Onset and dose-related efficacy of house dust mite sublingual immunotherapy tablets in an environmental exposure chamber

The magnitude of effect of sublingual immunotherapy for house dust mite (HDM)–induced allergic rhinitis with or without conjunctivitis is uncertain, partly because there are few well-controlled trials with well-defined doses. We sought to determine the dose-related efficacy and onset of action of th...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 135; no. 6; pp. 1494 - 1501.e6
Main Authors:	Nolte, Hendrik, Maloney, Jennifer, Nelson, Harold S., Bernstein, David I., Lu, Susan, Li, Ziliang, Kaur, Amarjot, Zieglmayer, Petra, Zieglmayer, René, Lemell, Patrick, Horak, Friedrich
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.06.2015 Elsevier Limited
Subjects:	Adolescent Adult Allergen immunotherapy Allergens - administration & dosage Allergens - immunology allergic rhinoconjunctivitis Allergies Allergy and Immunology Animals Antigens, Dermatophagoides - administration & dosage Antigens, Dermatophagoides - immunology Asthma - complications Asthma - immunology Asthma - physiopathology Asthma - therapy Atmosphere Exposure Chambers Compliance Conjunctivitis - complications Conjunctivitis - immunology Conjunctivitis - physiopathology Conjunctivitis - therapy Dermatophagoides pteronyssinus Dermatophagoides pteronyssinus - chemistry Dermatophagoides pteronyssinus - immunology dose related dose response Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Drug dosages environmental exposure chamber Female house dust mite Humans Immunotherapy Male Middle Aged nasal symptoms ocular symptoms onset of action Pyroglyphidae - immunology Rhinitis, Allergic - complications Rhinitis, Allergic - immunology Rhinitis, Allergic - physiopathology Rhinitis, Allergic - therapy Studies Sublingual Immunotherapy sublingual immunotherapy tablet Tablets Time Factors Treatment Outcome allergic rhinoconjunctivitis VAS environmental exposure chamber HDM ocular symptoms DU dose response nasal symptoms dose related SCIT EEC SLIT house dust mite AE onset of action MID RQLQ(S)12 AR sublingual immunotherapy tablet AAR TSS VCC AR/C Allergen immunotherapy TOSS TNSS Vienna Challenge Chamber Developmental units Total symptom score Visual analog scale Total ocular symptom score Active anterior rhinomanometry Allergic rhinitis Rhinoconjunctivitis Quality of Life Questionnaire with Standardized Activities for subjects ≥12 years old Allergic rhinitis with or without conjunctivitis Adverse event Subcutaneous immunotherapy Sublingual immunotherapy Total nasal symptom score Minimally important difference
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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