SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

SARS-CoV-2 is thought to have emerged from bats, possibly via a secondary host. Here, we investigate the relationship of spike (S) glycoprotein from SARS-CoV-2 with the S protein of a closely related bat virus, RaTG13. We determined cryo-EM structures for RaTG13 S and for both furin-cleaved and uncl...

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Bibliographic Details
Published in:	Nature structural & molecular biology Vol. 27; no. 8; pp. 763 - 767
Main Authors:	Wrobel, Antoni G, Benton, Donald J, Xu, Pengqi, Roustan, Chloë, Martin, Stephen R, Rosenthal, Peter B, Skehel, John J, Gamblin, Steven J
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.08.2020
Subjects:	ACE2 Angiotensin-Converting Enzyme 2 Animals Betacoronavirus - genetics Betacoronavirus - metabolism Betacoronavirus - ultrastructure Binding Binding Sites Chiroptera - virology Cleavage Coronavirus Infections - virology COVID-19 Cryoelectron Microscopy Evolution, Molecular Furin Furin - chemistry Gene Expression Glycoproteins HEK293 Cells Host-Pathogen Interactions - genetics Humans Models, Molecular Pandemics Peptidyl-Dipeptidase A - chemistry Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - virology Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Stability Proteins Proteolysis Receptors Receptors, Virus - chemistry Receptors, Virus - genetics Receptors, Virus - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism Stability Structural Homology, Protein Viruses
ISSN:	1545-9993, 1545-9985, 1545-9985
Online Access:	Get full text
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