Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes

Background Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB), a pathological infection with significant economic impact. Recent studies have highlighted the role of functional genomics to better understand the molecular mechanisms governing the host immune response to M. bovis...

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Bibliographic Details
Published in:	BMC genomics Vol. 12; no. 1; p. 611
Main Authors:	Killick, Kate E, Browne, John A, Park, Stephen DE, Magee, David A, Martin, Irene, Meade, Kieran G, Gordon, Stephen V, Gormley, Eamonn, O'Farrelly, Cliona, Hokamp, Karsten, MacHugh, David E
Format:	Journal Article
Language:	English
Published:	London BioMed Central 19.12.2011 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Agriculture Animal Genetics and Genomics Animals Biomedical and Life Sciences Biomedical research Care and treatment Cattle Cluster analysis College campuses Data processing Diagnosis DNA probes Economic impact Economics Editing Female Food Gene expression Gene Expression Profiling Genetic aspects Genetic transcription Genome Genomes Genomics Immune response Immune system Immunity, Innate - genetics Infection Leukocytes Leukocytes - microbiology Life Sciences Lymphocytes Microarrays Microbial Genetics and Genomics Molecular modelling Monocytes Mycobacterium Mycobacterium bovis Mycobacterium bovis - immunology Non-human and non-rodent vertebrate genomics Peripheral blood Plant Genetics and Genomics Proteomics Research Article Reverse Transcriptase Polymerase Chain Reaction Risk factors Studies Systems analysis Technological change Transcription Transcription, Genetic Tuberculosis Tuberculosis in cattle University colleges Veterinary medicine Ireland Bovine Genome Array Differentially Express Gene Single Intradermal Comparative Tuberculin Test Differentially Express Peripheral Blood Leukocyte
ISSN:	1471-2164, 1471-2164
Online Access:	Get full text
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