Bone marrow PMN-MDSCs and neutrophils are functionally similar in protection of multiple myeloma from chemotherapy

•Myeloid cells play a critical role in regulation of myeloma growth.•PMN-MDSCs and neutrophils equally protect myeloma cells from chemotherapy.•PMN-MDSCs and neutrophils mediate chemoprotective effect through soluble factors. Multiple myeloma (MM) is an incurable cancer of plasma cells localized pre...

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Bibliographic Details
Published in:	Cancer letters Vol. 371; no. 1; pp. 117 - 124
Main Authors:	Ramachandran, Indu R., Condamine, Thomas, Lin, Cindy, Herlihy, Sarah E., Garfall, Alfred, Vogl, Dan T., Gabrilovich, Dmitry I., Nefedova, Yulia
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01.02.2016 Elsevier Limited
Subjects:	Animals Antibiotics Antibiotics, Antineoplastic - pharmacology Antigens Antineoplastic Agents, Alkylating - pharmacology Apoptosis - drug effects Bone marrow Cancer Cell Line, Tumor Cell Lineage Chemoresistance Chemotherapy Coculture Techniques Colleges & universities Disease Models, Animal Doxorubicin - pharmacology Drug Resistance, Neoplasm Experiments Genotype & phenotype Growth factors Hematology, Oncology and Palliative Medicine Humans Immunotherapy Melphalan - pharmacology Mice, Inbred C57BL Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - metabolism Multiple Myeloma - pathology Myeloid Cells - drug effects Myeloid Cells - metabolism Myeloid Cells - pathology Myeloid-derived suppressor cells Neutrophils Neutrophils - drug effects Neutrophils - metabolism Neutrophils - pathology Paracrine Communication Phenotype Time Factors Tumor Cells, Cultured Tumor Microenvironment MM cDC MDSC MNC M-MDSC Myeloid-derived suppressor cells Chemoresistance Multiple myeloma Neutrophils BMS BM TME pDC PMN-MDSC MΦ IMC DC immature myeloid cells macrophages dendritic cells monocytic MDSC plasmacytoid DC multiple myeloma conventional DC bone marrow stroma bone marrow myeloid-derived suppressor cells polymorphonuclear MDSC mononuclear cell tumor microenvironment
ISSN:	0304-3835, 1872-7980, 1872-7980
Online Access:	Get full text
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