Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes

Type 1 diabetes (T1D) involves the interaction of multiple gene variants, environmental factors, and immunoregulatory dysfunction. Major T1D genetic risk loci encode HLA-DR and -DQ. Genetic heterogeneity and linkage disequilibrium in the highly polymorphic HLA region confound attempts to identify ad...

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Vydané v:	Diabetes (New York, N.Y.) Ročník 68; číslo 7; s. 1523
Hlavní autori:	Aydemir, Özkan, Noble, Janelle A, Bailey, Jeffrey A, Lernmark, Åke, Marsh, Patrick, Andersson Svärd, Agnes, Bearoff, Frank, Blankenhorn, Elizabeth P, Mordes, John P
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.07.2019
Predmet:	Alleles Case-Control Studies Diabetes Mellitus, Type 1 - genetics Female Gene Frequency Genetic Predisposition to Disease Genetic Variation Genotype HLA-DR alpha-Chains - genetics HLA-DR3 Antigen - genetics Homozygote Humans Introns Male Polymorphism, Single Nucleotide
ISSN:	1939-327X, 1939-327X
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