Melanoma cell–derived exosomes promote epithelial–mesenchymal transition in primary melanocytes through paracrine/autocrine signaling in the tumor microenvironment

•Melanoma cell–derived exosomes promote phenotype switching in primary melanocytes.•MAPK pathway and let-7i were involved in exosome-mediated EMT.•EMT-related miRNAs (miR-191and let-7a) in exosomes may be used for melanoma diagnosis.•Targeting exosome-mediated EMT may be an approach to prevent tumor...

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Bibliographic Details
Published in:	Cancer letters Vol. 376; no. 2; pp. 318 - 327
Main Authors:	Xiao, Deyi, Barry, Samantha, Kmetz, Daniel, Egger, Michael, Pan, Jianmin, Rai, Shesh N., Qu, Jifu, McMasters, Kelly M., Hao, Hongying
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01.07.2016 Elsevier Limited
Subjects:	Adult Aged Autocrine Communication Case-Control Studies Cell culture Cell Line, Tumor Colleges & universities Conflicts of interest Epithelial-Mesenchymal Transition Epithelial-to-mesenchymal transition Exosomes Exosomes - metabolism Female Hematology, Oncology and Palliative Medicine Humans Kinases Male Melanocytes - metabolism Melanocytes - pathology Melanoma Melanoma - genetics Melanoma - metabolism Melanoma - secondary Metastasis Microenvironment MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Mitogen-Activated Protein Kinases - metabolism Paracrine Communication Paracrine/autocrine Signal Transduction Skin cancer Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Transfection Tumor Microenvironment Tumor progression PBS Melanoma ROC HEMa-LP NHEM-c Microenvironment Exosomes MAPK MKK EMT AUC PI3K/AKT Epithelial-to-mesenchymal transition Paracrine/autocrine RT-PCR Tumor progression MKKK MAP PCR mitogen-activated protein kinase mitogen-activated protein phosphoinositide 3-kinase/protein kinase B receiver operating characteristic polymerase chain reaction human epidermal melanocytes adult-lightly pigmented normal human epidermal melanocytes mitogen-activated protein kinase kinase kinase area under ROC (receiver operating characteristic) curve phosphate buffered saline reverse transcription polymerase chain reaction mitogen-activated protein kinase kinase
ISSN:	0304-3835, 1872-7980, 1872-7980
Online Access:	Get full text
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