk F. A., Schumacher, Ton N., Jonkers, Jos, de Visser, Karin E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.08.2019 Nature Publishing Group
Schlagworte:	13/106 13/109 13/31 13/51 13/89 38/91 45 45/22 45/41 45/90 631/250/580 631/67/1347 631/67/322 631/67/327 64/110 64/60 82/80 96/21 Analysis Animal models Animals Bioinformatics Bone marrow Breast cancer Breast Neoplasms - complications Breast Neoplasms - genetics Breast Neoplasms - pathology Causes of CRISPR Diagnosis Disease Models, Animal Female Gene expression Genetic aspects Genetic engineering Genomes Heterogeneity Humanities and Social Sciences IL-1β Inflammation Inflammation - complications Inflammation - genetics Inflammation - immunology Inflammation - pathology Influence Interleukin-1beta - immunology Interleukin-1beta - metabolism Letter Leukocytes (neutrophilic) Ligands Lymphocytes Macrophages Metastases Metastasis Mice multidisciplinary Mutation Neoplasm Metastasis - pathology Neutrophilia Neutrophils Neutrophils - immunology p53 Protein Principal components analysis Science Science (multidisciplinary) Tumor proteins Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics Tumors Wnt protein Wnt proteins Wnt Proteins - metabolism Netherlands
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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