Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

Cytotoxic cancer therapy can induce accelerated growth of surviving cancer cells, a phenomenon known as tumor repopulation. This report uncovers a mechanism by which caspase 3 activation in treated cells promotes growth of surviving cells, mediated by iPLA 2 and PGE 2 . The level of caspase 3 activa...

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Veröffentlicht in:	Nature medicine Jg. 17; H. 7; S. 860 - 866
Hauptverfasser:	Huang, Qian, Li, Fang, Liu, Xinjian, Li, Wenrong, Shi, Wei, Liu, Fei-Fei, O'Sullivan, Brian, He, Zhimin, Peng, Yuanlin, Tan, Aik-Choon, Zhou, Ling, Shen, Jingping, Han, Gangwen, Wang, Xiao-Jing, Thorburn, Jackie, Thorburn, Andrew, Jimeno, Antonio, Raben, David, Bedford, Joel S, Li, Chuan-Yuan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.07.2011 Nature Publishing Group
Schlagworte:	631/67/1059/485 631/80/82/23 631/80/86 692/699/67 Animals Apoptosis Apoptosis - radiation effects Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Caspase 3 - metabolism Caspase 3 - physiology Cell Death - physiology Cell Death - radiation effects Cell Line, Tumor Cell Proliferation Cytotoxicity Dinoprostone - metabolism Dinoprostone - physiology Group VI Phospholipases A2 - metabolism Health aspects Humans Infectious Diseases Metabolic Diseases Mice Molecular Medicine Mortality Neoplasms, Experimental - radiotherapy Neurosciences Physiological aspects Prostaglandins E Radiation therapy Radiotherapy Repopulation Tumors United States
ISSN:	1078-8956, 1546-170X, 1546-170X
Online-Zugang:	Volltext
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