Recurrent SMARCA4 mutations in small cell carcinoma of the ovary

Douglas Levine and colleagues identify recurrent inactivating mutations in the SWI/SNF complex member SMARCA4 in 12 of 12 samples of small cell carcinoma of the ovary, hypercalcemic type. These findings open the door for the development of targeted therapies to treat this rare but deadly cancer. Sma...

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Veröffentlicht in:	Nature genetics Jg. 46; H. 5; S. 424 - 426
Hauptverfasser:	Jelinic, Petar, Mueller, Jennifer J, Olvera, Narciso, Dao, Fanny, Scott, Sasinya N, Shah, Ronak, Gao, JianJiong, Schultz, Nikolaus, Gonen, Mithat, Soslow, Robert A, Berger, Michael F, Levine, Douglas A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.05.2014 Nature Publishing Group
Schlagworte:	45/23 631/208/212/2166 82/51 Agriculture Amino acids Animal Genetics and Genomics Base Sequence Biomedicine brief-communication Cancer Research Cancer therapies Carcinoma, Small Cell - genetics Chromatin Assembly and Disassembly - genetics Computational Biology DNA binding proteins DNA Helicases - genetics DNA, Complementary - genetics Female Gene Components Gene expression Gene Function Gene mutations Genetic aspects Health aspects Human Genetics Humans Immunohistochemistry Medical research Molecular Sequence Data Mutation Mutation - genetics Nuclear Proteins - genetics Ovarian cancer Ovarian Neoplasms - genetics Protein expression Proteins Sequence Analysis, DNA Studies Transcription Factors - genetics Tumors
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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