Replication stress and chromatin context link ATM activation to a role in DNA replication

ATM-mediated signaling in response to DNA damage is a barrier to tumorigenesis. Here we asked whether replication stress could also contribute to ATM signaling. We demonstrate that, in the absence of DNA damage, ATM responds to replication stress in a hypoxia-induced heterochromatin-like context. In...

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Bibliographische Detailangaben

Veröffentlicht in:	Molecular cell Jg. 52; H. 5; S. 758
Hauptverfasser:	Olcina, Monica M, Foskolou, Iosifina P, Anbalagan, Selvakumar, Senra, Joana M, Pires, Isabel M, Jiang, Yanyan, Ryan, Anderson J, Hammond, Ester M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 12.12.2013
Schlagworte:	Animals Ataxia Telangiectasia Mutated Proteins - genetics Cell Hypoxia - genetics Cell Line DNA Damage DNA Replication - genetics DNA-Binding Proteins - genetics HEK293 Cells Heterochromatin - genetics Histones - genetics Humans Mice NIH 3T3 Cells Nuclear Proteins - genetics Signal Transduction
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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